Gene: CNPY1

285888
-
canopy FGF signaling regulator 1
protein-coding
7q36.3
Ensembl:ENSG00000146910 MIM:612493 Vega:OTTHUMG00000151353 UniprotKB:Q3B7I2
NC_000007.14
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.750e-1 (AD)  7.515e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6459707chr7:155512409 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs6971850chr7:155511477 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDK40.609
CREB3L40.607
BAZ2B0.606
DNAH120.597
ARHGAP190.588
CCDC150.582
FAM227B0.58
CTPS20.575
SFT2D20.573
AP3B10.57

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELFN1-0.441
PHOSPHO1-0.418
RHO-0.412
OPRD1-0.407
ADRA1D-0.401
NPAS1-0.39
VGF-0.39
WNT7A-0.382
SBK1-0.382
PRTN3-0.378

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CNPY1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CNPY1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CNPY1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CNPY1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CNPY1 mRNA"25510870
C006780bisphenol Abisphenol A affects the expression of CNPY1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CNPY1 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CNPY1 mRNA25979313
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CNPY1 mRNA28472532
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CNPY1 mRNA]27941970
D004147DioxinsDioxins affects the expression of CNPY1 mRNA20463971
D007213IndomethacinIndomethacin results in increased expression of CNPY1 mRNA28201806
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CNPY1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CNPY1 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CNPY1 mRNA"25510870
D010578PetroleumPetroleum affects the expression of CNPY1 mRNA25208076
D012969Sodium FluorideSodium Fluoride results in increased expression of CNPY1 mRNA27862939
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CNPY1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CNPY1 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of CNPY1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of CNPY1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of CNPY1 mRNA24896083
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of CNPY1 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007167enzyme linked receptor protein signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal