Gene: ANPEP

290
APN|CD13|GP150|LAP1|P150|PEPN
alanyl aminopeptidase, membrane
protein-coding
15q26.1
Ensembl:ENSG00000166825 MIM:151530 Vega:OTTHUMG00000149814 UniprotKB:P15144
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.466e-1 (AD)  3.930e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23161492chr15:90357202ANPEP2.430e-8Maternal smoking in pregnancy27040690
cg23161492chr15:90357202ANPEP1.400e-18Smoking27651444
cg23161492chr15:90357202ANPEP1.150e-21Tobacco smoking28225026
cg23161492chr15:90357202ANPEP2.950e-23Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDGFRB0.76
NDUFA4L20.725
PEAR10.712
TBX20.693
GJC10.685
GJA40.683
P2RY140.674
GGT50.671
PTH1R0.665
KANK20.662

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FSTL5-0.532
GLRA2-0.52
SMIM18-0.518
KHDRBS2-0.517
PTPRR-0.506
ANKRD34C-0.503
EPHA5-0.498
GLRA3-0.497
ROBO2-0.496
GABRG3-0.494

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00973EzetimibeSmall Molecule163222-33-1ApprovedTarget
DB06196IcatibantSmall Molecule130308-48-4Approved|InvestigationalTarget
DB06773Human calcitoninBiotechDrug21215-62-3Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in decreased activity of ANPEP protein"17109655
C0252051,10-phenanthroline"Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]"17109655
C0252051,10-phenanthroline"1,10-phenanthroline results in decreased activity of ANPEP protein"17109655
C0252051,10-phenanthroline"Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]"17109655
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ANPEP mRNA19933214
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ANPEP mRNA]"19467301
D000081AcetamidesAcetamides analog binds to and results in decreased activity of ANPEP protein17433673
D000082AcetaminophenAcetaminophen results in decreased expression of ANPEP mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ANPEP mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ANPEP mRNA27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of ANPEP mRNA"23195993
C115761alanyl-4-methoxy-2-naphthylamideANPEP protein results in increased metabolism of alanyl-4-methoxy-2-naphthylamide11732752
C115761alanyl-4-methoxy-2-naphthylamideANPEP protein results in increased metabolism of alanyl-4-methoxy-2-naphthylamide11732752
C115761alanyl-4-methoxy-2-naphthylamideANPEP protein results in increased metabolism of alanyl-4-methoxy-2-naphthylamide11732752
C115761alanyl-4-methoxy-2-naphthylamideANPEP protein results in increased metabolism of alanyl-4-methoxy-2-naphthylamide11732752
C115761alanyl-4-methoxy-2-naphthylamideANPEP protein results in increased metabolism of alanyl-4-methoxy-2-naphthylamide11732752
D000485AllergensAllergens results in increased expression of ANPEP protein18180381
D000485AllergensDasatinib inhibits the reaction [Allergens results in increased expression of ANPEP protein]18180381
D000617AminoglycosidesAminoglycosides results in increased secretion of ANPEP protein6142864
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ANPEP mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ANPEP mRNA24449571
D001151ArsenicArsenic affects the methylation of ANPEP gene25304211
D001151ArsenicArsenic results in increased expression of ANPEP mRNA18315880
D001152ArsenicalsArsenicals results in increased methylation of ANPEP promoter26039340
C006632arsenic trioxidearsenic trioxide results in decreased expression of ANPEP mRNA15949261
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ANPEP mRNA"24160326
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ANPEP mRNA"19446018
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of ANPEP mRNA17639512
D001241AspirinAspirin results in increased activity of ANPEP protein16216591
D001241AspirinAspirin results in increased expression of ANPEP mRNA16216591
D001241AspirinAspirin results in increased expression of ANPEP protein16216591
D001280AtrazineAtrazine results in increased expression of ANPEP mRNA25929836
C547126AZM551248AZM551248 results in increased expression of ANPEP mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ANPEP mRNA27858113
D001554BenzeneBenzene results in increased expression of ANPEP mRNA19162166
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ANPEP mRNA17905399
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ANPEP mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ANPEP mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANPEP mRNA21839799
D004958EstradiolEstradiol affects the expression of ANPEP mRNA22574217
D004958EstradiolEstradiol results in increased expression of ANPEP mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ANPEP mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ANPEP mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ANPEP mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ANPEP mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of ANPEP mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ANPEP mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ANPEP mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ANPEP mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ANPEP mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ANPEP mRNA27858113
C018021cobaltous chloridecobaltous chloride affects the expression of ANPEP mRNA20105288
C018021cobaltous chloridecobaltous chloride results in decreased expression of ANPEP mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of ANPEP mRNA24386269
D003300CopperCopper results in decreased expression of ANPEP mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of ANPEP mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of ANPEP mRNA17211630
D016572CyclosporineCyclosporine results in decreased expression of ANPEP mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased secretion of ANPEP protein7514309
C004742daidzein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA27424125
C013908daidzin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA27424125
D000069439DasatinibDasatinib inhibits the reaction [Allergens results in increased expression of ANPEP protein]18180381
D000069439DasatinibDasatinib results in decreased expression of ANPEP protein18180381
D003634DDTDDT results in increased activity of ANPEP protein9755473
C014347decitabinedecitabine promotes the reaction [Phenylbutyrates results in increased expression of ANPEP protein]15946563
C014347decitabinedecitabine results in increased expression of ANPEP mRNA19194470
D013759DronabinolDronabinol results in increased expression of ANPEP mRNA17578508
D002945CisplatinCisplatin results in decreased expression of ANPEP mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of ANPEP mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of ANPEP mRNA26924002
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ANPEP mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of ANPEP mRNA19467301
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ANPEP mRNA19371625
C024629dimethyl phthalatedimethyl phthalate affects the expression of ANPEP mRNA26924002
D004237DiuronDiuron results in decreased expression of ANPEP mRNA21551480|2515243
D004492Edetic Acid"Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]"17109655
D004492Edetic Acid"Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]"17109655
D004745EnkephalinsANPEP protein results in increased metabolism of Enkephalins17906961
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of ANPEP mRNA20064776
D005485FlutamideFlutamide results in decreased expression of ANPEP mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of ANPEP mRNA19167457
C039281furanfuran results in increased expression of ANPEP mRNA26194646
C039281furanfuran results in increased methylation of ANPEP gene22079235
D019833Genistein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA27424125
C040641genistin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA27424125
D005839GentamicinsGentamicins results in increased secretion of ANPEP protein582724
C086566glycitein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA27424125
C433283glycitin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA27424125
C412815GW 4064GW 4064 results in increased expression of ANPEP mRNA26655953
D017313FenretinideFenretinide results in decreased activity of ANPEP protein15958647
C492448ICG 001ICG 001 results in decreased expression of ANPEP mRNA26191083
C410337K 7174K 7174 results in decreased expression of ANPEP mRNA24086573
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ANPEP mRNA26378955
D008727MethotrexateMethotrexate results in increased expression of ANPEP protein2877729
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ANPEP mRNA28001369
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ANPEP mRNA17905399
D015735MifepristoneMifepristone results in decreased expression of ANPEP mRNA17584828
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ANPEP mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of ANPEP mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ANPEP mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of ANPEP mRNA24136188
D009532NickelNickel results in decreased expression of ANPEP mRNA23195993
D009532NickelNickel results in increased expression of ANPEP mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of ANPEP mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of ANPEP mRNA16166746
C012655nimesulidenimesulide results in decreased expression of ANPEP mRNA24136188
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of ANPEP mRNA24888373
C506614PD 0325901PD 0325901 results in decreased expression of ANPEP mRNA25119042
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ANPEP mRNA26705709
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ANPEP mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of ANPEP mRNA17097637
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ANPEP mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of ANPEP mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ANPEP mRNA19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ANPEP mRNA19162173
D010654Phenylbutyratesdecitabine promotes the reaction [Phenylbutyrates results in increased expression of ANPEP protein]15946563
D010654PhenylbutyratesPhenylbutyrates results in increased expression of ANPEP protein15946563
C014153pirimiphos methylpirimiphos methyl results in decreased activity of ANPEP protein9204212
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ANPEP mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ANPEP mRNA18301758|2381119
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of ANPEP mRNA24888373
D011166PorphyrinsPorphyrins analog results in decreased activity of ANPEP protein19189318
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ANPEP mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ANPEP mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of ANPEP mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of ANPEP mRNA23018184
D011374ProgesteroneProgesterone results in decreased expression of ANPEP mRNA19690047
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of ANPEP mRNA17639512
D012402RotenoneRotenone results in increased expression of ANPEP protein8833408
D012643SeleniumSelenium results in increased expression of ANPEP mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ANPEP mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ANPEP mRNA25895662
D019821SimvastatinSimvastatin results in increased expression of ANPEP mRNA19262002
C009277sodium arsenatesodium arsenate results in decreased expression of ANPEP mRNA21795629
D012999SomanSoman results in decreased expression of ANPEP mRNA19281266
D012999SomanSoman results in increased expression of ANPEP mRNA19281266
D013311StreptozocinStreptozocin results in decreased expression of ANPEP protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of ANPEP protein]19634143
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ANPEP mRNA26378955
D016559TacrolimusTacrolimus results in increased secretion of ANPEP protein7514309
D013629TamoxifenTamoxifen affects the expression of ANPEP mRNA20937368
C501413tesaglitazartesaglitazar results in increased expression of ANPEP mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANPEP mRNA11489354|2010694
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ANPEP mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANPEP mRNA18796159|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANPEP mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANPEP mRNA21215274
D013849ThimerosalThimerosal results in decreased expression of ANPEP mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of ANPEP mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ANPEP mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of ANPEP gene26756918
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ANPEP mRNA20133372
D014031TobramycinTobramycin results in decreased activity of ANPEP protein6653171
D014050TolueneToluene results in increased expression of ANPEP mRNA22967744
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ANPEP mRNA17905399
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of ANPEP protein]19634143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ANPEP mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of ANPEP mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of ANPEP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ANPEP mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in decreased methylation of ANPEP gene28853863
C025643vinclozolinvinclozolin affects the expression of ANPEP mRNA19015723
C111237vorinostatvorinostat results in decreased expression of ANPEP mRNA27188386
D015032ZincZinc deficiency results in decreased expression of ANPEP mRNA11717422
D019287Zinc SulfateZinc Sulfate results in decreased expression of ANPEP mRNA27215404
C088658zoledronic acidzoledronic acid results in increased expression of ANPEP mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0004177aminopeptidase activity-TAS10734069  
GO:0008237metallopeptidase activity-TAS2564851  
GO:0008270zinc ion binding-IBA21873635  
GO:0038023signaling receptor activity-TAS1350662  
GO:0042277peptide binding-IBA21873635  
GO:0070006metalloaminopeptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0008217regulation of blood pressure-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0043171peptide catabolic process-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0046718viral entry into host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IDA25645918  
GO:0005737cytoplasm-IBA21873635  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IDA15308636  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA2564851  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030667secretory granule membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:0070062extracellular exosome-IDA15326289  21082674  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa01100Metabolic pathways
hsa04614Renin-angiotensin system
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2022377Metabolism of Angiotensinogen to AngiotensinsIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19330903Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans. (2009 Mar)Montasser MEJ Hypertens