Gene: GRIA1

2890
GLUH1|GLUR1|GLURA|GluA1|HBGR1
glutamate ionotropic receptor AMPA type subunit 1
protein-coding
5q33.2
Ensembl:ENSG00000155511 MIM:138248 Vega:OTTHUMG00000130148 UniprotKB:P42261
NG_047078.1
PubMed|SNP Mapped
6   ANCO-SNPs
AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.424e-1 (AD)  7.097e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2963998chr5:153797493 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7445323chr5:153757225 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4128572chr5:153749155 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6889794chr5:153743895 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4273649chr5:153740488 (GRCh38.p7)A>C / A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1973372chr5:153582064 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRB30.97
SCN3B0.969
ST8SIA30.967
DLG30.963
ADD20.963
NSF0.961
SYN20.961
SCN2A0.959
GDA0.958
PAK30.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.539
CNN2-0.525
TFPI2-0.523
RNF135-0.521
REST-0.52
HEY2-0.515
MYL3-0.514
WWTR1-0.513
YES1-0.511
RUNX3-0.506

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB04982TalampanelSmall Molecule161832-65-1InvestigationalTarget
DB05047CX717Small Molecule-Illicit|InvestigationalTarget
DB06247CX516Small Molecule154235-83-3InvestigationalTarget
DB08883PerampanelSmall Molecule380917-97-5ApprovedTarget
DB09289TianeptineSmall Molecule72797-41-2Approved|InvestigationalTarget
DB13146Fluciclovine (18F)Small Molecule222727-39-1ApprovedTarget
ID Drug Name Action PubMed
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of GRIA1 mRNA27417517
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of GRIA1 protein]17585341
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIA1 protein"17589592
C4748292-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid binds to and results in increased activity of [GRIA1 protein binds to GRIA2 protein]21923187
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of GRIA1 mRNA16014739
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
C0233664-bromohomoibotenic acid4-bromohomoibotenic acid binds to and results in increased activity of [GRIA1 protein binds to GRIA2 protein]21923187
C0951785-fluorowillardiine5-fluorowillardiine binds to GRIA1 protein21923187
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of GRIA1 protein]17680995
D020106AcrylamideAcrylamide results in decreased expression of GRIA1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRIA1 gene27153756
D018350alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of KLC2 protein] inhibits the reaction [GRIA1 protein binds to KLC2 protein]20534517
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRIA1 mRNA16483693
C025657arsenic acidarsenic acid analog results in decreased expression of GRIA1 mRNA19761793
C006632arsenic trioxidearsenic trioxide results in decreased expression of GRIA1 mRNA24831965
D001280AtrazineAtrazine results in decreased expression of GRIA1 mRNA25929836
D001565BenzoatesBenzoates analog binds to and results in decreased activity of GRIA1 protein14667236
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GRIA1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRIA1 mRNA28412278
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRIA1 protein28412278
D001564Benzo(a)pyreneSNAP25 protein affects the reaction [Benzo(a)pyrene results in decreased expression of GRIA1 mRNA]28412278
D001564Benzo(a)pyreneSNAP25 protein affects the reaction [Benzo(a)pyrene results in decreased expression of GRIA1 protein]28412278
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRIA1 mRNA17606297
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRIA1 protein17606297|2841227
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIA1 mRNA21839799|2210833
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased localization of GRIA1 protein19674091
D004958EstradiolNR3C1 protein inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA]23275455
D004958EstradiolNR3C2 protein promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA]23275455
D004958Estradiol[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA23275455
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GRIA1 mRNA22154832
D004958EstradiolEstradiol results in decreased expression of GRIA1 mRNA22154832
D001640BicucullineBicuculline results in decreased expression of and results in decreased localization of GRIA1 protein19674091
C006780bisphenol Abisphenol A results in decreased expression of GRIA1 protein23240141|2349018
C006780bisphenol Abisphenol A results in decreased expression of GRIA1 mRNA24820113
C006780bisphenol Abisphenol A results in decreased expression of GRIA1 protein24820113
C006780bisphenol Abisphenol A results in increased methylation of GRIA1 gene28505145
D0151248-Bromo Cyclic Adenosine MonophosphateNR3C1 protein inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA]23275455
D0151248-Bromo Cyclic Adenosine MonophosphateNR3C2 protein promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA]23275455
D0151248-Bromo Cyclic Adenosine Monophosphate[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA23275455
D002118CalciumCalcium deficiency inhibits the reaction [Excitatory Amino Acid Agonists results in decreased phosphorylation of GRIA1 protein]28404816
D002211CapsaicinCapsaicin results in increased phosphorylation of GRIA1 protein12019337
D002211CapsaicinKN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of GRIA1 protein]12019337
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GRIA1 mRNA12734012
