Gene: DCPS

28960
ARS|DCS1|HINT-5|HINT5|HSL1|HSPC015
decapping enzyme, scavenger
protein-coding
11q24.2
Ensembl:ENSG00000110063 MIM:610534 Vega:OTTHUMG00000165829 UniprotKB:Q96C86
NG_053153.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.672e-1 (AD)  4.785e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09694921chr11:126215608DCPS5.630e-11Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TACO10.873
WRNIP10.865
CLPTM1L0.863
MRPL40.86
RUVBL20.859
COASY0.857
HM130.856
MALSU10.856
MRPS20.852
VPS720.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.623
OR4F29-0.562
P2RY14-0.353
CTNNA3-0.321
C9orf153-0.316
IL18RAP-0.31
HBD-0.298
OR6C74-0.283
CPA3-0.272
MTRNR2L6-0.271

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB016497-Methyl-GpppaSmall MoleculeExperimentalTarget
DB019607n-Methyl-8-Hydroguanosine-5'-DiphosphateSmall MoleculeExperimentalTarget
DB03593N7-Methyl-Guanosine-5'-MonophosphateSmall MoleculeExperimentalTarget
DB039587-methyl-guanosine-5'-triphosphate-5'-guanosineSmall MoleculeExperimentalTarget
DB076425-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamineSmall MoleculeExperimentalTarget
DB076435-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamineSmall MoleculeExperimentalTarget
DB076445-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DCPS mRNA"25510870
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of DCPS mRNA"18343893
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DCPS mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DCPS mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DCPS mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DCPS mRNA"25510870
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of DCPS mRNA28522335
D000082AcetaminophenAcetaminophen results in decreased expression of DCPS mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of DCPS mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DCPS mRNA16483693
D001151ArsenicArsenic affects the methylation of DCPS gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DCPS mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DCPS mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DCPS mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DCPS mRNA22300585
C044887beta-methylcholinebeta-methylcholine affects the expression of DCPS mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of DCPS mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of DCPS mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DCPS protein24527689
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of DCPS mRNA21356183
D002994ClofibrateClofibrate results in decreased expression of DCPS mRNA17585979|2381119
C018021cobaltous chloridecobaltous chloride results in decreased expression of DCPS mRNA19320972
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of DCPS mRNA21356183
D003300CopperCopper results in decreased expression of DCPS mRNA21356183
D019327Copper SulfateCopper Sulfate results in decreased expression of DCPS mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of DCPS mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of DCPS mRNA25562108|2798913
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DCPS mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DCPS mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of DCPS mRNA25016146
D004317DoxorubicinDCPS protein affects the susceptibility to Doxorubicin16217747
D005419FlavonoidsFlavonoids results in increased expression of DCPS mRNA18035473
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of DCPS mRNA26846883
C544151jinfukangjinfukang results in increased expression of DCPS mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DCPS mRNA23086925
C410337K 7174K 7174 results in decreased expression of DCPS mRNA24086573
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DCPS mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DCPS mRNA"25510870
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DCPS mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of DCPS mRNA23012394
D011794QuercetinQuercetin results in decreased expression of DCPS mRNA21632981
C059514resveratrolresveratrol results in decreased expression of DCPS protein25505154
D012999SomanSoman results in decreased expression of DCPS mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DCPS mRNA18343893|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DCPS mRNA15328365
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DCPS mRNA25729387
D014520UrethaneUrethane results in decreased expression of DCPS mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of DCPS mRNA29154799
D014747VinblastineDCPS protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin affects the expression of DCPS mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000340RNA 7-methylguanosine cap binding-IBA21873635  
GO:0000340RNA 7-methylguanosine cap binding-IDA12198172  15383679  18426921  18441014  22985415  
GO:0004532exoribonuclease activity-TAS-  
GO:0005515protein binding-IPI16140270  
GO:0050072m7G(5')pppN diphosphatase activity-IBA21873635  
GO:0050072m7G(5')pppN diphosphatase activity-IDA12198172  15383679  18426921  18441014  18839960  22985415  
GO ID GO Term Qualifier Evidence PubMed
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-TAS12198172  15383679  22985415  
GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA-IBA21873635  
GO:0036245cellular response to menadione-IDA16140270  
GO:0043069negative regulation of programmed cell death-IDA16140270  
GO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay-TAS-  
GO:0045292mRNA cis splicing, via spliceosome-IDA18426921  
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12871939  18441014  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA18441014  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-429914Deadenylation-dependent mRNA decayTAS
R-HSA-429958mRNA decay by 3' to 5' exoribonucleaseTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23792392Evidence of improved access to dental care with direct access arrangements. (2013)Innes NPEvid Based Dent
27555999Postoperative Delayed Cervical Palsies: Understanding the Etiology. (2016 Sep)Planchard RFGlobal Spine J