Gene: GRIA3

2892
GLUR-C|GLUR-K3|GLUR3|GLURC|GluA3|MRX94
glutamate ionotropic receptor AMPA type subunit 3
protein-coding
Xq25
Ensembl:ENSG00000125675 MIM:305915 Vega:OTTHUMG00000022685 UniprotKB:P42263
NG_009377.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12559898chrX:123197971 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBFOX10.965
HSPA12A0.962
ADAM230.961
SV2B0.959
ST8SIA30.959
SYT10.959
ATP2B10.959
KCNMA10.959
GLS0.958
SCN2A0.958

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.514
CNN2-0.503
MYL3-0.501
RAB13-0.501
WWTR1-0.499
ZNF114-0.496
RNF135-0.492
RUNX3-0.492
YES1-0.491
EMP3-0.49

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01356LithiumSmall Molecule7439-93-2ApprovedTarget
DB04599AniracetamSmall Molecule72432-10-1ExperimentalTarget
DB04982TalampanelSmall Molecule161832-65-1InvestigationalTarget
DB05047CX717Small Molecule-Illicit|InvestigationalTarget
DB13146Fluciclovine (18F)Small Molecule222727-39-1ApprovedTarget
ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in decreased expression of GRIA3 mRNA"17070881
C0362601-hexanol1-hexanol results in decreased activity of GRIA3 protein11429388
C0353141-nitropropane1-nitropropane results in decreased expression of GRIA3 mRNA17070881
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIA3 mRNA"19114083
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of GRIA3 mRNA"21724226
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of GRIA3 mRNA"17070881
C0252352,6-diaminotoluene"2,6-diaminotoluene results in decreased expression of GRIA3 mRNA"17070881
C0065932-anthramine2-anthramine results in increased expression of GRIA3 mRNA23038007
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in increased expression of GRIA3 mRNA17070881
C0194992-nitrofluorene2-nitrofluorene results in increased expression of GRIA3 mRNA22484513
C0166172-nitropropane2-nitropropane results in increased expression of GRIA3 mRNA17070881
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
C0286764-acetylaminofluorene4-acetylaminofluorene results in decreased expression of GRIA3 mRNA17070881
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GRIA3 mRNA22484513
C0951785-fluorowillardiineGRIA3 protein affects the susceptibility to 5-fluorowillardiine15264227
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GRIA3 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of GRIA3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRIA3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GRIA3 mRNA22484513|2338521
D000452AldrinAldrin results in increased expression of GRIA3 mRNA18579281
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of GRIA3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRIA3 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of GRIA3 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of GRIA3 mRNA22323515
C487081belinostatbelinostat results in increased expression of GRIA3 mRNA27188386
D001565BenzoatesBenzoates analog binds to and results in decreased activity of GRIA3 protein14667236
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GRIA3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIA3 mRNA20106945|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIA3 mRNA21964900|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIA3 mRNA21839799
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of GRIA3 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of GRIA3 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of GRIA3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GRIA3 mRNA25181051
D0200011-Butanol1-Butanol results in decreased activity of GRIA3 protein11429388
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GRIA3 mRNA25993096
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of GRIA3 mRNA19395590
D000068579CelecoxibCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA]21589914
D002509CephaloridineCephaloridine results in decreased expression of GRIA3 mRNA18500788
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of GRIA3 mRNA26272509
D004390ChlorpyrifosChlorpyrifos affects the expression of GRIA3 mRNA19440498
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GRIA3 mRNA18668222
D004390ChlorpyrifosChlorpyrifos results in increased expression of GRIA3 mRNA17452286
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRIA3 mRNA20938992
D015283CitalopramGRIA3 polymorphism affects the susceptibility to Citalopram19295509
D003024ClozapineClozapine results in increased expression of GRIA3 mRNA17141476
D003042CocaineCocaine results in increased expression of GRIA3 protein16363995
D003042CocaineCocaine results in increased expression of GRIA3 protein16363995
D003042CocaineCocaine results in decreased expression of GRIA3 mRNA9886066
D003042CocaineCocaine affects the expression of GRIA3 protein12511956|1514020
D003471CuprizoneCuprizone results in decreased expression of GRIA3 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GRIA3 mRNA23914054
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GRIA3 mRNA28962523
D002945CisplatinCisplatin results in increased expression of GRIA3 mRNA25270620
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GRIA3 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of GRIA3 mRNA25016146
C014476diethyl maleatediethyl maleate results in decreased expression of GRIA3 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GRIA3 mRNA21607683|2453584
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GRIA3 mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of GRIA3 promoter25374375
D000431EthanolEthanol results in increased expression of GRIA3 mRNA20655511
D000431EthanolEthanol results in decreased activity of GRIA3 protein11429388
D005047EtoposideEtoposide results in increased expression of GRIA3 mRNA25270620
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of GRIA3 mRNA21607683
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of GRIA3 mRNA17070881
D005485FlutamideFlutamide results in increased expression of GRIA3 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRIA3 mRNA20938992
