Gene: TRIM59

286827
IFT80L|MRF1|RNF104|TRIM57|TSBF1
tripartite motif containing 59
protein-coding
3q25.33
Ensembl:ENSG00000213186 MIM:616148 Vega:OTTHUMG00000159034 UniprotKB:Q8IWR1
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.805e-1 (AD)  2.007e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NIPAL40.948
C21orf910.932
HHIP0.924
ST180.922
SGK20.919
SLC45A30.915
GJB10.912
ERBB30.912
FA2H0.911
COL4A50.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WTIP-0.372
PAX2-0.356
CALB2-0.343
LTK-0.336
SLC29A4-0.334
CUX2-0.333
SHISA8-0.33
GPR153-0.329
CHRNA2-0.329
PRTN3-0.325

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TRIM59 mRNA"28903501
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of TRIM59 mRNA26821219
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of TRIM59 mRNA26821219
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TRIM59 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TRIM59 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TRIM59 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TRIM59 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TRIM59 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TRIM59 mRNA"25510870
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of TRIM59 mRNA"24172598
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TRIM59 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM59 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM59 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRIM59 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRIM59 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRIM59 mRNA23630614
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of TRIM59 mRNA"22863853
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TRIM59 mRNA"19446018
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TRIM59 mRNA26377693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRIM59 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of TRIM59 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TRIM59 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TRIM59 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TRIM59 mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TRIM59 mRNA28472532
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TRIM59 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TRIM59 mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of TRIM59 mRNA22077320
D003471CuprizoneCuprizone results in decreased expression of TRIM59 mRNA27523638
D003976DiazinonDiazinon results in increased methylation of TRIM59 gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TRIM59 mRNA28962523
D002117CalcitriolCalcitriol results in decreased expression of TRIM59 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TRIM59 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of TRIM59 mRNA25380136
D004237DiuronDiuron metabolite results in decreased expression of TRIM59 mRNA24172598
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRIM59 mRNA22079256
C061365flusilazoleflusilazole affects the expression of TRIM59 mRNA21195148
C001277geldanamycingeldanamycin results in increased expression of TRIM59 mRNA26705709
C409722hexaconazolehexaconazole affects the expression of TRIM59 mRNA21195148
C031927hydroquinonehydroquinone results in decreased expression of TRIM59 mRNA23416264
C008261lead acetatelead acetate results in increased expression of TRIM59 mRNA20542052
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TRIM59 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TRIM59 mRNA26272509
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TRIM59 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TRIM59 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of TRIM59 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of TRIM59 mRNA25380136
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of TRIM59 mRNA26821219
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TRIM59 mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TRIM59 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TRIM59 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TRIM59 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of TRIM59 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of TRIM59 mRNA18301758|2381119
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRIM59 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TRIM59 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TRIM59 mRNA22714537
D011441PropylthiouracilPropylthiouracil affects the expression of TRIM59 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of TRIM59 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TRIM59 mRNA19167446
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of TRIM59 mRNA21427059
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TRIM59 mRNA26378955
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of TRIM59 mRNA"26680231
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TRIM59 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TRIM59 mRNA21592394
D013849ThimerosalThimerosal results in decreased expression of TRIM59 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TRIM59 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TRIM59 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TRIM59 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TRIM59 mRNA21934132
C032910triadimefontriadimefon affects the expression of TRIM59 mRNA21195148
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM59 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TRIM59 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of TRIM59 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of TRIM59 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of TRIM59 mRNA20546886|2142705
D014638VanadatesVanadates results in decreased expression of TRIM59 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRIM59 gene25560391
C111237vorinostatvorinostat results in decreased expression of TRIM59 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008270zinc ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IEA-  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IMP22588174  
GO:0045087innate immune response-IEA-  
GO:0046597negative regulation of viral entry into host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-ISS-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005813centrosome-IBA21873635  
GO:0005929cilium-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030992intraciliary transport particle B-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28789440TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. (2017 Aug)Hao LOncol Lett