Gene: SCARA5

286133
NET33|Tesr
scavenger receptor class A member 5
protein-coding
8p21.1
Ensembl:ENSG00000168079 MIM:611306 Vega:OTTHUMG00000132172 UniprotKB:Q6ZMJ2
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.649e-2 (AD)  3.882e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANO10.749
BMP50.745
TNFRSF190.698
TEX410.695
LGI20.689
GADL10.674
SLC47A10.672
BMX0.672
DSG20.658
IRF60.657

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.475
KLF15-0.451
IZUMO4-0.449
PLIN4-0.44
ALDH4A1-0.439
SDC4-0.439
PLIN5-0.433
CYP2J2-0.431
SLC6A11-0.43
ABHD1-0.429

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SCARA5 mRNA"28903501
C0072971,6-diaminohexane"SCARA5 gene modified form results in increased abundance of 1,6-diaminohexane"25445006
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SCARA5 mRNA19933214
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SCARA5 mRNA25088246
C496492abrineabrine results in increased expression of SCARA5 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of SCARA5 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SCARA5 mRNA17562736
D020106AcrylamideAcrylamide affects the expression of SCARA5 mRNA28959563
D001151ArsenicArsenic affects the methylation of SCARA5 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCARA5 mRNA19770486|2261060
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SCARA5 mRNA27195522
D004958EstradiolEstradiol results in decreased expression of SCARA5 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of SCARA5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SCARA5 gene28505145
D002737ChloropreneChloroprene results in increased expression of SCARA5 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCARA5 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of SCARA5 mRNA18353800
D016572CyclosporineCyclosporine results in increased expression of SCARA5 mRNA25270620
C014347decitabinedecitabine affects the expression of SCARA5 mRNA23300844
C007262deoxynivalenoldeoxynivalenol results in decreased expression of SCARA5 mRNA26763390
D003907DexamethasoneDexamethasone results in increased expression of SCARA5 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SCARA5 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of SCARA5 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SCARA5 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SCARA5 mRNA28962523
D002945CisplatinCisplatin affects the expression of SCARA5 mRNA23300844
D004008DiclofenacDiclofenac results in increased expression of SCARA5 mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of SCARA5 mRNA19680557
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SCARA5 mRNA24535843
D004237DiuronDiuron results in decreased expression of SCARA5 mRNA25152437
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCARA5 mRNA20938992
C039281furanfuran results in decreased expression of SCARA5 mRNA25539665
C039281furanfuran results in increased expression of SCARA5 mRNA27387713
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SCARA5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SCARA5 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of SCARA5 mRNA20003209
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SCARA5 mRNA27339419
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCARA5 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SCARA5 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SCARA5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SCARA5 mRNA"25620056
D000073878Palm OilPalm Oil affects the expression of SCARA5 mRNA19680557
C016030pantogabpantogab results in increased expression of SCARA5 mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased expression of SCARA5 mRNA22178795
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SCARA5 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of SCARA5 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of SCARA5 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SCARA5 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SCARA5 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SCARA5 mRNA28903501
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SCARA5 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of SCARA5 mRNA23221170
C013698tallowtallow affects the expression of SCARA5 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of SCARA5 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCARA5 mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of SCARA5 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCARA5 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCARA5 mRNA19933214
C009495titanium dioxidetitanium dioxide results in decreased expression of SCARA5 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SCARA5 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of SCARA5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SCARA5 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SCARA5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005044scavenger receptor activity-IEA-  
GO:0070287ferritin receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006879cellular iron ion homeostasis-ISS-  
GO:0006897endocytosis-ISS-  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0034605cellular response to heat-IEA-  
GO:0034755iron ion transmembrane transport-ISS-  
GO:0070207protein homotrimerization-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-ISS-  
GO:0009986cell surface-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsIEA
R-HSA-3000480Scavenging by Class A ReceptorsIEA
R-HSA-5653656Vesicle-mediated transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25828346Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. (2015)Hermanns MIInt J Cardiol