Gene: HIPK2

28996
PRO0593
homeodomain interacting protein kinase 2
protein-coding
7q34
Ensembl:ENSG00000064393 MIM:606868 Vega:OTTHUMG00000157704 UniprotKB:Q9H2X6
NC_000007.14
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.976e-2 (AD)  3.008e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10954654chr7:139674341 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25748521chr7:139366758HIPK25.300e-13Smoking27651444
cg15535471chr7:139332087HIPK25.460e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP4K40.958
ANKRD400.947
PAIP2B0.93
LPAR10.929
WNK10.927
KIF1C0.922
DAAM20.917
ZCCHC240.91
TP53INP20.901
BCAS10.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH8-0.502
FFAR4-0.485
TPBG-0.484
FBLN7-0.482
KCNK3-0.479
NOS2-0.475
IGSF3-0.472
RHOV-0.471
LINGO2-0.47
RTP1-0.469

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of HIPK2 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HIPK2 mRNA"21346803
C0127962-butenal2-butenal results in decreased expression of HIPK2 mRNA20471460
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HIPK2 mRNA"23146750
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HIPK2 mRNA"18648102
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of HIPK2 mRNA20829426
D000082AcetaminophenAcetaminophen results in decreased expression of HIPK2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of HIPK2 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of HIPK2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HIPK2 gene27153756
C068073Am 580Am 580 results in increased expression of HIPK2 mRNA16982809
D001280AtrazineAtrazine results in decreased expression of HIPK2 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of HIPK2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HIPK2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HIPK2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HIPK2 mRNA19770486|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HIPK2 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein]19714248
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of HIPK2 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of HIPK2 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of HIPK2 mRNA21185374
D004958EstradiolEstradiol results in increased expression of HIPK2 mRNA23019147|2337363
D004958EstradiolEstradiol results in increased expression of HIPK2 mRNA25210133
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HIPK2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of HIPK2 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HIPK2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of HIPK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HIPK2 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HIPK2 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of HIPK2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of HIPK2 mRNA26921506
D002104CadmiumCadmium results in increased expression of HIPK2 mRNA24376830
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HIPK2 mRNA17484886
C073316carvacrolcarvacrol results in decreased expression of HIPK2 mRNA20008804
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of HIPK220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIPK2 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HIPK2 mRNA20938992
C018021cobaltous chloridebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein]19714248
C018021cobaltous chloridecobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]19714248
C018021cobaltous chloridecobaltous chloride inhibits the reaction [HIPK2 protein binds to HIF1A promoter]19714248
C018021cobaltous chloridecobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]19714248
C018021cobaltous chloridecobaltous chloride results in decreased expression of HIPK2 protein19714248
C018021cobaltous chlorideHIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of ABCB1 mRNA]]19128456
C018021cobaltous chlorideHIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of BCL2 mRNA]]19128456
C018021cobaltous chlorideHIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of EPO mRNA]]19128456
C018021cobaltous chlorideHIPK2 protein inhibits the reaction [cobaltous chloride results in decreased degradation of and results in increased activity of HIF1A protein]19128456
C018021cobaltous chlorideHIPK2 protein inhibits the reaction [cobaltous chloride results in decreased susceptibility to Doxorubicin]19128456
C018021cobaltous chlorideMDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]]19714248
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]19714248
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein]19714248
D019327Copper SulfateCopper Sulfate results in decreased expression of HIPK2 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of HIPK2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of HIPK2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of HIPK2 mRNA21865292
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HIPK2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HIPK2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HIPK2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HIPK2 mRNA21266533
D002945CisplatinCisplatin results in increased activity of HIPK2 protein20573984
D002945CisplatinCisplatin results in increased expression of HIPK221928122
C000944dicrotophosdicrotophos results in increased expression of HIPK2 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of HIPK2 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HIPK2 mRNA22467019
D002117CalcitriolCalcitriol results in increased expression of HIPK2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of HIPK2 mRNA21592394
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of HIPK2 mRNA16314067
D004317Doxorubicincobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]19714248
D004317Doxorubicincobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]19714248
