Gene: DCBLD1

285761
dJ94G16.1
discoidin, CUB and LCCL domain containing 1
protein-coding
6q22.1
Ensembl:ENSG00000164465 Vega:OTTHUMG00000015455 UniprotKB:Q8N8Z6
NC_000006.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.126e-1 (AD)  2.103e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11412288chr6:117802725DCBLD1Promoter4.541e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF30.911
LRFN50.909
SATB20.906
SRPK10.905
NLK0.905
PTPRK0.903
EPHA40.902
PREP0.901
PIP4K2C0.899
ZNF3650.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.48
HEY2-0.475
ACAP1-0.455
MYOM1-0.446
MDFI-0.444
BCL7C-0.441
EVA1A-0.44
MBNL3-0.437
YES1-0.432
SH2D1A-0.431

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DCBLD1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of DCBLD1 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of DCBLD1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DCBLD1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DCBLD1 mRNA22100608
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of DCBLD1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of DCBLD1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of DCBLD1 mRNA25270620
C006780bisphenol Abisphenol A affects the expression of DCBLD1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of DCBLD1 mRNA26496021
D019327Copper SulfateCopper Sulfate results in increased expression of DCBLD1 mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DCBLD1 mRNA27392435
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DCBLD1 mRNA22079256
D005485FlutamideFlutamide results in decreased expression of DCBLD1 mRNA24793618
D017313FenretinideFenretinide results in increased expression of DCBLD1 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DCBLD1 protein18951874
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DCBLD1 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DCBLD1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DCBLD1 mRNA26011545
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of DCBLD1 mRNA23602845
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of DCBLD1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of DCBLD1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DCBLD1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DCBLD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DCBLD1 mRNA22079256|2271453
C010327salinomycinsalinomycin results in decreased expression of DCBLD1 mRNA19682730
C009277sodium arsenatesodium arsenate results in increased expression of DCBLD1 mRNA23922661
D012969Sodium FluorideSodium Fluoride results in increased expression of DCBLD1 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DCBLD1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DCBLD1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of DCBLD1 mRNA25975270
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DCBLD1 protein18951874
C009495titanium dioxidetitanium dioxide results in increased expression of DCBLD1 mRNA23557971
D014212TretinoinTretinoin results in increased expression of DCBLD1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of DCBLD1 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of DCBLD1 mRNA28973697
D014520UrethaneUrethane results in increased expression of DCBLD1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCBLD1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of DCBLD1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of DCBLD1 mRNA17292431|1796380

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26689248Polymorphism of rs9387478 correlates with overall survival in female nonsmoking patients with lung cancer. (2016 May 28)Han JFInt J Biol Markers
28025329Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. (2017 Jan 15)Seow WJHum Mol Genet