Gene: SCAI

286205
C9orf126|NET40
suppressor of cancer cell invasion
protein-coding
9q33.3
Ensembl:ENSG00000173611 Vega:OTTHUMG00000020667 UniprotKB:Q8N9R8
NG_016620.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.895e-1 (AD)  7.798e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRXN30.964
PLCB10.961
OLFM30.96
SCN2A0.959
C11orf870.957
HCN10.956
GPR1580.956
FRMPD40.956
FAXC0.955
MYT1L0.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.602
RAB13-0.584
MYL3-0.569
RNF135-0.564
HEY2-0.557
CHST14-0.55
COPZ2-0.549
ROM1-0.548
EMP3-0.537
YES1-0.535

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SCAI mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAI mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of SCAI mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SCAI gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SCAI mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SCAI mRNA24449571
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SCAI mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of SCAI mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of SCAI protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of SCAI mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SCAI mRNA26472689
D003471CuprizoneCuprizone results in decreased expression of SCAI mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of SCAI mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SCAI mRNA23640034
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SCAI mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SCAI mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SCAI mRNA23649840
C039281furanfuran results in decreased expression of SCAI mRNA24183702
C051890irinotecanirinotecan analog results in decreased expression of SCAI mRNA18927307
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SCAI mRNA"24972896
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of SCAI mRNA25926378
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SCAI mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SCAI mRNA23649840
D010634PhenobarbitalPhenobarbital affects the expression of SCAI mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of SCAI mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SCAI mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SCAI mRNA22079256
C009277sodium arsenatesodium arsenate results in increased expression of SCAI mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCAI mRNA21354282
C483909torcetrapibtorcetrapib results in increased expression of SCAI mRNA23228038
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SCAI mRNA"26743178
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCAI mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SCAI mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SCAI mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SCAI gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IMP19350017  
GO:0005515protein binding-IPI19350017  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0030336negative regulation of cell migration-IMP19350017  
GO:0035024negative regulation of Rho protein signal transduction-ISS-  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23988721Prognostic implications of percutaneous coronary interventions performed according to the appropriate use criteria for coronary revascularization. (2013 Nov-Dec)Barbash IMCardiovasc Revasc Med
16909697API expert consensus document on management of ischemic heart disease. (2006 Jun)-J Assoc Physicians India