Gene: COX18

285521
COX18HS
COX18, cytochrome c oxidase assembly factor
protein-coding
4q13.3
Ensembl:ENSG00000163626 MIM:610428 Vega:OTTHUMG00000129917 UniprotKB:Q8N8Q8
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.511e-1 (AD)  6.427e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4694155chr4:73065809 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAF9B0.901
NUP1330.89
CDC230.888
TATDN30.879
APH1B0.874
CLIP40.873
ACADSB0.872
ORC30.87
COX150.87
NHLRC30.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.588
OR4F29-0.528
MTRNR2L6-0.358
MTRNR2L9-0.334
MTRNR2L10-0.33
TTLL10-0.282
MTRNR2L2-0.273
MTRNR2L8-0.266
MMP23B-0.261
RNF223-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of COX18 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of COX18 gene27153756
D001280AtrazineAtrazine results in increased expression of COX18 mRNA26518232
C006780bisphenol Abisphenol A results in increased expression of COX18 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of COX18 mRNA26079696
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of COX18 mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of COX18 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of COX18 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of COX18 mRNA21266533
D005485FlutamideFlutamide results in increased expression of COX18 mRNA17702527
D005485FlutamideFlutamide results in increased expression of COX18 mRNA24136188|2479361
D005557FormaldehydeFormaldehyde results in decreased expression of COX18 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of COX18 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of COX18 mRNA"25554681
D010416PentachlorophenolPentachlorophenol results in increased expression of COX18 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of COX18 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of COX18 mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of COX18 mRNA23012394
D012999SomanSoman results in increased expression of COX18 mRNA19281266
D014520UrethaneUrethane results in decreased expression of COX18 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of COX18 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of COX18 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased expression of COX18 mRNA29078374
D001335Vehicle EmissionsVehicle Emissions results in increased expression of COX18 mRNA29078374

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI28330871  
GO:0008565protein transporter activity-IGI16911509  
GO:0032977membrane insertase activity-IDA28330871  
GO ID GO Term Qualifier Evidence PubMed
GO:0008535respiratory chain complex IV assembly-IGI16911509  
GO:0015031protein transport-IEA-  
GO:0032979protein insertion into mitochondrial membrane from inner side-IDA28330871  
GO:0033617mitochondrial respiratory chain complex IV assembly-IMP28330871  
GO:0051204protein insertion into mitochondrial membrane-IGI16911509  
GO ID GO Term Qualifier Evidence PubMed
GO:0031305integral component of mitochondrial inner membrane-IDA16212937  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal