Gene info: ID 2876

Gene: GPX1

GENE ID: 2876

Synonyms: GPXD|GSHPX1

Description: glutathione peroxidase 1

Gene type: protein-coding

Location: 3p21.31

dbXrefs: Ensembl:ENSG00000233276 MIM:138320 Vega:OTTHUMG00000156837 UniprotKB:P07203

RefSeq: NG_012264.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 24

Sherlock p-value : 1.123e-1 (AD) 5.710e-1 (ND) (Frontal_Cortex)

Pascal p-value : 5.751e-1 (AD) 3.842e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg18642234	chr3:49394622	GPX1		1.200e-16	Smoking	27651444
cg18642234	chr3:49394622	GPX1		5.430e-11	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NME1-NME2	0.922
GNB2	0.911
BRI3	0.907
C19orf53	0.907
JTB	0.905
NOP10	0.897
EIF3G	0.891
AURKAIP1	0.891
GADD45GIP1	0.89
SEC61B	0.889

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.817
OR4F29	-0.789
PRDM14	-0.176
PPIAP10	-0.173
OR2A14	-0.169
OR10K1	-0.167
PRAMEF17	-0.166
RGPD1	-0.165
CCR8	-0.162
TAS2R41	-0.158

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Enzyme
DB09221	Polaprezinc	Small Molecule	107667-60-7	Approved\|Investigational	Enzyme
DB11127	Selenious acid	Small Molecule	7783-00-8	Approved\|Investigational	Enzyme
DB11590	Thimerosal	Small Molecule	54-64-8	Approved	Enzyme

ID	Drug Name	Action	PubMed
C084012	1,1-diethyl-2-hydroxy-2-nitrosohydrazine	"GPX1 gene mutant form results in decreased susceptibility to 1,1-diethyl-2-hydroxy-2-nitrosohydrazine"	24296279
C021201	12-HPETE	GPX1 protein results in increased susceptibility to 12-HPETE	11115402
C032904	2,2',3,5',6-pentachlorobiphenyl	"2,2',3,5',6-pentachlorobiphenyl results in decreased expression of GPX1 mRNA"	29233657
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GPX1 mRNA"	25305463
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of GPX1 protein"	22889935
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of GPX1 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of GPX1 mRNA"	21346803
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of GPX1 protein]	28583816
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of GPX1 protein	28583816
C046062	2-thiomalic acid	2-thiomalic acid results in decreased activity of GPX1 protein	21892612
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl results in decreased expression of GPX1 mRNA"	11434900
C511179	3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine	"3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [GPX1 gene mutant form results in increased abundance of Reactive Oxygen Species]"	24296279
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of GPX1 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of GPX1 protein"	25670856
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPX1 mRNA"	27188386
C069037	4(G)-alpha-glucopyranosyl-rutin	[Luteolin co-treated with 4(G)-alpha-glucopyranosyl-rutin] inhibits the reaction [Doxorubicin results in decreased activity of GPX1 protein]	9242351
C027576	4-hydroxy-2-nonenal	GPX1 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal	24296279
C041594	4-nonylphenol	4-nonylphenol results in decreased expression of GPX1 mRNA	27109770
C029370	4-toluidine	4-toluidine results in decreased expression of GPX1 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPX1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased activity of GPX1 protein	16831125
D000082	Acetaminophen	Acetaminophen results in decreased expression of GPX1 mRNA	19799668
D000082	Acetaminophen	Carnosine inhibits the reaction [Acetaminophen results in decreased expression of GPX1 mRNA]	19799668
D000082	Acetaminophen	GPX1 protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione]	16636302
D000082	Acetaminophen	GPX1 protein affects the susceptibility to Acetaminophen	16636302
D000082	Acetaminophen	[GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]	16636302
D000082	Acetaminophen	[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Acetaminophen	16636302
D000082	Acetaminophen	GPX1 results in decreased susceptibility to Acetaminophen	16831125
D000082	Acetaminophen	Acetaminophen results in decreased activity of GPX1 protein	15707775
D000082	Acetaminophen	Acetaminophen results in decreased expression of and results in decreased activity of GPX1 protein	24910983
D000082	Acetaminophen	Acetaminophen results in decreased expression of GPX1 mRNA	17522070
D000082	Acetaminophen	Acetaminophen results in increased expression of GPX1 protein	15800402
D000082	Acetaminophen	isocytisoside inhibits the reaction [Acetaminophen results in decreased activity of GPX1 protein]	15707775
D000082	Acetaminophen	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Acetaminophen results in decreased expression of and results in decreased activity of GPX1 protein]	24910983
C056165	acetovanillone	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]	29037473
C056165	acetovanillone	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]	29037473
C056165	acetovanillone	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]	29037473
C056165	acetovanillone	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]	29037473
C056165	acetovanillone	acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]	22431579
D000109	Acetylcholine	GPX1 gene mutant form results in decreased susceptibility to Acetylcholine	24296279
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]	25341683
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [raspberry ketone results in decreased expression of GPX1 protein]	26867644
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [rhododendrol results in decreased expression of GPX1 protein]	26867644
D000111	Acetylcysteine	Acetylcysteine results in increased expression of GPX1 protein	26867644
D000117	Acetylglucosamine	Acetylglucosamine results in increased expression of GPX1 mRNA	18047607
D020106	Acrylamide	Acrylamide results in decreased expression of GPX1 mRNA	28159594
D020106	Acrylamide	salvin inhibits the reaction [Acrylamide results in decreased expression of GPX1 mRNA]	28159594
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in decreased expression of GPX1 mRNA	10822027
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GPX1 mRNA	21641981
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased activity of GPX1 protein	25154877
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GPX1 mRNA	28442411
D016604	Aflatoxin B1	Benzopyrans inhibits the reaction [Aflatoxin B1 results in decreased activity of GPX1 protein]	25154877
D000395	Air Pollutants, Occupational	"GPX1 gene polymorphism affects the susceptibility to Air Pollutants, Occupational"	20480816
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of GPX1 mRNA	28522335
C011512	alpha-naphthoflavone	[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in increased expression of GPX1 mRNA	19233942
D000535	Aluminum	Aluminum results in decreased activity of GPX1 protein	17709913
D000535	Aluminum	Vitamin E inhibits the reaction [Aluminum results in decreased activity of GPX1 protein]	17709913
C104223	aluminum lactate	[aluminum lactate co-treated with Melatonin] results in increased expression of GPX1 mRNA	15589378
C050609	aluminum nitrate	aluminum nitrate results in increased expression of GPX1 mRNA	18096288
C050609	aluminum nitrate	Silicic Acid inhibits the reaction [aluminum nitrate results in increased expression of GPX1 mRNA]	18096288
C103505	AM 251	AM 251 results in increased expression of GPX1 mRNA	16500647
D000616	Aminoglutethimide	Aminoglutethimide results in increased expression of GPX1 protein	26102013
D006710	Homocysteine	Homocysteine results in decreased activity of GPX1 protein	15734734
D006710	Homocysteine	Homocysteine results in decreased expression of GPX1 protein	15734734
D000638	Amiodarone	Amiodarone affects the expression of GPX1 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GPX1 mRNA	16483693
C010680	antibiotic G 418	antibiotic G 418 results in increased expression of and results in decreased activity of GPX1 protein	16354666
D047310	Apigenin	Apigenin results in increased expression of GPX1 mRNA	22359648
D016718	Arachidonic Acid	[Iodoacetates results in decreased activity of GPX1 protein] which affects the metabolism of Arachidonic Acid	11115402
C025657	arsenic acid	arsenic acid results in increased expression of GPX1 mRNA	19429247
C025657	arsenic acid	arsenic acid results in increased expression of GPX1 protein	19429247
C050510	arsenic trichloride	GPX1 protein inhibits the reaction [arsenic trichloride results in increased expression of GADD45A protein]	16814109
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of GPX1 protein	16867262
C015001	arsenite	GPX1 protein inhibits the reaction [arsenite results in increased expression of DDIT4 mRNA]	16008523
C015001	arsenite	arsenite results in decreased expression of GPX1 mRNA	18929588
C015001	arsenite	arsenite results in increased expression of GPX1 mRNA	19429247
C015001	arsenite	arsenite results in increased expression of GPX1 protein	19429247
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of GPX1 mRNA]	18929588
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of GPX1 protein"	20855422
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with Vitamin E] results in increased expression of GPX1 mRNA	22207723
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA	20530418
D001205	Ascorbic Acid	nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]	20530418
D001205	Ascorbic Acid	[Vitamin A co-treated with Ascorbic Acid co-treated with Vitamin E] results in increased expression of GPX1 protein	17179735
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GPX1 protein]	16248992\|1629875
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of GPX1 mRNA	15372504
D001241	Aspirin	Aspirin results in decreased expression of GPX1 mRNA	21353610
C098644	atrasentan	atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]	22431579
D001280	Atrazine	Atrazine results in increased expression of GPX1 mRNA	27957240
D001280	Atrazine	Atrazine results in increased expression of GPX1 mRNA	23070809\|2313281
D001280	Atrazine	Quercetin inhibits the reaction [Atrazine results in increased expression of GPX1 mRNA]	23070809\|2313281
D001310	Auranofin	Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]	21355852
D001310	Auranofin	Auranofin results in increased expression of GPX1 protein	21355852
D001310	Auranofin	[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]	21355852
D001553	Benzbromarone	Benzbromarone affects the expression of GPX1 mRNA	19483382
D019324	beta-Naphthoflavone	[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in increased expression of GPX1 mRNA	19233942
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GPX1 mRNA	18164116
D001578	Benzopyrans	Benzopyrans inhibits the reaction [Aflatoxin B1 results in decreased activity of GPX1 protein]	25154877
D001578	Benzopyrans	Benzopyrans results in increased activity of GPX1 protein	25154877
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GPX1 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GPX1 mRNA	22228805
D001564	Benzo(a)pyrene	[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GPX1 mRNA	25820237
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GPX1 mRNA"	28593498
D001599	Berberine	Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA]	24751971
D004958	Estradiol	Estradiol results in decreased expression of GPX1 mRNA	23373633
C099952	bifenthrin	bifenthrin results in decreased expression of GPX1 mRNA	27916261
C099952	bifenthrin	bifenthrin results in increased expression of GPX1 mRNA	26071804
C004541	biochanin A	biochanin A results in decreased expression of GPX1 mRNA	12111696
C006780	bisphenol A	bisphenol A results in decreased expression of and results in decreased activity of GPX1 protein	28490175
C006780	bisphenol A	bisphenol A affects the expression of GPX1 mRNA	26049153
C006780	bisphenol A	bisphenol A results in increased expression of GPX1 mRNA	26746108
C006780	bisphenol A	bisphenol A results in increased expression of GPX1 mRNA	25181051\|2872155
C006780	bisphenol A	bisphenol A results in decreased expression of GPX1 mRNA	28819136
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of GPX1 mRNA	17553608
D001761	Bleomycin	Bleomycin affects the expression of GPX1 protein	25933445
D001966	Bromine	Bromine results in increased expression of GPX1 mRNA	21391292
C032036	bromobenzene	bromobenzene results in decreased expression of GPX1 mRNA	12628495
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GPX1 mRNA	22079614
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of GPX1 mRNA]	25341683
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine affects the activity of GPX1 protein	15707499
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine promotes the reaction [Microcystins analog results in increased expression of GPX1 mRNA]	24964298
C027561	butylbenzyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of GPX1 mRNA	28013214
D020122	tert-Butylhydroperoxide	NFE2L2 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of GPX1 mRNA]	19233942
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GPX1 mRNA	19233942
D020122	tert-Butylhydroperoxide	GPX1 protein results in increased reduction of tert-Butylhydroperoxide	8428933
D020122	tert-Butylhydroperoxide	GPX1 gene mutant form results in increased susceptibility to tert-Butylhydroperoxide	15182862
D020122	tert-Butylhydroperoxide	GPX1 protein results in decreased susceptibility to tert-Butylhydroperoxide	9741587
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GPX1 mRNA	18804290
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GPX1 mRNA	19720132
D020122	tert-Butylhydroperoxide	GPX1 protein binds to and affects the metabolism of tert-Butylhydroperoxide	16540359
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of GPX1 mRNA	16122865
D002104	Cadmium	Cadmium results in decreased expression of GPX1 mRNA	17369103
D002104	Cadmium	Cadmium results in decreased activity of GPX1 protein	16674991
D002104	Cadmium	Cadmium results in increased expression of GPX1 mRNA	21787725\|2391656
C028031	cadmium acetate	cadmium acetate results in increased expression of GPX1 protein	29140578
C028031	cadmium acetate	Trehalose inhibits the reaction [cadmium acetate results in increased expression of GPX1 protein]	29140578
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GPX1 mRNA	17369103
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GPX1 mRNA	12760830
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GPX1 mRNA	20061341
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GPX1 mRNA	25409916
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GPX1 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of GPX1 mRNA	20107868
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GPX1 mRNA	18636176
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GPX1 protein	17098586
D002122	Calcium Chloride	Calcium Chloride results in increased expression of GPX1 mRNA	21530968\|2433735
D002122	Calcium Chloride	Quercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]	24337353
D002122	Calcium Chloride	resveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]	21530968
D002211	Capsaicin	Capsaicin inhibits the reaction [Ethanol results in decreased expression of GPX1 mRNA]	18926900
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GPX1 mRNA	25432964
D002251	Carbon Tetrachloride	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]]	25432964
D002251	Carbon Tetrachloride	PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]	25432964
D002251	Carbon Tetrachloride	SC 560 promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]	25432964
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased activity of GPX1 protein	17030452
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GPX1 mRNA	17522070\|2547806
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GPX1 protein	25478064
D002251	Carbon Tetrachloride	Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]	25478064
D002251	Carbon Tetrachloride	Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 protein]	25478064
D002251	Carbon Tetrachloride	Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GPX1 protein]	17030452
D002331	Carnitine	Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA]	23213347
D002336	Carnosine	Carnosine inhibits the reaction [Acetaminophen results in decreased expression of GPX1 mRNA]	19799668
C024714	caryophyllene	caryophyllene inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of GPX1 mRNA]	29097836
D000068579	Celecoxib	Celecoxib results in increased expression of GPX1 protein	20883674
D002518	Ceramides	GPX1 protein inhibits the reaction [Doxorubicin results in increased abundance of Ceramides]	11502879
D048271	Chitosan	[Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]	27923682
D048271	Chitosan	[Chitosan analog co-treated with Quercetin] results in increased expression of GPX1 mRNA	27923682
D048271	Chitosan	Chitosan analog inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]	27923682
D048271	Chitosan	Chitosan analog results in increased expression of GPX1 mRNA	27923682
C016300	chloramine-T	chloramine-T results in increased expression of GPX1 protein	24213014
D020111	Chlorodiphenyl (54% Chlorine)	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GPX1 protein]	16248992\|1629875
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased activity of GPX1 protein	15808795\|1595560
D020111	Chlorodiphenyl (54% Chlorine)	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GPX1 protein]	16298753
D002725	Chloroform	Chloroform results in decreased expression of GPX1 mRNA	17522070
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPX1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of GPX1 mRNA	26272509
C100187	chloropicrin	chloropicrin results in decreased expression of GPX1 mRNA	26352163
D004390	Chlorpyrifos	[cypermethrin co-treated with Chlorpyrifos] results in decreased activity of GPX1 protein	15991261
D004390	Chlorpyrifos	Plant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in decreased activity of GPX1 protein]	15991261
C000474	cholestane-3,5,6-triol	"cholestane-3,5,6-triol results in increased expression of GPX1 mRNA"	16039982
C000474	cholestane-3,5,6-triol	"Sodium Selenite inhibits the reaction [cholestane-3,5,6-triol results in increased expression of GPX1 mRNA]"	16039982
D002791	Cholesterol, Dietary	"[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA"	28734741
D002791	Cholesterol, Dietary	"Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D002791	Cholesterol, Dietary	"Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D002791	Cholesterol, Dietary	"thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D002791	Cholesterol, Dietary	"Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D002794	Choline	caryophyllene inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of GPX1 mRNA]	29097836
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of GPX1 mRNA	29097836
D002857	Chromium	Chromium results in increased expression of GPX1 protein	16488005
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of GPX1 mRNA	23462276
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of and results in decreased activity of GPX1 protein	29069462
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of GPX1 mRNA	29069462
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of GPX1 protein	17098216
C074702	chromium hexavalent ion	[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GPX1 mRNA	25820237
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of GPX1 protein	28077780
C499843	chromium histidinate	chromium histidinate inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 mRNA]	19902159
C012843	cinnamic aldehyde	cinnamic aldehyde affects the expression of GPX1 mRNA	28219650
C012843	cinnamic aldehyde	NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX1 mRNA]	28219650
C019304	ciprofibrate	ciprofibrate results in decreased activity of GPX1 protein	19544052
D002994	Clofibrate	Clofibrate results in decreased expression of GPX1 mRNA	16081524
D002994	Clofibrate	Clofibrate affects the expression of GPX1 mRNA	19483382
D002994	Clofibrate	Clofibrate results in decreased expression of GPX1 mRNA	17522070
D002994	Clofibrate	Clofibrate results in decreased expression of GPX1 mRNA	17437637
D003024	Clozapine	Clozapine results in increased expression of GPX1 mRNA	14647396
D003033	Coal Tar	Coal Tar results in increased expression of GPX1 mRNA	16882163
D003035	Cobalt	Cobalt results in increased expression of GPX1 protein	16488005
D003035	Cobalt	[Cobalt co-treated with Organometallic Compounds] results in increased expression of GPX1 mRNA	22147119
D003035	Cobalt	Cobalt results in increased expression of GPX1 mRNA	22147119
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of GPX1 mRNA	24386269
D003078	Colchicine	Colchicine results in increased expression of GPX1 mRNA	18255150
D003300	Copper	Copper deficiency results in decreased expression of GPX1 protein	18993053
D003300	Copper	Copper deficiency results in increased expression of GPX1 mRNA	19497425
D003300	Copper	Copper results in decreased expression of GPX1 mRNA	19781568
D003300	Copper	Copper results in increased expression of GPX1 mRNA	19497425
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of GPX1 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate affects the expression of GPX1 mRNA	20116453
C058120	cordycepin	cordycepin results in decreased expression of GPX1 mRNA	28987792
C065868	COSS-86 protocol	GPX1 results in decreased susceptibility to COSS-86 protocol	14767549
C030123	coumarin	coumarin affects the expression of GPX1 mRNA	16963487
D003407	Creosote	Creosote results in increased expression of GPX1 mRNA	19389177
C010561	crocetin	crocetin inhibits the reaction [cupric oxide results in decreased expression of GPX1 mRNA]	25701151
C007164	cumene hydroperoxide	GPX1 protein results in decreased susceptibility to cumene hydroperoxide	1740415\|1939125
C007164	cumene hydroperoxide	GPX1 protein results in increased reduction of cumene hydroperoxide	8428933
C007164	cumene hydroperoxide	GPX1 protein results in increased metabolism of cumene hydroperoxide	9126277
C007164	cumene hydroperoxide	GPX1 protein results in decreased oxidation of cumene hydroperoxide	17544198
C007164	cumene hydroperoxide	GPX1 protein binds to and affects the metabolism of cumene hydroperoxide	16540359
C030973	cupric oxide	crocetin inhibits the reaction [cupric oxide results in decreased expression of GPX1 mRNA]	25701151
C030973	cupric oxide	cupric oxide results in decreased expression of GPX1 mRNA	25701151
D003471	Cuprizone	Cuprizone results in increased expression of GPX1 mRNA	26577399
D003474	Curcumin	[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]	19914224
D003474	Curcumin	Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]	23267840
D003474	Curcumin	Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]	19914224
D003474	Curcumin	Curcumin results in decreased expression of GPX1 mRNA	18299980
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of GPX1 mRNA	23542512
D003520	Cyclophosphamide	Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of GPX1 mRNA]	23542512
C017160	cypermethrin	[cypermethrin co-treated with Chlorpyrifos] results in decreased activity of GPX1 protein	15991261
C017160	cypermethrin	cypermethrin results in increased expression of GPX1 mRNA	21397294
C017160	cypermethrin	Plant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in decreased activity of GPX1 protein]	15991261
C108338	cyprodinil	cyprodinil affects the expression of GPX1 mRNA	22880100
C108338	cyprodinil	[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA	22880100
D003630	Daunorubicin	Daunorubicin results in increased expression of GPX1 mRNA	26537877\|2894005
C014347	decitabine	decitabine affects the expression of GPX1 mRNA	23300844
D013759	Dronabinol	Dronabinol results in increased expression of GPX1 mRNA	18163980
D013759	Dronabinol	Dronabinol results in increased expression of GPX1 protein	18163980
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of GPX1 protein	23811945
D003907	Dexamethasone	Dexamethasone results in increased expression of GPX1 mRNA	21041162
D003907	Dexamethasone	Dexamethasone affects the expression of GPX1 mRNA	15102944
D003907	Dexamethasone	Dexamethasone results in decreased expression of GPX1 mRNA	11328961\|1752207
D003976	Diazinon	Diazinon affects the expression of GPX1 mRNA	22546817
D003976	Diazinon	Diazinon results in increased expression of GPX1 mRNA	19440498
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased activity of GPX1 protein	11181109
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GPX1 mRNA	21266533
D003993	Dibutyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of GPX1 mRNA	28013214
D002945	Cisplatin	Cisplatin affects the expression of GPX1 mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of GPX1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of GPX1 mRNA	27392435
D002945	Cisplatin	[Quercetin co-treated with Cisplatin] results in increased expression of GPX1 mRNA	24999622
D002945	Cisplatin	Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]	24865317
D002945	Cisplatin	Cisplatin results in decreased expression of GPX1 mRNA	16837816
D002945	Cisplatin	Selenium inhibits the reaction [Cisplatin results in decreased expression of GPX1 mRNA]	16837816
D004008	Diclofenac	Diclofenac results in increased expression of GPX1 protein	25772430
C121718	dicyclanil	dicyclanil results in increased expression of GPX1 mRNA	15664270
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of GPX1 mRNA	26924002
D004026	Dieldrin	GPX1 protein results in decreased activity of and results in decreased susceptibility to Dieldrin	12621067
D004026	Dieldrin	Dieldrin affects the expression of GPX1 mRNA	22546817
D004026	Dieldrin	Dieldrin results in decreased expression of GPX1 mRNA	19440498
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GPX1 mRNA	21462320
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX1 mRNA	26042203
D004041	Dietary Fats	Dietary Fats results in decreased expression of GPX1 mRNA	18042831
D004041	Dietary Fats	GPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX1 mRNA]	26042203
D004041	Dietary Fats	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GPX1 mRNA]	21462320
D004041	Dietary Fats	"[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA"	28734741
D004041	Dietary Fats	"Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D004041	Dietary Fats	"Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D004041	Dietary Fats	"thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D004041	Dietary Fats	"Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GPX1 mRNA	21462320
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX1 mRNA	26042203
D019422	Dietary Sucrose	GPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX1 mRNA]	26042203
D019422	Dietary Sucrose	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GPX1 mRNA]	21462320
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased activity of GPX1 protein	20659492
D004051	Diethylhexyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of GPX1 mRNA	28013214
D004051	Diethylhexyl Phthalate	Selenomethionine inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of GPX1 protein]	20659492
D004051	Diethylhexyl Phthalate	Sodium Selenite inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of GPX1 protein]	20659492
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of GPX1 mRNA	19107877
D004052	Diethylnitrosamine	indoleacetic acid inhibits the reaction [Diethylnitrosamine results in decreased expression of GPX1 mRNA]	19107877
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GPX1 mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GPX1 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GPX1 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPX1 mRNA	27048571
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPX1 protein	20935162
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GPX1 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of GPX1 protein	20935162
D004052	Diethylnitrosamine	DMU-212 inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPX1 mRNA]	27048571
C007379	diethyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of GPX1 mRNA	28013214
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GPX1 mRNA	21041162
C025605	diisobutyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of GPX1 mRNA	28013214
C012125	diisononyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of GPX1 mRNA	28013214
C060658	dimethyl mercaptosuccinate	dimethyl mercaptosuccinate results in decreased activity of GPX1 protein	12621067
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of GPX1 mRNA	26924002
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of GPX1 mRNA	28219650
D004137	Dinitrochlorobenzene	NFE2L2 protein promotes the reaction [Dinitrochlorobenzene results in increased expression of GPX1 mRNA]	28219650
D004178	Diquat	Diquat results in decreased expression of GPX1 protein	11672444
D004178	Diquat	GPX1 gene mutant form results in increased susceptibility to Diquat	15182862
D004178	Diquat	GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]	11672444
D004178	Diquat	GPX1 protein affects the reaction [Diquat results in increased abundance of F2-Isoprostanes]	10490281
D004178	Diquat	GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]	11672444
D004178	Diquat	GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]	11672444
D004178	Diquat	GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]	11672444
D004178	Diquat	GPX1 protein affects the susceptibility to Diquat	11672444
D004178	Diquat	GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]	11672444
D004178	Diquat	GPX1 protein results in decreased susceptibility to Diquat	11568445
D004178	Diquat	GPX1 protein results in increased susceptibility to Diquat	10490281
D004178	Diquat	S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein]	11672444
C521792	DMU-212	DMU-212 inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPX1 mRNA]	27048571
C521792	DMU-212	DMU-212 results in decreased expression of GPX1 mRNA	27048571
C001114	dodecylbenzenesulfonic acid	dodecylbenzenesulfonic acid results in increased activity of GPX1 protein	20045192
C001114	dodecylbenzenesulfonic acid	dodecylbenzenesulfonic acid affects the activity of GPX1 protein	19121837
D007980	Levodopa	GPX1 protein results in decreased susceptibility to Levodopa	9741587
D004317	Doxorubicin	Doxorubicin results in increased activity of GPX1 protein	15473893
D004317	Doxorubicin	Doxorubicin results in increased expression of GPX1 mRNA	15059885\|2653787
D004317	Doxorubicin	GPX1 protein inhibits the reaction [Doxorubicin results in increased abundance of Ceramides]	11502879
D004317	Doxorubicin	GPX1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]	11502879
D004317	Doxorubicin	GPX1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein]	11502879
D004317	Doxorubicin	TP53 protein affects the reaction [Doxorubicin results in increased expression of GPX1 mRNA]	15059885
D004317	Doxorubicin	Doxorubicin results in decreased activity of GPX1 protein	9242351
D004317	Doxorubicin	Doxorubicin results in decreased expression of GPX1 protein	21463615
D004317	Doxorubicin	Doxorubicin results in increased activity of GPX1 protein	21920376
D004317	Doxorubicin	Doxorubicin results in increased expression of GPX1 mRNA	21920376\|2871050
D004317	Doxorubicin	GPX1 protein affects the susceptibility to Doxorubicin	16781452
D004317	Doxorubicin	Lovastatin inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA]	28710503
D004317	Doxorubicin	[Luteolin co-treated with 4(G)-alpha-glucopyranosyl-rutin] inhibits the reaction [Doxorubicin results in decreased activity of GPX1 protein]	9242351
D004317	Doxorubicin	MT1 affects the reaction [Doxorubicin results in decreased expression of GPX1 protein]	21463615
D004317	Doxorubicin	MT2 affects the reaction [Doxorubicin results in decreased expression of GPX1 protein]	21463615
D004317	Doxorubicin	NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA]	28710503
D004317	Doxorubicin	Doxorubicin results in decreased expression of GPX1 mRNA	11014987
D004317	Doxorubicin	Doxorubicin results in decreased expression of GPX1 protein	7805190
D004317	Doxorubicin	GPX1 protein inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]	15799720
D004317	Doxorubicin	GPX1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]	15799720
D004317	Doxorubicin	GPX1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]	15799720
D004317	Doxorubicin	Probucol inhibits the reaction [Doxorubicin results in decreased expression of GPX1 protein]	7805190
C000599870	doxorubicin-transferrin conjugate	doxorubicin-transferrin conjugate results in increased expression of GPX1 mRNA	26607004
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of GPX1 protein"	16190393
C509867	E804 bisindole	E804 bisindole results in decreased expression of GPX1 mRNA	23107598
C509867	E804 bisindole	Lipopolysaccharides inhibits the reaction [E804 bisindole results in decreased expression of GPX1 mRNA]	23107598
C042986	ebselen	ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]	23795780
D004642	Emodin	Emodin results in increased expression of GPX1 mRNA	16045814
D004726	Endosulfan	Endosulfan results in decreased activity of GPX1 protein	12711413
D004726	Endosulfan	Endosulfan results in increased activity of GPX1 protein	15337585
D004726	Endosulfan	Vitamin E inhibits the reaction [Endosulfan results in increased activity of GPX1 protein]	15337585
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of GPX1 mRNA	20064776
C045651	epigallocatechin gallate	[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of GPX1 mRNA	25922640
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of GPX1 mRNA	18851785
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of GPX1 mRNA	29175576
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of GPX1 protein	25585349\|2917557
C045651	epigallocatechin gallate	[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of GPX1 mRNA	22742579
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of GPX1 mRNA	17522070
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in decreased expression of GPX1 mRNA	24316378
C074283	estradiol 3-benzoate	Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased expression of GPX1 mRNA]	24316378
D000431	Ethanol	Capsaicin inhibits the reaction [Ethanol results in decreased expression of GPX1 mRNA]	18926900
D000431	Ethanol	Ethanol results in decreased expression of GPX1 mRNA	18926900\|1899232
D000431	Ethanol	Ethanol results in decreased expression of GPX1 protein	15920153
D000431	Ethanol	Plant Extracts inhibits the reaction [Ethanol results in decreased expression of GPX1 mRNA]	18992320
D000431	Ethanol	Zinc Sulfate inhibits the reaction [Ethanol results in decreased expression of GPX1 protein]	15920153
D000431	Ethanol	Ethanol affects the expression of GPX1 mRNA	23273579
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GPX1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPX1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GPX1 mRNA	15953391
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GPX1 mRNA	15576828
D005001	Ethionine	Ethionine affects the expression of GPX1 mRNA	19483382
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of GPX1 mRNA	23649840
C098546	ethyl tert-butyl ether	ethyl tert-butyl ether results in increased expression of GPX1 protein	24090815
D028441	F2-Isoprostanes	GPX1 protein affects the reaction [Diquat results in increased abundance of F2-Isoprostanes]	10490281
D015025	Zearalenone	Zearalenone results in increased expression of GPX1 mRNA	23727178
D005230	Fatty Acids, Nonesterified	"[Fatty Acids, Nonesterified binds to ALB protein] which results in decreased expression of GPX1 protein"	21338618
C540355	fenamidone	fenamidone results in increased expression of GPX1 mRNA	27029645
C020748	ferrous sulfate	2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of GPX1 protein]	28583816
C020748	ferrous sulfate	ferrous sulfate results in increased expression of GPX1 protein	28583816
D005419	Flavonoids	Flavonoids results in decreased expression of GPX1 mRNA	18035473
C108339	fludioxonil	fludioxonil results in increased expression of GPX1 mRNA	22880100
C108339	fludioxonil	[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA	22880100
D005459	Fluorides	Fluorides results in decreased activity of GPX1 protein	25417050
D005472	Fluorouracil	Fluorouracil results in increased expression of GPX1 mRNA	17982676
D005472	Fluorouracil	TP53 protein promotes the reaction [Fluorouracil results in increased expression of GPX1 mRNA]	17982676
D005485	Flutamide	Flutamide results in decreased expression of GPX1 mRNA	24136188
D005492	Folic Acid	Folic Acid affects the activity of GPX1 protein	16251605
D005492	Folic Acid	Folic Acid affects the expression of GPX1 protein	16251605
D005557	Formaldehyde	Formaldehyde results in increased expression of GPX1 mRNA	23649840
D005632	Fructose	Fructose results in decreased expression of GPX1 mRNA	16815490\|2047078
C473894	fujiflavone P40	fujiflavone P40 results in increased expression of GPX1 mRNA	14656947
C056933	fumonisin B1	fumonisin B1 results in decreased expression of GPX1 mRNA	21256206
D019833	Genistein	Genistein results in increased expression of GPX1 mRNA	18686095
D019833	Genistein	Genistein results in increased expression of GPX1 mRNA	24967385
D005839	Gentamicins	Gentamicins results in decreased expression of GPX1 protein	21081137\|2206182
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]	29037473
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]	29037473
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]	29037473
C049864	ginsenoside Re	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]	29037473
D005897	Glafenine	Glafenine results in decreased expression of GPX1 mRNA	24136188
D005947	Glucose	ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]	23795780
D005947	Glucose	GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]	23795780
D005947	Glucose	Glucose results in decreased expression of GPX1 mRNA	21818840\|2319236
D005947	Glucose	naringenin inhibits the reaction [Glucose results in decreased expression of GPX1 mRNA]	23192364
D005978	Glutathione	GPX1 protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione]	16636302
D005978	Glutathione	[GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]	16636302
D005978	Glutathione	GPX1 protein binds to and affects the metabolism of Glutathione	16540359
D005978	Glutathione	GPX1 protein results in increased oxidation of Glutathione	16008523
D019803	Glutathione Disulfide	GPX1 protein results in increased chemical synthesis of Glutathione Disulfide	16008523
C010974	glyphosate	glyphosate affects the expression of GPX1 mRNA	25450935
C010974	glyphosate	glyphosate results in increased activity of GPX1 protein	25450935
C412815	GW 4064	GW 4064 results in increased expression of GPX1 mRNA	26655953
D006220	Haloperidol	Haloperidol results in increased expression of GPX1 mRNA	14647396
D017313	Fenretinide	Fenretinide results in increased expression of GPX1 protein	25246272
C012351	HT-2 toxin	[T-2 Toxin co-treated with HT-2 toxin] results in increased expression of GPX1 mRNA	26683309
C029424	hydrazine	hydrazine results in decreased expression of GPX1 mRNA	15370871
D006861	Hydrogen Peroxide	chromium histidinate inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 mRNA]	19902159
D006861	Hydrogen Peroxide	GPX1 gene polymorphism affects the susceptibility to Hydrogen Peroxide	20444272
D006861	Hydrogen Peroxide	[GPX1 gene polymorphism co-treated with ACE gene polymorphism] affects the susceptibility to Hydrogen Peroxide	20444272
D006861	Hydrogen Peroxide	GPX1 protein affects the abundance of Hydrogen Peroxide	8824885
D006861	Hydrogen Peroxide	GPX1 protein results in decreased susceptibility to Hydrogen Peroxide	14660625\|1939125
D006861	Hydrogen Peroxide	GPX1 protein results in increased reduction of Hydrogen Peroxide	8428933
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased activity of GPX1 protein	23639522
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of GPX1 mRNA	19902159\|2927443
D006861	Hydrogen Peroxide	myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of GPX1 protein]	23639522
D006861	Hydrogen Peroxide	Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 mRNA]	29274434
D006861	Hydrogen Peroxide	GPX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased acetylation of HIST3H3 protein]	18560803
D006861	Hydrogen Peroxide	GPX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased acetylation of HIST4H4 protein]	18560803
D006861	Hydrogen Peroxide	GPX1 protein results in decreased susceptibility to Hydrogen Peroxide	16721761
D006861	Hydrogen Peroxide	GPX1 protein results in increased metabolism of Hydrogen Peroxide	9126277
D006861	Hydrogen Peroxide	GPX1 protein results in decreased oxidation of Hydrogen Peroxide	17544198
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of GPX1 protein	28544404
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GPX1 mRNA	19720132
D006861	Hydrogen Peroxide	[Iron co-treated with Hydrogen Peroxide] results in decreased expression of and results in decreased activity of GPX1 protein	17280487
D006861	Hydrogen Peroxide	Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein]	28544404
D006861	Hydrogen Peroxide	GPX1 protein binds to and affects the metabolism of Hydrogen Peroxide	16540359
D006861	Hydrogen Peroxide	GPX1 protein results in decreased abundance of Hydrogen Peroxide	16008523
D006861	Hydrogen Peroxide	GPX1 protein results in increased metabolism of Hydrogen Peroxide	11861405\|2135585
D006861	Hydrogen Peroxide	[GPX1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased chemical synthesis of Water	11861405
D006861	Hydrogen Peroxide	GPX1 protein results in increased reduction of Hydrogen Peroxide	15184668
D003900	Desoxycorticosterone	acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]	22431579
D003900	Desoxycorticosterone	atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]	22431579
D003900	Desoxycorticosterone	[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein	22431579
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of GPX1 mRNA	19376150
D007069	Ifosfamide	Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA]	23213347
D007069	Ifosfamide	Ifosfamide results in decreased expression of GPX1 mRNA	23213347
D016285	Iloprost	GPX1 gene mutant form results in decreased susceptibility to Iloprost	24296279
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime results in decreased expression of GPX1 mRNA	18958680
C030737	indoleacetic acid	indoleacetic acid inhibits the reaction [Diethylnitrosamine results in decreased expression of GPX1 mRNA]	19107877
D007461	Iodoacetates	Iodoacetates results in decreased activity of GPX1 protein	11115402
D007461	Iodoacetates	[Iodoacetates results in decreased activity of GPX1 protein] which affects the metabolism of Arachidonic Acid	11115402
D007501	Iron	GPX1 protein results in decreased susceptibility to Iron	16721761
D007501	Iron	[Iron co-treated with Hydrogen Peroxide] results in decreased expression of and results in decreased activity of GPX1 protein	17280487
C111464	isocytisoside	isocytisoside inhibits the reaction [Acetaminophen results in decreased activity of GPX1 protein]	15707775
C489556	isoline	isoline results in increased expression of GPX1 protein	24641316
C545474	JAI-51	JAI-51 results in decreased activity of GPX1 protein	24134853
C545474	JAI-51	JAI-51 results in increased expression of GPX1 mRNA	24134853
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of GPX1 mRNA	27392435
C079969	kappa-selenocarrageenan	kappa-selenocarrageenan results in increased activity of GPX1 protein	19269156
C079969	kappa-selenocarrageenan	kappa-selenocarrageenan results in increased expression of GPX1 mRNA	19269156
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GPX1 mRNA	18544905
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GPX1 mRNA	18544905
C099406	L 742694	L 742694 affects the expression of GPX1 mRNA	15102944
D007854	Lead	Lead results in decreased activity of GPX1 protein	16674991
C008261	lead acetate	lead acetate results in decreased expression of GPX1 mRNA	15014207\|2219770
C008261	lead acetate	lead acetate results in decreased expression of GPX1 protein	22197700
C052901	lemongrass oil	lemongrass oil affects the expression of GPX1 mRNA	25976427
C038753	leptomycin B	[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of GPX1 mRNA	25922640
C038753	leptomycin B	leptomycin B results in increased expression of GPX1 mRNA	25922640
C008281	limonene	limonene results in increased expression of GPX1 mRNA	12815608
C008285	linoleic acid hydroperoxide	GPX1 protein results in increased reduction of linoleic acid hydroperoxide	8428933
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of GPX1 protein"	25772430
D008070	Lipopolysaccharides	Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]	21355852
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein	21355852
D008070	Lipopolysaccharides	[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]	21355852
D008070	Lipopolysaccharides	[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Thiomalates results in increased expression of GPX1 protein]	21355852
D008070	Lipopolysaccharides	Thiomalates promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]	21355852
D008070	Lipopolysaccharides	[usnic acid co-treated with Lipopolysaccharides] results in increased expression of GPX1 mRNA	22777745
D008070	Lipopolysaccharides	GPX1 protein affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]	11498278
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [E804 bisindole results in decreased expression of GPX1 mRNA]	23107598
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of GPX1 mRNA	22040935
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of GPX1 protein	21775527
D008070	Lipopolysaccharides	Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA]	22040935
D008070	Lipopolysaccharides	[Organoselenium Compounds co-treated with Lipopolysaccharides] results in increased expression of GPX1 protein	20883674
D008070	Lipopolysaccharides	Selenium deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of GPX1 protein]	21775527
D008148	Lovastatin	Lovastatin inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA]	28710503
D014975	Lutein	Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]	24865317
D014975	Lutein	Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA]	22040935
D014975	Lutein	Lutein results in increased expression of GPX1 mRNA	24865317
D047311	Luteolin	[Luteolin co-treated with 4(G)-alpha-glucopyranosyl-rutin] inhibits the reaction [Doxorubicin results in decreased activity of GPX1 protein]	9242351
C500223	lycium barbarum polysaccharide	lycium barbarum polysaccharide results in increased expression of GPX1 protein	23743330
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles affects the expression of GPX1 mRNA	25532727
C005498	magnolol	magnolol promotes the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]	28919305
D008344	Maneb	GPX1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]	15824117
D008344	Maneb	Maneb results in decreased expression of GPX1 mRNA	26210702
C025340	manganese chloride	manganese chloride results in decreased expression of GPX1 protein	24969583\|2528810
C025340	manganese chloride	Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein]	25288107
D008550	Melatonin	Melatonin analog results in increased expression of GPX1 mRNA	27233482
D008550	Melatonin	Melatonin results in increased expression of GPX1 mRNA	27233482
D008550	Melatonin	Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein]	25288107
D008550	Melatonin	[aluminum lactate co-treated with Melatonin] results in increased expression of GPX1 mRNA	15589378
D008550	Melatonin	Melatonin results in increased expression of GPX1 mRNA	15589378
C548233	mephedrone	mephedrone results in increased expression of GPX1 protein	26747301
C548233	mephedrone	mephedrone results in decreased expression of GPX1 protein	25817894
D008627	Mercuric Chloride	Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA]	24751971
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of GPX1 mRNA	24751971
D008628	Mercury	GPX1 gene SNP affects the susceptibility to Mercury	22236634
D008628	Mercury	Mercury results in increased expression of GPX1 protein	16451871
C019003	methaneselenol	methaneselenol affects the expression of GPX1 protein	16444005
D008715	Methionine	caryophyllene inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of GPX1 mRNA]	29097836
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of GPX1 mRNA	29097836
C517785	methionine selenoxide	methionine selenoxide results in increased expression of GPX1 mRNA	16444005
C517785	methionine selenoxide	methionine selenoxide results in increased expression of GPX1 protein	16444005
C517785	methionine selenoxide	propargylglycine inhibits the reaction [methionine selenoxide results in increased expression of GPX1 mRNA]	16444005
D008727	Methotrexate	Methotrexate results in increased expression of GPX1 mRNA	25330300
D008727	Methotrexate	SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of GPX1 mRNA]	25330300
D008731	Methoxychlor	Methoxychlor results in decreased expression of and results in decreased activity of GPX1 protein	16890261
D008731	Methoxychlor	Methoxychlor results in decreased expression of GPX1 mRNA	16807286
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of GPX1 mRNA	23712962
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of GPX1 mRNA	23273579
C004925	methylmercuric chloride	methylmercuric chloride results in decreased activity of GPX1 protein	19770487
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GPX1 protein	27012723
C004925	methylmercuric chloride	GPX1 protein results in decreased susceptibility to methylmercuric chloride	19770487
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GPX1 mRNA	12215206\|2800136
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GPX1 protein	27180086
C004925	methylmercuric chloride	methylmercuric chloride results in decreased activity of GPX1 protein	19770487
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GPX1 mRNA	20061341\|2745624
C004925	methylmercuric chloride	Probucol inhibits the reaction [methylmercuric chloride results in decreased activity of GPX1 protein]	19770487
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of GPX1 mRNA	21947502
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of GPX1 protein	22885222
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of GPX1 mRNA	23832298
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of GPX1 protein	23832298
C030588	methylmercury glutathione	methylmercury glutathione affects the expression of GPX1 mRNA	29030019
C030588	methylmercury glutathione	methylmercury glutathione results in decreased expression of and results in decreased activity of GPX1 protein	29030019
C030957	methylmercury II	methylmercury II results in decreased expression of GPX1 mRNA	27241350
C030957	methylmercury II	Probucol promotes the reaction [methylmercury II results in decreased expression of GPX1 mRNA]	27241350
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of GPX1 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	GPX1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]	12523938
D015655	1-Methyl-4-phenylpyridinium	[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of GPX1 mRNA	22742579
D015655	1-Methyl-4-phenylpyridinium	GPX1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]	12523938
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"GPX1 protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA alternative form]"	19857570
D008775	Methylprednisolone	[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein	1942778
D008775	Methylprednisolone	Methylprednisolone results in increased activity of GPX1 protein	1942778
C078588	microcystin	microcystin results in increased expression of GPX1 mRNA	19135122
D052998	Microcystins	Buthionine Sulfoximine promotes the reaction [Microcystins analog results in increased expression of GPX1 mRNA]	24964298
D052998	Microcystins	Microcystins analog results in increased expression of GPX1 mRNA	24964298
D008942	Mitoxantrone	Mitoxantrone results in increased expression of GPX1 mRNA	26537877\|2894005
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased activity of GPX1 protein	20659492
C016599	mono-(2-ethylhexyl)phthalate	Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased activity of GPX1 protein]	20659492
C016599	mono-(2-ethylhexyl)phthalate	Sodium Selenite inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased activity of GPX1 protein]	20659492
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of GPX1 mRNA	22087261
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of GPX1 mRNA	19095002
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of GPX1 mRNA	26924002
C437683	motexafin gadolinium	[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA	20530418
C437683	motexafin gadolinium	nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]	20530418
D009151	Mustard Gas	Mustard Gas results in increased expression of GPX1 mRNA	18955075
C008577	myricitrin	myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of GPX1 protein]	23639522
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Acetaminophen results in decreased expression of and results in decreased activity of GPX1 protein]	24910983
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of GPX1 protein	18848576
C028473	N-acetyl-4-benzoquinoneimine	GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine	16636302
C028473	N-acetyl-4-benzoquinoneimine	[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine	16636302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GPX1 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of GPX1 mRNA	17522070
C005273	naringenin	naringenin inhibits the reaction [Glucose results in decreased expression of GPX1 mRNA]	23192364
C005274	naringin	naringin results in increased activity of GPX1 protein	23603004
C051752	nefazodone	nefazodone results in decreased expression of GPX1 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of GPX1 mRNA	19440498
C022838	nickel chloride	nickel chloride results in decreased expression of GPX1 mRNA	25253428
C022838	nickel chloride	nickel chloride affects the expression of GPX1 mRNA	22110744\|2254681
C028007	nickel monoxide	nickel monoxide results in increased expression of GPX1 mRNA	19167457
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of GPX1 mRNA	12760830
