Gene: GRIA4

2893
GLUR4|GLUR4C|GLURD|GluA4|NEDSGA
glutamate ionotropic receptor AMPA type subunit 4
protein-coding
11q22.3
Ensembl:ENSG00000152578 MIM:138246 Vega:OTTHUMG00000166236 UniprotKB:P48058
NC_000011.10
PubMed|SNP Mapped
1   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.624e-2 (AD)  8.561e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs609665chr11:105973338 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRTM40.951
CA100.951
C11orf870.95
CBLN40.942
VSTM2A0.942
CHL10.938
OLFM30.938
CBLN20.937
FAM19A20.936
SYT130.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.55
CNN2-0.544
WWTR1-0.533
HEY2-0.532
REST-0.524
RNF135-0.522
TFPI2-0.513
TIMP1-0.511
CMTM3-0.51
KCNJ15-0.507

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB04982TalampanelSmall Molecule161832-65-1InvestigationalTarget
DB05047CX717Small Molecule-Illicit|InvestigationalTarget
DB13146Fluciclovine (18F)Small Molecule222727-39-1ApprovedTarget
ID Drug Name Action PubMed
C0363611-amino-1,3-dicarboxycyclopentane"1-amino-1,3-dicarboxycyclopentane inhibits the reaction [2-amino-4-phosphonobutyric acid binds to GRIA4 protein]"10556940
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIA4 mRNA"19114083
C0127292-amino-4-phosphonobutyric acid"1-amino-1,3-dicarboxycyclopentane inhibits the reaction [2-amino-4-phosphonobutyric acid binds to GRIA4 protein]"10556940
C0127292-amino-4-phosphonobutyric acid2-amino-4-phosphonobutyric acid binds to GRIA4 protein10556940
C0127292-amino-4-phosphonobutyric acidQuisqualic Acid inhibits the reaction [2-amino-4-phosphonobutyric acid binds to GRIA4 protein]10556940
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GRIA4 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRIA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRIA4 mRNA"27188386
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIA4 mRNA25607892
D020106AcrylamideAcrylamide affects the expression of GRIA4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRIA4 gene27153756
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIA4 mRNA25607892
C015001arsenitearsenite results in increased methylation of GRIA4 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of GRIA4 mRNA22323515
D001565BenzoatesBenzoates analog binds to and results in decreased activity of GRIA4 protein14667236
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GRIA4 mRNA22154832
D004958EstradiolEstradiol results in increased expression of GRIA4 mRNA22154832
C006780bisphenol Abisphenol A results in increased expression of GRIA4 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIA4 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIA4 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of GRIA4 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of GRIA4 protein28903499
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIA4 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIA4 mRNA25607892
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GRIA4 mRNA17484886
D000068579CelecoxibCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA]21589914
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GRIA4 mRNA18668222|1944049
D003042CocaineCocaine affects the expression of GRIA4 mRNA9886066
D003042CocaineCocaine affects the expression of GRIA4 protein15140200
D003474CurcuminCurcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein]23267840
C014347decitabinedecitabine results in decreased methylation of GRIA4 gene27923600
D003976DiazinonDiazinon results in decreased expression of GRIA4 mRNA19440498
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIA4 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIA4 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA25607892
D000431EthanolEthanol results in decreased expression of GRIA4 mRNA20655511
D004397FonofosFonofos results in increased methylation of GRIA4 promoter22847954
C039281furanfuran results in increased expression of GRIA4 mRNA27387713
D007608Kainic AcidCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA]21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIA4 mRNA21589914
C008261lead acetatelead acetate results in decreased expression of GRIA4 mRNA24260418
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA25607892
D009020MorphineMorphine results in decreased expression of GRIA4 mRNA15183518
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIA4 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIA4 mRNA25607892
D010278ParathionParathion results in increased methylation of GRIA4 promoter22847954
C410127PCB 180PCB 180 results in increased expression of GRIA4 mRNA23829299
D010622PhencyclidinePhencyclidine results in increased expression of GRIA4 mRNA17266109
D010795Phthalic AcidsPhthalic Acids results in decreased expression of GRIA4 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of GRIA4 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of GRIA4 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in increased expression of GRIA4 mRNA23608068
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA25607892
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GRIA4 mRNA22154832
D011441PropylthiouracilPropylthiouracil affects the expression of GRIA4 mRNA24780913
D016318Quisqualic AcidQuisqualic Acid inhibits the reaction [2-amino-4-phosphonobutyric acid binds to GRIA4 protein]10556940
D013311StreptozocinCurcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein]23267840
D013311StreptozocinINS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein]23267840
D013311StreptozocinStreptozocin results in increased expression of GRIA4 protein23267840
C012568terbufosterbufos results in increased methylation of GRIA4 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GRIA4 mRNA21354282
D014212TretinoinTretinoin results in increased expression of GRIA4 mRNA21934132
D014229TriazolamTriazolam results in decreased expression of GRIA4 protein27489535
C011559tributyltintributyltin results in increased expression of GRIA4 mRNA19591855
C012589trichostatin Atrichostatin A results in increased expression of GRIA4 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of GRIA4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GRIA4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GRIA4 mRNA23179753|2438349
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA25607892
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRIA4 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004970ionotropic glutamate receptor activity-ISS-  
GO:0004971AMPA glutamate receptor activity-IBA21873635  
GO:0004971AMPA glutamate receptor activity-IDA21172611  
GO:0005231excitatory extracellular ligand-gated ion channel activity-TAS-  
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO:0005515protein binding-IPI10366608  
GO ID GO Term Qualifier Evidence PubMed
GO:0007215glutamate receptor signaling pathway-TAS8589990  
GO:0034220ion transmembrane transport-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0030054cell junction-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0032281AMPA glutamate receptor complex-IBA21873635  
GO:0032281AMPA glutamate receptor complex-ISS-  
GO:0043025neuronal cell body-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0045211postsynaptic membrane-IEA-  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-399710Activation of AMPA receptorsTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS
R-HSA-438066Unblocking of NMDA receptor, glutamate binding and activationTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25262781Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. (2014 Nov)Enoch MAGenes Brain Behav
22291662Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. (2011)Acosta GFront Psychiatry