Gene: SLC6A16

28968
NT5|NTT5
solute carrier family 6 member 16
protein-coding
19q13.33
Ensembl:ENSG00000063127 MIM:607972 Vega:OTTHUMG00000183179 UniprotKB:Q9GZN6
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.928e-1 (AD)  5.370e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBMS30.683
FAM111A0.626
PDGFRB0.623
CNTLN0.606
LAMB20.595
UBA70.59
CC2D2B0.582
CASP100.581
SLC30A100.579
SHE0.573

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC12-0.342
MYADML2-0.339
CHST8-0.338
MYCN-0.327
GALNT14-0.312
CBLN1-0.311
PRDM12-0.309
MND1-0.302
RDH12-0.3
MAGIX-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC6A16 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC6A16 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC6A16 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC6A16 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC6A16 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC6A16 mRNA21298039
C006632arsenic trioxidearsenic trioxide results in increased expression of SLC6A16 mRNA20458559
C006780bisphenol Abisphenol A results in decreased expression of SLC6A16 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SLC6A16 mRNA26079696
D002220CarbamazepineCarbamazepine results in increased expression of SLC6A16 mRNA17112801
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC6A16 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SLC6A16 mRNA26272509
D016572CyclosporineCyclosporine results in increased expression of SLC6A16 mRNA20106945
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SLC6A16 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SLC6A16 mRNA]19850644
C010974glyphosateglyphosate results in increased expression of SLC6A16 mRNA25636363
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC6A16 mRNA25613284
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SLC6A16 mRNA24810058
D009532NickelNickel results in decreased expression of SLC6A16 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of SLC6A16 mRNA19167457
D010634PhenobarbitalPhenobarbital affects the expression of SLC6A16 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of SLC6A16 mRNA18301758|2381119
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC6A16 mRNA25895662
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC6A16 mRNA25613284
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC6A16 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SLC6A16 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of SLC6A16 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-IBA21873635  
GO:0005326neurotransmitter transporter activity-NAS11112352  
GO:0005328neurotransmitter:sodium symporter activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003333amino acid transmembrane transport-IEA-  
GO:0006836neurotransmitter transport-NAS11112352  
GO:0035725sodium ion transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-NAS11112352  
GO:0005886plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27134767Genome-wide time-to-event analysis on smoking progression stages in a family-based study. (2016 May)He LBrain Behav