Gene info: ID 2896

Gene: GRN

GENE ID: 2896

Description: granulin precursor

Gene type: protein-coding

Location: 17q21.31

dbXrefs: Ensembl:ENSG00000030582 MIM:138945 Vega:OTTHUMG00000181816 UniprotKB:P28799

RefSeq: NG_007886.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.166e-1 (AD) 9.161e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg10591948	chr17:42421375	GRN		2.100e-11	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MGAT1	0.89
TMEM109	0.866
COLGALT1	0.855
IRF3	0.847
CTSZ	0.834
BAX	0.83
FLII	0.83
GSTK1	0.827
RNPEP	0.827
P4HB	0.825

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.634
OR4F29	-0.617
HES5	-0.189
REN	-0.189
DIO2	-0.183
DIAPH3	-0.168
PON1	-0.164
ENDOU	-0.152
HPDL	-0.152
RNASE8	-0.148

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GRN mRNA"	28903501
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"	21820214
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"	21820214
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"	21820214
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium"	21820214
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"U 0126 inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"	21820214
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"	21820214
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"	21820214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"	21820214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of MAPK1 protein]	21820214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of MAPK3 protein]	21820214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"	21820214
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GRN mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of GRN mRNA]"	19414516
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"	21820214
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]	21820214
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of GRN mRNA"	25380136
D000082	Acetaminophen	Acetaminophen results in increased expression of GRN mRNA	22230336\|2570463
D000082	Acetaminophen	Acetaminophen affects the expression of GRN mRNA	17562736
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GRN mRNA]"	19414516
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GRN mRNA	21641981
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of GRN mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GRN mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of GRN mRNA	24449571
C006632	arsenic trioxide	[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of GRN mRNA	25555879
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GRN mRNA	25555879
D001205	Ascorbic Acid	[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of GRN mRNA	25555879
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of GRN mRNA	25555879
C005948	astaxanthine	astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]	16964424
D001280	Atrazine	Atrazine results in decreased expression of GRN mRNA	22982499
D001564	Benzo(a)pyrene	AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of GRN mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GRN mRNA	15034205\|1977048
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GRN mRNA"	20382639
D004958	Estradiol	Estradiol results in increased expression of GRN mRNA	11813992
D004958	Estradiol	Estradiol results in increased expression of GRN mRNA	19484750
C044887	beta-methylcholine	beta-methylcholine affects the expression of GRN mRNA	21179406
C006780	bisphenol A	bisphenol A results in increased expression of GRN mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased methylation of GRN promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of GRN mRNA	25181051
D020148	Butyric Acid	Butyric Acid results in increased expression of GRN mRNA	12800193
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of GRN mRNA	16122865
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GRN mRNA	23178640
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GRN mRNA	27339419
D002330	Carmustine	Carmustine results in decreased expression of GRN mRNA	15980968
D002392	Catechin	Catechin results in increased expression of GRN mRNA	15465739
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of GRN mRNA	23650126
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of GRN mRNA	25270620
D002726	Chlorogenic Acid	Chlorogenic Acid results in increased expression of GRN mRNA	20706672
C100187	chloropicrin	chloropicrin results in decreased expression of GRN mRNA	26352163\|2847649
D002922	Ciguatoxins	Ciguatoxins affects the expression of GRN mRNA	18353800
D002994	Clofibrate	Clofibrate results in increased expression of GRN mRNA	25270620
C018021	cobaltous chloride	cobaltous chloride results in decreased secretion of GRN protein	22079246
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GRN mRNA	19376846
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of GRN mRNA	19167446
C030973	cupric oxide	cupric oxide results in increased expression of GRN mRNA	22077320
D003513	Cycloheximide	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of GRN mRNA	19684285
D016572	Cyclosporine	Cyclosporine results in decreased expression of GRN mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of GRN mRNA	22147139
C093628	cyproconazole	cyproconazole results in increased expression of GRN mRNA	22334560
D003907	Dexamethasone	GRN protein results in decreased susceptibility to Dexamethasone	16397023
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of GRN mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GRN mRNA	16493179
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of GRN mRNA	27392435
D002945	Cisplatin	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of GRN mRNA]	21858171
D002945	Cisplatin	Cisplatin results in increased expression of GRN mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of GRN mRNA	21151649
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in decreased expression of GRN mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of GRN mRNA	18042831
C012125	diisononyl phthalate	diisononyl phthalate results in increased expression of GRN mRNA	16493179
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of GRN mRNA	25380136
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of GRN mRNA	16873554
C013966	dioctyl adipate	dioctyl adipate results in decreased expression of GRN mRNA	16493179
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of GRN mRNA	20706672
C109476	epoxiconazole	epoxiconazole results in decreased expression of GRN mRNA	22334560
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of GRN mRNA	11137762
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of GRN mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GRN mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GRN mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GRN mRNA	11137762
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of GRN mRNA	23649840
C047360	felbamate	felbamate results in decreased expression of GRN mRNA	17381134
C540355	fenamidone	fenamidone results in increased expression of GRN mRNA	27029645
D005419	Flavonoids	Flavonoids results in increased expression of GRN mRNA	15465739
D005485	Flutamide	Flutamide results in decreased expression of GRN mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in increased expression of GRN mRNA	23649840
C056933	fumonisin B1	fumonisin B1 results in increased expression of GRN mRNA	16221962
D005839	Gentamicins	Gentamicins results in increased expression of GRN mRNA	22061828
D006861	Hydrogen Peroxide	GRN protein results in decreased susceptibility to Hydrogen Peroxide	21820214
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of GRN mRNA	19376150
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRN mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of GRN mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of GRN mRNA	27392435
D048628	Ketolides	Ketolides analog results in increased expression of GRN mRNA	24967691
C008261	lead acetate	lead acetate results in increased expression of GRN mRNA	21829687
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of GRN mRNA	27339419
D018021	Lithium Chloride	Lithium Chloride results in increased expression of GRN mRNA	23527032
D008727	Methotrexate	GRN protein affects the susceptibility to Methotrexate	16217747
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of GRN mRNA	23649840
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of GRN mRNA	26924002
C523799	MRK 003	GRN results in increased susceptibility to MRK 003	19903844
C568376	MT19c compound	MT19c compound results in decreased expression of GRN mRNA	21781307
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of GRN mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GRN mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of GRN mRNA	25380136
C022838	nickel chloride	nickel chloride affects the expression of GRN mRNA	22110744
C028007	nickel monoxide	nickel monoxide results in increased expression of GRN mRNA	19167457
C012655	nimesulide	nimesulide results in decreased expression of GRN mRNA	24136188
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of GRN mRNA	12102619
C485800	osajin	osajin results in increased expression of GRN mRNA	20706672
D000073878	Palm Oil	Palm Oil results in decreased expression of GRN mRNA	18042831
C016030	pantogab	pantogab results in increased expression of GRN mRNA	17379144
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of GRN protein	26879310
D010634	Phenobarbital	Phenobarbital results in decreased expression of GRN mRNA	17381134
C006253	pirinixic acid	pirinixic acid results in increased expression of GRN mRNA	18301758\|1844570
D010894	Piroxicam	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of GRN mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of GRN mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of GRN mRNA	15465739
D059808	Polyphenols	Polyphenols results in increased expression of GRN mRNA	15465739
C474837	pomiferin	pomiferin results in increased expression of GRN mRNA	20706672
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of GRN mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of GRN mRNA	23018184
C045950	propiconazole	propiconazole results in increased expression of GRN mRNA	22334560
D011429	Propolis	Propolis results in increased expression of GRN mRNA	20706672
D011441	Propylthiouracil	Propylthiouracil results in increased expression of GRN mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of GRN mRNA	27029645
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of GRN mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of GRN mRNA	20706672
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of GRN mRNA	21427059
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of GRN mRNA	19244175
D012643	Selenium	Selenium results in increased expression of GRN mRNA	19244175
C017947	sodium arsenite	sodium arsenite affects the methylation of GRN gene	28589171
D012999	Soman	Soman results in increased expression of GRN mRNA	19281266
D013467	Sulindac	Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA]	15190207
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of GRN mRNA	16184548
D016559	Tacrolimus	Tacrolimus results in increased expression of GRN mRNA	25270620
C061133	tamibarotene	tamibarotene results in increased expression of GRN mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of GRN mRNA	17555576
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of GRN mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GRN mRNA	19684285
D013749	Tetrachlorodibenzodioxin	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GRN mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GRN mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GRN mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of GRN mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GRN mRNA	15034205\|1968428
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of GRN mRNA	16873554
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRN mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased expression of GRN mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of GRN mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of GRN mRNA	20133372
D014212	Tretinoin	Tretinoin affects the expression of GRN mRNA	16873554
D014212	Tretinoin	Tretinoin results in increased expression of GRN mRNA	15498508\|1605412
C012589	trichostatin A	trichostatin A results in increased expression of GRN mRNA	15901671
C113580	U 0126	"U 0126 inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"	21820214
C113580	U 0126	U 0126 inhibits the reaction [GRN protein results in increased phosphorylation of MAPK1 protein]	21820214
C113580	U 0126	U 0126 inhibits the reaction [GRN protein results in increased phosphorylation of MAPK3 protein]	21820214
C113580	U 0126	"U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"	21820214
D014520	Urethane	Urethane results in increased expression of GRN mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of GRN mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of GRN mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid results in increased methylation of GRN gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of GRN mRNA	20546886\|2142705
D014635	Valproic Acid	Valproic Acid results in increased expression of GRN mRNA	15901671
D014638	Vanadates	Vanadates results in decreased expression of GRN mRNA	22714537
D014640	Vancomycin	Vancomycin results in decreased expression of GRN mRNA	18930951
C029297	vinylidene chloride	vinylidene chloride results in increased expression of GRN mRNA	26682919
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of GRN mRNA	19244175
D014810	Vitamin E	Vitamin E results in increased expression of GRN mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of GRN mRNA	20044591
C111237	vorinostat	vorinostat results in increased expression of GRN mRNA	21454553
C111237	vorinostat	vorinostat results in increased expression of GRN protein	21454553
C111237	vorinostat	vorinostat results in increased expression of GRN mRNA	21454553
C111237	vorinostat	vorinostat results in increased expression of GRN protein	21454553
C009687	wortmannin	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"	21820214
C009687	wortmannin	"U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]"	21820214
C009687	wortmannin	"wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]"	21820214
C009687	wortmannin	wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]	21820214

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0005125	cytokine activity	-	IEA	-
GO:0005515	protein binding	-	IPI	12900424 16189514 21078624 21516116 23088713 23236149 24070898 25416956 25839164 25910212
GO:0008083	growth factor activity	-	TAS	1542665

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	NAS	1542665
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005764	lysosome	-	IDA	-
GO:0005768	endosome	-	IDA	-
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0035578	azurophil granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24641868	Classifying patients for breast cancer by detection of autoantibodies against a panel of conformation-carrying antigens. (2014 May)	Evans RL	Cancer Prev Res (Phila)