Gene: GRB10

2887
GRB-IR|Grb-10|IRBP|MEG1|RSS
growth factor receptor bound protein 10
protein-coding
7p12.1
Ensembl:ENSG00000106070 MIM:601523 Vega:OTTHUMG00000150622 UniprotKB:Q13322
NG_012305.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.056e-2 (AD)  6.786e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2190498chr7:50621817 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13879047chr7:50774217GRB101.260e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRDM40.901
UBN10.897
PDXDC10.897
RNF1450.893
KPNA60.888
UBP10.887
APAF10.885
SENP20.885
AFTPH0.882
STX60.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.52
OR4F29-0.513
S100A14-0.396
PON1-0.369
NXNL1-0.366
ENDOU-0.362
SLC22A6-0.361
GPR143-0.361
S100A1-0.358
MAPKAPK3-0.353

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRB10 mRNA"19114083
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GRB10 mRNA"17547211
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of GRB10 mRNA"25710175
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GRB10 mRNA"18648102
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of GRB10 mRNA14583596
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of GRB10 mRNA20829426
D000082AcetaminophenAcetaminophen results in increased expression of GRB10 mRNA29067470
D020106AcrylamideAcrylamide affects the expression of GRB10 mRNA28959563
D020106AcrylamideAcrylamide results in decreased expression of GRB10 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GRB10 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GRB10 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GRB10 mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GRB10 mRNA24449571
D001151ArsenicArsenic affects the methylation of GRB10 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of GRB10 mRNA20458559|2782922
C006632arsenic trioxideGRB10 mRNA affects the susceptibility to arsenic trioxide23911876
D001379AzathioprineAzathioprine results in increased expression of GRB10 mRNA22623647
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of GRB10 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GRB10 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GRB10 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRB10 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GRB10 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRB10 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GRB10 mRNA"20382639|2623829
D004958EstradiolEstradiol affects the expression of GRB10 mRNA14699072
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in increased expression of GRB10 mRNA18192240
C006780bisphenol Abisphenol A results in increased expression of GRB10 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of GRB10 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of GRB10 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GRB10 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of GRB10 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GRB10 mRNA12160620
D002220CarbamazepineCarbamazepine affects the expression of GRB10 mRNA24752500|2597931
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GRB10 mRNA17484886
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GRB10 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GRB1020938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRB10 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRB10 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GRB10 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of GRB10 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of GRB10 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of GRB10 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of GRB10 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of GRB10 mRNA19167446
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA]18200517
D016572CyclosporineCyclosporine results in increased expression of GRB10 mRNA20106945|2214713
D016572CyclosporineCyclosporine results in increased expression of GRB10 mRNA19770486
D003907DexamethasoneDexamethasone results in increased expression of GRB10 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with RELB mutant form] results in increased expression of GRB10 mRNA23625948
D002945CisplatinCisplatin results in decreased expression of GRB10 mRNA22023808
D004008DiclofenacDiclofenac affects the expression of GRB10 mRNA24752500
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GRB10 mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GRB10 mRNA17547211
D004237DiuronDiuron results in decreased expression of GRB10 mRNA25152437
C479799(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of GRB10 mRNA15528975
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GRB10 mRNA28196854
C024565ethylene dichlorideethylene dichloride results in decreased expression of GRB10 mRNA28189721
D015025ZearalenoneZearalenone results in decreased expression of GRB10 mRNA25455459
D005485FlutamideFlutamide results in decreased expression of GRB10 mRNA24793618
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in increased methylation of GRB10 mRNA22959928
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GRB1020938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRB10 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRB10 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of GRB10 mRNA27664576
C069837fullerene C60fullerene C60 results in decreased expression of GRB10 mRNA19167457
C004312glycidolglycidol results in increased expression of GRB10 mRNA24915197
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GRB10 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GRB10 mRNA26752646
C008261lead acetatelead acetate results in increased expression of GRB10 mRNA25270620
C045463leflunomideleflunomide results in increased expression of GRB10 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of GRB1020938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRB10 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRB10 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of GRB10 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GRB10 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRB10 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GRB10 mRNA24810058
D015735MifepristoneMifepristone results in decreased expression of GRB10 mRNA25972201
C568376MT19c compoundMT19c compound results in decreased expression of GRB10 protein21803404
D009532NickelNickel results in decreased expression of GRB10 mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GRB10 mRNA25729387
D052638Particulate Matter[GRB10 gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of GRB10 mRNA21222557|2122255
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of GRB10 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GRB10 mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in increased expression of GRB10 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of GRB10 mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GRB10 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of GRB10 mRNA21795739
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of GRB10 mRNA"21152443
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of GRB10 mRNA"21152443
D011794QuercetinQuercetin results in increased expression of GRB10 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of GRB10 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GRB10 mRNA19059307
C059514resveratrolresveratrol results in increased expression of GRB10 mRNA18586690
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GRB10 mRNA25895662
D012834SilverSilver results in increased expression of GRB10 mRNA26014281
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in increased methylation of GRB10 mRNA22959928
C017947sodium arsenitesodium arsenite results in decreased expression of GRB10 mRNA19072884
C016104sodium bichromatesodium bichromate results in decreased expression of GRB10 mRNA17685462
D018038Sodium SeleniteSodium Selenite results in decreased expression of GRB10 mRNA16705456
D013467SulindacSulindac results in increased expression of GRB10 mRNA11906190
D013605T-2 ToxinT-2 Toxin results in increased expression of GRB10 mRNA26141394
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of GRB10 mRNA19059307
D013739TestosteroneTestosterone results in decreased expression of GRB10 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRB10 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GRB10 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRB10 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GRB10 mRNA25613284
D013876ThiophenesThiophenes analog promotes the reaction [Tretinoin results in decreased expression of GRB10 mRNA]16140955
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GRB10 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GRB10 mRNA25729387
D014212TretinoinThiophenes analog promotes the reaction [Tretinoin results in decreased expression of GRB10 mRNA]16140955
D014212TretinoinTretinoin results in decreased expression of GRB10 mRNA16140955|2193413
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA18200517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GRB10 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of GRB10 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of GRB10 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRB10 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of GRB10 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of GRB10 mRNA19136453
D001335Vehicle Emissions[GRB10 gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of GRB10 mRNA21222557|2122255
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GRB10 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of GRB10 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005070SH3/SH2 adaptor activity-IEA-  
GO:0005158insulin receptor binding-ISS15664450  
GO:0005515protein binding-IPI8798570  9506989  15060076  15722337  20670374  20878056  
23246379  24658140  25814554  
GO ID GO Term Qualifier Evidence PubMed
GO:0007411axon guidance-TAS-  
GO:0030178negative regulation of Wnt signaling pathway-IDA17376403  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-IDA15060076  
GO:0042326negative regulation of phosphorylation-IEA-  
GO:0046325negative regulation of glucose import-ISS15664450  
GO:0046627negative regulation of insulin receptor signaling pathway-ISS15664450  
GO:0048009insulin-like growth factor receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS9006901  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS9006901  
GO:0032991protein-containing complex-IDA20878056  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-162582Signal TransductionTAS
R-HSA-422475Axon guidanceTAS
R-HSA-74713IRS activationTAS
R-HSA-74749Signal attenuationTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-8853659RET signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23116464Beckwith Wiedemann imprinting defect found in leucocyte but not buccal DNA in a child born small for gestational age. (2012 Nov 1)Murphy RBMC Med Genet