Gene: GRIN1

2902
GluN1|MRD8|NDHMSD|NDHMSR|NMD-R1|NMDA1|NMDAR1|NR1
glutamate ionotropic receptor NMDA type subunit 1
protein-coding
9q34.3
Ensembl:ENSG00000176884 MIM:138249 Vega:OTTHUMG00000020976 UniprotKB:Q05586
NG_011507.1
PubMed
OD|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.652e-1 (AD)  6.882e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15122716chr9:140050568GRIN1Gene body5.478e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UNC5A0.968
SPTBN40.967
LPCAT40.959
DNM10.959
RAPGEFL10.958
PHYHIP0.957
EPHB60.957
RUSC20.956
KLC20.956
STX1B0.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.572
TFPI2-0.549
OR4F29-0.536
WWTR1-0.518
REST-0.514
RAI14-0.509
CNN2-0.491
C9orf135-0.487
YES1-0.485
KIAA0040-0.481

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00454PethidineSmall Molecule57-42-1ApprovedTarget
DB01043MemantineSmall Molecule19982-08-2Approved|InvestigationalTarget
DB01173OrphenadrineSmall Molecule83-98-7ApprovedTarget
DB01931Dcka, 5,7-Dichlorokynurenic AcidSmall MoleculeExperimentalTarget
DB03929D-SerineSmall Molecule312-84-5Approved|Experimental|InvestigationalTarget
DB04620CycloleucineSmall Molecule52-52-8ExperimentalTarget
DB05824CNS-5161Small Molecule-InvestigationalTarget
DB06151AcetylcysteineSmall Molecule616-91-1Approved|InvestigationalTarget
DB08838AgmatineSmall Molecule306-60-5Experimental|InvestigationalTarget
DB08954IfenprodilSmall Molecule23210-56-2Approved|Investigational|WithdrawnTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB06741GavestinelSmall Molecule153436-22-7InvestigationalTarget
DB09409Magnesium acetate tetrahydrateSmall Molecule16674-78-5ApprovedTarget
DB09481Magnesium carbonateSmall Molecule546-93-0Approved|InvestigationalTarget
DB13146Fluciclovine (18F)Small Molecule222727-39-1ApprovedTarget
DB00289AtomoxetineSmall Molecule83015-26-3ApprovedTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00418SecobarbitalSmall Molecule76-73-3ApprovedTarget
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalTarget
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB04896MilnacipranSmall Molecule92623-85-3Approved|InvestigationalTarget
DB06738KetobemidoneSmall Molecule469-79-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased activity of [GRIN1 protein binds to GRIN2A protein]"11090101
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased activity of [GRIN1 protein binds to GRIN2B protein]"11090101
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid affects the activity of GRIN1 protein"16139540
C0282891,5-dihydroxynaphthalene"1,5-dihydroxynaphthalene metabolite results in increased activity of [GRIN1 protein binds to GRIN2D protein]"20858708
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of GRIN1 protein"20297801
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIN1 mRNA"22467012
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIN1 protein"22467012
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF results in increased activity of GRIN1 protein]20383154
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIN1 mRNA"19114083
C0717382-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate co-treated with resveratrol] affects the phosphorylation of GRIN1 protein24885036
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GRIN1 mRNA"21346803
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased expression of GRIN1 protein18503570
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid analog binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]"14718249
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid analog binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]"14718249
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid analog binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]"14718249
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid analog binds to and results in decreased activity of [GRIN2D protein binds to GRIN1 protein]"14718249
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]"14718249
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]"14718249
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]"14718249
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid binds to and results in decreased activity of [GRIN2D protein binds to GRIN1 protein]"14718249
C0505923-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]14718249
C0505923-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]14718249
C0505923-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]14718249
C0505923-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid binds to and results in decreased activity of [GRIN2D protein binds to GRIN1 protein]14718249
C0792153,5-dihydroxyphenylglycine"3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein"16600209
C0792153,5-dihydroxyphenylglycine"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]"16600209
C0792153,5-dihydroxyphenylglycine"N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]"16600209
C4985545-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione"5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]"14718249
C4985545-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione"5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]"14718249
C4985545-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione"5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]"14718249
C4985545-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione"5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione binds to and results in decreased activity of [GRIN2D protein binds to GRIN1 protein]"14718249
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of GRIN1 protein]17680995
C1214656-methyl-2-(phenylethynyl)pyridine"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]"16600209
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of GRIN1 mRNA25607892
D020106AcrylamideAcrylamide results in increased expression of GRIN1 mRNA28606764
D000336Aerosols[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in increased expression of GRIN1 mRNA25361045
D000336Aerosols[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in increased expression of GRIN1 mRNA25361045
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRIN1 gene27153756
D000376AgmatineAgmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]20950603
D000376AgmatineAgmatine results in decreased activity of [GRIN2A protein binds to GRIN1 protein]15982768
D000376AgmatineAgmatine results in decreased activity of [GRIN2B protein binds to GRIN1 protein]15982768
D000376AgmatineAgmatine results in decreased activity of [GRIN2C protein binds to GRIN1 protein]15982768
D000376AgmatineAgmatine results in decreased activity of [GRIN2D protein binds to GRIN1 protein]15982768
C010845aluminum chloridealuminum chloride results in decreased expression of GRIN1 protein21619818|2206710
