Gene: GRN

2896
CLN11|GEP|GP88|PCDGF|PEPI|PGRN
granulin precursor
protein-coding
17q21.31
Ensembl:ENSG00000030582 MIM:138945 Vega:OTTHUMG00000181816 UniprotKB:P28799
NG_007886.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.166e-1 (AD)  9.161e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10591948chr17:42421375GRN2.100e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGAT10.89
TMEM1090.866
COLGALT10.855
IRF30.847
CTSZ0.834
BAX0.83
FLII0.83
GSTK10.827
RNPEP0.827
P4HB0.825

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.634
OR4F29-0.617
HES5-0.189
REN-0.189
DIO2-0.183
DIAPH3-0.168
PON1-0.164
ENDOU-0.152
HPDL-0.152
RNASE8-0.148

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GRN mRNA"28903501
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"21820214
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"21820214
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"21820214
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium"21820214
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"U 0126 inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"21820214
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"21820214
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"21820214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"21820214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of MAPK1 protein]21820214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of MAPK3 protein]21820214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"21820214
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GRN mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of GRN mRNA]"19414516
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"21820214
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]21820214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GRN mRNA"25380136
D000082AcetaminophenAcetaminophen results in increased expression of GRN mRNA22230336|2570463
D000082AcetaminophenAcetaminophen affects the expression of GRN mRNA17562736
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GRN mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GRN mRNA21641981
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GRN mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRN mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GRN mRNA24449571
C006632arsenic trioxide[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of GRN mRNA25555879
C006632arsenic trioxidearsenic trioxide results in increased expression of GRN mRNA25555879
D001205Ascorbic Acid[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of GRN mRNA25555879
D001205Ascorbic AcidAscorbic Acid results in increased expression of GRN mRNA25555879
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]16964424
D001280AtrazineAtrazine results in decreased expression of GRN mRNA22982499
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of GRN mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRN mRNA15034205|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GRN mRNA"20382639
D004958EstradiolEstradiol results in increased expression of GRN mRNA11813992
D004958EstradiolEstradiol results in increased expression of GRN mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of GRN mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of GRN mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of GRN promoter27312807
C006780bisphenol Abisphenol A results in increased expression of GRN mRNA25181051
D020148Butyric AcidButyric Acid results in increased expression of GRN mRNA12800193
D002101Cacodylic AcidCacodylic Acid results in increased expression of GRN mRNA16122865
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GRN mRNA23178640
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GRN mRNA27339419
D002330CarmustineCarmustine results in decreased expression of GRN mRNA15980968
D002392CatechinCatechin results in increased expression of GRN mRNA15465739
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of GRN mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of GRN mRNA25270620
D002726Chlorogenic AcidChlorogenic Acid results in increased expression of GRN mRNA20706672
C100187chloropicrinchloropicrin results in decreased expression of GRN mRNA26352163|2847649
D002922CiguatoxinsCiguatoxins affects the expression of GRN mRNA18353800
D002994ClofibrateClofibrate results in increased expression of GRN mRNA25270620
C018021cobaltous chloridecobaltous chloride results in decreased secretion of GRN protein22079246
C018021cobaltous chloridecobaltous chloride results in increased expression of GRN mRNA19376846
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of GRN mRNA19167446
C030973cupric oxidecupric oxide results in increased expression of GRN mRNA22077320
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of GRN mRNA19684285
D016572CyclosporineCyclosporine results in decreased expression of GRN mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of GRN mRNA22147139
C093628cyproconazolecyproconazole results in increased expression of GRN mRNA22334560
D003907DexamethasoneGRN protein results in decreased susceptibility to Dexamethasone16397023
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GRN mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GRN mRNA16493179
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GRN mRNA27392435
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of GRN mRNA]21858171
D002945CisplatinCisplatin results in increased expression of GRN mRNA27594783
D002945CisplatinCisplatin results in increased expression of GRN mRNA21151649
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of GRN mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of GRN mRNA18042831
C012125diisononyl phthalatediisononyl phthalate results in increased expression of GRN mRNA16493179
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GRN mRNA25380136
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of GRN mRNA16873554
C013966dioctyl adipatedioctyl adipate results in decreased expression of GRN mRNA16493179
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of GRN mRNA20706672
C109476epoxiconazoleepoxiconazole results in decreased expression of GRN mRNA22334560
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of GRN mRNA11137762
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GRN mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GRN mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GRN mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GRN mRNA11137762
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GRN mRNA23649840
C047360felbamatefelbamate results in decreased expression of GRN mRNA17381134
C540355fenamidonefenamidone results in increased expression of GRN mRNA27029645
D005419FlavonoidsFlavonoids results in increased expression of GRN mRNA15465739
D005485FlutamideFlutamide results in decreased expression of GRN mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of GRN mRNA23649840
C056933fumonisin B1fumonisin B1 results in increased expression of GRN mRNA16221962
D005839GentamicinsGentamicins results in increased expression of GRN mRNA22061828
D006861Hydrogen PeroxideGRN protein results in decreased susceptibility to Hydrogen Peroxide21820214