D009538	Nicotine	Nicotine results in decreased expression of GPX1 mRNA	16949557
D009538	Nicotine	Nicotine results in increased expression of GPX1 protein	18343235
C012655	nimesulide	nimesulide results in decreased expression of GPX1 protein	18848576
C012655	nimesulide	nimesulide results in decreased expression of GPX1 mRNA	24136188
D009569	Nitric Oxide	GPX1 protein affects the metabolism of Nitric Oxide	11498278
D009569	Nitric Oxide	GPX1 protein affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]	11498278
C102148	nitroaspirin	nitroaspirin results in increased expression of GPX1 mRNA	14504662
D005996	Nitroglycerin	GPX1 gene mutant form results in decreased susceptibility to Nitroglycerin	24296279
D026423	S-Nitroso-N-Acetylpenicillamine	GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]	11672444
D026423	S-Nitroso-N-Acetylpenicillamine	GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]	11672444
D026423	S-Nitroso-N-Acetylpenicillamine	GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]	11672444
D026423	S-Nitroso-N-Acetylpenicillamine	S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein]	11672444
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of GPX1 mRNA	17616710
C487513	NSC 23766	NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA]	28710503
C482205	nutlin 3	nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]	20530418
C464660	obeticholic acid	obeticholic acid results in increased expression of GPX1 mRNA	26655953
C025589	ochratoxin A	ochratoxin A results in increased acetylation of GPX1 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of GPX1 promoter] which results in increased expression of GPX1 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of GPX1 mRNA	17316727\|2909832
C025589	ochratoxin A	[Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]	27923682
C025589	ochratoxin A	Chitosan analog inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]	27923682
C025589	ochratoxin A	ochratoxin A results in decreased expression of GPX1 mRNA	23358140\|2792368
C025589	ochratoxin A	ochratoxin A results in increased expression of GPX1 mRNA	24120684
C025589	ochratoxin A	Quercetin inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]	27923682
D009828	Oleanolic Acid	Oleanolic Acid results in increased expression of GPX1 mRNA	18706400
C405603	Omacor	Omacor results in increased expression of GPX1 mRNA	24597798
D009853	Omeprazole	Omeprazole affects the expression of GPX1 mRNA	19483382
D009942	Organometallic Compounds	[Cobalt co-treated with Organometallic Compounds] results in increased expression of GPX1 mRNA	22147119
D016566	Organoselenium Compounds	[Organoselenium Compounds co-treated with Lipopolysaccharides] results in increased expression of GPX1 protein	20883674
D016566	Organoselenium Compounds	Organoselenium Compounds results in increased expression of GPX1 protein	20883674
D010100	Oxygen	GPX1 protein inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]	17087917
D010100	Oxygen	GPX1 protein results in decreased susceptibility to Oxygen	18638544
D010100	Oxygen	Oxygen results in decreased activity of GPX1 protein	15680347
D010100	Oxygen	Oxygen results in increased expression of GPX1 mRNA	15680347
D019308	Palmitic Acid	Palmitic Acid results in decreased expression of GPX1 mRNA	18155663
D019308	Palmitic Acid	rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of GPX1 mRNA]	18155663
D000073878	Palm Oil	Palm Oil results in decreased expression of GPX1 mRNA	18042831
D010269	Paraquat	GPX1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]	15824117
D010269	Paraquat	Paraquat results in increased expression of GPX1 mRNA	18686095
D010269	Paraquat	[Plant Extracts co-treated with Paraquat] results in increased expression of GPX1 mRNA	24141985
D010269	Paraquat	GPX1 gene mutant form results in increased susceptibility to Paraquat	15182862
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat affects the expression of BAX mRNA]	12654481
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat affects the expression of BCL2L2 mRNA]	12654481
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat affects the expression of BCL2 mRNA]	12654481
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat affects the expression of GADD45A mRNA]	12654481
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat affects the expression of MDM2 mRNA]	12654481
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat affects the expression of MYC mRNA]	12654481
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat results in increased activity of CASP3 protein]	12654481
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat results in increased expression of BCL2L1 protein]	12654481
D010269	Paraquat	GPX1 protein affects the reaction [Paraquat results in increased expression of CASP3 protein]	12654481
D010269	Paraquat	GPX1 protein results in decreased susceptibility to Paraquat	11568445
D010269	Paraquat	Paraquat results in decreased expression of GPX1 mRNA	21371552\|2610857
D010269	Paraquat	Paraquat results in increased expression of GPX1 mRNA	12595580
D010269	Paraquat	pirfenidone inhibits the reaction [Paraquat results in decreased expression of GPX1 mRNA]	29273418
D010269	Paraquat	Sodium Selenite affects the reaction [GPX1 gene mutant form affects the susceptibility to Paraquat]	12654481
D010269	Paraquat	Paraquat results in increased expression of GPX1 mRNA	17275934\|2011645
D010269	Paraquat	Paraquat results in decreased expression of GPX1 mRNA	17935786
D010269	Paraquat	[Paraquat results in increased abundance of Reactive Oxygen Species] which results in decreased expression of GPX1 mRNA	24376630
D052638	Particulate Matter	Particulate Matter results in decreased expression of GPX1 mRNA	26856867\|2712597
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of GPX1 mRNA	19442831
D010457	Peptidoglycan	Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]	21355852
D010457	Peptidoglycan	[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein	21355852
D010457	Peptidoglycan	[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]	21355852
D010457	Peptidoglycan	[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Thiomalates results in increased expression of GPX1 protein]	21355852
D010457	Peptidoglycan	Thiomalates promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]	21355852
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of GPX1 mRNA	18611081
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GPX1 protein	26879310
D026023	Permethrin	Permethrin results in decreased activity of GPX1 protein	12965126
D030421	Peroxynitrous Acid	GPX1 gene mutant form results in increased abundance of Peroxynitrous Acid	24296279
D030421	Peroxynitrous Acid	GPX1 protein affects the susceptibility to Peroxynitrous Acid	16636302
D030421	Peroxynitrous Acid	[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Peroxynitrous Acid	16636302
D015232	Dinoprostone	Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]]	25432964
D010622	Phencyclidine	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]	29037473
D010622	Phencyclidine	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]	29037473
D010622	Phencyclidine	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]	29037473
D010622	Phencyclidine	acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]	29037473
D010622	Phencyclidine	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]	29037473
D010622	Phencyclidine	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]	29037473
D010622	Phencyclidine	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]	29037473
D010622	Phencyclidine	ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]	29037473
D010622	Phencyclidine	GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]	29037473
D010622	Phencyclidine	GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]	29037473
D010622	Phencyclidine	GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]	29037473
D010622	Phencyclidine	GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]	29037473
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPX1 mRNA	27048571
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPX1 protein	20935162
D010634	Phenobarbital	DMU-212 inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPX1 mRNA]	27048571
D010634	Phenobarbital	Phenobarbital results in decreased expression of GPX1 mRNA	23273579
D010634	Phenobarbital	Phenobarbital results in increased expression of GPX1 protein	24090815
D010665	Phenylpropanolamine	Phenylpropanolamine results in increased expression of GPX1 mRNA	21989786
D010695	Phlorhizin	Phlorhizin results in decreased expression of GPX1 mRNA	16123366
D010707	Phosphamidon	GPX1 protein results in decreased activity of and results in decreased susceptibility to Phosphamidon	12621067
C004479	pimagedine	pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]	28919305
C093844	pirfenidone	pirfenidone inhibits the reaction [Paraquat results in decreased expression of GPX1 mRNA]	29273418
C006253	pirinixic acid	pirinixic acid results in increased activity of GPX1 protein	11181109
C006253	pirinixic acid	pirinixic acid results in increased expression of GPX1 mRNA	11181109
C006253	pirinixic acid	pirinixic acid affects the expression of GPX1 mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in decreased activity of GPX1 protein	11181109
D010936	Plant Extracts	[Plant Extracts co-treated with Paraquat] results in increased expression of GPX1 mRNA	24141985
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of GPX1 mRNA]	23542512
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in decreased activity of GPX1 protein]	15991261
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Ethanol results in decreased expression of GPX1 mRNA]	18992320
D010936	Plant Extracts	Plant Extracts results in increased expression of GPX1 mRNA	25236610\|2831577
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Rotenone results in increased activity of GPX1 protein]	17079513
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Rotenone results in increased expression of GPX1 mRNA]	17070561\|1707951
C010770	polysaccharide-K	polysaccharide-K results in increased activity of GPX1 protein	10912287
C010770	polysaccharide-K	polysaccharide-K results in increased expression of GPX1 mRNA	10912287
C010770	polysaccharide-K	polysaccharide-K results in increased activity of GPX1 protein	10999442
D011134	Polysaccharides	Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of GPX1 mRNA]	28692354
D011166	Porphyrins	Porphyrins results in decreased expression of GPX1 mRNA	26468117
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of GPX1 mRNA	19162173
D011341	Probucol	Probucol results in increased activity of GPX1 protein	19770487
D011341	Probucol	Probucol inhibits the reaction [methylmercuric chloride results in decreased activity of GPX1 protein]	19770487
D011341	Probucol	Probucol promotes the reaction [methylmercury II results in decreased expression of GPX1 mRNA]	27241350
D011341	Probucol	Probucol results in increased activity of GPX1 protein	19770487
D011341	Probucol	"Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D011341	Probucol	Probucol inhibits the reaction [Doxorubicin results in decreased expression of GPX1 protein]	7805190
C009055	propargylglycine	propargylglycine inhibits the reaction [methionine selenoxide results in increased expression of GPX1 mRNA]	16444005
C005556	propionaldehyde	propionaldehyde results in increased expression of GPX1 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil affects the expression of GPX1 mRNA	19483382
D015237	Dinoprost	GPX1 gene mutant form results in increased susceptibility to Dinoprost	24296279
C107773	pterostilbene	Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]	25341683
C107773	pterostilbene	Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of GPX1 mRNA]	25341683
C107773	pterostilbene	CAT protein inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]	25341683
C107773	pterostilbene	pterostilbene results in increased expression of GPX1 mRNA	25341683
D011692	Puromycin Aminonucleoside	[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein	1942778
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of GPX1 mRNA	20685819
C108337	pyrimethanil	pyrimethanil affects the expression of GPX1 mRNA	22880100
C108337	pyrimethanil	[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA	22880100
C010423	pyrithione zinc	pyrithione zinc results in increased expression of GPX1 mRNA	21424779
D011765	Pyruvaldehyde	magnolol promotes the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]	28919305
D011765	Pyruvaldehyde	pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]	28919305
D011765	Pyruvaldehyde	Pyruvaldehyde results in increased expression of GPX1 mRNA	28919305
D011794	Quercetin	[Quercetin co-treated with Cisplatin] results in increased expression of GPX1 mRNA	24999622
D011794	Quercetin	Quercetin results in increased expression of GPX1 mRNA	18686095\|2219797
D011794	Quercetin	SB 203580 inhibits the reaction [Quercetin results in increased expression of GPX1 mRNA]	22197970
D011794	Quercetin	Quercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]	24337353
D011794	Quercetin	Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GPX1 mRNA]	21462320
D011794	Quercetin	[Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]	27923682
D011794	Quercetin	[Chitosan analog co-treated with Quercetin] results in increased expression of GPX1 mRNA	27923682
D011794	Quercetin	Quercetin analog inhibits the reaction [Rotenone results in increased expression of GPX1 mRNA]	17079513
D011794	Quercetin	Quercetin inhibits the reaction [Atrazine results in increased expression of GPX1 mRNA]	23070809\|2313281
D011794	Quercetin	Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased expression of GPX1 mRNA]	24316378
D011794	Quercetin	Quercetin inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]	27923682
D011794	Quercetin	Quercetin inhibits the reaction [Rotenone results in increased expression of GPX1 mRNA]	17070561
D011794	Quercetin	Quercetin results in increased expression of GPX1 mRNA	23132811\|2557868
C035522	raspberry ketone	Acetylcysteine inhibits the reaction [raspberry ketone results in decreased expression of GPX1 protein]	26867644
C035522	raspberry ketone	raspberry ketone results in decreased expression of GPX1 protein	26867644
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in increased expression of GPX1 protein	21042727
D017382	Reactive Oxygen Species	TP53 protein promotes the reaction [Reactive Oxygen Species results in increased expression of GPX1 protein]	21042727
D017382	Reactive Oxygen Species	"3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [GPX1 gene mutant form results in increased abundance of Reactive Oxygen Species]"	24296279
D017382	Reactive Oxygen Species	GPX1 gene mutant form results in increased abundance of Reactive Oxygen Species	24296279
D017382	Reactive Oxygen Species	GPX1 protein results in increased susceptibility to Reactive Oxygen Species	11672444
D017382	Reactive Oxygen Species	[Paraquat results in increased abundance of Reactive Oxygen Species] which results in decreased expression of GPX1 mRNA	24376630
D017382	Reactive Oxygen Species	GPX1 protein affects the abundance of Reactive Oxygen Species	17010595
D017382	Reactive Oxygen Species	GPX1 protein affects the susceptibility to Reactive Oxygen Species	21593737
D017382	Reactive Oxygen Species	GPX1 protein results in decreased abundance of Reactive Oxygen Species	16008523
C059514	resveratrol	resveratrol results in increased activity of GPX1 protein	17261084
C059514	resveratrol	resveratrol results in increased expression of GPX1	20610621
C059514	resveratrol	resveratrol results in increased expression of GPX1 mRNA	17261084\|2008385
C059514	resveratrol	resveratrol results in increased expression of GPX1 protein	20083859\|2189261
C059514	resveratrol	resveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]	21530968
C059514	resveratrol	resveratrol inhibits the reaction [stearic acid results in decreased expression of GPX1 mRNA]	17374693
C059514	resveratrol	resveratrol results in increased expression of GPX1 mRNA	20610621\|2261019
C059514	resveratrol	resveratrol results in increased expression of GPX1 protein	25505154\|2595201
C059514	resveratrol	resveratrol inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]	24740756
C115945	rhododendrol	Acetylcysteine inhibits the reaction [rhododendrol results in decreased expression of GPX1 protein]	26867644
C115945	rhododendrol	rhododendrol results in decreased expression of GPX1 protein	26867644
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of GPX1 mRNA]	18155663
D012402	Rotenone	Rotenone results in increased expression of and results in increased activity of GPX1 protein	15904944
D012402	Rotenone	Rotenone results in decreased expression of GPX1 mRNA	17657281
D012402	Rotenone	Plant Extracts inhibits the reaction [Rotenone results in increased activity of GPX1 protein]	17079513
D012402	Rotenone	Plant Extracts inhibits the reaction [Rotenone results in increased expression of GPX1 mRNA]	17070561\|1707951
D012402	Rotenone	Quercetin analog inhibits the reaction [Rotenone results in increased expression of GPX1 mRNA]	17079513
D012402	Rotenone	Quercetin inhibits the reaction [Rotenone results in increased expression of GPX1 mRNA]	17070561
D012402	Rotenone	Rotenone results in increased activity of GPX1 protein	17079513
D012402	Rotenone	Rotenone results in increased expression of GPX1 mRNA	17079513
D012431	Rutin	Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]	25478064
D012431	Rutin	Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 protein]	25478064
C018381	salvin	salvin inhibits the reaction [Acrylamide results in decreased expression of GPX1 mRNA]	28159594
