Gene: KRT6C

286887
K6E|KRT6E|PPKNEFD
keratin 6C
protein-coding
12q13.13
Ensembl:ENSG00000170465 MIM:612315 Vega:OTTHUMG00000169596 UniprotKB:P48668
NG_012416.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.338e-1 (AD)  8.555e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT6B0.834
KRT6A0.825
KRT160.77
SPINK50.752
SPRR1A0.751
MUC210.726
SERPINB30.721
ADH70.715
SPRR2D0.7
KRT40.699

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD1-0.227
ONECUT2-0.223
CARTPT-0.219
NPIPB15-0.219
CUX2-0.215
CALB2-0.214
ACVR1C-0.214
AGAP4-0.213
TMEM56-0.213
NEK4-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KRT6C gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KRT6C mRNA22100608
D004958EstradiolEstradiol results in decreased expression of KRT6C mRNA23019147
D002104CadmiumKRT6C protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KRT6C mRNA26472689
C100187chloropicrinchloropicrin affects the expression of KRT6C mRNA26352163
C100187chloropicrinchloropicrin results in decreased expression of KRT6C mRNA28476498
D019327Copper SulfateCopper Sulfate results in decreased expression of KRT6C mRNA20599845
D007854LeadKRT6C protein binds to Lead23896426
D009532NickelKRT6C protein binds to Nickel23896426
D010634PhenobarbitalPhenobarbital affects the expression of KRT6C mRNA19159669
D011192Potassium DichromatePotassium Dichromate results in decreased expression of KRT6C mRNA11678601
D011192Potassium DichromatePotassium Dichromate results in decreased expression of KRT6C protein23718831
C017947sodium arsenitesodium arsenite results in decreased expression of KRT6C mRNA12634122

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0031424keratinization-TAS-  
GO:0045104intermediate filament cytoskeleton organization-IMP23662636  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005882intermediate filament-NAS9054461  
GO:0045095keratin filament-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28619761Exhaled breath condensate biomarkers for the early diagnosis of lung cancer using proteomics. (2017 Oct 1)Lopez-Sanchez LMAm J Physiol Lung Cell Mol Physiol