D004317DoxorubicinDoxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]19714248
D004317DoxorubicinHIPK2 protein inhibits the reaction [cobaltous chloride results in decreased susceptibility to Doxorubicin]19128456
D004317DoxorubicinHIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]19714248
D004317DoxorubicinHIPK2 protein results in increased susceptibility to Doxorubicin19128456
D004317DoxorubicinMDM2 protein inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]19714248
D004317DoxorubicinMDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]]19714248
D004317Doxorubicinzinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]19714248
D004317Doxorubicin[Doxorubicin co-treated with zinc chloride] results in increased expression of HIPK2 mRNA19714248
D004317DoxorubicinHIPK2 protein promotes the reaction [Doxorubicin results in increased expression of FTH1 mRNA]20980392
D000431EthanolEthanol results in decreased expression of HIPK2 mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HIPK2 mRNA29097150
D005047EtoposideEtoposide results in increased activity of HIPK2 protein20573984
D005047EtoposideHIPK2 mutant form inhibits the reaction [Etoposide results in increased expression of BDNF mRNA]20573984
D005047EtoposideHIPK2 gene mutant form inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein]20573984
D005047EtoposideHIPK2 gene mutant form promotes the reaction [Etoposide results in increased activity of CASP3 protein]20573984
D005047EtoposideHIPK2 protein promotes the reaction [Etoposide results in increased expression of FTH1 mRNA]20980392
D005047EtoposideHIPK2 protein promotes the reaction [Etoposide results in increased expression of NQO1 mRNA]20980392
D005047EtoposideHIPK2 results in decreased susceptibility to Etoposide20573984
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of HIPK220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIPK2 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HIPK2 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of HIPK2 mRNA23649840
D005897GlafenineGlafenine results in decreased expression of HIPK2 mRNA24136188
D006533HeptachlorHeptachlor results in decreased expression of HIPK2 mRNA23153324
D017313FenretinideFenretinide results in decreased expression of HIPK2 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of HIPK2 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HIPK2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HIPK2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HIPK2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HIPK2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HIPK2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HIPK2 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of HIPK2 mRNA20003209
C533894LG 100815LG 100815 results in increased expression of HIPK2 mRNA16951191
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of HIPK220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIPK2 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HIPK2 mRNA20938992
D008731MethoxychlorMethoxychlor affects the expression of HIPK2 mRNA20829426
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of HIPK2 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HIPK2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HIPK2 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of HIPK2 mRNA29191790
C028577monobutyl phthalatemonobutyl phthalate affects the expression of HIPK2 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HIPK2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HIPK2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of HIPK2 mRNA19812364
C029938nickel sulfatenickel sulfate results in increased expression of HIPK2 mRNA16314067
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of HIPK2 mRNA"16951191
C018620oleoresinsoleoresins results in decreased expression of HIPK2 mRNA20008804
D010100OxygenOxygen deficiency results in decreased expression of HIPK2 protein19714248
D010100Oxygenzinc chloride inhibits the reaction [Oxygen deficiency results in decreased expression of HIPK2 protein]19714248
D010100OxygenOxygen deficiency results in increased expression of HIPK2 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of HIPK2 mRNA]22629407
D000073878Palm OilPalm Oil results in decreased expression of HIPK2 mRNA18042831
C016030pantogabpantogab results in decreased expression of HIPK2 mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of HIPK2 mRNA23892564
D010634PhenobarbitalPhenobarbital results in decreased expression of HIPK2 mRNA23091169
D010705PhosgenePhosgene affects the expression of HIPK2 mRNA16300373
C006253pirinixic acidpirinixic acid results in decreased expression of HIPK2 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of HIPK2 mRNA18301758
C006253pirinixic acidpirinixic acid results in increased expression of HIPK2 mRNA22484513
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of HIPK2 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of HIPK2 mRNA18070364
C059514resveratrolresveratrol results in decreased expression of HIPK2 mRNA23525482
C089730rosiglitazonerosiglitazone results in increased expression of HIPK2 mRNA16982809
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of HIPK2 mRNA21427059
D012524SarinSarin results in increased expression of HIPK2 mRNA19522546
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of HIPK2 mRNA19244175
D012643SeleniumSelenium results in decreased expression of HIPK2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HIPK2 mRNA23221170
D012834SilverSilver results in decreased expression of HIPK2 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of HIPK2 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of HIPK2 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased stability of and affects the localization of HIPK2 protein27884605
C017947sodium arsenite[sodium arsenite results in increased stability of and affects the localization of HIPK2 protein] which results in increased phosphorylation of CREB1 protein27884605
C017947sodium arseniteHIPK2 protein promotes the reaction [sodium arsenite results in increased expression of FTH1 mRNA]20980392
D018038Sodium SeleniteSodium Selenite results in decreased expression of HIPK2 mRNA18175754
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of HIPK2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of HIPK2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HIPK2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HIPK2 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HIPK2 mRNA17035482
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HIPK2 mRNA22298810
D013849ThimerosalThimerosal results in decreased expression of HIPK2 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HIPK2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HIPK2 mRNA18087596
C483909torcetrapibtorcetrapib results in increased expression of HIPK2 mRNA23228038
D014212TretinoinTretinoin results in increased expression of HIPK2 mRNA23830798
C012589trichostatin Atrichostatin A results in decreased expression of HIPK2 mRNA27188386
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HIPK2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HIPK2 mRNA"26743178
C057693troglitazonetroglitazone results in increased expression of HIPK2 mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of HIPK2 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of HIPK2 mRNA12732648
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of HIPK2 mRNA12732648
D014635Valproic AcidValproic Acid results in decreased methylation of HIPK2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of HIPK2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HIPK2 gene25560391
C025643vinclozolinvinclozolin affects the expression of HIPK2 mRNA19015723
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of HIPK2 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of HIPK2 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of HIPK2 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of HIPK2 mRNA27188386
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]19714248
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein]19714248
C016837zinc chloridezinc chloride inhibits the reaction [Oxygen deficiency results in decreased expression of HIPK2 protein]19714248
C016837zinc chloride[Doxorubicin co-treated with zinc chloride] results in increased expression of HIPK2 mRNA19714248
D015034Zinc OxideZinc Oxide analog results in decreased expression of HIPK2 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of HIPK2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001102RNA polymerase II activating transcription factor binding-ISS-  
GO:0003713transcription coactivator activitycontributes_toISS-  
GO:0003714transcription corepressor activity-IDA12874272  
GO:0004672protein kinase activity-IDA19448668  
GO:0004674protein serine/threonine kinase activity-EXP16917507  18695000  
GO:0004674protein serine/threonine kinase activity-ISS-  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI12220523  12874272  14647468  15896780  16212962  16917507  
19448668  19549727  19820693  20936779  20940704  21057547  
23393140  
GO:0005524ATP binding-IEA-  
GO:0046332SMAD binding-IPI12874272  
GO:0046790virion binding-IPI14990717  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001654eye development-ISS20579985  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-IDA19448668  
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator-IDA14647468  
GO:0007179transforming growth factor beta receptor signaling pathway-IEA-  
GO:0007224smoothened signaling pathway-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0010842retina layer formation-IEA-  
GO:0018105peptidyl-serine phosphorylation-ISS-  
GO:0018107peptidyl-threonine phosphorylation-ISS-  
GO:0019048modulation by virus of host morphology or physiology-NAS14990717  
GO:0030182neuron differentiation-IEA-  
GO:0030218erythrocyte differentiation-ISS20231426  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IMP14678985  
GO:0030514negative regulation of BMP signaling pathway-IMP12874272  
GO:0030578PML body organization-TAS18974774  
GO:0032092positive regulation of protein binding-ISS-  
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-TAS18974774  
GO:0043388positive regulation of DNA binding-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045766positive regulation of angiogenesis-IDA19046997  
GO:0045893positive regulation of transcription, DNA-templated-IMP14647468  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046330positive regulation of JNK cascade-IMP14678985  
GO:0048596embryonic camera-type eye morphogenesis-IEA-  
GO:0050882voluntary musculoskeletal movement-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-ISS-  
GO:0051726regulation of cell cycle-TAS18974774  
GO:0060059embryonic retina morphogenesis in camera-type eye-IEA-  
GO:0060235lens induction in camera-type eye-IEA-  
GO:0060395SMAD protein signal transduction-IDA12874272  
GO:0061072iris morphogenesis-IEA-  
GO:0071456cellular response to hypoxia-TAS18974774  
GO:0097193intrinsic apoptotic signaling pathway-NAS15122315  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:2000059negative regulation of ubiquitin-dependent protein catabolic process-IMP21628596  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12220523  14647468  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
GO:0016604nuclear body-IDA12874272  
GO:0016604nuclear body-TAS14626429  
GO:0016605PML bodycolocalizes_withIDA14647468  
GO:0090575RNA polymerase II transcription factor complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578768Physiological factorsTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26361040HIF-1alpha Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. (2015)Singh SPPLoS One