Gene: HTR3E

285242
5-HT3-E|5-HT3E|5-HT3c1
5-hydroxytryptamine receptor 3E
protein-coding
3q27.1
Ensembl:ENSG00000186038 MIM:610123 Vega:OTTHUMG00000156857 UniprotKB:A5X5Y0
NG_012452.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.418e-1 (AD)  9.114e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAS2R410.571
CD1B0.571
OR2M70.571
FAM71C0.563
POU5F20.563
PRDM140.554
OPRM10.549
OR2M50.549
MTRNR2L50.545
OR56A30.541

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLYATL2-0.237
KRT17-0.211
TMC1-0.21
SLC28A2-0.207
TNFRSF13B-0.194
ACTRT2-0.191
TBX5-0.19
TSPAN8-0.184
MMP7-0.181
HSD17B3-0.179

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
ID Drug Name Action PubMed
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of HTR3E gene25435355
D010936Plant ExtractsPlant Extracts results in decreased expression of HTR3E mRNA23557933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0022850serotonin-gated cation-selective channel activity-IDA17392525  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007210serotonin receptor signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22933845Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)Herman AISubst Abuse Rehabil