Gene info: ID 2879

Gene: GPX4

GENE ID: 2879

Description: glutathione peroxidase 4

Gene type: protein-coding

Location: 19p13.3

dbXrefs: Ensembl:ENSG00000167468 MIM:138322 Vega:OTTHUMG00000181874 UniprotKB:P36969

RefSeq: NG_050621.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.199e-1 (AD) 5.773e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NDUFB10	0.976
NDUFB7	0.975
NDUFA13	0.97
UQCR10	0.962
COX8A	0.962
COX5B	0.962
PARK7	0.96
PRDX5	0.959
NDUFB11	0.958
NDUFS8	0.957

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.864
OR4F29	-0.849
MTRNR2L6	-0.249
KCNJ15	-0.246
PZP	-0.244
CCDC36	-0.24
SULT1C2	-0.239
CLEC12A	-0.237
MTRNR2L9	-0.236
PABPC4L	-0.236

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C021201	12-HPETE	GPX4 protein results in increased chemical synthesis of 12-HPETE	11115402
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPX4 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPX4 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPX4 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPX4 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPX4 mRNA"	25510870
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX4 mRNA"	15215175
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of GPX4 mRNA"	20206263
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of GPX4 mRNA	14610520
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of GPX4 mRNA"	18648102
D000082	Acetaminophen	Acetaminophen results in increased expression of GPX4 mRNA	25704631
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of GPX4 mRNA]	12208374
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]	14642406
D000638	Amiodarone	Amiodarone affects the expression of GPX4 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GPX4 mRNA	16483693
D016718	Arachidonic Acid	Arachidonic Acid promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein]	14642406
D016718	Arachidonic Acid	[Iodoacetates results in decreased activity of GPX4 protein] which affects the metabolism of Arachidonic Acid	11115402
C025657	arsenic acid	arsenic acid results in increased expression of GPX4 mRNA	19429247
C025657	arsenic acid	arsenic acid results in increased expression of GPX4 protein	19429247
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GPX4 mRNA	20458559
C015001	arsenite	arsenite results in increased expression of GPX4 mRNA	19429247
C015001	arsenite	arsenite results in increased expression of GPX4 protein	19429247
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of GPX4 mRNA	15372504
D016589	Astemizole	Astemizole results in increased expression of GPX4 mRNA	20221588
D001553	Benzbromarone	Benzbromarone affects the expression of GPX4 mRNA	19483382
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of GPX4 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GPX4 mRNA	20504355
D001564	Benzo(a)pyrene	[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GPX4 mRNA	25820237
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GPX4 mRNA"	19150397
D004958	Estradiol	Estradiol results in decreased expression of GPX4 mRNA	23019147
C095105	bexarotene	bexarotene results in increased expression of GPX4 mRNA	16648578
C006780	bisphenol A	bisphenol A results in increased expression of GPX4 protein	25772901
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of GPX4 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of GPX4 mRNA	25181051
D020122	tert-Butylhydroperoxide	GPX4 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]	15496407
D020122	tert-Butylhydroperoxide	GPX4 protein results in decreased susceptibility to tert-Butylhydroperoxide	15496407
D020122	tert-Butylhydroperoxide	GPX4 gene mutant form results in increased susceptibility to tert-Butylhydroperoxide	12566075
D020122	tert-Butylhydroperoxide	GPX4 protein results in decreased susceptibility to tert-Butylhydroperoxide	12566075
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GPX4 mRNA	18804290
D002087	Butyrates	Butyrates results in increased expression of GPX4 mRNA	14674679
D002104	Cadmium	GPX4 results in decreased susceptibility to Cadmium	18206984
D002104	Cadmium	Cadmium results in increased expression of GPX4 mRNA	25388156
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GPX4 mRNA	17499415
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GPX4 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GPX4 mRNA	20643113
D019256	Cadmium Chloride	Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of GPX4 mRNA]	20643113
D000001	Calcimycin	Calcimycin results in decreased expression of GPX4 protein	10432307
D002166	Camptothecin	GPX4 mRNA results in decreased susceptibility to Camptothecin	25269479
D002211	Capsaicin	Capsaicin inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA]	18926900
D002248	Carbon Monoxide	Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]	18037988
D002308	Cardiolipins	GPX4 affects the oxidation of Cardiolipins	18206984
C026690	cerous chloride	cerous chloride affects the expression of GPX4 mRNA	28954213
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of GPX4 mRNA	23650126
C100187	chloropicrin	chloropicrin results in decreased expression of GPX4 mRNA	26352163
