Gene info: ID 2877

Gene: GPX2

GENE ID: 2877

Description: glutathione peroxidase 2

Gene type: protein-coding

Location: 14q23.3

dbXrefs: Ensembl:ENSG00000176153 MIM:138319 Vega:OTTHUMG00000171677 UniprotKB:P18283

RefSeq: NC_000014.9

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.631e-1 (AD) 8.167e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLA2G2E	0.716
FAM83C	0.679
DEFB115	0.655
MUC17	0.651
OPN1MW2	0.624
OR7C2	0.619
ACTL7B	0.618
OTOR	0.605
PRPS1L1	0.588
TMPRSS9	0.583

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RFTN2	-0.235
GPR17	-0.222
C9orf43	-0.215
OTC	-0.212
RAB41	-0.205
ACSM5	-0.199
RAD9B	-0.185
DIAPH3	-0.183
MRO	-0.182
APCDD1	-0.181

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GPX2 mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GPX2 mRNA]"	27071940
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of GPX2 mRNA"	19162173
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of GPX2 mRNA"	21920950
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GPX2 mRNA"	20005886\|2185183
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GPX2 mRNA]"	21851831
C425784	2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole	2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of GPX2 mRNA	25781201
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX2 mRNA"	18056462
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX2 protein"	18056462
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX2 mRNA]"	25843059
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid results in increased expression of GPX2 mRNA"	25843059
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of GPX2 mRNA	12419474
C029370	4-toluidine	4-toluidine results in increased expression of GPX2 mRNA	27638505
D000082	Acetaminophen	Acetaminophen results in decreased expression of GPX2 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen results in increased expression of GPX2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in increased expression of GPX2 mRNA	25242409
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA]	22129741
D020106	Acrylamide	Acrylamide results in increased expression of GPX2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of GPX2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GPX2 mRNA	23385219\|2363061
D000393	Air Pollutants	Air Pollutants results in increased expression of GPX2 mRNA	18367723
C103303	alitretinoin	alitretinoin results in increased expression of GPX2 mRNA	15623509
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased expression of GPX2 mRNA	17785943
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of GPX2 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of GPX2 mRNA	23912714
D001149	Arsenates	[Arsenates co-treated with chromium hexavalent ion] results in increased expression of GPX2 mRNA	19895865
D001151	Arsenic	Arsenic results in increased expression of GPX2 mRNA	19945496
C025657	arsenic acid	arsenic acid results in decreased expression of GPX2 mRNA	19429247
C015001	arsenite	arsenite results in decreased expression of GPX2 mRNA	19429247
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in increased expression of GPX2 mRNA	17639512
D001205	Ascorbic Acid	[Tretinoin co-treated with Ascorbic Acid] results in increased expression of GPX2 mRNA	16443354
D001379	Azathioprine	Azathioprine results in increased expression of GPX2 mRNA	18222062
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GPX2 mRNA	19389873\|2120374
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GPX2 protein	19389873
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX2 mRNA	18164116\|2004503
D001564	Benzo(a)pyrene	Benzo(a)pyrene inhibits the reaction [glucoraphanin results in increased expression of GPX2 mRNA]	20868228
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GPX2 mRNA	15735009
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GPX2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GPX2 mRNA	25908611
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GPX2 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of GPX2 mRNA	20106945
D004958	Estradiol	Estradiol results in increased expression of GPX2 mRNA	19619570\|2118537
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of GPX2 mRNA	17404688
C099952	bifenthrin	bifenthrin results in decreased expression of GPX2 mRNA	27916261
C099952	bifenthrin	bifenthrin results in increased expression of GPX2 mRNA	26071804
C452139	BIRB 796	BIRB 796 results in increased expression of GPX2 mRNA	21328587
C006780	bisphenol A	bisphenol A results in increased expression of GPX2 mRNA	28159858
C006780	bisphenol A	bisphenol A affects the expression of GPX2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of GPX2 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of GPX2 mRNA	21601586
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of GPX2 mRNA	21601586
C032036	bromobenzene	bromobenzene results in increased expression of GPX2 mRNA	17538237
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of GPX2 mRNA	15878706
D020122	tert-Butylhydroperoxide	GPX2 protein results in increased reduction of tert-Butylhydroperoxide	8428933
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of GPX2 mRNA	12419474
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GPX2 mRNA	10806356\|1241465
C018475	butyraldehyde	butyraldehyde results in decreased expression of GPX2 mRNA	26079696
D002104	Cadmium	Cadmium affects the activity of GPX2 protein	16865233
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of GPX2 mRNA	18974090
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GPX2 mRNA	22677785\|2350362
D019256	Cadmium Chloride	Cadmium Chloride affects the activity of GPX2 protein	16865233
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPX2 mRNA	18654764
D002220	Carbamazepine	Carbamazepine affects the expression of GPX2 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GPX2 mRNA	23341968
D002251	Carbon Tetrachloride	Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX2 mRNA]	23341968
D002509	Cephaloridine	Cephaloridine results in increased expression of GPX2 mRNA	18500788
C026690	cerous chloride	cerous chloride results in decreased expression of GPX2 mRNA	28954213
D002737	Chloroprene	Chloroprene results in increased expression of GPX2 mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of GPX2 mRNA	19440498
D002784	Cholesterol	[cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of GPX2 mRNA	26606054
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPX2 mRNA	20938992
C074702	chromium hexavalent ion	[Arsenates co-treated with chromium hexavalent ion] results in increased expression of GPX2 mRNA	19895865
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of GPX2 mRNA	19000754
C012843	cinnamic aldehyde	cinnamic aldehyde affects the expression of GPX2 mRNA	28219650
C012843	cinnamic aldehyde	NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX2 mRNA]	28219650
D003035	Cobalt	[Cobalt co-treated with Organometallic Compounds] results in increased expression of GPX2 mRNA	22147119
D003035	Cobalt	Cobalt results in increased expression of GPX2 mRNA	22147119
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPX2 mRNA	18654764
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of GPX2 mRNA	19376846
C052387	cocoa butter	[cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of GPX2 mRNA	26606054
D003300	Copper	Copper deficiency results in decreased expression of GPX2 mRNA	19497425
D003300	Copper	Copper results in decreased expression of GPX2 mRNA	19497425
D003300	Copper	Copper results in increased expression of GPX2 mRNA	22465980
C007164	cumene hydroperoxide	GPX2 protein results in increased reduction of cumene hydroperoxide	8428933
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of GPX2 mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in decreased expression of GPX2 mRNA	20106945\|2798913
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of GPX2 mRNA	24921660
C017160	cypermethrin	cypermethrin results in increased expression of GPX2 mRNA	21397294
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of GPX2 mRNA	29038839
C093628	cyproconazole	cyproconazole results in decreased expression of GPX2 mRNA	25182419
C093628	cyproconazole	cyproconazole results in increased expression of GPX2 mRNA	29038839
C007262	deoxynivalenol	deoxynivalenol results in increased expression of GPX2 mRNA	25701311
D003976	Diazinon	Diazinon affects the expression of GPX2 mRNA	17452286\|1944049
D003976	Diazinon	Diazinon results in increased expression of GPX2 mRNA	19440498
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of GPX2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of GPX2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of GPX2 mRNA	24865317
D002945	Cisplatin	[Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA	24865317
D004008	Diclofenac	Diclofenac affects the expression of GPX2 mRNA	24752500
C121718	dicyclanil	[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	19182440
C121718	dicyclanil	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of GPX2 mRNA]	19182440
D004042	Dietary Fats, Unsaturated	"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of GPX2 mRNA"	23626681
D004052	Diethylnitrosamine	[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	19182440
D004052	Diethylnitrosamine	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of GPX2 mRNA]	19182440
D004052	Diethylnitrosamine	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	16158176
D004052	Diethylnitrosamine	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA]	22129741
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GPX2 mRNA	14656948
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX2 mRNA	18164116\|2004503
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA	20033131
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA	20033131
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GPX2 mRNA	20033131
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA	23830814
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GPX2 mRNA	23830814
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GPX2 mRNA	19638242\|2524240
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	18253720\|1877588
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	22129741
D004052	Diethylnitrosamine	[Mastic Resin co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	18977376
D004052	Diethylnitrosamine	[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	22687989
D004052	Diethylnitrosamine	[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	23665939
D004052	Diethylnitrosamine	[oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	18754104
D002117	Calcitriol	Calcitriol results in increased expression of GPX2 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of GPX2 mRNA	21592394
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of GPX2 mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GPX2 mRNA"	18056462
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GPX2 protein"	18056462
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of GPX2 mRNA	28219650
D004137	Dinitrochlorobenzene	NFE2L2 protein promotes the reaction [Dinitrochlorobenzene results in increased expression of GPX2 mRNA]	28219650
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of GPX2 mRNA"	23262642
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of GPX2 mRNA	26159488
D004726	Endosulfan	Endosulfan results in increased expression of GPX2 mRNA	26159488
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of GPX2 mRNA	29038839
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of GPX2 mRNA	24412560
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of GPX2 mRNA	17347304
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPX2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GPX2 mRNA	15576828\|1617478
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	18253720\|1877588
D011345	Fenofibrate	Fenofibrate results in increased expression of GPX2 mRNA	17264098\|1877588
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of GPX2 mRNA	17347304
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	16158176
D015073	2-Acetylaminofluorene	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GPX2 mRNA	14656948
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of GPX2 mRNA]	15016801
D005485	Flutamide	Flutamide results in decreased expression of GPX2 mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of GPX2 mRNA	21203749\|2413618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPX2 mRNA	20938992
C039281	furan	furan results in increased expression of GPX2 mRNA	25539665\|2619464
C048308	glucobrassicin	glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA]	20868228
C048308	glucobrassicin	glucobrassicin analog results in decreased expression of GPX2 protein	20868228
C119494	glucoraphanin	Benzo(a)pyrene inhibits the reaction [glucoraphanin results in increased expression of GPX2 mRNA]	20868228
C119494	glucoraphanin	glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA]	20868228
C119494	glucoraphanin	glucoraphanin analog results in increased expression of GPX2 mRNA	20868228
C119494	glucoraphanin	glucoraphanin analog results in increased expression of GPX2 protein	20868228
D005947	Glucose	Glucose results in increased expression of GPX2 mRNA	28027979
C071834	glycidamide	glycidamide results in increased expression of GPX2 mRNA	17822822
D006034	Glycyrrhetinic Acid	Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX2 mRNA]	23341968
D006046	Gold	Gold results in increased expression of GPX2 mRNA	25523186
D017313	Fenretinide	Fenretinide results in increased expression of GPX2 mRNA	15623509
D006861	Hydrogen Peroxide	GPX2 protein results in increased reduction of Hydrogen Peroxide	8428933
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GPX2 mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GPX2 mRNA	12414654
C016517	indole-3-carbinol	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA]	22129741
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of GPX2 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	22129741
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Phenobarbital] results in increased expression of GPX2 mRNA	24418717
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GPX2 mRNA	21203749\|2441871
D007501	Iron	Iron deficiency results in increased expression of GPX2 mRNA	16629162
D019266	Iron, Dietary	"Iron, Dietary affects the expression of GPX2 mRNA"	15637178
C016527	isoquercitrin	[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA	20033131
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of GPX2 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of GPX2 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of GPX2 mRNA	24086573
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPX2 mRNA	18654764
C029891	lead chloride	lead chloride results in increased expression of GPX2 mRNA	23503628
C008285	linoleic acid hydroperoxide	GPX2 protein results in increased reduction of linoleic acid hydroperoxide	8428933
D008070	Lipopolysaccharides	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX2 mRNA]"	25843059
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of GPX2 mRNA	25843059
D014975	Lutein	[Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA	24865317
D000069997	Mastic Resin	[Mastic Resin co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	18977376
D008550	Melatonin	[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA	20033131
D015122	Mercaptopurine	Mercaptopurine results in increased expression of GPX2 mRNA	18222062
D008701	Methapyrilene	Methapyrilene results in increased expression of GPX2 mRNA	25242409
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPX2 mRNA	20938992
D008727	Methotrexate	GPX2 protein affects the susceptibility to Methotrexate	16217747
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GPX2 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GPX2 protein	22265609
C020771	methylmercury hydroxide	methylmercury hydroxide results in increased expression of GPX2 mRNA	20493249
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GPX2 mRNA"	20188158
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of GPX2 mRNA	18056462
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of GPX2 protein	18056462
D016686	Monocrotaline	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA	21224054
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of GPX2 mRNA	20886546\|2387685
D009151	Mustard Gas	Mustard Gas results in increased expression of GPX2 mRNA	25102026
C005273	naringenin	naringenin results in increased expression of GPX2 mRNA	24561720
C005273	naringenin	[Paraquat co-treated with naringenin] results in increased expression of GPX2 mRNA	24561720
D009532	Nickel	Nickel results in increased expression of GPX2 mRNA	25583101
D009532	Nickel	Nickel results in decreased expression of GPX2 mRNA	19440498
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased expression of GPX2 mRNA	15878706
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of GPX2 mRNA	19716841
C464660	obeticholic acid	obeticholic acid results in decreased expression of GPX2 mRNA	27939613
C025589	ochratoxin A	ochratoxin A results in increased expression of GPX2 mRNA	24120684
D009853	Omeprazole	[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	22687989
C016340	o,p'-DDT	"o,p'-DDT affects the expression of GPX2 mRNA"	17984292
D009942	Organometallic Compounds	[Cobalt co-treated with Organometallic Compounds] results in increased expression of GPX2 mRNA	22147119
D009966	Orphenadrine	Orphenadrine affects the expression of GPX2 mRNA	23665939\|2366594
D009966	Orphenadrine	[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	23665939
D009966	Orphenadrine	[Phenobarbital co-treated with Orphenadrine] affects the expression of GPX2 mRNA	23665940
D008939	Mitotane	Mitotane analog results in increased expression of GPX2 mRNA	23485034
D008939	Mitotane	Mitotane results in increased expression of GPX2 mRNA	23485034
C011030	oxfendazole	[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA	20033131
C011030	oxfendazole	[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA	20033131
C011030	oxfendazole	[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GPX2 mRNA	20033131
C011030	oxfendazole	[oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA	18754104
D010126	Ozone	Ozone results in increased expression of GPX2 mRNA	17095637
D019308	Palmitic Acid	Palmitic Acid results in increased expression of GPX2 mRNA	28027979
D010269	Paraquat	[Paraquat co-treated with naringenin] results in increased expression of GPX2 mRNA	24561720
D010269	Paraquat	Paraquat results in increased expression of GPX2 mRNA	10806356
D010269	Paraquat	APOD protein affects the reaction [Paraquat results in decreased expression of GPX2 mRNA]	21688324
D010269	Paraquat	Paraquat affects the expression of GPX2 mRNA	12732627
D010269	Paraquat	Paraquat results in decreased expression of GPX2 mRNA	21688324
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of GPX2 mRNA	19162173
C023036	perfluorooctanoic acid	"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of GPX2 mRNA"	23626681
C023036	perfluorooctanoic acid	[perfluorooctanoic acid co-treated with PPARA] results in increased expression of GPX2 mRNA	20118188
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GPX2 mRNA	20118188
C023036	perfluorooctanoic acid	PPARA promotes the reaction [perfluorooctanoic acid results in decreased expression of GPX2 mRNA]	20118188
D015232	Dinoprostone	[GPX2 protein affects the activity of PTGS2 protein] which affects the metabolism of Dinoprostone	18479189