C001277geldanamycingeldanamycin results in increased expression of GRIA3 mRNA26705709
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GRIA3 mRNA25982114
D007608Kainic AcidCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA]21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIA3 mRNA21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIA3 mRNA7529610
D007608Kainic AcidKainic Acid results in increased expression of GRIA3 mRNA7529610
C008261lead acetatelead acetate results in decreased expression of GRIA3 mRNA24260418
D008094Lithium[Lithium co-treated with Pilocarpine] results in decreased expression of GRIA3 mRNA16819974
C042720mercuric bromidemercuric bromide results in decreased expression of GRIA3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of GRIA3 mRNA18419818
D000432MethanolMethanol results in decreased activity of GRIA3 protein11429388
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRIA3 mRNA20938992
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GRIA3 mRNA23519560
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRIA3 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRIA3 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of GRIA3 mRNA26558463
D016685MitomycinMitomycin results in increased expression of GRIA3 mRNA25270620
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GRIA3 mRNA26924002
D009020MorphineMorphine results in decreased expression of GRIA3 mRNA15183518
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of GRIA3 mRNA"25554681
D009532NickelNickel results in decreased expression of GRIA3 mRNA24768652
C024999n-pentanoln-pentanol results in decreased activity of GRIA3 protein11429388
C076029olanzapineolanzapine results in increased expression of GRIA3 mRNA11526992
D009966OrphenadrineOrphenadrine affects the expression of GRIA3 mRNA23665939
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of GRIA3 mRNA26272509
D052638Particulate Matter[GRIA3 gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of GRIA3 mRNA21222557|2122255
D010634PhenobarbitalPhenobarbital results in decreased expression of GRIA3 mRNA23091169
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GRIA3 mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of GRIA3 promoter25374375
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIA3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GRIA3 mRNA26272509
D010862Pilocarpine[Lithium co-treated with Pilocarpine] results in decreased expression of GRIA3 mRNA16819974
D010862PilocarpinePilocarpine results in decreased expression of GRIA3 mRNA7529610
D010862PilocarpinePilocarpine results in increased expression of GRIA3 mRNA7529610
D010862PilocarpinePilocarpine results in increased expression of GRIA3 protein15857427
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GRIA3 mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of GRIA3 mRNA23018184
D0004331-Propanol1-Propanol results in decreased activity of GRIA3 protein11429388
D011441PropylthiouracilPropylthiouracil results in decreased expression of GRIA3 mRNA24780913
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of GRIA3 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRIA3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GRIA3 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRIA3 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GRIA3 mRNA23519560
D013853ThioacetamideThioacetamide results in increased expression of GRIA3 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of GRIA3 mRNA27760801
D014050TolueneToluene affects the expression of GRIA3 mRNA21827849
D014212TretinoinTretinoin results in decreased expression of GRIA3 mRNA21934132
D014212TretinoinTretinoin results in increased expression of GRIA3 mRNA23724009
D014212TretinoinTretinoin results in increased expression of GRIA3 mRNA20488242
C011559tributyltintributyltin results in increased expression of GRIA3 mRNA19591855
C012589trichostatin Atrichostatin A results in decreased expression of GRIA3 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of GRIA3 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of GRIA3 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of GRIA3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRIA3 mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in increased expression of GRIA3 mRNA23179753|2718838
D001335Vehicle Emissions[GRIA3 gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of GRIA3 mRNA21222557|2122255
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GRIA3 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of GRIA3 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of GRIA3 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of GRIA3 mRNA23034163
C111237vorinostatvorinostat results in increased expression of GRIA3 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-ISS-  
GO:0004971AMPA glutamate receptor activity-IBA21873635  
GO:0004971AMPA glutamate receptor activity-IDA21172611  
GO:0005231excitatory extracellular ligand-gated ion channel activity-TAS-  
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007215glutamate receptor signaling pathway-TAS1709304  
GO:0034220ion transmembrane transport-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0030054cell junction-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0032281AMPA glutamate receptor complex-IBA21873635  
GO:0032281AMPA glutamate receptor complex-ISS-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04730Long-term depression
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-399710Activation of AMPA receptorsTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS
R-HSA-438066Unblocking of NMDA receptor, glutamate binding and activationTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27490364High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model. (2016 Aug)Lo CLPLoS Genet
22291662Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. (2011)Acosta GFront Psychiatry