D002738	Chloroquine	Chloroquine results in decreased expression of GPX4 mRNA	23607047
D002738	Chloroquine	Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA]	23607047
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of GPX4 mRNA	17452286
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GPX4 gene	20938992
C074702	chromium hexavalent ion	[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GPX4 mRNA	25820237
D002994	Clofibrate	Clofibrate results in increased expression of GPX4 mRNA	16081524
D002994	Clofibrate	Clofibrate affects the expression of GPX4 mRNA	19483382
C480342	clothianidin	clothianidin results in decreased expression of GPX4 protein	25960033
D003300	Copper	Copper deficiency results in decreased expression of GPX4 protein	21781943
C010561	crocetin	crocetin inhibits the reaction [cupric oxide results in decreased expression of GPX4 mRNA]	25701151
C007164	cumene hydroperoxide	GPX4 results in decreased susceptibility to cumene hydroperoxide	18206984
C030973	cupric oxide	crocetin inhibits the reaction [cupric oxide results in decreased expression of GPX4 mRNA]	25701151
C030973	cupric oxide	cupric oxide results in decreased expression of GPX4 mRNA	25701151
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of GPX4 mRNA	17654400
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of GPX4 protein	17475930
C017160	cypermethrin	cypermethrin results in increased expression of GPX4 mRNA	21142847
C093628	cyproconazole	cyproconazole results in increased expression of GPX4 mRNA	22334560
D003671	DEET	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX4 mRNA	28659758
D013759	Dronabinol	Dronabinol results in decreased expression of GPX4 mRNA	11015613
D003847	Deoxyglucose	GPX4 protein inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein]	10506188
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of GPX4 mRNA	25701311
D003976	Diazinon	Diazinon affects the expression of GPX4 mRNA	17452286
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of GPX4 mRNA	17361019
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GPX4 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of GPX4 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GPX4 mRNA	21266533
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of GPX4 protein	25410718
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of GPX4 mRNA	25410718
C121718	dicyclanil	dicyclanil results in increased expression of GPX4 mRNA	15664270
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of GPX4 mRNA	26924002
D018119	Stavudine	Stavudine results in decreased expression of GPX4 mRNA	18299183
D004026	Dieldrin	Dieldrin results in increased expression of GPX4 mRNA	19440498
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX4 mRNA	26042203
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX4 protein	26042203
D004041	Dietary Fats	GPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX1 mRNA]	26042203
D004041	Dietary Fats	GPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of NPPB protein]	26042203
D004041	Dietary Fats	GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of AGER mRNA	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of COL1A1 mRNA	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of GSR mRNA	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of HMOX1 mRNA	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of IL6 mRNA	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of MYH7 mRNA	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of NOS2 mRNA	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of NQO1 mRNA	26042203
D004041	Dietary Fats	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of TXNRD2 mRNA	26042203
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX4 mRNA	26042203
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX4 protein	26042203
D019422	Dietary Sucrose	GPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of GPX1 mRNA]	26042203
D019422	Dietary Sucrose	GPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of NPPB protein]	26042203
D019422	Dietary Sucrose	GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of AGER mRNA	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of COL1A1 mRNA	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of GSR mRNA	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of HMOX1 mRNA	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of IL6 mRNA	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of MYH7 mRNA	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of NOS2 mRNA	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of NQO1 mRNA	26042203
D019422	Dietary Sucrose	[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of TXNRD2 mRNA	26042203
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GPX4 mRNA	17679765
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of GPX4 mRNA	26924002
D004178	Diquat	GPX4 protein alternative form results in decreased susceptibility to Diquat	19744930
D004178	Diquat	GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein]	15496407
D004178	Diquat	GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]	15496407
