Gene: GRK4

2868
GPRK2L|GPRK4|GRK4a|IT11
G protein-coupled receptor kinase 4
protein-coding
4p16.3
Ensembl:ENSG00000125388 MIM:137026 Vega:OTTHUMG00000159914 UniprotKB:P32298
NG_029102.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.764e-1 (AD)  9.777e-4 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2798303chr4:3038860 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1801058chr4:3037423 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2857839chr4:3034903 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2857845chr4:3026386 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C7orf55-LUC7L20.833
SPG70.827
HKR10.821
DCAF80.819
CENPT0.818
WDR600.814
ERCC30.813
ANAPC50.811
RHOT20.81
CDK90.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.588
OR4F29-0.585
EVC2-0.349
MTRNR2L9-0.316
FOXJ1-0.31
MTRNR2L6-0.293
PDZK1IP1-0.292
SH2D4A-0.288
C4orf19-0.281
WDR38-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRK4 mRNA"19114083
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of GRK4 mRNA"26186136
D000082AcetaminophenAcetaminophen results in decreased expression of GRK4 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRK4 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRK4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GRK4 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of GRK4 mRNA15761015|2253515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to GRK4 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of GRK4 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GRK4 mRNA26472689
C515055darinaparsindarinaparsin results in increased expression of GRK4 mRNA22535156
C515055darinaparsinOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of GRK4 mRNA]22535156
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GRK4 mRNA23914054
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRK4 mRNA17942748
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of GRK4 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GRK4 mRNA25613284
D008727MethotrexateMethotrexate results in increased expression of GRK4 mRNA24449571
D008790MetoprololGRK4 gene SNP affects the susceptibility to Metoprolol19119263
D010100OxygenOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of GRK4 mRNA]22535156
D011441PropylthiouracilPropylthiouracil results in decreased expression of GRK4 mRNA18077114
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GRK4 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of GRK4 gene28589171
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRK4 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GRK4 mRNA25613284
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of GRK4 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of GRK4 mRNA25979313
C025643vinclozolinvinclozolin results in increased expression of GRK4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004703G-protein coupled receptor kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO:0050254rhodopsin kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002031G-protein coupled receptor internalization-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0007165signal transduction-IEA-  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-TAS1338872  
GO:0022400regulation of rhodopsin mediated signaling pathway-TAS-  
GO:0031623receptor internalization-IDA20074556  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0005938cell cortex-IEA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0097381photoreceptor disc membrane-TAS-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-2514856The phototransduction cascadeTAS
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20448640G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese. (2010 Jul)Sun CJHypertens Res