D000068579CelecoxibCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]21589914
D004390ChlorpyrifosChlorpyrifos results in increased expression of GRIA1 mRNA19440498
D015283CitalopramGRIA1 polymorphism affects the susceptibility to Citalopram19295509
D003024ClozapineClozapine results in decreased expression of GRIA1 mRNA17141476
D003042CocaineCocaine results in increased expression of GRIA1 protein16363995
D003042CocaineCocaine affects the expression of GRIA1 mRNA9886066
D003042CocaineCocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein28194001
D003042CocaineCocaine results in increased expression of GRIA1 protein19070590
D003042CocaineCocaine results in increased phosphorylation of GRIA1 protein16473939|2349995
D003042CocaineGRIA1 results in decreased susceptibility to Cocaine18701074
D003042CocaineNifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein]28194001
D003042Cocaineresveratrol promotes the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]23499958
D003042CocaineSL 327 inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]16473939
D003042Cocaine6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of GRIA1 protein]17680995
D003042CocaineCocaine affects the expression of GRIA1 mRNA12511956|2018794
D003042CocaineCocaine affects the expression of GRIA1 protein12511956|1514020
D003042CocaineCocaine affects the phosphorylation of and affects the expression of GRIA1 protein17680995
D003042CocaineCocaine results in decreased expression of GRIA1 mRNA24810662
D003042CocaineCocaine results in decreased expression of GRIA1 protein24810662
D003042CocaineCocaine results in decreased phosphorylation of GRIA1 protein11268215
D003042CocaineCocaine results in increased expression of GRIA1 mRNA17898221
D003042CocaineCocaine results in increased expression of GRIA1 protein11801363|1278707
D003042CocaineCocaine results in increased phosphorylation of and results in increased transport of GRIA1 protein18278040
D003042CocaineCocaine results in increased phosphorylation of GRIA1 protein16794574|1962975
D003042CocaineDizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]11801363
D003042CocaineGRIA1 protein affects the susceptibility to Cocaine11801363|1843003
D003042CocaineGRIA1 protein mutant form results in decreased susceptibility to Cocaine14684464
D003042CocaineGRIA1 protein results in increased susceptibility to Cocaine14684464
D003042CocaineGRIA1 results in decreased susceptibility to Cocaine12511956
D003042Cocaineifenprodil inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]19474322
D003042CocaineILK mutant form inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]19629758
D003042CocaineOndansetron inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]16794574
D003042Cocaineroscovitine inhibits the reaction [Cocaine results in decreased phosphorylation of GRIA1 protein]11268215
D003042CocaineU 0126 inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]19474322
D003042CocaineCocaine results in increased phosphorylation of GRIA1 protein17596442
D003471CuprizoneCuprizone results in decreased expression of GRIA1 mRNA26577399
D003471CuprizoneCuprizone results in decreased expression of GRIA1 protein26577399
D0187506-Cyano-7-nitroquinoxaline-2,3-dione"6-Cyano-7-nitroquinoxaline-2,3-dione results in increased expression of and results in increased localization of GRIA1 protein"19674091
C017160cypermethrincypermethrin affects the expression of GRIA1 protein26143737
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of GRIA1]19912468
D013759DronabinolDronabinol results in decreased expression of and results in increased import of GRIA1 protein19912468
D013759DronabinolDronabinol results in decreased expression of GRIA1 mRNA19912468
D013759Dronabinolrimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIA1]19912468
D003976DiazinonDiazinon results in decreased expression of GRIA1 mRNA17452286
D003976DiazinonDiazinon results in increased expression of GRIA1 mRNA19440498
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GRIA1 mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GRIA1 mRNA26924002
D004026DieldrinDieldrin results in increased expression of GRIA1 mRNA19440498
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GRIA1 mRNA18164116
C024629dimethyl phthalatedimethyl phthalate affects the expression of GRIA1 mRNA26924002
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]11801363
C012301domoic aciddomoic acid results in increased phosphorylation of GRIA1 protein19564213
D007980Levodopaistradefylline inhibits the reaction [Levodopa affects the phosphorylation of GRIA1 protein]14637099
D007980LevodopaLevodopa affects the phosphorylation of GRIA1 protein14637099
D004298DopamineDopamine results in increased localization of GRIA1 protein19674091
D004298Dopamine[NTS protein results in increased secretion of Dopamine] which results in increased phosphorylation of GRIA1 protein12064480
D004298DopaminePPP1R1B protein affects the reaction [[NTS protein results in increased secretion of Dopamine] which results in increased phosphorylation of GRIA1 protein]12064480
D004726EndosulfanEndosulfan results in increased expression of GRIA1 protein26143737
C118739entinostatentinostat results in decreased expression of GRIA1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
D000431EthanolEthanol results in decreased expression of GRIA1 mRNA20655511
D018690Excitatory Amino Acid AgonistsCalcium deficiency inhibits the reaction [Excitatory Amino Acid Agonists results in decreased phosphorylation of GRIA1 protein]28404816
