Gene: GRIK3

2899
EAA5|GLR7|GLUR7|GluK3|GluR7a
glutamate ionotropic receptor kainate type subunit 3
protein-coding
1p34.3
Ensembl:ENSG00000163873 MIM:138243 Vega:OTTHUMG00000004189 UniprotKB:Q13003
NG_011447.1
PubMed
0   ANCO-SNPs
AD
6   
NA (AD)  9.371e-2 (ND)   (Frontal_Cortex)
1.213e-2 (AD)  1.487e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10126715chr1:37500195GRIK3Promoter3.753e-4Alcohol use disorders26763658
cg23715749chr1:37413867GRIK32.000e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GALNT140.872
HS3ST40.857
CLSTN20.845
CYP26A10.843
SLC35F10.841
RASGRP10.829
CHRM20.828
B3GALT20.824
RXFP10.818
KCNK20.818

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP11A1-0.509
ASB4-0.504
RHOD-0.502
CDC14A-0.496
IMPA2-0.477
NXT2-0.477
LRAT-0.468
HORMAD2-0.465
MSX1-0.461
ZIC5-0.46

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIK3 mRNA"19114083
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of GRIK3 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of GRIK3 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRIK3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GRIK3 mRNA24449571
D001151ArsenicArsenic affects the methylation of GRIK3 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of GRIK3 mRNA26705709
C015001arsenitearsenite results in increased methylation of GRIK3 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of GRIK3 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of GRIK3 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GRIK3 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of GRIK3 gene28505145
D001761BleomycinBleomycin results in decreased expression of GRIK3 mRNA15808516
D000068579Celecoxib[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA21589914
D004390ChlorpyrifosChlorpyrifos affects the expression of GRIK3 mRNA19440498
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIK3 gene20938992
D003042CocaineCocaine affects the expression of GRIK3 protein15140200
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GRIK3 mRNA23640034
D013759DronabinolDronabinol results in increased expression of GRIK3 mRNA17578508
D003976DiazinonDiazinon results in decreased expression of GRIK3 mRNA19440498
D004026DieldrinDieldrin results in decreased expression of GRIK3 mRNA19440498
D002117CalcitriolCalcitriol results in decreased expression of GRIK3 mRNA26485663
D000431EthanolEthanol results in decreased expression of GRIK3 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GRIK3 mRNA29097150
C540355fenamidonefenamidone results in decreased expression of GRIK3 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIK3 gene20938992
D004397FonofosFonofos results in increased methylation of GRIK3 promoter22847954
C004312glycidolglycidol results in increased expression of GRIK3 mRNA24915197
D007608Kainic Acid[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIK3 mRNA21589914
C008261lead acetatelead acetate affects the expression of GRIK3 mRNA24260418
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of GRIK3 mRNA"24972896
C025340manganese chloridemanganese chloride results in increased methylation of GRIK3 gene27913844
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIK3 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of GRIK3 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRIK3 mRNA28001369
D008774MethylphenidateMethylphenidate results in decreased expression of GRIK3 mRNA22470460
C028007nickel monoxidenickel monoxide results in decreased expression of GRIK3 mRNA19167457
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of GRIK3 mRNA26272509
D010269ParaquatParaquat results in decreased expression of GRIK3 mRNA18198484
D010278ParathionParathion results in increased methylation of GRIK3 promoter22847954
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GRIK3 mRNA26272509
D011441PropylthiouracilPropylthiouracil results in increased expression of GRIK3 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of GRIK3 mRNA27029645
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of GRIK3 mRNA18514395
D018038Sodium SeleniteSodium Selenite results in increased expression of GRIK3 mRNA18514395
C012568terbufosterbufos results in increased methylation of GRIK3 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRIK3 mRNA22298810
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of GRIK3 mRNA26272509
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of GRIK3 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of GRIK3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of GRIK3 gene29154799
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIK3 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001640adenylate cyclase inhibiting G-protein coupled glutamate receptor activity-IDA9144652  
GO:0001664G-protein coupled receptor binding-TAS-  
GO:0004970ionotropic glutamate receptor activity-IDA11124978  
GO:0004970ionotropic glutamate receptor activity-ISS-  
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO:0008066glutamate receptor activity-IBA21873635  
GO:0008066glutamate receptor activity-TAS8128318  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0015277kainate selective glutamate receptor activity-IBA21873635  
GO:0015277kainate selective glutamate receptor activity-IDA7719709  
GO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-IEA-  
GO:0007215glutamate receptor signaling pathway-IDA7719709  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IDA9144652  
GO:0034220ion transmembrane transport-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-IEA-  
GO:0035249synaptic transmission, glutamatergic-IBA21873635  
GO:0042391regulation of membrane potential-IDA11124978  
GO:0042391regulation of membrane potential-ISS-  
GO:0050804modulation of chemical synaptic transmission-IBA21873635  
GO:0051967negative regulation of synaptic transmission, glutamatergic-ISS-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA7719709  
GO:0030054cell junction-IEA-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0032839dendrite cytoplasm-ISS-  
GO:0032983kainate selective glutamate receptor complex-IBA21873635  
GO:0042734presynaptic membrane-IBA21873635  
GO:0043195terminal bouton-ISS-  
GO:0043204perikaryon-ISS-  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0098839postsynaptic density membrane-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-451306Ionotropic activity of kainate receptorsTAS
R-HSA-451308Activation of Ca-permeable Kainate ReceptorTAS
R-HSA-451326Activation of kainate receptors upon glutamate bindingTAS
R-HSA-500657Presynaptic function of Kainate receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25262781Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. (2014 Nov)Enoch MAGenes Brain Behav
22232963[Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]. (2011 May-Jun)Grochans EPsychiatr Pol
16356644Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence. (2006 Mar 27)Samochowiec JNeurosci Lett
16314883Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics. (2006 Jan-Feb)Preuss UWPharmacogenomics J
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
23006490Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence. (2013)Grzywacz AEur Addict Res