Gene info: ID 2901

Gene: GRIK5

GENE ID: 2901

Synonyms: EAA2|GRIK2|GluK5|KA2

Description: glutamate ionotropic receptor kainate type subunit 5

Gene type: protein-coding

Location: 19q13.2

dbXrefs: Ensembl:ENSG00000105737 MIM:600283 Vega:OTTHUMG00000044573 UniprotKB:Q16478

RefSeq: NC_000019.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.867e-2 (AD) 5.002e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg27167613	chr19:42569967	GRIK5	Promoter	5.945e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NRXN2	0.965
SLC4A3	0.95
MARK4	0.945
DLG4	0.943
MEGF8	0.943
MGAT3	0.943
NYAP1	0.941
DMTN	0.94
KNDC1	0.94
DNAJC5	0.939

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.617
OR4F29	-0.55
RAI14	-0.475
TFPI2	-0.473
SGMS2	-0.462
REST	-0.456
KCNJ15	-0.447
CTNNA3	-0.446
SEPT10	-0.445
VRK2	-0.432

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GRIK5 mRNA"	28903501
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIK5 mRNA"	25614096
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of GRIK5 mRNA	16788091
D000082	Acetaminophen	Acetaminophen results in increased expression of GRIK5 mRNA	17585979
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GRIK5 mRNA	16483693
D001151	Arsenic	Arsenic results in increased methylation of GRIK5 gene	24525453
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of GRIK5 mRNA]	22228805
C006780	bisphenol A	bisphenol A affects the expression of GRIK5 mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK5 mRNA	25607892
C006780	bisphenol A	bisphenol A results in increased expression of GRIK5 mRNA	25181051
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK5 mRNA	25607892
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GRIK5 mRNA	20360939
D000068579	Celecoxib	Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]	21589914
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of GRIK5 mRNA	19440498
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIK5 gene	20938992
D002994	Clofibrate	Clofibrate affects the expression of GRIK5 mRNA	17585979
D003024	Clozapine	Clozapine affects the expression of GRIK5 mRNA	14647396
D003024	Clozapine	Clozapine results in decreased expression of GRIK5 mRNA	18923069
D003042	Cocaine	Cocaine affects the expression of GRIK5 protein	15140200
D003976	Diazinon	Diazinon affects the expression of GRIK5 mRNA	19440498
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of GRIK5 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of GRIK5 mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of GRIK5 mRNA	25016146
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GRIK5 mRNA	20360939
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK5 mRNA	25607892
D000431	Ethanol	Ethanol results in increased expression of GRIK5 mRNA	20655511
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIK5 gene	20938992
D006220	Haloperidol	Haloperidol results in increased expression of GRIK5 mRNA	14647396
D006220	Haloperidol	Haloperidol results in increased expression of GRIK5 mRNA	15860345
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of GRIK5 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of GRIK5 mRNA	27392435
D007608	Kainic Acid	Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]	21589914
D007608	Kainic Acid	Kainic Acid results in decreased expression of GRIK5 mRNA	21589914
D007608	Kainic Acid	PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]	21589914
D007649	Ketamine	Ketamine results in increased expression of GRIK5 mRNA	20080153
D007854	Lead	Lead results in increased expression of GRIK5 mRNA	19921347
C008261	lead acetate	lead acetate results in decreased expression of GRIK5 mRNA	24260418
D008094	Lithium	[Lithium co-treated with Pilocarpine] results in decreased expression of GRIK5 mRNA	16819974
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIK5 gene	20938992
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GRIK5 mRNA	23519560
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRIK5 mRNA"	20188158
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GRIK5 mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in decreased expression of GRIK5 mRNA	19167457
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK5 mRNA	25607892
D009966	Orphenadrine	Orphenadrine affects the expression of GRIK5 mRNA	23665939
D052638	Particulate Matter	Particulate Matter results in decreased methylation of GRIK5 gene	28495853
D010862	Pilocarpine	[Lithium co-treated with Pilocarpine] results in decreased expression of GRIK5 mRNA	16819974
D059808	Polyphenols	Polyphenols results in decreased expression of GRIK5 mRNA	16293270
D012524	Sarin	Sarin results in increased expression of GRIK5 mRNA	19522546
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GRIK5 mRNA	21570461\|2637764
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GRIK5 mRNA	23519560
D013849	Thimerosal	Thimerosal affects the expression of GRIK5 protein	15184908
D013853	Thioacetamide	Thioacetamide results in increased expression of GRIK5 mRNA	23411599
D014212	Tretinoin	Tretinoin results in decreased expression of GRIK5 mRNA	16788091
D014520	Urethane	Urethane results in decreased expression of GRIK5 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of GRIK5 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of GRIK5 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of GRIK5 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GRIK5 gene	28495853

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005234	extracellularly glutamate-gated ion channel activity	-	IEA	-
GO:0008066	glutamate receptor activity	-	IBA	21873635
GO:0015276	ligand-gated ion channel activity	-	TAS	-
GO:0015277	kainate selective glutamate receptor activity	-	IBA	21873635
GO:0015277	kainate selective glutamate receptor activity	-	IDA	1321949
GO:0017124	SH3 domain binding	-	IEA	-
GO:0030165	PDZ domain binding	-	IEA	-
GO:0042802	identical protein binding	-	IEA	-
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006621	protein retention in ER lumen	-	IEA	-
GO:0031630	regulation of synaptic vesicle fusion to presynaptic active zone membrane	-	IEA	-
GO:0034220	ion transmembrane transport	-	IEA	-
GO:0035235	ionotropic glutamate receptor signaling pathway	-	IEA	-
GO:0035249	synaptic transmission, glutamatergic	-	IBA	21873635
GO:0035249	synaptic transmission, glutamatergic	-	IEA	-
GO:0043113	receptor clustering	-	IEA	-
GO:0043525	positive regulation of neuron apoptotic process	-	IEA	-
GO:0050804	modulation of chemical synaptic transmission	-	IBA	21873635
GO:0051649	establishment of localization in cell	-	IEA	-
GO:0060079	excitatory postsynaptic potential	-	IEA	-
GO:0071333	cellular response to glucose stimulus	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005783	endoplasmic reticulum	-	IEA	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0014069	postsynaptic density	-	IEA	-
GO:0030054	cell junction	-	IEA	-
GO:0030425	dendrite	-	IEA	-
GO:0032983	kainate selective glutamate receptor complex	-	IBA	21873635
GO:0032983	kainate selective glutamate receptor complex	-	IEA	-
GO:0042734	presynaptic membrane	-	IBA	21873635
GO:0042734	presynaptic membrane	-	IEA	-
GO:0043195	terminal bouton	-	IEA	-
GO:0043204	perikaryon	-	IEA	-
GO:0045211	postsynaptic membrane	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0098839	postsynaptic density membrane	-	IBA	21873635

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-451306	Ionotropic activity of kainate receptors	TAS
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	TAS
R-HSA-451326	Activation of kainate receptors upon glutamate binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28900078	[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. (2017 Jul-Aug)	Korytina GF	Mol Biol (Mosk)