D004178	Diquat	Diquat results in increased expression of GPX4 mRNA	16962985
D004237	Diuron	Diuron results in decreased expression of GPX4 mRNA	21551480
D019297	2,4-Dinitrophenol	"GPX4 protein results in decreased susceptibility to 2,4-Dinitrophenol"	19818760
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids inhibits the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein]	14642406
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]	14642406
D004317	Doxorubicin	Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]	18037988
D004317	Doxorubicin	Doxorubicin results in decreased expression of GPX4 protein	18037988
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of GPX4 mRNA	19118595
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GPX4 protein	23301498
C109476	epoxiconazole	epoxiconazole results in increased expression of GPX4 mRNA	22334560
D000431	Ethanol	Ethanol results in decreased expression of GPX4 mRNA	26177723
D000431	Ethanol	Capsaicin inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA]	18926900
D000431	Ethanol	Ethanol results in decreased expression of GPX4 mRNA	18926900\|1899232
D000431	Ethanol	Plant Extracts inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA]	18992320
D000431	Ethanol	Ethanol results in increased expression of GPX4 mRNA	23155471
D000431	Ethanol	Ethanol results in increased expression of GPX4 protein	23155471
D005001	Ethionine	Ethionine affects the expression of GPX4 mRNA	19483382
D005485	Flutamide	Flutamide results in increased expression of GPX4 mRNA	17679765
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GPX4 gene	20938992
D005632	Fructose	Fructose results in decreased expression of GPX4 protein	21781943
C027235	gallium nitrate	gallium nitrate results in decreased expression of GPX4 mRNA	18586083
D005839	Gentamicins	Gentamicins results in decreased expression of GPX4 mRNA	22061828
D006861	Hydrogen Peroxide	GPX4 protein results in decreased susceptibility to Hydrogen Peroxide	14660625
D006861	Hydrogen Peroxide	GPX4 gene mutant form results in increased susceptibility to Hydrogen Peroxide	12566075
D006861	Hydrogen Peroxide	GPX4 protein results in decreased susceptibility to Hydrogen Peroxide	12566075
D006861	Hydrogen Peroxide	GPX4 results in decreased susceptibility to Hydrogen Peroxide	18206984
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of GPX4 mRNA	19376150
D007461	Iodoacetates	Iodoacetates results in decreased activity of GPX4 protein	11115402
D007461	Iodoacetates	[Iodoacetates results in decreased activity of GPX4 protein] which affects the metabolism of Arachidonic Acid	11115402
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of GPX4 protein	17337753
D007654	Ketoconazole	Ketoconazole results in increased expression of GPX4 mRNA	17679765
C008261	lead acetate	lead acetate affects the expression of GPX4 mRNA	15014207
C008281	limonene	limonene results in increased expression of GPX4 mRNA	12815608
D044243	Linoleic Acids, Conjugated	"Linoleic Acids, Conjugated promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]"	14642406
D008054	Lipid Peroxides	GPX4 protein results in increased reduction of Lipid Peroxides	15014207
D008054	Lipid Peroxides	GPX4 results in decreased susceptibility to Lipid Peroxides	15014207
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of GPX4 mRNA"	24972896
C015329	lycopene	lycopene results in decreased expression of GPX4 mRNA	16886892
D008344	Maneb	Maneb results in increased expression of GPX4 mRNA	23764462
D008344	Maneb	NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]	23764462
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GPX4 gene	20938992
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of GPX4 protein	22885222
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 mRNA	24399507
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of GPX4 mRNA	24128854
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of GPX4 mRNA	26924002
D009281	Naphthalenes	Naphthalenes results in decreased expression of GPX4 protein	17337753
C051752	nefazodone	nefazodone results in increased expression of GPX4 mRNA	24136188
C029938	nickel sulfate	nickel sulfate results in increased expression of GPX4 mRNA	18651567
D009585	Nitrogen Dioxide	Nitrogen Dioxide affects the expression of GPX4 mRNA	16049373
C025256	nonylphenol	nonylphenol results in increased expression of GPX4 mRNA	17679765
C025589	ochratoxin A	ochratoxin A results in increased acetylation of GPX4 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of GPX4 promoter] which results in increased expression of GPX4 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of GPX4 mRNA	29098329
C405603	Omacor	Omacor results in increased expression of GPX4 mRNA	24597798
D009853	Omeprazole	Omeprazole affects the expression of GPX4 mRNA	19483382
D019308	Palmitic Acid	Palmitic Acid results in increased expression of GPX4 mRNA	28027979
D010269	Paraquat	GPX4 gene mutant form results in increased susceptibility to Paraquat	12566075
D010269	Paraquat	GPX4 protein results in decreased susceptibility to Paraquat	12566075
