Gene: EPHA6

285220
EHK-2|EHK2|EK12|EPA6|HEK12|PRO57066
EPH receptor A6
protein-coding
3q11.2
Ensembl:ENSG00000080224 MIM:600066 Vega:OTTHUMG00000159208 UniprotKB:Q9UF33
NC_000003.12
PubMed|SNP Mapped
4   ANCO-SNPs
CD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.291e-1 (AD)  5.268e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6439361chr3:97753712 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6795420chr3:97496739 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1379842chr3:97482906 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1598915chr3:97386708 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNG30.759
EFR3B0.746
GNAL0.727
NYAP20.716
HS6ST30.716
MED12L0.71
CNGB10.709
SLC9A70.705
FAM163A0.701
TMEM200A0.699

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG8-0.492
TGFB3-0.467
CTNNA3-0.444
BCAS1-0.436
KIF19-0.425
ZFP57-0.425
FAM107B-0.423
MYOT-0.421
MOBP-0.42
RTKN-0.419

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA6 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of EPHA6 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EPHA6 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of EPHA6 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of EPHA6 mRNA25979313
D003300CopperCopper deficiency results in increased expression of EPHA6 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of EPHA6 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of EPHA6 mRNA26577399
D019422Dietary SucroseDietary Sucrose results in increased expression of EPHA6 mRNA26033743
D000431EthanolEthanol results in decreased expression of EPHA6 mRNA29018328
D019833GenisteinGenistein results in decreased expression of EPHA6 mRNA21810550
D007213IndomethacinIndomethacin results in increased expression of EPHA6 mRNA28201806
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of EPHA6 mRNA12057914
C011272perfosfamideperfosfamide results in decreased expression of EPHA6 mRNA19429390
D011374ProgesteroneProgesterone results in decreased expression of EPHA6 mRNA21770760
D011441PropylthiouracilPropylthiouracil results in decreased expression of EPHA6 mRNA24780913
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of EPHA6 gene26756918
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA6 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of EPHA6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EPHA6 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of EPHA6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005003ephrin receptor activity-IEA-  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IBA21873635  
GO:0008150biological_process-ND-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26384852Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. (2015 Nov)Levran OCNS Neurosci Ther
29208002EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population. (2017 Dec 6)Kim MLipids Health Dis