D012503	Saponins	Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 mRNA]	29274434
C093642	SB 203580	SB 203580 inhibits the reaction [Quercetin results in increased expression of GPX1 mRNA]	22197970
C115461	SC 560	SC 560 promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]	25432964
D064586	Selenic Acid	Selenic Acid results in increased activity of GPX1 protein	16443359
D012643	Selenium	Selenium deficiency results in decreased activity of GPX1 protein	11456113\|1918176
D012643	Selenium	Selenium deficiency results in decreased expression of GPX1 mRNA	11456113\|1918176
D012643	Selenium	GPX1 gene polymorphism affects the susceptibility to Selenium	19415410
D012643	Selenium	GPX1 protein polymorphism affects the susceptibility to Selenium	12810669
D012643	Selenium	Selenium affects the activity of GPX1 protein	19125369
D012643	Selenium	Selenium deficiency results in decreased expression of GPX1 mRNA	15670848
D012643	Selenium	Selenium results in increased activity of GPX1 protein	15203190\|1715032
D012643	Selenium	Selenium results in increased expression of GPX1 mRNA	10874123\|1177606
D012643	Selenium	Selenium results in increased expression of GPX1 protein	17052796
D012643	Selenium	Selenium affects the activity of GPX1 protein	17513408\|1907606
D012643	Selenium	Selenium affects the expression of GPX1 mRNA	19076066
D012643	Selenium	Selenium affects the expression of GPX1 protein	17709542
D012643	Selenium	Selenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein]	21775527
D012643	Selenium	Selenium deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of GPX1 protein]	21775527
D012643	Selenium	Selenium deficiency results in decreased activity of GPX1 protein	15795427
D012643	Selenium	Selenium deficiency results in decreased expression of and results in decreased activity of GPX1 protein	16170372
D012643	Selenium	Selenium deficiency results in decreased expression of GPX1 mRNA	15795427\|1617037
D012643	Selenium	Selenium affects the expression of GPX1 mRNA	12452969
D012643	Selenium	Selenium deficiency results in decreased activity of GPX1 protein	12452969
D012643	Selenium	Selenium deficiency results in decreased expression of GPX1 mRNA	12452969
D012643	Selenium	Selenium affects the activity of GPX1 protein	19106321
D012643	Selenium	Selenium affects the expression of GPX1 mRNA	19106321
D012643	Selenium	[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GPX1 mRNA	11444866
D012643	Selenium	Selenium deficiency results in decreased activity of GPX1 protein	12031252\|1520338
D012643	Selenium	Selenium deficiency results in decreased expression of GPX1 mRNA	10949970\|1129490
D012643	Selenium	Selenium deficiency results in decreased expression of GPX1 protein	15203381
D012643	Selenium	Selenium inhibits the reaction [Cisplatin results in decreased expression of GPX1 mRNA]	16837816
D012643	Selenium	Selenium results in increased activity of GPX1 protein	10949970\|1902295
D012643	Selenium	Selenium results in increased expression of and results in decreased degradation of GPX1 mRNA	11463357
D012643	Selenium	Selenium results in increased expression of GPX1 mRNA	15792362\|1902295
D012645	Selenomethionine	Selenomethionine results in increased activity of GPX1 protein	19269156\|1944800
D012645	Selenomethionine	Selenomethionine results in increased expression of GPX1 mRNA	19269156
D012645	Selenomethionine	Selenomethionine results in increased expression of GPX1 protein	19448000
D012645	Selenomethionine	Selenomethionine affects the expression of GPX1 mRNA	17222674
D012645	Selenomethionine	Selenomethionine results in increased activity of GPX1 protein	16632112
D012645	Selenomethionine	Selenomethionine results in increased expression of GPX1 mRNA	16632112
D012645	Selenomethionine	Selenomethionine results in increased expression of GPX1 protein	16632112
D012645	Selenomethionine	[SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of GPX1 mRNA	28495429
D012645	Selenomethionine	Selenomethionine inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of GPX1 protein]	20659492
D012645	Selenomethionine	Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased activity of GPX1 protein]	20659492
D012645	Selenomethionine	Selenomethionine results in increased activity of GPX1 protein	20659492
D012645	Selenomethionine	Selenomethionine inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of GPX1 protein]	17280487
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in increased activity of GPX1 protein	19033020
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in increased expression of GPX1 mRNA	18514395
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in increased expression of GPX1 protein	19033020
D012824	Silicic Acid	Silicic Acid inhibits the reaction [aluminum nitrate results in increased expression of GPX1 mRNA]	18096288
D012834	Silver	Silver results in decreased expression of GPX1 mRNA	24974767
D012834	Silver	Silver results in decreased expression of GPX1 mRNA	19781568
D012835	Silver Nitrate	Silver Nitrate results in increased expression of GPX1 mRNA	19508889
D012838	Silymarin	Silymarin results in increased expression of GPX1 mRNA	28137608
D019821	Simvastatin	Simvastatin results in decreased expression of GPX1 mRNA	20883752
D019821	Simvastatin	"Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
C009277	sodium arsenate	sodium arsenate results in increased expression of GPX1 mRNA	16882884
C017947	sodium arsenite	sodium arsenite results in decreased expression of GPX1 protein	24866292
C017947	sodium arsenite	sodium arsenite results in decreased expression of GPX1 protein	24866292
C017947	sodium arsenite	sodium arsenite results in increased expression of GPX1 mRNA	14691202\|1745185
C017947	sodium arsenite	sodium arsenite results in increased expression of GPX1 mRNA	23603382
C017947	sodium arsenite	Sodium Selenite inhibits the reaction [sodium arsenite results in increased expression of GPX1 mRNA]	23603382
C016104	sodium bichromate	sodium bichromate results in decreased expression of GPX1 mRNA	12760830
C016104	sodium bichromate	sodium bichromate results in decreased expression of GPX1 protein	21047991
C016104	sodium bichromate	sodium bichromate results in increased expression of GPX1 mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of GPX1 mRNA	12325037
D012965	Sodium Chloride	acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]	22431579
D012965	Sodium Chloride	atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]	22431579
D012965	Sodium Chloride	[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein	22431579
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased activity of GPX1 protein	20045192
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of GPX1 mRNA	28918527
D012977	Sodium Nitrite	Sodium Nitrite results in increased expression of GPX1 mRNA	23474501
D018038	Sodium Selenite	Sodium Selenite results in increased activity of GPX1 protein	19269156
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX1 mRNA	19269156
D018038	Sodium Selenite	GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased activity of GPX1 protein]	18400727
D018038	Sodium Selenite	GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased expression of GPX1 protein]	18400727
D018038	Sodium Selenite	Sodium Selenite results in increased activity of GPX1 protein	15203190\|1663211
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX1 mRNA	12896980\|1663211
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX1 protein	16632112\|1675751
D018038	Sodium Selenite	SEPHS1 protein affects the reaction [Sodium Selenite results in increased expression of GPX1 protein]	21669866
D018038	Sodium Selenite	Sodium Selenite affects the reaction [GPX1 gene mutant form affects the susceptibility to Paraquat]	12654481
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of GPX1 protein]	20659492
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased activity of GPX1 protein]	20659492
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Streptozocin results in decreased activity of GPX1 protein]	18789669
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]	18789669
D018038	Sodium Selenite	Sodium Selenite results in increased activity of GPX1 protein	16443359\|1848133
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX1 protein	18481333\|2166986
D018038	Sodium Selenite	Sodium Selenite affects the activity of GPX1 protein	12449240
D018038	Sodium Selenite	Sodium Selenite affects the expression of GPX1 mRNA	12449240
D018038	Sodium Selenite	Sodium Selenite deficiency results in decreased expression of GPX1 protein	19716792
D018038	Sodium Selenite	"Sodium Selenite inhibits the reaction [cholestane-3,5,6-triol results in increased expression of GPX1 mRNA]"	16039982
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein]	28544404
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [sodium arsenite results in increased expression of GPX1 mRNA]	23603382
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX1 mRNA	12667700
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX1 protein	24140496
D053260	Soot	Soot results in increased expression of GPX1 mRNA	19165387
D053260	Soot	Soot affects the expression of GPX1 mRNA	23065132
D053260	Soot	Soot results in increased expression of GPX1 mRNA	21914721
D053260	Soot	Soot results in increased expression of GPX1 protein	23065132
C031183	stearic acid	resveratrol inhibits the reaction [stearic acid results in decreased expression of GPX1 mRNA]	17374693
C031183	stearic acid	stearic acid results in decreased expression of GPX1 mRNA	17374693
D013311	Streptozocin	Sodium Selenite inhibits the reaction [Streptozocin results in decreased activity of GPX1 protein]	18789669
D013311	Streptozocin	Sodium Selenite inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]	18789669
D013311	Streptozocin	Streptozocin results in decreased activity of GPX1 protein	18789669
D013311	Streptozocin	Streptozocin results in decreased expression of GPX1 mRNA	18789669
D013311	Streptozocin	Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]	23267840
D013311	Streptozocin	INS1 protein inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]	23267840
D013311	Streptozocin	resveratrol inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]	24740756
D013311	Streptozocin	Streptozocin results in decreased expression of GPX1 mRNA	23267840\|2474075
D013311	Streptozocin	Streptozocin results in increased expression of GPX1 protein	19634143
D013311	Streptozocin	Trientine inhibits the reaction [Streptozocin results in increased expression of GPX1 protein]	19634143
D013605	T-2 Toxin	[T-2 Toxin co-treated with HT-2 toxin] results in increased expression of GPX1 mRNA	26683309
D013605	T-2 Toxin	T-2 Toxin results in increased expression of GPX1 mRNA	26141394
C061133	tamibarotene	tamibarotene affects the expression of GPX1 mRNA	15498508
D013662	Tea	Tea results in increased activity of GPX1 protein	18382860
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GPX1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPX1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GPX1 mRNA	18467041
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GPX1 mRNA	21041162
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GPX1 mRNA	12225545
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GPX1 mRNA	18465118\|1879615
D013752	Tetracycline	Tetracycline results in decreased expression of GPX1 mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of GPX1 protein	10432307
D013792	Thalidomide	Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GPX1 protein]	17030452
D013806	Theophylline	Theophylline results in decreased expression of GPX1 mRNA	17522070
C417209	thiacloprid	Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of GPX1 mRNA]	28692354
C417209	thiacloprid	thiacloprid results in decreased expression of GPX1 mRNA	28692354
D013853	Thioacetamide	CYP2E1 protein affects the reaction [Thioacetamide results in decreased expression of GPX1 mRNA]	18374380
D013853	Thioacetamide	Thioacetamide results in decreased expression of GPX1 mRNA	18374380
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GPX1 mRNA	28943392
D013853	Thioacetamide	Thioacetamide affects the expression of GPX1 mRNA	19483382
D013853	Thioacetamide	Thioacetamide results in increased activity of GPX1 protein	12009419
D013853	Thioacetamide	Thioacetamide results in increased expression of GPX1 mRNA	12009419
D008063	Thioctic Acid	Thioctic Acid results in increased expression of GPX1 mRNA	23649336
D013870	Thiomalates	[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Thiomalates results in increased expression of GPX1 protein]	21355852
D013870	Thiomalates	Thiomalates promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]	21355852
D013870	Thiomalates	Thiomalates results in decreased activity of GPX1 protein	21355852
D013870	Thiomalates	Thiomalates results in increased expression of GPX1 protein	21355852
D013974	Thyroxine	[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]	19914224
D013974	Thyroxine	Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]	19914224
D013974	Thyroxine	Thyroxine results in decreased activity of GPX1 protein	19914224
D013974	Thyroxine	Thyroxine results in decreased expression of GPX1 mRNA	19914224
D013974	Thyroxine	Thyroxine results in increased activity of GPX1 protein	19914224
D013974	Thyroxine	Thyroxine results in increased expression of GPX1 protein	19914224
D013974	Thyroxine	Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]	19914224
C003466	thymoquinone	"thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
D014025	Titanium	Titanium results in decreased expression of GPX1 mRNA	26878849
C009495	titanium dioxide	titanium dioxide results in decreased expression of GPX1 mRNA	25578686
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of GPX1 mRNA	27480279
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of GPX1 gene	26756918
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of GPX1 protein	22595367
D014199	Trehalose	Trehalose inhibits the reaction [cadmium acetate results in increased expression of GPX1 protein]	29140578
D014212	Tretinoin	Tretinoin results in decreased expression of GPX1 mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of GPX1 mRNA	17218384
D014212	Tretinoin	Tretinoin results in increased expression of GPX1 mRNA	15498508\|1716956
C012589	trichostatin A	trichostatin A results in increased expression of GPX1 mRNA	15901671
D014266	Trientine	Trientine inhibits the reaction [Streptozocin results in increased expression of GPX1 protein]	19634143
D014304	Triolein	"Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]"	28734741
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of GPX1 mRNA	26049154\|2618380
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of GPX1 mRNA	25808963
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of GPX1 mRNA	26049154\|2618380
C057693	troglitazone	troglitazone results in increased expression of GPX1 mRNA	19631733
C057693	troglitazone	troglitazone results in decreased expression of GPX1 protein	11328671
C057693	troglitazone	troglitazone results in increased expression of GPX1 protein	21315101
D014501	Uranium	Uranium affects the expression of GPX1 mRNA	15672453
D014501	Uranium	Uranium analog results in decreased expression of GPX1 mRNA	27544493
C005460	uranyl acetate	uranyl acetate affects the expression of GPX1 mRNA	15672453
C073339	usnic acid	[usnic acid co-treated with Lipopolysaccharides] results in increased expression of GPX1 mRNA	22777745
D014635	Valproic Acid	Valproic Acid results in increased methylation of GPX1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of GPX1 mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of GPX1 mRNA	26856867
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of GPX1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of GPX1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of GPX1 mRNA	23034163
D014800	Vitallium	Vitallium analog results in decreased expression of GPX1 mRNA	23825117
D014801	Vitamin A	[Vitamin A co-treated with Ascorbic Acid co-treated with Vitamin E] results in increased expression of GPX1 protein	17179735
D014810	Vitamin E	[Ascorbic Acid co-treated with Vitamin E] results in increased expression of GPX1 mRNA	22207723
D014810	Vitamin E	[Vitamin A co-treated with Ascorbic Acid co-treated with Vitamin E] results in increased expression of GPX1 protein	17179735
D014810	Vitamin E	Vitamin E inhibits the reaction [Aluminum results in decreased activity of GPX1 protein]	17709913
D014810	Vitamin E	[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]	19914224
D014810	Vitamin E	[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GPX1 mRNA	11444866
D014810	Vitamin E	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GPX1 protein]	16298753
D014810	Vitamin E	Vitamin E inhibits the reaction [Endosulfan results in increased activity of GPX1 protein]	15337585
D014810	Vitamin E	Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]	19914224
D024483	Vitamin K 3	GPX1 protein results in decreased susceptibility to Vitamin K 3	1939125
D014867	Water	[GPX1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased chemical synthesis of Water	11861405
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of GPX1 mRNA"	24096237
C403304	zerumbone	zerumbone results in increased expression of GPX1 mRNA	15122579
D015032	Zinc	Zinc affects the expression of GPX1 mRNA	16413754
D015032	Zinc	Zinc deficiency results in increased expression of GPX1 mRNA	12672911\|2012868
D019345	Zinc Acetate	[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA	20530418
D019345	Zinc Acetate	nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]	20530418
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [Ethanol results in decreased expression of GPX1 protein]	15920153