D015232	Dinoprostone	[GPX2 protein affects the expression of PTGES protein] which affects the metabolism of Dinoprostone	18479189
D015232	Dinoprostone	GPX2 protein affects the secretion of Dinoprostone	18479189
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GPX2 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of GPX2 mRNA	19482888
D010634	Phenobarbital	[indole-3-carbinol co-treated with Phenobarbital] results in increased expression of GPX2 mRNA	24418717
D010634	Phenobarbital	Phenobarbital affects the expression of GPX2 mRNA	23665940\|2402578
D010634	Phenobarbital	[Phenobarbital co-treated with Orphenadrine] affects the expression of GPX2 mRNA	23665940
D010634	Phenobarbital	Phenobarbital results in increased expression of GPX2 mRNA	24418717
D010634	Phenobarbital	Piperonyl Butoxide affects the reaction [Phenobarbital affects the expression of GPX2 mRNA]	24025784
D010672	Phenytoin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA	21224054
D010705	Phosgene	Phosgene affects the expression of GPX2 mRNA	16300373
D010882	Piperonyl Butoxide	Piperonyl Butoxide affects the expression of GPX2 mRNA	24025784
D010882	Piperonyl Butoxide	Piperonyl Butoxide affects the reaction [Phenobarbital affects the expression of GPX2 mRNA]	24025784
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of GPX2 mRNA	17498859\|1854491
D010882	Piperonyl Butoxide	Triterpenes promotes the reaction [Piperonyl Butoxide results in increased expression of GPX2 mRNA]	18544911
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GPX2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of GPX2 mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of GPX2 mRNA	16985257
D010936	Plant Extracts	Plant Extracts results in decreased expression of GPX2 mRNA	17210444\|2355793
D010936	Plant Extracts	Plant Extracts results in increased expression of GPX2 mRNA	17210444
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of GPX2 mRNA]	19182440
D010936	Plant Extracts	Plant Extracts results in increased expression of GPX2 mRNA	23262642
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in decreased expression of GPX2 mRNA	24583197
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of GPX2 mRNA	19162173
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of GPX2 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of GPX2 mRNA	17404688
D011374	Progesterone	Progesterone affects the expression of GPX2 mRNA	17251523
C005556	propionaldehyde	propionaldehyde results in decreased expression of GPX2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of GPX2 mRNA	24780913
C031280	pyrazole	pyrazole results in increased expression of GPX2 mRNA	17945193
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in increased expression of GPX2 mRNA	17639512
D011794	Quercetin	Quercetin results in decreased expression of GPX2 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of GPX2 mRNA	17210444
D011794	Quercetin	Quercetin results in decreased expression of GPX2 mRNA	16455785
D011794	Quercetin	Quercetin results in increased expression of GPX2 mRNA	18095365
C059514	resveratrol	resveratrol results in increased expression of GPX2 mRNA	17210444
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of GPX2 mRNA	25905778
C059514	resveratrol	resveratrol results in increased expression of GPX2 mRNA	25905778
D015474	Isotretinoin	Isotretinoin results in increased expression of GPX2 mRNA	15623509
D012293	Rifampin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA	21224054
C079198	S 1 (combination)	GPX2 protein results in increased susceptibility to S 1 (combination)	16734730
D012643	Selenium	Selenium deficiency results in decreased activity of GPX2 protein	15795427
D012643	Selenium	Selenium deficiency results in decreased expression of GPX2 mRNA	15795427
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of GPX2 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of GPX2 mRNA	25351596
D012834	Silver	NFE2L2 protein affects the reaction [Silver results in increased expression of GPX2 mRNA]	22546375
D012834	Silver	Silver results in increased expression of GPX2 mRNA	22546375
D012834	Silver	Silver results in decreased expression of GPX2 mRNA	19429238
D012834	Silver	Silver analog results in decreased expression of GPX2 mRNA	22727896
D019821	Simvastatin	Simvastatin results in increased expression of GPX2 mRNA	18787804
D012906	Smoke	Smoke results in increased expression of GPX2 mRNA	20015843
C009277	sodium arsenate	sodium arsenate results in increased expression of GPX2 mRNA	12727804
C017947	sodium arsenite	sodium arsenite results in increased expression of GPX2 mRNA	20886546\|2387685
C017947	sodium arsenite	sodium arsenite results in increased expression of GPX2 mRNA	21396911
C016104	sodium bichromate	sodium bichromate results in increased expression of GPX2 mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of GPX2 mRNA	22561333
D020358	Sodium Cholate	[cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of GPX2 mRNA	26606054
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX2 protein	25187657
D053260	Soot	Soot results in increased expression of GPX2 mRNA	21914721
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of GPX2 mRNA	25905778
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of GPX2 mRNA	26141394
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of GPX2 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of GPX2 mRNA	21592394
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of GPX2 mRNA	25260812
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of GPX2 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GPX2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GPX2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GPX2 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPX2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	"Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GPX2 mRNA]"	21851831
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GPX2 mRNA	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GPX2 mRNA	21215274
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of GPX2 mRNA	28973375
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA	23830814
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GPX2 mRNA	23830814
D013853	Thioacetamide	Thioacetamide results in increased expression of GPX2 mRNA	23411599\|2524240
D008063	Thioctic Acid	[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA	23830814
C009495	titanium dioxide	titanium dioxide affects the expression of GPX2 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of GPX2 mRNA	25447457
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GPX2 mRNA	27404394\|2786577
D014028	Tobacco Smoke Pollution	NFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of GPX2 mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of GPX2 mRNA	20133372
D014050	Toluene	Toluene affects the expression of GPX2 mRNA	18653662
D014212	Tretinoin	[Tretinoin co-treated with Ascorbic Acid] results in increased expression of GPX2 mRNA	16443354
D014212	Tretinoin	Tretinoin results in increased activity of GPX2 protein	10498757
D014212	Tretinoin	Tretinoin results in increased expression of GPX2 mRNA	10498757\|1704516
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GPX2 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of GPX2 mRNA	29024780
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of GPX2 mRNA	25808963
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of GPX2 mRNA	26049154\|2618380
D014315	Triterpenes	Triterpenes promotes the reaction [Piperonyl Butoxide results in increased expression of GPX2 mRNA]	18544911
D014315	Triterpenes	Triterpenes results in increased expression of GPX2 mRNA	18544911
C057693	troglitazone	troglitazone results in increased expression of GPX2 mRNA	25572481
C406224	valdecoxib	valdecoxib results in increased expression of GPX2 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of GPX2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased methylation of GPX2 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of GPX2 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of GPX2 mRNA	19015723
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of GPX2 mRNA	12414654
C016837	zinc chloride	zinc chloride results in increased expression of GPX2 mRNA	18947441

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004602	glutathione peroxidase activity	-	TAS	-
GO:0009055	electron transfer activity	-	TAS	8428933

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0022900	electron transport chain	-	IEA	-
GO:0034599	cellular response to oxidative stress	-	TAS	-
GO:0098869	cellular oxidant detoxification	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	TAS	8428933
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism
hsa00590	Arachidonic acid metabolism

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	IEA
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	TAS
R-HSA-2142753	Arachidonic acid metabolism	IEA
R-HSA-2142753	Arachidonic acid metabolism	TAS
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3299685	Detoxification of Reactive Oxygen Species	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8978868	Fatty acid metabolism	IEA
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25447457	Tobacco smoking-response genes in blood and buccal cells. (2015 Jan 22)	Na HK	Toxicol Lett
18559366	Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. (2008 Oct)	Goven D	Thorax
21940907	Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. (2011 Nov)	Hakenewerth AM	Cancer Epidemiol Biomarkers Prev
25524402	Association between plasma selenium level and NRF2 target genes expression in humans. (2015 Apr)	Reszka E	J Trace Elem Med Biol