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of GRN mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRN mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GRN mRNA27392435
C544151jinfukangjinfukang results in increased expression of GRN mRNA27392435
D048628KetolidesKetolides analog results in increased expression of GRN mRNA24967691
C008261lead acetatelead acetate results in increased expression of GRN mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GRN mRNA27339419
D018021Lithium ChlorideLithium Chloride results in increased expression of GRN mRNA23527032
D008727MethotrexateGRN protein affects the susceptibility to Methotrexate16217747
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GRN mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GRN mRNA26924002
C523799MRK 003GRN results in increased susceptibility to MRK 00319903844
C568376MT19c compoundMT19c compound results in decreased expression of GRN mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GRN mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GRN mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GRN mRNA25380136
C022838nickel chloridenickel chloride affects the expression of GRN mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of GRN mRNA19167457
C012655nimesulidenimesulide results in decreased expression of GRN mRNA24136188
D005996NitroglycerinNitroglycerin results in decreased expression of GRN mRNA12102619
C485800osajinosajin results in increased expression of GRN mRNA20706672
D000073878Palm OilPalm Oil results in decreased expression of GRN mRNA18042831
C016030pantogabpantogab results in increased expression of GRN mRNA17379144
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GRN protein26879310
D010634PhenobarbitalPhenobarbital results in decreased expression of GRN mRNA17381134
C006253pirinixic acidpirinixic acid results in increased expression of GRN mRNA18301758|1844570
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of GRN mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of GRN mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of GRN mRNA15465739
D059808PolyphenolsPolyphenols results in increased expression of GRN mRNA15465739
C474837pomiferinpomiferin results in increased expression of GRN mRNA20706672
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GRN mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of GRN mRNA23018184
C045950propiconazolepropiconazole results in increased expression of GRN mRNA22334560
D011429PropolisPropolis results in increased expression of GRN mRNA20706672
D011441PropylthiouracilPropylthiouracil results in increased expression of GRN mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of GRN mRNA27029645
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of GRN mRNA19167446
C059514resveratrolresveratrol results in increased expression of GRN mRNA20706672
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of GRN mRNA21427059
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of GRN mRNA19244175
D012643SeleniumSelenium results in increased expression of GRN mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of GRN gene28589171
D012999SomanSoman results in increased expression of GRN mRNA19281266
D013467SulindacSulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA]15190207
C025462sulindac sulfidesulindac sulfide results in decreased expression of GRN mRNA16184548
D016559TacrolimusTacrolimus results in increased expression of GRN mRNA25270620
C061133tamibarotenetamibarotene results in increased expression of GRN mRNA15498508
D013629TamoxifenTamoxifen affects the expression of GRN mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of GRN mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GRN mRNA19684285
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GRN mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRN mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GRN mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of GRN mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GRN mRNA15034205|1968428
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GRN mRNA16873554
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRN mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of GRN mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GRN mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GRN mRNA20133372
D014212TretinoinTretinoin affects the expression of GRN mRNA16873554
D014212TretinoinTretinoin results in increased expression of GRN mRNA15498508|1605412
C012589trichostatin Atrichostatin A results in increased expression of GRN mRNA15901671
C113580U 0126"U 0126 inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"21820214
C113580U 0126U 0126 inhibits the reaction [GRN protein results in increased phosphorylation of MAPK1 protein]21820214
C113580U 0126U 0126 inhibits the reaction [GRN protein results in increased phosphorylation of MAPK3 protein]21820214
C113580U 0126"U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"21820214
D014520UrethaneUrethane results in increased expression of GRN mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GRN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GRN mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of GRN gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GRN mRNA20546886|2142705
D014635Valproic AcidValproic Acid results in increased expression of GRN mRNA15901671
D014638VanadatesVanadates results in decreased expression of GRN mRNA22714537
D014640VancomycinVancomycin results in decreased expression of GRN mRNA18930951
C029297vinylidene chloridevinylidene chloride results in increased expression of GRN mRNA26682919
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of GRN mRNA19244175
D014810Vitamin EVitamin E results in increased expression of GRN mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of GRN mRNA20044591
C111237vorinostatvorinostat results in increased expression of GRN mRNA21454553
C111237vorinostatvorinostat results in increased expression of GRN protein21454553
C111237vorinostatvorinostat results in increased expression of GRN mRNA21454553
C111237vorinostatvorinostat results in increased expression of GRN protein21454553
C009687wortmannin"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"21820214
C009687wortmannin"U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"21820214
C009687wortmannin"wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"21820214
C009687wortmanninwortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]21820214

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005125cytokine activity-IEA-  
GO:0005515protein binding-IPI12900424  16189514  21078624  21516116  23088713  23236149  
24070898  25416956  25839164  25910212  
GO:0008083growth factor activity-TAS1542665  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-NAS1542665  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005764lysosome-IDA-  
GO:0005768endosome-IDA-  
GO:0005783endoplasmic reticulum-IDA-  
GO:0035578azurophil granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24641868Classifying patients for breast cancer by detection of autoantibodies against a panel of conformation-carrying antigens. (2014 May)Evans RLCancer Prev Res (Phila)