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists results in decreased phosphorylation of GRIA1 protein28404816
D005411Flame RetardantsFlame Retardants results in decreased expression of GRIA1 protein17589592
D005419FlavonoidsFlavonoids results in decreased expression of GRIA1 mRNA18035473
D005473FluoxetineFluoxetine affects the phosphorylation of GRIA1 protein11880651
D005473FluoxetinePPP1R1B protein promotes the reaction [Fluoxetine affects the phosphorylation of GRIA1 protein]11880651
D005473FluoxetineFluoxetine affects the expression of GRIA1 protein20417256
D019833GenisteinGenistein results in decreased expression of GRIA1 mRNA21782745
D005998GlycineGlycine results in increased expression of and results in increased phosphorylation of GRIA1 protein24990929
D005998GlycineHNRNPK mutant form inhibits the reaction [Glycine results in increased expression of and results in increased phosphorylation of GRIA1 protein]24990929
D006220HaloperidolHaloperidol results in decreased expression of GRIA1 mRNA15860345
C110702IEM 1460IEM 1460 binds to and results in decreased activity of GRIA1 protein19145339
C010739ifenprodilifenprodil inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]19474322
C111599istradefyllineistradefylline inhibits the reaction [Levodopa affects the phosphorylation of GRIA1 protein]14637099
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GRIA1 mRNA26301327
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GRIA1 protein26301327
D007608Kainic AcidCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIA1 mRNA21589914
D007608Kainic AcidPTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]21589914
D007608Kainic Acid2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of GRIA1 protein]17585341
D007608Kainic AcidKainic Acid binds to and results in increased activity of GRIA1 protein11812690
D007608Kainic AcidKainic Acid results in decreased expression of GRIA1 mRNA7529610
D007608Kainic AcidKainic Acid results in decreased expression of GRIA1 protein17585341
D007608Kainic AcidUrethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA1 protein]11812690
C072105KN 93KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of GRIA1 protein]12019337
C067713lactacystinlactacystin results in increased localization of GRIA1 protein19674091
D007854LeadLead affects the splicing of GRIA1 mRNA28903495
C008261lead acetatelead acetate affects the expression of GRIA1 mRNA24260418
D008094LithiumLithium results in decreased expression of GRIA1 protein18171924
C030272maleic acidmaleic acid results in increased expression of GRIA1 mRNA28392987
D008694MethamphetamineMethamphetamine affects the expression of GRIA1 mRNA18419818
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRIA1 mRNA28001369
D015735MifepristoneMifepristone results in decreased expression of GRIA1 mRNA17584828
D008911MinocyclineMinocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA]19660546
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GRIA1 mRNA26924002
D009020MorphineGRIA1 protein affects the susceptibility to Morphine11404432
D009020MorphineMorphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]25643298
D009020MorphineMorphine results in decreased expression of GRIA1 mRNA15183518
D009020MorphineMorphine results in decreased expression of GRIA1 protein23711322
D009020MorphineMorphine results in decreased phosphorylation of GRIA1 protein15287884
D009020MorphineMorphine results in increased expression of GRIA1 mRNA15183518
D009151Mustard GasMustard Gas results in decreased expression of GRIA1 mRNA15674843
C479831N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea"N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea affects the localization of GRIA1 protein"20534517
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GRIA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GRIA1 mRNA"25554681
D009532NickelNickel results in increased expression of GRIA1 mRNA19440498
D009543NifedipineNifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein]28194001
C025589ochratoxin Aochratoxin A results in increased expression of GRIA1 mRNA27346841
D017294OndansetronOndansetron inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]16794574
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
D052638Particulate MatterParticulate Matter results in decreased expression of GRIA121724521
D010406PenicillinsPenicillins results in increased expression of GRIA1 mRNA19666089
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GRIA1 mRNA26705709
D010862PilocarpinePilocarpine results in decreased expression of GRIA1 mRNA7529610
D010862PilocarpinePilocarpine results in increased expression of GRIA1 protein15857427
C006253pirinixic acidpirinixic acid results in increased expression of GRIA1 mRNA20813756
D011066Poly CMinocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA]19660546
D011066Poly CPoly C results in increased expression of GRIA1 mRNA19660546
D011374ProgesteroneNR3C1 protein inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA]23275455
D011374ProgesteroneNR3C2 protein promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA]23275455
D011374Progesterone[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA23275455
D011374ProgesteroneProgesterone results in increased expression of GRIA1 mRNA21795739
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GRIA1 mRNA22154832
D011441PropylthiouracilPropylthiouracil results in decreased expression of GRIA1 mRNA24780913
