Gene info: ID 2885

Gene: GRB2

GENE ID: 2885

Description: growth factor receptor bound protein 2

Gene type: protein-coding

Location: 17q25.1

dbXrefs: Ensembl:ENSG00000177885 MIM:108355 Vega:OTTHUMG00000134332 UniprotKB:P62993

RefSeq: NG_029556.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.295e-1 (AD) 6.233e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CIAO1	0.956
POLR2B	0.953
WDR82	0.951
UBQLN1	0.95
TOX4	0.949
UBE3C	0.946
CSNK2A1	0.944
RAB35	0.943
XPO7	0.942
KPNA6	0.942

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.634
OR4F29	-0.59
MTRNR2L6	-0.385
MTRNR2L10	-0.361
MTRNR2L9	-0.353
KLRK1	-0.323
CSAG1	-0.306
HEY2	-0.3
P2RY14	-0.286
KLRB1	-0.281

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00061	Pegademase bovine	BiotechDrug	9026-93-1	Approved	Target
DB03276	4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen affects the expression of GRB2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen affects the expression of GRB2 mRNA	16701773
C031143	AICA ribonucleotide	GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]	11978788
C038491	allyl sulfide	allyl sulfide results in decreased expression of GRB2 protein	21695758
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of GRB2 protein	26597043
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GRB2 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of GRB2 protein	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of GRB2 mRNA	24449571
C025657	arsenic acid	arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein]	14674888
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of GRB2 protein	25419056
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GRB2 mRNA	20458559
C015001	arsenite	arsenite promotes the reaction [SHC1 protein binds to GRB2 protein]	14674888
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of GRB2 mRNA"	17331233
C547126	AZM551248	AZM551248 results in increased expression of GRB2 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GRB2 protein	21467743
D004958	Estradiol	Estradiol results in increased expression of GRB2 mRNA	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of GRB2 mRNA]	23094148
D004958	Estradiol	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA	22465879
D004958	Estradiol	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein	22465879
C006780	bisphenol A	bisphenol A affects the expression of GRB2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of GRB2 mRNA	25181051
C022777	bufalin	bufalin results in decreased expression of GRB2 protein	23949904
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased expression of GRB2 mRNA	15878706
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GRB2 mRNA	15336504
D002104	Cadmium	Cadmium results in increased expression of GRB2 protein	14499349
C054133	casticin	casticin results in decreased expression of GRB2 protein	28444820
C026690	cerous chloride	cerous chloride affects the expression of GRB2 mRNA	23139204
D002994	Clofibrate	Clofibrate results in decreased expression of GRB2 mRNA	23811191
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GRB2 mRNA	19376846
D003042	Cocaine	Cocaine results in increased expression of GRB2 protein	25100957
D019327	Copper Sulfate	Copper Sulfate results in increased expression of GRB2 mRNA	19549813
D003474	Curcumin	Curcumin analog results in decreased expression of GRB2 mRNA	26409325
C017160	cypermethrin	cypermethrin results in decreased expression of GRB2 mRNA	27704156
D003634	DDT	DDT promotes the reaction [GRB2 protein binds to SOS1 protein]	9070211
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of GRB2 mRNA	23640034
D003907	Dexamethasone	Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]	10807665
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]]	10807665
C028009	diallyl disulfide	diallyl disulfide affects the expression of GRB2 protein	21695758
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of GRB2 protein	21695758
D004041	Dietary Fats	Dietary Fats results in decreased expression of GRB2 mRNA	18042831
D002117	Calcitriol	Calcitriol results in increased expression of GRB2 mRNA	15951637
D004147	Dioxins	Dioxins affects the expression of GRB2 mRNA	20463971
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GRB2 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GRB2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRB2 mRNA	17942748
D018120	Finasteride	Finasteride results in increased expression of GRB2 mRNA	24136188
D005419	Flavonoids	Flavonoids results in increased expression of GRB2 mRNA	18035473
D005707	Gallic Acid	Gallic Acid results in decreased expression of GRB2 protein	22387266
D019833	Genistein	Genistein results in decreased expression of GRB2 mRNA	16705744
D019833	Genistein	Genistein results in increased expression of GRB2 mRNA	20884965
D005839	Gentamicins	Gentamicins results in increased expression of GRB2 mRNA	22061828
D017313	Fenretinide	Fenretinide results in increased expression of GRB2 protein	15059897
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GRB2 mRNA	21179406
C031927	hydroquinone	hydroquinone affects the expression of GRB2 protein	20021034
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRB2 mRNA	25613284
C067431	letrozole	letrozole results in increased expression of GRB2 protein	15967659
