Gene: ABR

29
MDB
ABR, RhoGEF and GTPase activating protein
protein-coding
17p13.3
Ensembl:ENSG00000159842 MIM:600365 Vega:OTTHUMG00000090313 UniprotKB:Q12979
NG_011987.2
PubMed
0   ANCO-SNPs
CD|ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.098e-1 (AD)  8.680e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25027863chr17:907729ABR3'UTR4.343e-5Alcohol use disorders26763658
cg25681774chr17:957287ABRGene body1.800e-4Alcohol use disorders26763658
cg19029445chr17:907732ABR3'UTR3.528e-4Alcohol use disorders26763658
cg09580592chr17:907643ABR3'UTR3.680e-4Alcohol use disorders26763658
cg26235490chr17:1047567ABRPromoter5.135e-4Alcohol use disorders26763658
cg15842208chr17:1053674ABRPromoter6.326e-4Alcohol use disorders26763658
cg00196407chr17:959496ABR1.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNPO20.968
DCAF110.957
SEPT30.955
ARNT20.952
PRRC2A0.951
SREBF20.951
CBX70.951
PIP4K2B0.95
MEGF80.949
DNAJC50.948

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.732
OR4F29-0.678
TFPI2-0.423
CST7-0.393
C9orf135-0.393
SGMS2-0.39
BEST3-0.389
KCNJ15-0.384
CLEC2B-0.384
IL18RAP-0.379

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABR mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABR mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABR mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABR mRNA"25510870
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ABR mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ABR mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ABR mRNA24449571
D001151ArsenicArsenic affects the methylation of ABR gene25304211
D001280AtrazineAtrazine results in decreased expression of ABR mRNA25929836
D001280AtrazineAtrazine results in decreased expression of ABR mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABR mRNA20064835|2231617
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABR mRNA"26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of ABR mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of ABR mRNA27685785
C006780bisphenol Abisphenol A affects the expression of ABR mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ABR mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of ABR gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ABR mRNA15003993
C584509C646 compoundC646 compound results in increased expression of ABR mRNA26191083
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ABR mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ABR mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in increased expression of ABR mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ABR mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ABR mRNA21266533
D002945CisplatinABR protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in decreased expression of ABR mRNA19561079|2759478
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of ABR gene23968726
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ABR mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ABR mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ABR mRNA20938992
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ABR mRNA21179406
C492448ICG 001ICG 001 results in increased expression of ABR mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABR mRNA25613284
C544151jinfukangjinfukang results in increased expression of ABR mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ABR mRNA"15522845
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ABR mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ABR mRNA20864626
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ABR mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ABR promoter"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ABR mRNA24810058
C028007nickel monoxidenickel monoxide results in increased expression of ABR mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ABR mRNA"25510870
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of ABR gene23968726
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ABR mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ABR mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of ABR mRNA24780913
D012643SeleniumSelenium results in increased expression of ABR mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of ABR mRNA17879257
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABR mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ABR gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABR mRNA20819909
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABR mRNA25613284
D014520UrethaneUrethane results in decreased expression of ABR mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ABR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ABR mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ABR gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ABR gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of ABR mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0005096GTPase activator activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002692negative regulation of cellular extravasation-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007264small GTPase mediated signal transduction-TAS8262969  
GO:0007420brain development-IEA-  
GO:0030036actin cytoskeleton organization-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0042472inner ear morphogenesis-IEA-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0043114regulation of vascular permeability-IEA-  
GO:0043314negative regulation of neutrophil degranulation-IEA-  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0050766positive regulation of phagocytosis-IEA-  
GO:0050885neuromuscular process controlling balance-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0060313negative regulation of blood vessel remodeling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665419Prenatal smoke exposure: effects on infant auditory system and placental gene expression. (2013 Jul-Aug)Katbamna BNeurotoxicol Teratol