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004602	glutathione peroxidase activity	-	IDA	12829378
GO:0004602	glutathione peroxidase activity	-	TAS	-
GO:0017124	SH3 domain binding	-	IPI	12893824

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001659	temperature homeostasis	-	IEA	-
GO:0001885	endothelial cell development	-	IEA	-
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	-	IEA	-
GO:0006195	purine nucleotide catabolic process	-	TAS	-
GO:0006641	triglyceride metabolic process	-	IEA	-
GO:0006749	glutathione metabolic process	-	IDA	12829378
GO:0007605	sensory perception of sound	-	IEA	-
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	-	IEA	-
GO:0009410	response to xenobiotic stimulus	-	IEA	-
GO:0009609	response to symbiotic bacterium	-	IEA	-
GO:0009650	UV protection	-	IMP	17097614
GO:0010269	response to selenium ion	-	IMP	12810669
GO:0010332	response to gamma radiation	-	IEA	-
GO:0018158	protein oxidation	-	IEA	-
GO:0019372	lipoxygenase pathway	-	TAS	-
GO:0033194	response to hydroperoxide	-	IEA	-
GO:0033599	regulation of mammary gland epithelial cell proliferation	-	IMP	16945136
GO:0034599	cellular response to oxidative stress	-	NAS	18853169
GO:0034599	cellular response to oxidative stress	-	TAS	-
GO:0040029	regulation of gene expression, epigenetic	-	IDA	16132718
GO:0042311	vasodilation	-	IEA	-
GO:0042542	response to hydrogen peroxide	-	IMP	12829378
GO:0042744	hydrogen peroxide catabolic process	-	IDA	15203190
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IMP	12221075
GO:0043403	skeletal muscle tissue regeneration	-	IEA	-
GO:0043523	regulation of neuron apoptotic process	-	IEA	-
GO:0043534	blood vessel endothelial cell migration	-	IEA	-
GO:0045444	fat cell differentiation	-	IEA	-
GO:0045454	cell redox homeostasis	-	IDA	12829378
GO:0048741	skeletal muscle fiber development	-	IEA	-
GO:0051450	myoblast proliferation	-	IEA	-
GO:0051702	interaction with symbiont	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	IEA	-
GO:0060047	heart contraction	-	IMP	14573732
GO:0060055	angiogenesis involved in wound healing	-	IEA	-
GO:0061136	regulation of proteasomal protein catabolic process	-	IDA	12751788
GO:0090201	negative regulation of release of cytochrome c from mitochondria	-	IMP	12221075
GO:0098869	cellular oxidant detoxification	-	IEA	-
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	IMP	12221075
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	-	IEA	-
GO:1902905	positive regulation of supramolecular fiber organization	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	10833429
GO:0005739	mitochondrion	-	IDA	10833429
GO:0005759	mitochondrial matrix	-	TAS	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0097413	Lewy body	colocalizes_with	IDA	18853169

