Gene: DTWD2

285605
-
DTW domain containing 2
protein-coding
5q23.1
Ensembl:ENSG00000169570 Vega:OTTHUMG00000162956 UniprotKB:Q8NBA8
NC_000005.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.490e-1 (AD)  5.661e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPIP5K20.852
TBC1D320.848
DOPEY10.845
FKTN0.845
ICA1L0.843
MYSM10.835
WDR170.835
TRAPPC110.834
TRPC10.831
SLC25A160.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.428
CCDC102A-0.373
SPINK8-0.364
OR4F5-0.355
HSPB1-0.348
C7orf61-0.343
RAB13-0.343
MTRNR2L10-0.341
PGF-0.334
MTRNR2L9-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in increased expression of DTWD2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DTWD2 mRNA27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DTWD2 mRNA19770486
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA24657404
C006780bisphenol Abisphenol A results in decreased expression of DTWD2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DTWD2 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of DTWD2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of DTWD2 mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of DTWD2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of DTWD2 mRNA25562108
D004026DieldrinDieldrin results in increased expression of DTWD2 mRNA23041725
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DTWD2 mRNA22079256
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DTWD2 mRNA21179406
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of DTWD2 mRNA19376150
C492448ICG 001ICG 001 results in increased expression of DTWD2 mRNA26191083
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DTWD2 mRNA25729387
C046012pentanalpentanal results in decreased expression of DTWD2 mRNA26079696
D010795Phthalic AcidsPhthalic Acids results in increased expression of DTWD2 mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DTWD2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DTWD2 mRNA22079256
D012839SimazineSimazine results in increased expression of DTWD2 mRNA22984576
C009495titanium dioxidetitanium dioxide results in increased expression of DTWD2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DTWD2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DTWD2 mRNA25729387
D014520UrethaneUrethane results in decreased expression of DTWD2 mRNA28818685
C025643vinclozolinvinclozolin results in increased methylation of DTWD2 promoter22570695
C088658zoledronic acidzoledronic acid results in decreased expression of DTWD2 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23953852Genome-wide association studies of maximum number of drinks. (2013 Nov)Pan YJ Psychiatr Res