D0014983-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of GRIA1 protein"28194001
D0014983-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased phosphorylation of GRIA1 protein"28194001
C059514resveratrolresveratrol promotes the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]23499958
D012293RifampinRifampin results in decreased expression of GRIA1 mRNA24552687
C089032rimonabantrimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIA1]19912468
C104586roscovitineroscovitine inhibits the reaction [Cocaine results in decreased phosphorylation of GRIA1 protein]11268215
C067113SK&F 81297SK&F 81297 results in increased phosphorylation of and results in increased expression of GRIA1 protein19217379
C424127SL 327SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]16473939
C009277sodium arsenatesodium arsenate results in increased expression of GRIA1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of GRIA1 gene28589171
C017947sodium arseniteGRIA1 protein results in decreased susceptibility to sodium arsenite23694735
C017947sodium arsenitesodium arsenite affects the expression of GRIA1 protein23694735
C017947sodium arsenitesodium arsenite results in decreased expression of GRIA1 protein29204679
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of GRIA1 mRNA25534910
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GRIA1 mRNA16839606
D013779TetrodotoxinTetrodotoxin results in increased localization of GRIA1 protein19674091
C009495titanium dioxidetitanium dioxide results in decreased expression of GRIA1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GRIA1 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of GRIA1 mRNA21934132
D014229TriazolamTriazolam results in decreased expression of GRIA1 protein27489535
C011559tributyltintributyltin results in decreased expression of GRIA1 mRNA19591855
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of GRIA1 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of GRIA1 mRNA24935251
C025541tri-o-cresyl phosphatetri-o-cresyl phosphate results in decreased expression of GRIA1 protein25199799
C113580U 0126U 0126 inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]19474322
D014520UrethaneUrethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA1 protein]11812690
D014635Valproic AcidValproic Acid affects the expression of GRIA1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRIA1 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased methylation of GRIA1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GRIA1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of GRIA1 mRNA24896083
D014635Valproic AcidValproic Acid results in decreased expression of GRIA1 protein18171924
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of GRIA1 mRNA25423262
C111237vorinostatvorinostat results in decreased expression of GRIA1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-ISS-  
GO:0004971AMPA glutamate receptor activity-IBA21873635  
GO:0004971AMPA glutamate receptor activity-IDA20805473  21172611  
GO:0005231excitatory extracellular ligand-gated ion channel activity-TAS-  
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO:0005515protein binding-IPI20805473  
GO:0008066glutamate receptor activity-TAS1320959  
GO:0030165PDZ domain binding-ISS-  
GO:0099583neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration-IBA21873635  
GO:0099583neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration-IEA-  
GO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007165signal transduction-TAS1311100  
GO:0007268chemical synaptic transmission-TAS1311100  
GO:0007616long-term memory-IEA-  
GO:0031623receptor internalization-IEA-  
GO:0034220ion transmembrane transport-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-IEA-  
GO:0048208COPII vesicle coating-TAS-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060292long term synaptic depression-IEA-  
GO:0099566regulation of postsynaptic cytosolic calcium ion concentration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0008021synaptic vesicle-IEA-  
GO:0009986cell surface-ISS-  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0014069postsynaptic density-ISS-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-ISS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0031901early endosome membrane-IEA-  
GO:0032281AMPA glutamate receptor complex-IBA21873635  
GO:0032281AMPA glutamate receptor complex-ISS-  
GO:0032591dendritic spine membrane-IDA20434989  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-TAS-  
GO:0043025neuronal cell body-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0044308axonal spine-IEA-  
GO:0044309neuron spine-ISS-  
GO:0055037recycling endosome-IDA20434989  
GO:0055038recycling endosome membrane-IEA-  
GO:0098839postsynaptic density membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa05014Amyotrophic lateral sclerosis (ALS)
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-399710Activation of AMPA receptorsTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS
R-HSA-438066Unblocking of NMDA receptor, glutamate binding and activationTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-8849932Synaptic adhesion-like moleculesTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18444252Neurotransmission and bipolar disorder: a systematic family-based association study. (2008 Oct 5)Shi JAm J Med Genet B Neuropsychiatr Genet
29032150Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)Sundararajan TGene
22511924Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. (2012)Wolen ARPLoS One