Gene: RNF149

284996
DNAPTP2
ring finger protein 149
protein-coding
2q11.2
Ensembl:ENSG00000163162 Vega:OTTHUMG00000130685 UniprotKB:Q8NC42
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
6.244e-1 (AD)  7.259e-1 (ND)   (Frontal_Cortex)
3.035e-2 (AD)  7.594e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPN20.866
ADPGK0.846
CAPZA10.839
SLC15A40.839
TMEM430.835
CWC250.828
IFNGR20.815
DDX50.815
MAPK1IP1L0.814
NSMAF0.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.579
OR4F29-0.55
HES5-0.258
ARSF-0.173
REN-0.17
HPSE2-0.164
DIO2-0.16
PYGM-0.159
HPDL-0.157
DIAPH3-0.154

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RNF149 mRNA"19114083
C0261142-xylene2-xylene results in increased expression of RNF149 mRNA20359517
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RNF149 gene28458013
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RNF149 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RNF149 mRNA24449571
D001151ArsenicArsenic results in increased expression of RNF149 mRNA18039032
D001554BenzeneBenzene results in increased expression of RNF149 mRNA20359517
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of RNF149 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of RNF149 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of RNF149 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of RNF149 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of RNF149 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of RNF149 mRNA26496021
D002065BuspironeBuspirone results in increased expression of RNF149 mRNA24136188
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of RNF149 mRNA23650126
D002922CiguatoxinsCiguatoxins affects the expression of RNF149 mRNA18353800
D016572CyclosporineCyclosporine results in decreased expression of RNF149 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of RNF149 mRNA20106945
D004041Dietary FatsDietary Fats results in decreased expression of RNF149 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of RNF149 mRNA16002434
C004912ethylbenzeneethylbenzene results in increased expression of RNF149 mRNA20359517
D005485FlutamideFlutamide results in increased expression of RNF149 mRNA24136188
C056507gemcitabinegemcitabine results in increased expression of RNF149 mRNA17039268
D005839GentamicinsGentamicins results in increased expression of RNF149 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of RNF149 mRNA24136188
D006046GoldGold results in decreased expression of RNF149 mRNA25523186
D017313FenretinideFenretinide results in increased expression of RNF149 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RNF149 mRNA25613284
C045463leflunomideleflunomide results in increased expression of RNF149 mRNA24136188
D008752Methylene ChlorideMethylene Chloride results in increased expression of RNF149 mRNA20359517
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RNF149 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RNF149 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of RNF149 mRNA24136188
C012655nimesulidenimesulide results in increased expression of RNF149 mRNA24136188
D000073878Palm OilPalm Oil results in decreased expression of RNF149 mRNA18042831
D010634PhenobarbitalPhenobarbital affects the expression of RNF149 mRNA19159669
D010936Plant ExtractsPlant Extracts results in increased expression of RNF149 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of RNF149 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of RNF149 mRNA23012394|2301818
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of RNF149 mRNA26496021
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RNF149 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of RNF149 mRNA23557971|2776080
D014050TolueneToluene results in increased expression of RNF149 mRNA20359517
D014241TrichloroethyleneTrichloroethylene results in increased expression of RNF149 mRNA20359517
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RNF149 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IEA-  
GO:0031647regulation of protein stability-IEA-  
GO:0035690cellular response to drug-IEA-  
GO:0043409negative regulation of MAPK cascade-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29182452Exome Array Analysis of Nuclear Lens Opacity. (2018 Jun)Loomis SJOphthalmic Epidemiol