Gene: ANK1

286
ANK|SPH1|SPH2
ankyrin 1
protein-coding
8p11.21
Ensembl:ENSG00000029534 MIM:612641 Vega:OTTHUMG00000150281 UniprotKB:P16157
NG_012820.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.173e-1 (AD)  3.395e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22746182chr8:41749867ANK1Gene body1.770e-5Alcohol use disorders26763658
cg12634208chr8:41570802ANK16.300e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM151B0.908
GRIP20.904
KCNAB30.895
INPP5J0.894
N4BP30.888
KCNC20.886
KCNQ40.886
KCNC10.883
DIRAS10.881
CDH220.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.57
SGMS2-0.563
SFT2D2-0.562
WWTR1-0.55
ACTL6A-0.54
BAZ1A-0.538
SNHG18-0.536
AGTRAP-0.532
TGIF1-0.529
CPM-0.527

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANK1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ANK1 mRNA"27291303
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANK1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANK1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANK1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANK1 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ANK1 mRNA25064622
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ANK1 gene27153756
D000638AmiodaroneAmiodarone affects the expression of ANK1 mRNA25064622
D001151ArsenicArsenic affects the methylation of ANK1 gene25304211
C547126AZM551248AZM551248 results in decreased expression of ANK1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANK1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ANK1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANK1 mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of ANK1 mRNA20068009
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of ANK1 mRNA25270620
C006780bisphenol Abisphenol A results in decreased expression of ANK1 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of ANK1 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of ANK1 mRNA26272509
D002746ChlorpromazineChlorpromazine affects the expression of ANK1 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of ANK1 mRNA25064622
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ANK1 mRNA23640034
D003907DexamethasoneDexamethasone results in decreased expression of ANK1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ANK1 mRNA]20032058
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ANK1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ANK1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of ANK1 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of ANK1 mRNA23041725
D002117CalcitriolCalcitriol results in increased expression of ANK1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ANK1 mRNA21592394
D004317DoxorubicinDoxorubicin results in increased expression of ANK1 mRNA28940058
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ANK1 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ANK1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ANK1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANK1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ANK1 mRNA23649840
D019833GenisteinGenistein results in decreased expression of ANK1 mRNA16705744
D019833GenisteinGenistein results in increased methylation of ANK1 gene28505145
D005839GentamicinsGentamicins results in decreased expression of ANK1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of ANK1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ANK1 mRNA27392435
D007854LeadLead affects the expression of ANK1 mRNA28903495
C042720mercuric bromidemercuric bromide results in increased expression of ANK1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
D008628MercuryMercury results in decreased expression of ANK1 mRNA19937285
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ANK1 protein25809596
C523184mocetinostatmocetinostat results in decreased expression of ANK1 mRNA27255383
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of ANK1 mRNA22401849
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ANK1 mRNA19812364
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ANK1 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ANK1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ANK1 mRNA25729387
C030110oxaliplatin[Topotecan co-treated with oxaliplatin] results in decreased expression of ANK1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of ANK1 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of ANK1 mRNA]22629407
D010269ParaquatParaquat affects the expression of ANK1 mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANK1 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ANK1 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ANK1 mRNA27935865
D011441PropylthiouracilPropylthiouracil results in decreased expression of ANK1 mRNA24780913
C009277sodium arsenatesodium arsenate results in increased expression of ANK1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of ANK1 gene28589171
D053260SootSoot results in increased expression of ANK1 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of ANK1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ANK1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ANK1 mRNA21592394
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ANK1 mRNA]20032058
C004648testosterone enanthatetestosterone enanthate affects the expression of ANK1 mRNA17440010
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANK1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANK1 mRNA28213091
D013752TetracyclineTetracycline affects the expression of ANK1 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of ANK1 mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased expression of ANK1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ANK1 mRNA25729387
D019772Topotecan[Topotecan co-treated with oxaliplatin] results in decreased expression of ANK1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ANK1 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of ANK1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of ANK1 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of ANK1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ANK1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ANK1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-NAS9430667  
GO:0005200structural constituent of cytoskeleton-TAS8640229  
GO:0005515protein binding-IPI379653  12527750  12719424  16580865  16962094  
GO:0008093cytoskeletal adaptor activity-IDA379653  
GO:0008093cytoskeletal adaptor activity-TAS11427698  
GO:0019899enzyme binding-IPI21177872  
GO:0019899enzyme binding-TAS11427698  
GO:0030507spectrin binding-IDA379653  
GO:0030507spectrin binding-IPI8159688  
GO:0030507spectrin binding-NAS8640229  
GO:0044325ion channel binding-IBA21873635  
GO:0051117ATPase binding-IPI8159688  
GO ID GO Term Qualifier Evidence PubMed
GO:0006887exocytosis-NAS1833445  
GO:0006888ER to Golgi vesicle-mediated transport-IDA18768923  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007010cytoskeleton organization-NAS9430667  
GO:0007165signal transduction-IEA-  
GO:0010638positive regulation of organelle organization-IEA-  
GO:0045199maintenance of epithelial cell apical/basal polarity-TAS11427698  
GO:0050808synapse organization-IBA21873635  
GO:0072659protein localization to plasma membrane-IBA21873635  
GO:0072659protein localization to plasma membrane-IMP18768923  
GO:0099612protein localization to axon-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-NAS1833445  
GO:0005886plasma membrane-IDA379653  
GO:0005886plasma membrane-NAS9430667  
GO:0014704intercalated disc-IBA21873635  
GO:0014731spectrin-associated cytoskeleton-IDA379653  
GO:0016020membrane-IBA21873635  
GO:0016323basolateral plasma membrane-NAS12409278  
GO:0016529sarcoplasmic reticulum-IEA-  
GO:0030018Z disc-IEA-  
GO:0030673axolemma-IEA-  
GO:0031430M band-IEA-  
GO:0033268node of Ranvier-IBA21873635  
GO:0033270paranode region of axon-IBA21873635  
GO:0042383sarcolemma-IEA-  
GO:0043194axon initial segment-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-373760L1CAM interactionsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-445095Interaction between L1 and AnkyrinsTAS
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-447038NrCAM interactionsIEA
R-HSA-447041CHL1 interactionsIEA
R-HSA-447043Neurofascin interactionsIEA
R-HSA-447043Neurofascin interactionsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28965852ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status. (2017 Dec 1)Tessema MCancer Lett