Gene: ANGPT2

285
AGPT2|ANG2
angiopoietin 2
protein-coding
8p23.1
Ensembl:ENSG00000091879 MIM:601922 Vega:OTTHUMG00000090365 UniprotKB:O15123
NG_029483.1
PubMed
2   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.436e-1 (AD)  2.469e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2442623chr8:6518817 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs3020213chr8:6512409 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STC10.83
CASP40.829
IL15RA0.822
PDLIM10.818
SHISA30.807
CLEC2B0.804
CD930.8
TEAD40.8
TM4SF10.794
TOR4A0.786

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLX1-0.552
NEUROD6-0.546
MARCH4-0.545
CRH-0.539
SLC7A4-0.538
GAD2-0.535
ZSCAN1-0.534
LRTM2-0.524
EXTL1-0.523
VWC2-0.52

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased expression of ANGPT2 mRNA"15313899
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ANGPT2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ANGPT2 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ANGPT2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ANGPT2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of ANGPT2 mRNA20458559
D016589AstemizoleAstemizole results in increased expression of ANGPT2 mRNA20221588
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of ANGPT2 mRNA16410222
C487081belinostatbelinostat results in decreased expression of ANGPT2 mRNA27188386
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ANGPT2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANGPT2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANGPT2 mRNA22228805|2261060
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ANGPT2 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ANGPT2 mRNA17404688
D004958EstradiolEstradiol affects the expression of ANGPT2 mRNA15598610
D004958Estradiol[letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT2 mRNA19620711
C006780bisphenol Abisphenol A results in increased expression of ANGPT2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of ANGPT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ANGPT2 gene28505145
D002104CadmiumCadmium results in decreased expression of ANGPT2 mRNA24376830
D002110CaffeineCaffeine results in increased expression of ANGPT2 mRNA26179615
D002211CapsaicinCapsaicin results in increased expression of ANGPT2 mRNA21310942
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ANGPT2 mRNA15135347
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ANGPT2 protein15135347
C018021cobaltous chloridecobaltous chloride results in decreased expression of ANGPT2 mRNA19320972
D003300CopperCopper results in decreased expression of ANGPT2 mRNA19747488
D019327Copper SulfateCopper Sulfate affects the expression of ANGPT2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of ANGPT2 mRNA26577399
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen results in increased expression of ANGPT2 mRNA]25203536
D003630DaunorubicinDaunorubicin results in increased expression of ANGPT2 mRNA16626513
D003630DaunorubicinDaunorubicin results in increased expression of ANGPT2 protein16626513
C014347decitabinedecitabine results in increased expression of ANGPT2 mRNA21856257
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of ANGPT2 mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ANGPT2 mRNA17034775
D004052DiethylnitrosaminePlant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPT2 mRNA]17034775
D002117CalcitriolCalcitriol results in increased expression of ANGPT2 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ANGPT2 mRNA21592394
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of ANGPT2 mRNA26924002
C007517diphenyleneiodoniumdiphenyleneiodonium promotes the reaction [Oxygen deficiency results in increased expression of ANGPT2 mRNA]10854229
C007517diphenyleneiodoniumdiphenyleneiodonium results in increased expression of ANGPT2 mRNA10854229
C031291diphenyliodoniumdiphenyliodonium results in increased expression of ANGPT2 mRNA10854229
D004656EnalaprilEnalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA]19958114
D005472FluorouracilANGPT2 protein promotes the reaction [Fluorouracil results in decreased expression of IFNA1 protein]17786339
D005472FluorouracilFluorouracil results in decreased expression of ANGPT2 protein17786339
D005665FurosemideFurosemide affects the expression of ANGPT2 mRNA16526316
D017313FenretinideFenretinide results in increased expression of ANGPT2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ANGPT2 mRNA26339600
D016285IloprostIloprost results in increased expression of ANGPT2 mRNA16373414
D016285Iloprosttyrphostin AG 1478 inhibits the reaction [Iloprost results in increased expression of ANGPT2 mRNA]16373414
D007213IndomethacinIndomethacin results in decreased expression of ANGPT2 mRNA25972201
D007545IsoproterenolIsoproterenol results in increased expression of ANGPT2 mRNA22908232
C067431letrozole[letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT2 mRNA19620711
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ANGPT2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ANGPT2 mRNA26378955
D008345ManganeseManganese results in decreased expression of ANGPT2 mRNA26745496
C025340manganese chloridemanganese chloride results in decreased expression of ANGPT2 mRNA26745496
D015122MercaptopurineMercaptopurine results in increased expression of ANGPT2 mRNA23358152
D008694MethamphetamineMethamphetamine results in increased expression of ANGPT2 mRNA25290377
D008727MethotrexateMethotrexate results in increased expression of ANGPT2 protein21819747
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ANGPT2 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ANGPT2 mRNA28001369
C059539midostaurinmidostaurin results in increased expression of ANGPT2 mRNA20980353
D015735MifepristoneMifepristone results in decreased expression of ANGPT2 mRNA25972201
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ANGPT2 mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ANGPT2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ANGPT2 mRNA"25554681
D009525NiacinNiacin results in decreased expression of ANGPT2 mRNA17557352
D009532NickelNickel results in increased expression of ANGPT2 mRNA24768652|2558310