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism
hsa00590	Arachidonic acid metabolism
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05016	Huntington's disease

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-15869	Metabolism of nucleotides	TAS
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	IEA
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	TAS
R-HSA-2142753	Arachidonic acid metabolism	IEA
R-HSA-2142753	Arachidonic acid metabolism	TAS
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3299685	Detoxification of Reactive Oxygen Species	TAS
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-74259	Purine catabolism	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8956319	Nucleobase catabolism	TAS
R-HSA-8978868	Fatty acid metabolism	IEA
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25026746	[Polymorphisms in the oxidative stress-related genes and cancer risk]. (2013)	Janicka A	Ann Acad Med Stetin
20609902	Blot-based detection of dehydroalanine-containing glutathione peroxidase with the use of biotin-conjugated cysteamine. (2010)	Rhee SG	Methods Enzymol
15829318	Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. (2005 May)	Skuladottir H	Lung Cancer
19728855	Level of selenoprotein transcripts in peripheral leukocytes of patients with bladder cancer and healthy individuals. (2009)	Reszka E	Clin Chem Lab Med
19428376	GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer. (2009 May 12)	Hansen RD	Mutat Res
21586620	GSTM1, GSTT1 null variants, and GPX1 single nucleotide polymorphism are not associated with bladder cancer risk in Egypt. (2011 Jul)	Goerlitz D	Cancer Epidemiol Biomarkers Prev
18298806	Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years. (2008 Feb 25)	Rosenberger A	BMC Cancer
16255782	CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. (2005 Oct 29)	Mullins DN	BMC Cancer
17548672	Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. (2007 Jun)	Choi JY	Cancer Epidemiol Biomarkers Prev
22986747	SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. (2012 Nov 15)	Beane J	Cancer Res
28198160	Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke. (2017 Mar)	Karahalil B	J Gene Med
25894374	K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation. (2015 Sep)	Cheng D	Tumour Biol
18062829	Effect of long-term selenium yeast intervention on activity and gene expression of antioxidant and xenobiotic metabolising enzymes in healthy elderly volunteers from the Danish Prevention of Cancer by Intervention by Selenium (PRECISE) pilot study. (2008 Jun)	Ravn-Haren G	Br J Nutr
24074040	Polymorphic variants of MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genotypes and the risk of laryngeal cancer in a smoking population. (2013 Oct)	Aynali G	J Laryngol Otol
20643115	Epistasis of oxidative stress-related enzyme genes on modulating the risks in oral cavity cancer. (2010 Nov 11)	Wu SH	Clin Chim Acta
23363810	Prostate disease risk factors among a New Zealand cohort. (2012)	Karunasinghe N	J Nutrigenet Nutrigenomics
16538174	Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. (2006 Apr)	Bastaki M	Pharmacogenet Genomics
20301895	[Lack of association between metabolic and antioxidant gene polymorphisms (GSTM1, GSTT1, CAT, MnSOD, GPX1) and maternal quitting of smoking in pregnancy--preliminary results]. (2009)	Hozyasz KK	Przegl Lek
16797832	GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer. (2007 Mar 18)	Raaschou-Nielsen O	Cancer Lett
28464886	A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells. (2017 May 2)	Yeo J	BMC Cancer
16615267	[Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer]. (2006 Mar)	Lee CH	J Prev Med Public Health
19125369	Sex determines the influence of smoking and gene polymorphism on glutathione peroxidase activity in erythrocytes. (2009)	Malling TH	Scand J Clin Lab Invest
26658762	DNA damage and oxidative stress response to selenium yeast in the non-smoking individuals: a short-term supplementation trial with respect to GPX1 and SEPP1 polymorphism. (2016 Dec)	Jablonska E	Eur J Nutr
21993316	Association between genetic variants in glutathione peroxidase 1 (GPx1) gene, GPx activity and the risk of prostate cancer. (2011 Sep)	Kucukgergin C	Minerva Urol Nefrol