Gene info: ID 2888

Gene: GRB14

GENE ID: 2888

Synonyms: -

Description: growth factor receptor bound protein 14

Gene type: protein-coding

Location: 2q24.3

dbXrefs: Ensembl:ENSG00000115290 MIM:601524 Vega:OTTHUMG00000132135 UniprotKB:Q14449

RefSeq: NG_052839.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.633e-1 (AD) 3.777e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4423615	chr2:164581720 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CTXN3	0.806
LRRC2	0.78
FAM84A	0.761
CUX2	0.75
LANCL3	0.738
WIPF3	0.733
UBXN10	0.731
PIP5K1B	0.731
PCDH8	0.73
CACNB2	0.728

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CTNNA3	-0.505
RASGRP3	-0.485
SGMS2	-0.483
BCAS1	-0.476
VRK2	-0.474
LPAR1	-0.471
GNG8	-0.47
TP53INP2	-0.469
MOBP	-0.463
SLCO1A2	-0.463

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GRB14 mRNA"	28433925
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GRB14 mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRB14 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRB14 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRB14 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRB14 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of GRB14 mRNA	21420995
D020106	Acrylamide	Acrylamide results in decreased expression of GRB14 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of GRB14 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GRB14 mRNA	22100608
D000393	Air Pollutants	GRB14 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]	27281273
D000452	Aldrin	Aldrin results in increased expression of GRB14 mRNA	18579281
D000638	Amiodarone	Amiodarone affects the expression of GRB14 mRNA	18355885
D000639	Amitriptyline	Amitriptyline affects the expression of GRB14 mRNA	18355885
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GRB14 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of GRB14 gene	25304211
C015001	arsenite	arsenite results in decreased expression of GRB14 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of GRB14 mRNA]	18929588
D001379	Azathioprine	Azathioprine results in decreased expression of GRB14 mRNA	22623647
C547126	AZM551248	AZM551248 results in decreased expression of GRB14 mRNA	22323515
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of GRB14 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GRB14 mRNA	19770486\|2156981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GRB14 mRNA	22228805
D004958	Estradiol	Estradiol affects the expression of GRB14 mRNA	21826169
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GRB14 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of GRB14 mRNA	16202921\|1961957
C006780	bisphenol A	bisphenol A affects the expression of GRB14 mRNA	21826169
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GRB14 mRNA	28628672
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GRB14 mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of GRB14 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of GRB14 gene	28505145
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of GRB14 mRNA	22079614
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in increased expression of GRB14 mRNA	15728792
D002220	Carbamazepine	Carbamazepine affects the expression of GRB14 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of GRB14 mRNA	17484886
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GRB14 mRNA	18668222
D002994	Clofibrate	Clofibrate results in decreased expression of GRB14 mRNA	23811191
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GRB14 mRNA	17602206
D002997	Clomipramine	Clomipramine affects the expression of GRB14 mRNA	18355885
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of GRB14 mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of GRB14 mRNA	20971185
D003471	Cuprizone	Cuprizone results in decreased expression of GRB14 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of GRB14 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of GRB14 mRNA	19770486
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GRB14 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GRB14 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate affects the expression of GRB14 protein	21745491
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GRB14 mRNA	15728792\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GRB14 protein	15728792
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GRB14 mRNA	28433925
D004041	Dietary Fats	Dietary Fats results in increased expression of GRB14 mRNA	18042831\|1903023
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of GRB14 mRNA]	19030233
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GRB14 mRNA	28433925
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GRB14 mRNA"	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of GRB14 mRNA	15728792
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GRB14 mRNA	17602206
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in increased expression of GRB14 mRNA	15728792
C118739	entinostat	entinostat results in increased expression of GRB14 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRB14 mRNA"	27188386
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of GRB14 mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GRB14 mRNA	12655037\|1583489
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of GRB14 mRNA	17347304
D005485	Flutamide	Flutamide results in decreased expression of GRB14 mRNA	24793618
D004397	Fonofos	Fonofos results in increased methylation of GRB14 promoter	22847954
C039281	furan	furan results in increased methylation of GRB14 gene	22079235
D017313	Fenretinide	Fenretinide results in decreased expression of GRB14 mRNA	28973697
D006918	Hydroxyurea	Hydroxyurea results in increased mutagenesis of GRB14 gene	16868089
D007099	Imipramine	Imipramine affects the expression of GRB14 mRNA	18355885
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GRB14 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GRB14 mRNA	28628672
D007654	Ketoconazole	Ketoconazole affects the expression of GRB14 mRNA	18355885
D008701	Methapyrilene	Methapyrilene results in decreased expression of GRB14 mRNA	16393664
D008770	Methylnitrosourea	Methylnitrosourea results in increased mutagenesis of GRB14 gene	16868089
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of GRB14 mRNA	29162477
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GRB14 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GRB14 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of GRB14 mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride affects the expression of GRB14 mRNA	22110744
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of GRB14 mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of GRB14 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of GRB14 mRNA	25729387
D000073878	Palm Oil	Palm Oil results in increased expression of GRB14 mRNA	18042831
D010278	Parathion	Parathion results in increased methylation of GRB14 promoter	22847954
D052638	Particulate Matter	GRB14 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]	27281273
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of GRB14 mRNA	23892564
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of GRB14 mRNA	27153767
C045950	propiconazole	propiconazole results in decreased expression of GRB14 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in increased expression of GRB14 mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of GRB14 mRNA	15309432\|2163298
C089032	rimonabant	rimonabant affects the expression of GRB14 mRNA	19030233
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of GRB14 mRNA]	19030233
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of GRB14 mRNA	21427059
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of GRB14 mRNA	25895662
D012906	Smoke	Smoke affects the expression of GRB14 mRNA	23693141
D053260	Soot	Soot results in decreased expression of GRB14 mRNA	26551751
C012568	terbufos	terbufos results in increased methylation of GRB14 promoter	22847954
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GRB14 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GRB14 mRNA	19619570\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GRB14 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GRB14 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GRB14 mRNA	19770486\|2135428
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GRB14 mRNA	21215274
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of GRB14 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of GRB14 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of GRB14 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of GRB14 mRNA	21934132
C012589	trichostatin A	trichostatin A results in increased expression of GRB14 mRNA	24935251
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of GRB14 mRNA	29024780
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of GRB14 mRNA	15885361
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRB14 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of GRB14 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of GRB14 mRNA	24935251\|2915479
D014635	Valproic Acid	Valproic Acid results in increased expression of GRB14 mRNA	23179753\|2352703
D014635	Valproic Acid	Valproic Acid affects the expression of GRB14 mRNA	17963808
D014635	Valproic Acid	Valproic Acid results in increased expression of GRB14 mRNA	21427059
C088658	zoledronic acid	zoledronic acid results in decreased expression of GRB14 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005070	SH3/SH2 adaptor activity	-	IEA	-
GO:0030971	receptor tyrosine kinase binding	-	IPI	16246733
GO:0042802	identical protein binding	-	IMP	16246733
GO:0042803	protein homodimerization activity	-	IMP	16246733

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	IEA	-
GO:0009967	positive regulation of signal transduction	-	IEA	-
GO:0046627	negative regulation of insulin receptor signaling pathway	-	IMP	16246733
GO:0050900	leukocyte migration	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	11278563
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	11278563
GO:0010008	endosome membrane	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	11278563

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-210993	Tie2 Signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23978819	Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)	Graff M	Nutr Diabetes
19268276	Genome-wide association study of smoking initiation and current smoking. (2009 Mar)	Vink JM	Am J Hum Genet