C069741norcantharidinnorcantharidin results in decreased expression of ANGPT2 mRNA16681930
C069741norcantharidinnorcantharidin results in decreased expression of ANGPT2 protein16681930
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ANGPT2 mRNA25729387
D010100Oxygendiphenyleneiodonium promotes the reaction [Oxygen deficiency results in increased expression of ANGPT2 mRNA]10854229
D010100OxygenOxygen deficiency results in increased expression of ANGPT2 mRNA10854229
D010100OxygenOxygen deficiency results in increased expression of ANGPT2 mRNA10854229
D010100Oxygencyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen results in increased expression of ANGPT2 mRNA]25203536
D010100OxygenOxygen results in increased expression of ANGPT2 mRNA25203536
D010100OxygenOxygen deficiency results in increased expression of ANGPT2 mRNA10854229
C010272palytoxinpalytoxin results in increased expression of ANGPT2 mRNA26436198
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ANGPT2 mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of ANGPT2 mRNA17987463
C073402PD 123319PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]14638905
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ANGPT2 mRNA26272509
C060836pioglitazone[ANGPT2 protein binds to and results in increased activity of AGTR2 protein] promotes the reaction [pioglitazone binds to and results in increased activity of PPARG protein]15992368
C006253pirinixic acidpirinixic acid results in increased expression of ANGPT2 mRNA23811191
D010936Plant ExtractsPlant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPT2 mRNA]17034775
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ANGPT2 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ANGPT2 mRNA17404688
D015237DinoprostDinoprost results in increased expression of ANGPT2 mRNA20484870
D019821SimvastatinSimvastatin inhibits the reaction [Streptozocin results in increased expression of ANGPT2 protein]20821229
D013311StreptozocinEnalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA]19958114
D013311StreptozocinSimvastatin inhibits the reaction [Streptozocin results in increased expression of ANGPT2 protein]20821229
D013311StreptozocinStreptozocin results in increased expression of ANGPT2 mRNA15643138|1995811
D013311StreptozocinStreptozocin results in increased expression of ANGPT2 protein15643138|2082122
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ANGPT2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ANGPT2 mRNA26378955
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ANGPT2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ANGPT2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANGPT2 mRNA21570461
C020809tetrathiomolybdatetetrathiomolybdate analog results in increased expression of ANGPT2 mRNA19323979
D013792ThalidomideThalidomide affects the expression of ANGPT2 mRNA15939924
C009495titanium dioxidetitanium dioxide results in decreased expression of ANGPT2 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of ANGPT2 mRNA23557971
D014050TolueneToluene results in increased expression of ANGPT2 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ANGPT2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ANGPT2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of ANGPT2 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of ANGPT2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of ANGPT2 protein18922099
D014212TretinoinTretinoin results in increased secretion of ANGPT2 protein17170094
D014241TrichloroethyleneTrichloroethylene results in increased expression of ANGPT2 mRNA28973375
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ANGPT2 mRNA26272509
D014303TrinitrotolueneTrinitrotoluene affects the expression of ANGPT2 mRNA21346803
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ANGPT2 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of ANGPT2 mRNA17569031
C057693troglitazone[Urethane co-treated with troglitazone] results in increased expression of ANGPT2 mRNA18465119
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Iloprost results in increased expression of ANGPT2 mRNA]16373414
D014520Urethane[Urethane co-treated with troglitazone] results in increased expression of ANGPT2 mRNA18465119
D014635Valproic AcidValproic Acid affects the expression of ANGPT2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ANGPT2 mRNA24383497
D014635Valproic AcidValproic Acid results in increased methylation of ANGPT2 gene29154799
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]14638905
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ANGPT2 mRNA17987463
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANGPT2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of ANGPT2 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS9204896  10766762  
GO:0005515protein binding-IPI20708158  
GO:0030971receptor tyrosine kinase binding-IPI19922791  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0007165signal transduction-TAS10766762  
GO:0007281germ cell development-IEA-  
GO:0009314response to radiation-IEA-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0009749response to glucose-IEA-  
GO:0010812negative regulation of cell-substrate adhesion-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0014823response to activity-IEA-  
GO:0016525negative regulation of angiogenesis-IEA-  
GO:0031100animal organ regeneration-IEA-  
GO:0043537negative regulation of blood vessel endothelial cell migration-IDA9660821  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0048014Tie signaling pathway-IDA19922791  
GO:0050900leukocyte migration-TAS-  
GO:0050928negative regulation of positive chemotaxis-IDA9660821  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0072012glomerulus vasculature development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA9660821  
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0042995cell projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-210993Tie2 SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15694966An Angiopoietin-2 gene polymorphism in unexplained intrauterine fetal death: a multi-center study. (2005 Feb)Huber AJ Reprod Immunol