D010269	Paraquat	Paraquat results in increased expression of GPX4 mRNA	12732627
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPX4 mRNA"	25510870
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of GPX4 mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GPX4 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of GPX4 mRNA	18281256
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of GPX4 mRNA	18804290
D026023	Permethrin	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX4 mRNA	28659758
D010713	Phosphatidylcholines	GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]	22433871
D010713	Phosphatidylcholines	GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]	22433871
D010743	Phospholipids	GPX4 mutant form promotes the reaction [TNF protein results in increased oxidation of Phospholipids]	22433871
D010743	Phospholipids	GPX4 protein inhibits the reaction [TNF protein results in increased oxidation of Phospholipids]	22433871
C006253	pirinixic acid	pirinixic acid results in increased expression of GPX4 mRNA	17950772\|2381119
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of GPX4 mRNA]	17950772
C006253	pirinixic acid	pirinixic acid affects the expression of GPX4 mRNA	19483382
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA]	18992320
D010936	Plant Extracts	Plant Extracts results in increased expression of GPX4 mRNA	27163856
D011374	Progesterone	Progesterone results in decreased expression of GPX4 mRNA	23018184
C045950	propiconazole	propiconazole results in increased expression of GPX4 mRNA	22334560
D011441	Propylthiouracil	Propylthiouracil affects the expression of GPX4 mRNA	19483382
C010313	pseudocumene	pseudocumene results in decreased expression of GPX4 protein	17337753
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX4 mRNA	28659758
D011739	Pyrimethamine	Pyrimethamine results in increased expression of GPX4 mRNA	20193682
D011794	Quercetin	Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA]	23607047
C059514	resveratrol	resveratrol results in increased expression of GPX4 mRNA	24314921
C059514	resveratrol	resveratrol results in increased expression of GPX4 mRNA	22610192
C059514	resveratrol	resveratrol results in increased expression of GPX4 protein	25505154
C488333	Ro 65-7199	Ro 65-7199 results in decreased expression of GPX4 mRNA	14610520
D012402	Rotenone	GPX4 protein inhibits the reaction [Rotenone results in increased expression of MT1 mRNA]	19818760
D012402	Rotenone	GPX4 protein inhibits the reaction [Rotenone results in increased expression of MT2 mRNA]	19818760
D012402	Rotenone	GPX4 protein results in decreased susceptibility to Rotenone	19818760
D012643	Selenium	Selenium analog results in increased activity of GPX4 protein	11673642
D012643	Selenium	Selenium deficiency results in decreased expression of GPX4 mRNA	15670848
D012643	Selenium	Selenium results in increased expression of and results in increased activity of GPX4 protein	17150329
D012643	Selenium	Selenium results in increased expression of GPX4 mRNA	19244175
D012643	Selenium	Selenium results in increased expression of GPX4 protein	17052796
D012643	Selenium	GPX4 gene mutant form results in decreased abundance of Selenium	16246897
D012643	Selenium	Selenium affects the activity of GPX4 protein	19106321
D012643	Selenium	Selenium deficiency results in decreased activity of GPX4 protein	12031252
D012643	Selenium	Selenium deficiency results in decreased expression of GPX4 mRNA	12031252\|1567084
D012643	Selenium	Selenium results in increased activity of GPX4 protein	19022953
D012643	Selenium	Selenium results in increased expression of GPX4 mRNA	15792362\|1902295
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in increased expression of GPX4 mRNA	18514395
D012906	Smoke	Smoke results in increased expression of GPX4 protein	23069111
C017947	sodium arsenite	Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of GPX4 mRNA]	12208374
C017947	sodium arsenite	GPX4 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]	12208374
C017947	sodium arsenite	GPX4 results in decreased susceptibility to sodium arsenite	12208374
C017947	sodium arsenite	sodium arsenite results in decreased expression of and results in decreased activity of GPX4 protein	12208374
C017947	sodium arsenite	sodium arsenite results in decreased expression of GPX4 mRNA	12208374
C017947	sodium arsenite	sodium arsenite results in increased expression of GPX4 mRNA	21396911
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of GPX4 mRNA	28918527
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of GPX4 protein	28918527
D018038	Sodium Selenite	alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]	14642406
D018038	Sodium Selenite	Arachidonic Acid promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein]	14642406
D018038	Sodium Selenite	Docosahexaenoic Acids inhibits the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein]	14642406
D018038	Sodium Selenite	Docosahexaenoic Acids promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]	14642406
D018038	Sodium Selenite	GPX4 gene SNP affects the susceptibility to Sodium Selenite	18400727
D018038	Sodium Selenite	GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased activity of GPX1 protein]	18400727
D018038	Sodium Selenite	GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased activity of GPX3 protein]	18400727
D018038	Sodium Selenite	GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased expression of GPX1 protein]	18400727
D018038	Sodium Selenite	GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased expression of GPX3 protein]	18400727
D018038	Sodium Selenite	IL1B protein promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein]	14642406
D018038	Sodium Selenite	IL1B protein promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]	14642406
D018038	Sodium Selenite	"Linoleic Acids, Conjugated promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]"	14642406
D018038	Sodium Selenite	Sodium Selenite affects the activity of GPX4 protein polymorphism	18400727
D018038	Sodium Selenite	Sodium Selenite affects the expression of GPX4 protein polymorphism	18400727
D018038	Sodium Selenite	Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein	14642406
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX4 mRNA	14642406\|1851439
D018038	Sodium Selenite	TNF protein affects the reaction [Sodium Selenite results in increased activity of GPX4 protein]	14642406
D018038	Sodium Selenite	TNF protein affects the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]	14642406
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of GPX4 mRNA]	20643113
D018038	Sodium Selenite	Sodium Selenite results in increased activity of GPX4 protein	10998458
D053260	Soot	Soot results in increased expression of GPX4 mRNA	19165387
D053260	Soot	Soot results in increased expression of GPX4 mRNA	21914721
C001803	tempol	tempol results in increased expression of GPX4 mRNA	22221582
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of GPX4 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GPX4 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GPX4 mRNA	21215274
D013752	Tetracycline	Tetracycline results in decreased expression of GPX4 mRNA	16917069
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of GPX4 protein	10432307
C014215	tetrahydropalmatine	tetrahydropalmatine results in decreased expression of GPX4 protein	20109541
D013853	Thioacetamide	Thioacetamide affects the expression of GPX4 mRNA	19483382
C009495	titanium dioxide	titanium dioxide results in increased expression of GPX4 mRNA	26277626
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in decreased expression of GPX4 mRNA	20920546
D014050	Toluene	Toluene affects the expression of GPX4 mRNA	21827849
D014212	Tretinoin	Tretinoin results in decreased activity of GPX4 protein	16445905
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of GPX4 mRNA	21346803
D014635	Valproic Acid	Valproic Acid results in increased methylation of GPX4 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of GPX4 mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GPX4 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004602	glutathione peroxidase activity	-	IMP	17630701
GO:0004602	glutathione peroxidase activity	-	TAS	9705830
GO:0005515	protein binding	-	IPI	23355646
GO:0042802	identical protein binding	-	IMP	17630701
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	-	ISS	-
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006644	phospholipid metabolic process	-	TAS	8039723
GO:0006979	response to oxidative stress	-	ISS	-
GO:0007275	multicellular organism development	-	IEA	-
GO:0007283	spermatogenesis	-	ISS	-
GO:0019372	lipoxygenase pathway	-	TAS	-
GO:0042759	long-chain fatty acid biosynthetic process	-	TAS	-
GO:0051258	protein polymerization	-	IMP	17630701
GO:0055114	oxidation-reduction process	-	TAS	9705830
GO:0098869	cellular oxidant detoxification	-	IEA	-
GO:0110076	negative regulation of ferroptosis	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005654	nucleoplasm	-	IDA	-
GO:0005739	mitochondrion	-	IDA	-
GO:0005739	mitochondrion	-	TAS	9705830
GO:0005829	cytosol	-	TAS	-
GO:0032991	protein-containing complex	-	IMP	17630701
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	IEA
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	TAS
R-HSA-2142753	Arachidonic acid metabolism	IEA
R-HSA-2142753	Arachidonic acid metabolism	TAS
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-8978868	Fatty acid metabolism	TAS
R-HSA-8978868	Fatty acid metabolism	IEA
R-HSA-9018676	Biosynthesis of D-series resolvins	TAS
R-HSA-9018677	Biosynthesis of DHA-derived SPMs	TAS
R-HSA-9018678	Biosynthesis of specialized proresolving mediators (SPMs)	TAS
R-HSA-9018679	Biosynthesis of EPA-derived SPMs	TAS
R-HSA-9018896	Biosynthesis of E-series 18(S)-resolvins	TAS
R-HSA-9020265	Biosynthesis of aspirin-triggered D-series resolvins	TAS
R-HSA-9023661	Biosynthesis of E-series 18(R)-resolvins	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25026746	[Polymorphisms in the oxidative stress-related genes and cancer risk]. (2013)	Janicka A	Ann Acad Med Stetin
26063603	Alteration of sperm protein profile induced by cigarette smoking. (2015 Jul)	Chen X	Acta Biochim Biophys Sin (Shanghai)