Gene: GRIK1

2897
EAA3|EEA3|GLR5|GLUR5|GluK1|gluR-5
glutamate ionotropic receptor kainate type subunit 1
protein-coding
21q21.3
Ensembl:ENSG00000171189 MIM:138245 Vega:OTTHUMG00000078879 UniprotKB:P39086
NC_000021.9
PubMed
0   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.690e-1 (AD)  8.499e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH10.868
GAD10.821
DLX10.82
PLD50.799
GNG40.798
BTBD110.796
VWC20.795
GAD20.784
KIT0.782
HAPLN10.78

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATOH8-0.459
ANGPT2-0.454
TGIF1-0.444
PLIN2-0.442
CDA-0.434
EVC2-0.428
HEBP2-0.427
HVCN1-0.425
NPIPB6-0.425
TMPRSS3-0.424

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00273TopiramateSmall Molecule97240-79-4ApprovedTarget
DB06354TezampanelSmall Molecule317819-68-4InvestigationalTarget
ID Drug Name Action PubMed
C0842735-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime"5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime binds to and results in decreased activity of GRIK1 protein"19596362
C081662alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionatealpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate binds to and results in increased activity of GRIK1 protein19417176
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GRIK1 mRNA21298039
D000639AmitriptylineAmitriptyline results in decreased expression of GRIK1 mRNA22341215
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRIK1 mRNA16483693
C487081belinostatbelinostat results in increased expression of GRIK1 mRNA27188386
D001565BenzoatesBenzoates analog binds to and results in decreased activity of GRIK1 protein14667236
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIK1 mRNA21802500
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of GRIK1 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of GRIK1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of GRIK1 mRNA26496021
D000068579CelecoxibCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]21589914
D003042CocaineCocaine results in increased expression of GRIK1 protein16363995
D003042CocaineCocaine affects the expression of GRIK1 mRNA12358776
D003042CocaineCocaine affects the expression of GRIK1 protein12358776|1514020
C443679CPW 399CPW 399 binds to GRIK1 protein21619066
D013759DronabinolDronabinol results in decreased expression of GRIK1 mRNA17578508
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA25607892
D000431EthanolEthanol results in decreased expression of GRIK1 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRIK1 mRNA]"20655511
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GRIK1 gene16495775
D018691Excitatory Amino Acid AntagonistsExcitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein12080343
D018691Excitatory Amino Acid Antagonists[Excitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein] which results in decreased susceptibility to Pilocarpine12080343
C069837fullerene C60fullerene C60 results in decreased expression of GRIK1 mRNA19167457
D007608Kainic AcidCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIK1 mRNA21589914
D007608Kainic AcidPTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]21589914
C008261lead acetatelead acetate results in decreased expression of GRIK1 mRNA24260418
C008261lead acetatelead acetate results in increased expression of GRIK1 mRNA24260418
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA25607892
C400802LY382884LY382884 binds to and results in decreased activity of GRIK1 protein12080343
D008727MethotrexateMethotrexate affects the expression of GRIK1 mRNA18502557
D009020MorphineGRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]20359526
D009020MorphineGRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]20359526
D009020MorphineGRIK1 protein affects the susceptibility to Morphine20359526
C028007nickel monoxidenickel monoxide results in decreased expression of GRIK1 mRNA19167457
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRIK1 mRNA]"20655511
D010862Pilocarpine[Excitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein] which results in decreased susceptibility to Pilocarpine12080343
D059808PolyphenolsPolyphenols results in decreased expression of GRIK1 mRNA16293270
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA25607892
D011374ProgesteroneProgesterone results in decreased expression of GRIK1 mRNA23018184
D011374ProgesteroneProgesterone results in decreased expression of GRIK1 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of GRIK1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of GRIK1 mRNA27029645
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of GRIK1 mRNA18514395
D018038Sodium SeleniteSodium Selenite results in increased expression of GRIK1 mRNA18514395
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GRIK1 mRNA21802500
C052342topiramateGRIK1 gene SNP affects the susceptibility to topiramate19331489
D014212TretinoinTretinoin results in increased expression of GRIK1 mRNA21934132
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA25607892
D015034Zinc OxideZinc Oxide analog results in decreased expression of GRIK1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO:0008066glutamate receptor activity-IBA21873635  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0015277kainate selective glutamate receptor activity-IBA21873635  
GO:0015277kainate selective glutamate receptor activity-IDA9335499  
GO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007215glutamate receptor signaling pathway-TAS8260617  
GO:0007268chemical synaptic transmission-TAS10580501  
GO:0007399nervous system development-TAS8260617  
GO:0007417central nervous system development-TAS10580501  
GO:0034220ion transmembrane transport-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-IEA-  
GO:0035249synaptic transmission, glutamatergic-IBA21873635  
GO:0050804modulation of chemical synaptic transmission-IBA21873635  
GO:0051966regulation of synaptic transmission, glutamatergic-TAS9335499  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8260617  
GO:0030054cell junction-IEA-  
GO:0032983kainate selective glutamate receptor complex-IBA21873635  
GO:0042734presynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0098839postsynaptic density membrane-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-451306Ionotropic activity of kainate receptorsTAS
R-HSA-451307Activation of Na-permeable kainate receptorsTAS
R-HSA-451308Activation of Ca-permeable Kainate ReceptorTAS
R-HSA-451326Activation of kainate receptors upon glutamate bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25941919Gene-gene interaction of mu-opioid receptor and GluR5 kainate receptor subunit is associated with smoking behavior in a Greek population: presence of a dose allele effect. (2015 Jun)Misailidis GDrug Metab Pers Ther
26289945The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving. (2015 Nov)Bach PAddict Biol
24525690Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism. (2014 Apr)Kranzler HRAm J Psychiatry
27447243Association study of DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence. (2016 Sep 1)Ragia GDrug Metab Pers Ther
19331489A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers. (2009 Apr)Ray LAExp Clin Psychopharmacol
19320626Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence. (2009 May)Kranzler HRAlcohol Clin Exp Res
20482509Pharmacogenetics of alcohol and alcohol dependence treatment. (2010)Kranzler HRCurr Pharm Des