Gene: RAPGEF1

2889
C3G|GRF2
Rap guanine nucleotide exchange factor 1
protein-coding
9q34.13
Ensembl:ENSG00000107263 MIM:600303 Vega:OTTHUMG00000020829 UniprotKB:Q13905
NG_050622.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.480e-1 (AD)  4.408e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10120010chr9:131685810 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs17148121chr9:131628423 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13784312chr9:134609065RAPGEF12.730e-10Maternal smoking in pregnancy27040690
cg13784312chr9:134609065RAPGEF11.630e-15Maternal smoking in pregnancy27040690
cg13784312chr9:134609065RAPGEF11.810e-12Maternal smoking in pregnancy27040690
cg04086928chr9:134612644RAPGEF16.000e-17Smoking27651444
cg14505439chr9:134605210RAPGEF13.700e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SKI0.919
PRRC2B0.918
LASP10.916
TNPO20.915
PPP6R10.907
DAB2IP0.904
PRRC2A0.904
WDTC10.903
MLLT10.9
ZC3H7B0.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.703
OR4F29-0.667
CTNNA3-0.311
MYOT-0.294
TNFRSF13B-0.292
C11orf88-0.274
ODAM-0.267
ANXA13-0.266
NANOGNB-0.265
SH2D1A-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RAPGEF1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RAPGEF1 mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAPGEF1 mRNA"20816883
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RAPGEF1 mRNA"18648102
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of RAPGEF1 mRNA20829426
D000082AcetaminophenAcetaminophen results in increased expression of RAPGEF1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of RAPGEF1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAPGEF1 mRNA16483693
D001151ArsenicArsenic affects the methylation of RAPGEF1 gene25304211
C547126AZM551248AZM551248 results in decreased expression of RAPGEF1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of RAPGEF1 mRNA22342234
C044887beta-methylcholinebeta-methylcholine affects the expression of RAPGEF1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of RAPGEF1 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of RAPGEF1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of RAPGEF1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of RAPGEF1 mRNA20977926
C013418bromfenacoumbromfenacoum results in decreased expression of RAPGEF1 protein28903499
C584509C646 compoundC646 compound results in increased expression of RAPGEF1 mRNA26191083
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of RAPGEF1 mRNA19684285
D016572CyclosporineCyclosporine results in increased expression of RAPGEF1 mRNA20106945
D002945CisplatinCisplatin results in decreased expression of RAPGEF1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of RAPGEF1 mRNA28302478
D005485FlutamideFlutamide results in increased expression of RAPGEF1 mRNA24136188
C492448ICG 001ICG 001 results in increased expression of RAPGEF1 mRNA26191083
D007854LeadLead affects the expression of RAPGEF1 mRNA28903495
D007854LeadLead results in increased expression of RAPGEF1 mRNA19921347
C045463leflunomideleflunomide results in increased expression of RAPGEF1 mRNA28988120
D008627Mercuric ChlorideMercuric Chloride results in increased phosphorylation of RAPGEF1 protein14551197
D010795Phthalic AcidsPhthalic Acids results in increased expression of RAPGEF1 mRNA21061450
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of RAPGEF1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RAPGEF1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAPGEF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAPGEF1 mRNA26290441
D014635Valproic AcidValproic Acid results in increased expression of RAPGEF1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of RAPGEF1 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI8621483  9748234  16443220  17474147  17515907  19380743  
20936779  26496610  
GO:0017034Rap guanyl-nucleotide exchange factor activity-IDA10548487  
GO:0017034Rap guanyl-nucleotide exchange factor activity-IMP21840392  
GO:0017124SH3 domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000186activation of MAPKK activity-TAS-  
GO:0001568blood vessel development-IEA-  
GO:0007165signal transduction-NAS7512734  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-TAS7512734  
GO:0010976positive regulation of neuron projection development-IMP17724123  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032486Rap protein signal transduction-IMP21840392  
GO:0038180nerve growth factor signaling pathway-IDA17724123  
GO:0043547positive regulation of GTPase activity-IDA10548487  
GO:0043547positive regulation of GTPase activity-IMP21840392  
GO:0046328regulation of JNK cascade-IEA-  
GO:0046580negative regulation of Ras protein signal transduction-IEA-  
GO:0048008platelet-derived growth factor receptor signaling pathway-IEA-  
GO:0051898negative regulation of protein kinase B signaling-IEA-  
GO:0061028establishment of endothelial barrier-IMP21840392  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:0071320cellular response to cAMP-IDA21840392  
GO:0090090negative regulation of canonical Wnt signaling pathway-IEA-  
GO:0098609cell-cell adhesion-IEA-  
GO:1901888regulation of cell junction assembly-IMP21840392  
GO:1905451positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis-IEA-  
GO:1990090cellular response to nerve growth factor stimulus-IDA17724123  
GO:2000178negative regulation of neural precursor cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA17515907  
GO:0005768endosome-TAS-  
GO:0005769early endosome-IDA17724123  
GO:0005829cytosol-TAS-  
GO:0030670phagocytic vesicle membrane-IEA-  
GO:0032991protein-containing complex-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-168256Immune SystemTAS
R-HSA-169893Prolonged ERK activation eventsTAS
R-HSA-169893Prolonged ERK activation eventsIEA
R-HSA-170968Frs2-mediated activationTAS
R-HSA-170968Frs2-mediated activationIEA
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187687Signalling to ERKsTAS
R-HSA-187687Signalling to ERKsIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-6806834Signaling by METTAS
R-HSA-8875555MET activates RAP1 and RAC1TAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-912631Regulation of signaling by CBLTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal