Gene: NSMCE2

286053
C8orf36|MMS21|NSE2|ZMIZ7
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
protein-coding
8q24.13
Ensembl:ENSG00000156831 MIM:617246 Vega:OTTHUMG00000164993 UniprotKB:Q96MF7
NG_053069.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.578e-2 (AD)  5.516e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7008482chr8:125255388 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMA10.887
GNL30.879
PSMA40.877
ACBD60.874
GGNBP20.873
PSMC60.869
PPHLN10.868
PMPCB0.867
PSMC20.865
OSTF10.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.543
OR4F29-0.509
ADAMTSL5-0.307
KCNK5-0.288
EYA2-0.284
PLA2G5-0.281
SALL3-0.281
NWD1-0.278
WDR38-0.27
SYPL2-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of NSMCE2 mRNA"20406850
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NSMCE2 mRNA]18700144
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NSMCE2 mRNA22100608
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NSMCE2 mRNA20064835|2623829
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of NSMCE2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NSMCE2 mRNA22228805
C006780bisphenol Abisphenol A results in increased methylation of NSMCE2 gene28505145
D003471CuprizoneCuprizone affects the expression of NSMCE2 mRNA27523638
D003471CuprizoneCuprizone results in decreased expression of NSMCE2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of NSMCE2 mRNA20106945
D002945CisplatinCisplatin results in increased expression of NSMCE2 mRNA19561079
C000944dicrotophosdicrotophos results in decreased expression of NSMCE2 mRNA28302478
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of NSMCE2 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NSMCE2 mRNA22079256
D018120FinasterideFinasteride results in increased expression of NSMCE2 mRNA24136188
D005485FlutamideFlutamide results in increased expression of NSMCE2 mRNA24136188
D007213IndomethacinIndomethacin results in increased expression of NSMCE2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NSMCE2 mRNA25613284
D007649KetamineKetamine results in decreased expression of NSMCE2 mRNA20080153
D048628KetolidesKetolides analog results in increased expression of NSMCE2 mRNA24967691
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NSMCE2 mRNA"25554681|2562005
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NSMCE2 mRNA25729387
C410127PCB 180PCB 180 results in increased expression of NSMCE2 mRNA23829299
C006253pirinixic acidpirinixic acid results in decreased expression of NSMCE2 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of NSMCE2 mRNA]21318169
D010936Plant ExtractsPlant Extracts results in increased expression of NSMCE2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NSMCE2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NSMCE2 mRNA22079256
D012834SilverSilver results in decreased expression of NSMCE2 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NSMCE2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NSMCE2 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NSMCE2 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NSMCE2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NSMCE2 gene27618143
D014520UrethaneUrethane results in increased expression of NSMCE2 mRNA28818685
C025643vinclozolinvinclozolin results in increased expression of NSMCE2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18086888  25416956  26496610  
GO:0008270zinc ion binding-IEA-  
GO:0019789SUMO transferase activity-EXP16055714  16810316  22751501  
GO:0019789SUMO transferase activity-IDA17589526  
GO ID GO Term Qualifier Evidence PubMed
GO:0000722telomere maintenance via recombination-IMP17589526  
GO:0000724double-strand break repair via homologous recombination-IMP16810316  
GO:0006303double-strand break repair via nonhomologous end joiningNOTIMP16810316  
GO:0007049cell cycle-IEA-  
GO:0016925protein sumoylation-IEA-  
GO:0034184positive regulation of maintenance of mitotic sister chromatid cohesion-IMP19502785  
GO:0045842positive regulation of mitotic metaphase/anaphase transition-IMP19502785  
GO:0051301cell division-IEA-  
GO:0090398cellular senescence-IMP17589526  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IDA17589526  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0016604nuclear body-IDA-  
GO:0016605PML body-IDA17589526  
GO:0030915Smc5-Smc6 complex-IDA18086888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal