Gene: GPX3

2878
GPx-P|GSHPx-3|GSHPx-P
glutathione peroxidase 3
protein-coding
5q33.1
Ensembl:ENSG00000211445 MIM:138321 Vega:OTTHUMG00000163693 UniprotKB:P22352
NC_000005.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.007e-1 (AD)  9.422e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSC22D10.776
FLOT20.74
ARF10.733
C19orf660.731
USF10.731
HEXB0.729
PRAF20.729
MPG0.728
FKBP1A0.721
APMAP0.72

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.598
OR4F29-0.572
CTNNA3-0.279
PDE11A-0.275
TRPV5-0.238
C5orf64-0.236
KLRC2-0.226
OR11L1-0.217
MTRNR2L6-0.216
RAI14-0.213

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in decreased expression of GPX3 mRNA"19502547
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of GPX3 mRNA"11509743
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of GPX3 mRNA"11509743
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GPX3 mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GPX3 mRNA"24378064
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GPX3 mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of GPX3 mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of GPX3 mRNA"25431849
D000082AcetaminophenAcetaminophen results in increased expression of GPX3 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of GPX3 mRNA17562736
C056165acetovanilloneacetovanillone inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA]21983654
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GPX3 mRNA16483693
D000728AndrogensAndrogens affects the expression of GPX310645275
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GPX3 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of GPX3 mRNA15073043
C015001arsenitearsenite results in increased expression of GPX3 mRNA19429247
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]16964424
D001379AzathioprineAzathioprine results in increased expression of GPX3 mRNA18222062
C547126AZM551248AZM551248 results in decreased expression of GPX3 mRNA22323515
C051597Bandrowski's baseBandrowski's base results in increased expression of GPX3 mRNA20566472
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX3 mRNA18164116
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of GPX3 mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GPX3 mRNA23178640
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPX3 mRNA27195522
D001564Benzo(a)pyrene"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GPX3 mRNA"28987381
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GPX3 mRNA21774909
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GPX3 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of GPX3 mRNA18191855
D004958EstradiolEstradiol results in increased expression of GPX3 protein18191855
D004958Estradiol"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of GPX3 mRNA"11509743
D004958Estradiol"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of GPX3 mRNA"11509743
D004958Estradiol[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of GPX3 mRNA11509743
D004958Estradiol[Estradiol co-treated with Methoxychlor metabolite] results in increased expression of GPX3 mRNA11509743
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GPX3 mRNA18556351|1969329
D004958EstradiolEstradiol results in decreased expression of GPX3 mRNA11509743
D004958EstradiolEstradiol results in increased expression of GPX3 mRNA11509743|1855635
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of GPX3 mRNA26496021
C099952bifenthrinbifenthrin results in increased expression of GPX3 mRNA26071804
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GPX3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of GPX3 mRNA26512966
C006780bisphenol Abisphenol A results in increased expression of GPX3 mRNA23798566
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of GPX3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GPX3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GPX3 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GPX3 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of GPX3 mRNA21601586
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of GPX3 mRNA15878706
D002087ButyratesButyrates results in increased expression of GPX3 mRNA14674679
D002104CadmiumCadmium results in decreased expression of GPX3 protein17120531
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GPX3 mRNA23178640
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA]"20230807
D002122Calcium ChlorideCalcium Chloride results in increased expression of GPX3 mRNA21530968|2433735
D002122Calcium ChlorideQuercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]24337353
D002122Calcium Chlorideresveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]21530968
D002507CephaloglycinCephaloglycin results in decreased activity of GPX3 protein9851889
C026690cerous chloridecerous chloride affects the expression of GPX3 mRNA28954213
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of GPX3 mRNA28954213
D002713ChlorineChlorine results in increased expression of GPX3 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of GPX3 mRNA18636392
C031294chlorobenzenechlorobenzene results in increased expression of GPX3 mRNA19800902
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GPX320938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GPX3 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPX3 mRNA20938992
C418118CI 1044CI 1044 results in increased expression of GPX3 mRNA17569694
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of GPX3 mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of GPX3 mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of GPX3 mRNA18353800
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of GPX3 mRNA20566472
C018021cobaltous chloridecobaltous chloride results in increased expression of GPX3 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of GPX3 mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of GPX3 mRNA15755911
C015763cumenecumene results in decreased expression of GPX3 mRNA18648096
D003471CuprizoneCuprizone results in increased expression of GPX3 mRNA27523638
C057862cyanoginosin LRcyanoginosin LR results in increased expression of GPX3 mRNA17654400
D003520CyclophosphamideCyclophosphamide results in increased expression of GPX3 mRNA21041162
D016572CyclosporineCyclosporine results in decreased expression of GPX3 mRNA20106945|2163298
C014347decitabine[decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 mRNA18664505|1866450
C014347decitabine[decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 protein18664505|1866450
C014347decitabinedecitabine results in increased expression of GPX3 mRNA19194470
C014347decitabinetrichostatin A promotes the reaction [[decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 protein]18664505|1866450
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX3 mRNA28659758
C007262deoxynivalenoldeoxynivalenol results in decreased expression of GPX3 mRNA25701311
D003907DexamethasoneDexamethasone results in increased expression of GPX3 mRNA21356098
D003907DexamethasoneDexamethasone results in increased expression of GPX3 mRNA19853017|2504701
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GPX3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GPX3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GPX3 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of GPX3 mRNA21041162|2273378
D003907DexamethasoneDexamethasone results in increased expression of GPX3 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of GPX3 mRNA]20032058
D003976DiazinonDiazinon results in increased expression of GPX3 mRNA19440498
C016366dibenzothiophenedibenzothiophene results in increased expression of GPX3 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GPX3 mRNA21266533
D002945CisplatinCisplatin results in increased expression of GPX3 mRNA27392435
D002945CisplatinGPX3 promoter modified form results in decreased susceptibility to Cisplatin21684681
D002945CisplatinGPX3 protein affects the susceptibility to Cisplatin16217747
D002945Cisplatin[Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA24865317
D002945CisplatinCisplatin results in decreased expression of GPX3 mRNA24865317
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of GPX3 mRNA26924002
D004026DieldrinDieldrin results in increased expression of GPX3 mRNA19440498
D004041Dietary FatsDietary Fats affects the expression of GPX3 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of GPX3 mRNA18042831
D004042Dietary Fats, Unsaturated"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of GPX3 mRNA"23626681
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX3 mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GPX3 mRNA19638242|2524240
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GPX3 mRNA21041162
C024629dimethyl phthalatedimethyl phthalate affects the expression of GPX3 mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of GPX3 mRNA20566472
D004221DisulfiramDisulfiram results in increased expression of GPX3 mRNA20566472
D004237DiuronDiuron results in decreased expression of GPX3 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of GPX3 mRNA16243910
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of GPX3 mRNA12655031
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of GPX3 mRNA19118595
D000431EthanolEthanol results in increased expression of GPX3 mRNA22253472
D000431EthanolNFE2L2 protein promotes the reaction [Ethanol results in increased expression of GPX3 mRNA]23994065
D000431EthanolNFE2L2 protein promotes the reaction [Ethanol results in increased expression of GPX3 protein]23994065
D000431EthanolEthanol results in increased expression of GPX3 mRNA23994065
D000431EthanolEthanol results in increased expression of GPX3 protein23994065
D005047EtoposideEtoposide results in increased expression of GPX3 mRNA25270620
D005054EugenolEugenol results in increased expression of GPX3 mRNA20566472
C436526EUK-189EUK-189 inhibits the reaction [SOD2 gene mutant form results in increased expression of GPX3 mRNA]15964507
D005473FluoxetineFluoxetine results in increased expression of GPX3 mRNA20924750
D005480FlurbiprofenFlurbiprofen results in decreased expression of GPX3 mRNA16949054
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GPX320938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GPX3 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPX3 mRNA20938992
D005557Formaldehydeacetovanillone inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA]21983654
D005557FormaldehydeFormaldehyde results in decreased expression of GPX3 mRNA12679049
D005557FormaldehydeFormaldehyde results in increased expression of GPX3 mRNA21983654
D005557FormaldehydeIndomethacin inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA]21983654
D005557FormaldehydeNitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA]21983654
C069837fullerene C60fullerene C60 results in increased expression of GPX3 mRNA19167457
C039281furanfuran results in increased expression of GPX3 mRNA27387713
D019833GenisteinGenistein results in increased expression of GPX3 mRNA23295412
D005839GentamicinsGentamicins results in decreased expression of GPX3 protein22061828
C071834glycidamideglycidamide results in increased expression of GPX3 mRNA17822822
C010176halofuginonehalofuginone results in increased expression of GPX3 mRNA17180598
D006581HexachlorobenzeneHexachlorobenzene affects the expression of GPX3 mRNA15159207
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of GPX3 mRNA20566472
D006861Hydrogen PeroxideHydrogen Peroxide affects the reaction [SHC1 protein affects the expression of GPX3 mRNA]16972253
D007069IfosfamideIfosfamide results in decreased activity of GPX3 protein9851889
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GPX3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GPX3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GPX3 mRNA28628672
D007213IndomethacinIndomethacin inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA]21983654
D007213IndomethacinIndomethacin results in increased expression of GPX3 mRNA18299717
D007213Indomethacinrebamipide inhibits the reaction [Indomethacin results in increased expression of GPX3 mRNA]18299717
C051890irinotecanirinotecan metabolite results in increased expression of GPX3 mRNA15956246
C051890irinotecanirinotecan results in increased expression of GPX3 mRNA15956246
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GPX3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GPX3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GPX3 mRNA28628672
C036643isoeugenolisoeugenol results in increased expression of GPX3 mRNA20566472
D007545IsoproterenolIsoproterenol results in increased expression of GPX3 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of GPX3 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GPX3 mRNA26644586
C410337K 7174K 7174 results in decreased expression of GPX3 mRNA24086573
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of GPX3 mRNA28954213
C028521lanthanum chloridelanthanum chloride results in increased expression of GPX3 mRNA28954213
C052901lemongrass oillemongrass oil affects the expression of GPX3 mRNA25976427
D001556LindaneLindane analog results in decreased expression of GPX3 mRNA16509360
D001556LindaneLindane results in increased expression of GPX3 mRNA18804290
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GPX3 mRNA"28987381
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GPX3 mRNA"20371263
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GPX3 mRNA19339665
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of GPX3 mRNA]19339665
D014975Lutein[Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA24865317
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of GPX3 mRNA20843944
D015122MercaptopurineMercaptopurine results in increased expression of GPX3 mRNA18222062
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
D008628MercuryMercury results in increased expression of GPX3 mRNA24788667
D008701MethapyrileneMethapyrilene results in increased expression of GPX3 mRNA25242409
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GPX320938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GPX3 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPX3 mRNA20938992
D008727MethotrexateGPX3 protein affects the susceptibility to Methotrexate16217747
D008731Methoxychlor[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of GPX3 mRNA11509743
D008731Methoxychlor[Estradiol co-treated with Methoxychlor metabolite] results in increased expression of GPX3 mRNA11509743
D008748MethylcholanthreneMethylcholanthrene results in increased expression of GPX3 mRNA18804290
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of GPX3 mRNA]19339665
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GPX3 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GPX3 mRNA20061341
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased activity of GPX3 protein25975991
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GPX3 mRNA26011545
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA]"20230807
D008777MethyltestosteroneMethyltestosterone results in increased expression of GPX3 mRNA29191790
D008942MitoxantroneGPX3 protein affects the susceptibility to Mitoxantrone16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of GPX3 mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of GPX3 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GPX3 mRNA"21624382
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GPX3 mRNA"25620056
C005273naringenin[Paraquat co-treated with naringenin] results in increased expression of GPX3 mRNA24561720
D009532NickelNickel affects the expression of GPX3 mRNA19440498
C029938nickel sulfatenickel sulfate results in increased expression of GPX3 mRNA20566472
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA]"20230807
D009569Nitric OxideNitric Oxide deficiency results in increased expression of GPX3 mRNA15878706
D009569Nitric OxideNitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA]21983654
D009585Nitrogen DioxideNitrogen Dioxide results in decreased expression of GPX3 mRNA16049373
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of GPX3 mRNA15336314
C423264(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate results in increased expression of GPX3 mRNA18598687
C024713n-tetradecanen-tetradecane results in decreased expression of GPX3 protein17337753
C464660obeticholic acidobeticholic acid results in increased expression of GPX3 mRNA27939613
C025589ochratoxin Aochratoxin A results in increased expression of GPX3 mRNA17316727
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GPX3 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GPX3 mRNA25729387
D010100OxygenOxygen results in increased expression of and results in increased activity of GPX3 protein10590029
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of GPX3 mRNA18636392
D010126OzoneOzone results in increased expression of GPX3 mRNA16716893
D000073878Palm OilPalm Oil affects the expression of GPX3 mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of GPX3 mRNA18042831
D010269Paraquat[Paraquat co-treated with naringenin] results in increased expression of GPX3 mRNA24561720
D010269Paraquat[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA23649336
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of GPX3 mRNA]21688324
D010269ParaquatParaquat results in increased expression of GPX3 mRNA12732627|2168832
D010269ParaquatParaquat affects the expression of GPX3 mRNA15206577
D010269ParaquatParaquat results in decreased expression of GPX3 mRNA18198484
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of GPX3 mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GPX3 mRNA27153767
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GPX3 mRNA18424238
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GPX3 mRNA23146750
C023036perfluorooctanoic acid"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of GPX3 mRNA"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GPX3 mRNA18804290
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX3 mRNA28659758
D010578PetroleumPetroleum analog results in decreased expression of GPX3 mRNA23266412
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GPX3 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GPX3 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GPX3 mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in decreased expression of GPX3 mRNA27845199
D010936Plant ExtractsPlant Extracts results in increased expression of GPX3 mRNA27163856
D010936Plant ExtractsPlant Extracts results in increased expression of GPX3 mRNA20924750
D028321Plant PreparationsPlant Preparations results in increased expression of GPX3 mRNA26597533
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of GPX3 mRNA24583197
D059808PolyphenolsPolyphenols results in decreased expression of GPX3 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of GPX3 mRNA11678601
D011374ProgesteroneProgesterone results in increased expression of GPX3 mRNA20864642
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GPX3 mRNA18556351|1969329
D011374ProgesteroneProgesterone affects the expression of GPX3 mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of GPX3 mRNA20726854
D011374ProgesteroneProgesterone results in decreased expression of GPX317510236
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of GPX3 mRNA20685819
C513428pyrachlostrobinpyrachlostrobin results in increased expression of GPX3 mRNA27029645
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX3 mRNA28659758
D011794QuercetinQuercetin results in increased expression of GPX3 mRNA21356098
D011794QuercetinQuercetin affects the expression of GPX3 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]24337353
D011794QuercetinQuercetin results in increased expression of GPX3 mRNA23295412
C052785rebamipiderebamipide inhibits the reaction [Indomethacin results in increased expression of GPX3 mRNA]18299717
C052785rebamipiderebamipide results in increased expression of GPX3 mRNA18299717
C059514resveratrolresveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]21530968
D015474IsotretinoinIsotretinoin results in decreased expression of GPX3 mRNA20436886
D012643SeleniumSelenium deficiency results in decreased activity of GPX3 protein19181766
D012643SeleniumSelenium results in increased expression of GPX3 mRNA19244175
D012643SeleniumSelenium results in increased expression of GPX3 mRNA15894816
D012643SeleniumSelenium affects the activity of GPX3 protein19106321|1935170
D012643SeleniumSelenium affects the expression of GPX3 mRNA19106321
D012643SeleniumSelenium results in increased activity of GPX3 protein19022953
D012645SelenomethionineSelenomethionine results in increased activity of GPX3 protein19448000
D012645SelenomethionineSelenomethionine results in increased expression of GPX3 protein19448000
C078903seocalcitolseocalcitol results in increased expression of GPX3 mRNA12040012
D012834SilverSilver results in increased expression of GPX3 mRNA19429238
D012906SmokeSmoke results in increased expression of GPX3 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of GPX3 mRNA28229933
C017947sodium arsenitesodium arsenite results in increased expression of GPX3 mRNA21396911
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of GPX3 mRNA21632023
C016104sodium bichromatesodium bichromate results in increased expression of GPX3 mRNA12325037
D012969Sodium FluorideSodium Fluoride results in increased expression of GPX3 protein28918527
D018038Sodium SeleniteGPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased activity of GPX3 protein]18400727
D018038Sodium SeleniteGPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased expression of GPX3 protein]18400727
D018038Sodium SeleniteSodium Selenite results in increased expression of GPX3 protein17536041
D018038Sodium SeleniteSodium Selenite results in increased activity of GPX3 protein16952904
D012999SomanSoman results in increased expression of GPX3 mRNA19281266
D013311StreptozocinStreptozocin results in increased expression of GPX3 protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of GPX3 protein]19634143
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GPX3 mRNA"20371263
C074269Sunphenon"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GPX3 mRNA"24378064
C013698tallowtallow affects the expression of GPX3 mRNA19680557
D013739TestosteroneTestosterone results in increased expression of GPX3 mRNA19693291
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of GPX3 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPX3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GPX3 mRNA19692669|2129612
D013749TetrachlorodibenzodioxinGPX3 protein results in increased susceptibility to Tetrachlorodibenzodioxin16682824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of GPX3 protein16682824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GPX3 mRNA16682824|1703548
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GPX3 protein16682824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GPX3 mRNA20959002
D013752TetracyclineTetracycline results in decreased expression of GPX3 mRNA16917069
C020809tetrathiomolybdatetetrathiomolybdate analog results in increased expression of GPX3 mRNA19323979
D013853ThioacetamideThioacetamide results in increased expression of GPX3 mRNA23411599
D008063Thioctic Acid[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA23649336
D008063Thioctic AcidThioctic Acid results in increased expression of GPX3 mRNA23649336
C009495titanium dioxidetitanium dioxide results in increased expression of GPX3 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GPX3 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GPX3 mRNA27404394|2786577
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GPX3 mRNA15289447
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of GPX3 mRNA"21356098
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GPX3 mRNA25729387
C012589trichostatin Atrichostatin A promotes the reaction [[decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 protein]18664505|1866450
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of GPX3 protein]19634143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GPX3 mRNA"24407104
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GPX3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of GPX3 protein11328671
D014415TunicamycinTunicamycin results in increased expression of GPX3 mRNA17127020
C022884undecaneundecane results in increased expression of GPX3 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPX3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GPX3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GPX3 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased expression of GPX3 mRNA24896083
D014638VanadatesVanadates results in increased expression of GPX3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GPX3 gene25560391
C025643vinclozolinvinclozolin affects the expression of GPX3 mRNA19015723
D014800VitalliumVitallium analog results in increased expression of GPX3 mRNA23825117
D012256RiboflavinRiboflavin results in increased expression of GPX3 mRNA21356098
D014810Vitamin EVitamin E results in increased expression of GPX3 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of GPX3 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004602glutathione peroxidase activity-EXP3619451  3693360  19219623  
GO:0004602glutathione peroxidase activity-IDA1897960  3693360  
GO:0005515protein binding-IPI25416956  
GO:0008134transcription factor binding-TAS8056346  
GO:0008430selenium binding-IDA2491950  3693360  
GO ID GO Term Qualifier Evidence PubMed
GO:0006982response to lipid hydroperoxide-TAS2491950  
GO:0034599cellular response to oxidative stress-TAS-  
GO:0042744hydrogen peroxide catabolic process-TAS2491950  
GO:0051289protein homotetramerization-IDA3693360  
GO:0055114oxidation-reduction process-IEA-  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA1897960  
GO:0070062extracellular exosome-HDA19199708  23533145  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa00590Arachidonic acid metabolism
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22719980Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's. (2012)Buijsse BPLoS One
26317789LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation. (2015 Sep 22)Lee CHOncotarget