D008344	Maneb	[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA	23963992
D008344	Maneb	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]	23963992
D008344	Maneb	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]	23963992
D008550	Melatonin	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]	23963992
D008694	Methamphetamine	Methamphetamine affects the expression of GRB2 protein	17904249
D008713	Methimazole	Methimazole results in increased expression of GRB2 mRNA	17403546
D008770	Methylnitrosourea	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA	22465879
D008770	Methylnitrosourea	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein	22465879
D052998	Microcystins	Microcystins results in decreased expression of GRB2 protein	22430071
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]]	10807665
D009532	Nickel	Nickel results in increased expression of GRB2 mRNA	24768652\|2558310
D009569	Nitric Oxide	Nitric Oxide deficiency results in decreased expression of GRB2 mRNA	15878706
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of GRB2 mRNA	26552463
C029341	oxophenylarsine	[oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein]	9281317
D000073878	Palm Oil	Palm Oil results in decreased expression of GRB2 mRNA	18042831
D010269	Paraquat	[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA	23963992
D010269	Paraquat	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]	23963992
D010269	Paraquat	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]	23963992
C494474	perchlorate	perchlorate results in increased expression of GRB2 mRNA	17403546
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of GRB2 mRNA	19162173
D010578	Petroleum	Petroleum affects the expression of GRB2 mRNA	25208076
C006253	pirinixic acid	pirinixic acid results in decreased expression of GRB2 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in decreased expression of GRB2 protein	23955962
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of GRB2 mRNA	28903501
D011374	Progesterone	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA	22465879
D011374	Progesterone	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein	22465879
C045950	propiconazole	propiconazole results in decreased expression of GRB2 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of GRB2 mRNA	17403546
D011794	Quercetin	Quercetin results in decreased expression of GRB2 protein	23645742
D011794	Quercetin	Quercetin results in increased expression of GRB2 mRNA	27514524
C059514	resveratrol	resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of GRB2 protein]	21467134
C059514	resveratrol	resveratrol results in decreased expression of GRB2 mRNA	12002526
D012715	Sesame Oil	Sesame Oil results in increased expression of GRB2 mRNA	29191790
D012838	Silymarin	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]	23963992
C017947	sodium arsenite	sodium arsenite results in increased expression of GRB2 mRNA	12016162
C017947	sodium arsenite	sodium arsenite promotes the reaction [SHC1 protein modified form binds to GRB2 protein]	9710602
C017947	sodium arsenite	[sodium arsenite results in increased phosphorylation of SHC1 protein] promotes the reaction [SHC1 protein modified form binds to GRB2 protein]	9710602
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of GRB2 mRNA	16705456
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GRB2 mRNA	18175754
C471405	sorafenib	sorafenib results in decreased expression of GRB2 mRNA	26409325
D010042	Ouabain	Ouabain results in decreased expression of GRB2 protein	28795476
D013467	Sulindac	Sulindac results in increased expression of GRB2 mRNA	24136188
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GRB2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRB2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GRB2 mRNA	19465110\|2266640
D013749	Tetrachlorodibenzodioxin	CBL protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [GRB2 protein binds to SOS1 protein]]	9918770
D013749	Tetrachlorodibenzodioxin	CBL protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [SHC1 protein binds to [GRB2 protein binds to SOS1 protein]]]	9918770
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GRB2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [GRB2 protein binds to SOS1 protein]	9918770
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [SHC1 protein binds to [GRB2 protein binds to SOS1 protein]]	9918770
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRB2 mRNA	25613284
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of GRB2 protein"	25852303
D013893	Thiram	Thiram results in decreased expression of GRB2 mRNA	20530235
D014118	Toxins, Biological	"Toxins, Biological affects the expression of GRB2 mRNA"	19682533
C046488	trimethyltin	trimethyltin results in increased expression of GRB2 mRNA	20833246
C001899	triptolide	triptolide results in decreased expression of GRB2 protein	26420756
D014501	Uranium	Uranium affects the expression of GRB2 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of GRB2 mRNA	15672453
D014635	Valproic Acid	Valproic Acid results in increased expression of GRB2 mRNA	23179753
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GRB2 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of GRB2 mRNA	19165385
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of GRB2 mRNA"	25208076

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001784	phosphotyrosine residue binding	-	IPI	20624904
GO:0003723	RNA binding	-	HDA	22658674
GO:0005070	SH3/SH2 adaptor activity	-	TAS	8253073
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005154	epidermal growth factor receptor binding	-	IPI	12577067
GO:0005168	neurotrophin TRKA receptor binding	-	IPI	15488758
GO:0005515	protein binding	-	IPI	7504175 7518560 7518772 7522233 7523381 7527043 7527391 7537265 7629138 7642581 7773779 8112292 8491186 8621483 8663178 8798570 8816475 8887653 8892607 8939605 8940013 8955135 8959326 8995379 9020117 9045636 9148935 9174058 9175774 9178760 9178913 9254595 9346925 9447984 9489702 9544989 9569023 9788432 10026169 10206341 10229072 10318918 10377264 10556826 10660596 10660620 10811803 10887132 10913131 10980613 11157975 11278465 11432792 11684012 11726515 11741929 11827484 11882361 11896612 11923305 12091307 12213123 12359715 12485888 12577067 14679214 14722116 14993658 15467741 15536091 15556869 15558030 15657067 15677445 15688026 15784897 15834155 15929943 16137687 16219545 16253990 16273093 16374509 16407827 16520382 16696976 16729043 16730941 16799092 16893902 16899217 16912232 16938345 17094785 17235283 17276458 17474147 18273061 18624398 18647389 18654987 18692475 19172738 19323566 19380743 19509291 19615732 19798056 19914172 20933011 20936779 21179510 21189249 21278786 21278788 21706016 21725282 21725358 21822214 21900206 21930792 21988832 22323290 22536782 22726438 23178716 23460737 23799367 24189400 24658140 24728074 25036637 25092874 25416956 25535246 25814554 25819436 27059931 27107012 28046066 28330616
GO:0016303	1-phosphatidylinositol-3-kinase activity	-	TAS	-
GO:0017124	SH3 domain binding	-	IDA	19509291
GO:0019901	protein kinase binding	-	IPI	20086093
GO:0019903	protein phosphatase binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	12577067 22536782 22726438
GO:0043560	insulin receptor substrate binding	-	IPI	8388384
GO:0046875	ephrin receptor binding	-	IPI	12925710
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0007173	epidermal growth factor receptor signaling pathway	-	TAS	1322798
GO:0007265	Ras protein signal transduction	-	TAS	8253073
GO:0007267	cell-cell signaling	-	TAS	8253073
GO:0007411	axon guidance	-	TAS	-
GO:0007568	aging	-	IEA	-
GO:0008286	insulin receptor signaling pathway	-	IPI	8388384
GO:0008286	insulin receptor signaling pathway	-	TAS	-
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	-
GO:0016032	viral process	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030838	positive regulation of actin filament polymerization	-	IEA	-
GO:0031295	T cell costimulation	-	TAS	-
GO:0031623	receptor internalization	-	IMP	14985334
GO:0035635	entry of bacterium into host cell	-	TAS	-
GO:0035723	interleukin-15-mediated signaling pathway	-	TAS	-
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	-	IEA	-
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0038128	ERBB2 signaling pathway	-	TAS	-
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	-	TAS	-
GO:0042770	signal transduction in response to DNA damage	-	IMP	20160708
GO:0043408	regulation of MAPK cascade	-	IEA	-
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0048011	neurotrophin TRK receptor signaling pathway	-	TAS	-
GO:0048646	anatomical structure formation involved in morphogenesis	-	IEA	-
GO:0050900	leukocyte migration	-	TAS	-
GO:0051291	protein heterooligomerization	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0060670	branching involved in labyrinthine layer morphogenesis	-	IEA	-
GO:0061024	membrane organization	-	TAS	-
GO:0071479	cellular response to ionizing radiation	-	IMP	20160708
GO:2000379	positive regulation of reactive oxygen species metabolic process	-	IMP	20160708

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	21179510
GO:0005654	nucleoplasm	-	IDA	-
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IDA	21179510
GO:0005768	endosome	-	IDA	21179510
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005829	cytosol	-	TAS	14722116
GO:0005886	plasma membrane	-	TAS	-
GO:0005911	cell-cell junction	-	IEA	-
GO:0008180	COP9 signalosome	-	IDA	22561606
GO:0012506	vesicle membrane	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145
GO:0070436	Grb2-EGFR complex	-	IDA	20086093

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04062	Chemokine signaling pathway
hsa04320	Dorso-ventral axis formation
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04540	Gap junction
hsa04630	Jak-STAT signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04910	Insulin signaling pathway
hsa04912	GnRH signaling pathway
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05211	Renal cell carcinoma
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05223	Non-small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-112399	IRS-mediated signalling	IEA
R-HSA-112412	SOS-mediated signalling	TAS
R-HSA-112412	SOS-mediated signalling	IEA
R-HSA-1226099	Signaling by FGFR in disease	TAS
R-HSA-1227986	Signaling by ERBB2	IEA
R-HSA-1227986	Signaling by ERBB2	TAS
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	TAS
R-HSA-1236394	Signaling by ERBB4	TAS
R-HSA-1250196	SHC1 events in ERBB2 signaling	IEA
R-HSA-1250347	SHC1 events in ERBB4 signaling	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1295596	Spry regulation of FGF signaling	TAS
R-HSA-1433557	Signaling by SCF-KIT	TAS
R-HSA-1433559	Regulation of KIT signaling	TAS
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-1643685	Disease	IEA
R-HSA-1643713	Signaling by EGFR in Cancer	TAS
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-167044	Signalling to RAS	TAS
R-HSA-167044	Signalling to RAS	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-177929	Signaling by EGFR	TAS
R-HSA-179812	GRB2 events in EGFR signaling	TAS
R-HSA-180292	GAB1 signalosome	TAS
R-HSA-180336	SHC1 events in EGFR signaling	TAS
R-HSA-182971	EGFR downregulation	TAS
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	TAS
R-HSA-1839124	FGFR1 mutant receptor activation	TAS
R-HSA-186763	Downstream signal transduction	TAS
R-HSA-186797	Signaling by PDGF	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	IEA
R-HSA-187687	Signalling to ERKs	TAS
R-HSA-187687	Signalling to ERKs	IEA
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194315	Signaling by Rho GTPases	IEA
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-195258	RHO GTPase Effectors	IEA
R-HSA-1963640	GRB2 events in ERBB2 signaling	IEA
R-HSA-1963640	GRB2 events in ERBB2 signaling	TAS
R-HSA-1963642	PI3K events in ERBB2 signaling	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	IEA
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	TAS
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	IEA
R-HSA-210993	Tie2 Signaling	TAS
R-HSA-2172127	DAP12 interactions	TAS
R-HSA-2179392	EGFR Transactivation by Gastrin	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	IEA
R-HSA-2424491	DAP12 signaling	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428924	IGF1R signaling cascade	IEA
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	IEA
R-HSA-2428933	SHC-related events triggered by IGF1R	IEA
R-HSA-2428933	SHC-related events triggered by IGF1R	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	TAS
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	IEA
R-HSA-2871796	FCERI mediated MAPK activation	TAS
R-HSA-2871809	FCERI mediated Ca+2 mobilization	IEA
R-HSA-2871809	FCERI mediated Ca+2 mobilization	TAS
R-HSA-354192	Integrin alphaIIb beta3 signaling	TAS
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-375165	NCAM signaling for neurite out-growth	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389356	CD28 co-stimulation	TAS
R-HSA-389359	CD28 dependent Vav1 pathway	TAS
R-HSA-391160	Signal regulatory protein family interactions	TAS
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	TAS
R-HSA-397795	G-protein beta:gamma signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-449147	Signaling by Interleukins	IEA
R-HSA-451927	Interleukin-2 family signaling	TAS
R-HSA-451927	Interleukin-2 family signaling	IEA
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	IEA
R-HSA-5637810	Constitutive Signaling by EGFRvIII	TAS
R-HSA-5637812	Signaling by EGFRvIII in Cancer	TAS
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5654687	Downstream signaling of activated FGFR1	TAS
R-HSA-5654688	SHC-mediated cascade:FGFR1	TAS
R-HSA-5654689	PI-3K cascade:FGFR1	TAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	TAS
R-HSA-5654695	PI-3K cascade:FGFR2	TAS
R-HSA-5654696	Downstream signaling of activated FGFR2	TAS
R-HSA-5654699	SHC-mediated cascade:FGFR2	TAS
R-HSA-5654700	FRS-mediated FGFR2 signaling	TAS
R-HSA-5654704	SHC-mediated cascade:FGFR3	TAS
R-HSA-5654706	FRS-mediated FGFR3 signaling	TAS
R-HSA-5654708	Downstream signaling of activated FGFR3	TAS
R-HSA-5654710	PI-3K cascade:FGFR3	TAS
R-HSA-5654712	FRS-mediated FGFR4 signaling	TAS
R-HSA-5654716	Downstream signaling of activated FGFR4	TAS
R-HSA-5654719	SHC-mediated cascade:FGFR4	TAS
R-HSA-5654720	PI-3K cascade:FGFR4	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654733	Negative regulation of FGFR4 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5654743	Signaling by FGFR4	TAS
R-HSA-5655253	Signaling by FGFR2 in disease	TAS
R-HSA-5655291	Signaling by FGFR4 in disease	TAS
R-HSA-5655302	Signaling by FGFR1 in disease	TAS
R-HSA-5655332	Signaling by FGFR3 in disease	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663205	Infectious disease	IEA
R-HSA-5663205	Infectious disease	TAS
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	TAS
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	IEA
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6806834	Signaling by MET	TAS
R-HSA-6807004	Negative regulation of MET activity	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-74749	Signal attenuation	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74751	Insulin receptor signalling cascade	IEA
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-74752	Signaling by Insulin receptor	IEA
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76009	Platelet Aggregation (Plug Formation)	TAS
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	TAS
R-HSA-8851805	MET activates RAS signaling	TAS
R-HSA-8851907	MET activates PI3K/AKT signaling	TAS
R-HSA-8853334	Signaling by FGFR3 fusions in cancer	TAS
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	TAS
R-HSA-8853659	RET signaling	TAS
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS
R-HSA-8865999	MET activates PTPN11	TAS
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	IEA
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	TAS
R-HSA-8875555	MET activates RAP1 and RAC1	TAS
R-HSA-8875656	MET receptor recycling	TAS
R-HSA-8875878	MET promotes cell motility	TAS
R-HSA-8876384	Listeria monocytogenes entry into host cells	IEA
R-HSA-8876384	Listeria monocytogenes entry into host cells	TAS
R-HSA-8983432	Interleukin-15 signaling	IEA
R-HSA-8983432	Interleukin-15 signaling	TAS
R-HSA-9006115	Signaling by NTRK2 (TRKB)	TAS
R-HSA-9006115	Signaling by NTRK2 (TRKB)	IEA
R-HSA-9006921	Integrin signaling	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9026519	Activated NTRK2 signals through RAS	IEA
R-HSA-9028335	Activated NTRK2 signals through PI3K	IEA
R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	TAS
R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	IEA
R-HSA-912526	Interleukin receptor SHC signaling	TAS
R-HSA-912631	Regulation of signaling by CBL	IEA
R-HSA-912631	Regulation of signaling by CBL	TAS
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
9178701	Differential inhibition of epidermal growth factor signaling pathways in rat hepatocytes by long-term ethanol treatment. (1997 Jun)	Saso K	Gastroenterology
25217982	Essential role of polymorphism of Gab1, EGFR, and EGF for the susceptibility of biliary tract cancer. (2014 Dec)	Meng LQ	Tumour Biol