Gene: GPS1

2873
COPS1|CSN1|SGN1
G protein pathway suppressor 1
protein-coding
17q25.3
Ensembl:ENSG00000169727 MIM:601934 Vega:OTTHUMG00000178484 UniprotKB:Q13098
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.311e-1 (AD)  1.819e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDUFV10.959
MCRS10.956
TRMT2A0.955
MRPL380.953
SUGP10.953
PUF600.953
VPS280.952
UQCRC10.949
ERAL10.948
ARFGAP20.948

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.793
OR4F29-0.751
MTRNR2L9-0.379
MTRNR2L6-0.367
MTRNR2L10-0.335
PABPC4L-0.331
KCNJ15-0.329
CXCR2-0.305
FCGR3B-0.302
KLRB1-0.294

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of GPS1 mRNA"22101062
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GPS1 mRNA"21346803
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of GPS1 mRNA"17331233
C547126AZM551248AZM551248 results in decreased expression of GPS1 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of GPS1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of GPS1 protein15215581
C006780bisphenol Abisphenol A results in decreased methylation of GPS1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of GPS1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GPS1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GPS1 protein26220685
D019327Copper SulfateCopper Sulfate results in decreased expression of GPS1 mRNA19549813
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPS1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of GPS1 mRNA24136188
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of GPS1 protein]20884965
D019833GenisteinGenistein results in decreased expression of GPS1 protein20884965
D005839GentamicinsGentamicins results in increased expression of GPS1 mRNA22061828
C544151jinfukangjinfukang results in increased expression of GPS1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GPS1 mRNA23086925
D007854LeadLead results in decreased expression of GPS1 mRNA19921347
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of GPS1 mRNA16966085
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GPS1 mRNA26011545
C006253pirinixic acidpirinixic acid results in increased expression of GPS1 mRNA23811191
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPS1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPS1 mRNA17942748
D013893ThiramThiram results in decreased expression of GPS1 mRNA20530235
D014303TrinitrotolueneTrinitrotoluene affects the expression of GPS1 mRNA21346803
D014635Valproic AcidValproic Acid results in increased methylation of GPS1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GPS1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005095GTPase inhibitor activity-TAS8943324  
GO:0005515protein binding-IPI15304329  18850735  19444310  19615732  20399188  24421388  
27029275  27173435  
GO ID GO Term Qualifier Evidence PubMed
GO:0000188inactivation of MAPK activity-TAS8943324  
GO:0000338protein deneddylation-IDA19141280  
GO:0000715nucleotide-excision repair, DNA damage recognition-TAS-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0007254JNK cascade-TAS8943324  
GO:0034260negative regulation of GTPase activity-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
GO:0008180COP9 signalosome-IBA21873635  
GO:0008180COP9 signalosome-IDA18850735  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-73894DNA RepairTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18671841PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells. (2008 Jul 31)Kriegova EBMC Mol Biol