D000547AmantadineAmantadine binds to and results in decreased activity of GRIN1 protein8101093
D0150742-Aminoadipic Acid2-Aminoadipic Acid binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]14718249
D0150742-Aminoadipic Acid2-Aminoadipic Acid binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]14718249
D0150742-Aminoadipic Acid2-Aminoadipic Acid binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]14718249
D0150742-Aminoadipic Acid2-Aminoadipic Acid binds to and results in decreased activity of [GRIN2D protein binds to GRIN1 protein]14718249
D006710HomocysteineHomocysteine analog results in increased expression of GRIN1 protein20406136
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRIN1 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride affects the localization of GRIN1 protein16678351
D000643Ammonium ChlorideAmmonium Chloride results in increased phosphorylation of GRIN1 protein16678351
D000661AmphetamineAmphetamine results in increased phosphorylation of GRIN1 protein14622123
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of GRIN1 mRNA25607892
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Herbicides results in decreased expression of GRIN1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [triclopyr results in decreased expression of GRIN1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of GRIN1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide results in decreased expression of GRIN1 mRNA"21318024
C058317arsenic disulfidearsenic disulfide results in decreased expression of GRIN1 protein24865513
C006632arsenic trioxidearsenic trioxide results in decreased expression of GRIN1 mRNA24831965
C015001arsenitearsenite results in increased methylation of GRIN1 promoter23974009
C005948astaxanthine"astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]"23538867
C005948astaxanthine"astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]"23538867
C005948astaxanthine"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]"23538867
C005948astaxanthine"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]"23538867
C005948astaxanthine"[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]"23538867
C005948astaxanthine"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]"23538867
C005948astaxanthine"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]"23538867
D001280AtrazineAtrazine results in decreased expression of GRIN1 mRNA25929836
D001554BenzeneBenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]11090101
D001554BenzeneBenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]11090101
D001554BenzeneBenzene binds to GRIN1 protein18488496
D001554BenzeneChlorine affects the reaction [Benzene binds to GRIN1 protein]18488496
D001578BenzopyransBenzopyrans metabolite results in decreased activity of [GRIN1 protein binds to GRIN2A protein]20858708
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIN1 mRNA23684556
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIN1 mRNA22265711
D004958Estradiol[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA19285052
D004958Estradiol[[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA] which affects the susceptibility to Excitatory Amino Acid Agonists19285052
D004958EstradiolEstradiol results in increased expression of GRIN1 protein12411739
C044887beta-methylcholinebeta-methylcholine affects the expression of GRIN1 mRNA21179406
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein]19632277
C006780bisphenol Abisphenol A affects the expression of GRIN1 protein23240141
C006780bisphenol Abisphenol A results in decreased expression of GRIN1 protein20206181|2349018
C006780bisphenol Abisphenol A results in increased expression of GRIN1 protein24333847
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of GRIN1 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIN1 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of GRIN1 mRNA24820113|2518105
C006780bisphenol Abisphenol A results in decreased expression of GRIN1 protein20821433|2482011
C006780bisphenol Abisphenol A results in increased expression of GRIN1 protein12411739
C006780bisphenol Abisphenol A results in increased methylation of GRIN1 gene28505145
C006780bisphenol Abisphenol A results in increased phosphorylation of GRIN1 protein21763338
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN1 protein]21763338
C006780bisphenol AU 0126 inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN1 protein]21763338
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of GRIN1 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIN1 mRNA25607892
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of GRIN1 promoter22457795
C031938calmidazoliumcalmidazolium affects the activity of GRIN1 protein16139540
C059041calyculin Acalyculin A results in increased activity of GRIN1 protein16139540
D002211CapsaicinCapsaicin results in increased expression of GRIN1 protein modified form17317010
D002211CapsaicinCapsaicin results in increased phosphorylation of GRIN1 protein20054487
D002211Capsaicin"N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Capsaicin results in increased phosphorylation of GRIN1 protein]"20054487
D002211Capsaicinphenyl-N-tert-butylnitrone inhibits the reaction [Capsaicin results in increased expression of GRIN1 protein modified form]17317010
C010059carbamylhydrazinecarbamylhydrazine results in decreased activity of GRIN1 protein19788891
D000068579CelecoxibCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA]21589914
D002713ChlorineChlorine affects the reaction [Benzene binds to GRIN1 protein]18488496
D004390ChlorpyrifosChlorpyrifos results in increased expression of GRIN1 mRNA19440498
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN1 gene20938992
D002794CholineCholine analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 mRNA]20381573
D002794CholineCholine analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 protein]20381573
D003024ClozapineClozapine results in decreased expression of GRIN1 mRNA17266109
D003024ClozapineClozapine results in decreased expression of GRIN1 mRNA12608697
D003024ClozapineClozapine results in increased expression of GRIN1 mRNA12020038|1892306
D003042CocaineCocaine results in increased expression of GRIN1 protein16363995
D003042CocaineCocaine results in increased expression of and results in increased phosphorylation of GRIN1 protein16363995
D003042CocaineCocaine results in decreased expression of GRIN1 mRNA9886066
D003042Cocaine6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of GRIN1 protein]17680995
D003042CocaineCocaine affects the expression of GRIN1 mRNA20187946
D003042CocaineCocaine affects the expression of GRIN1 protein11032893|1245726
D003042CocaineCocaine affects the phosphorylation of and affects the expression of GRIN1 protein17680995
D003042CocaineCocaine affects the phosphorylation of GRIN1 protein12457264
D003042CocaineCocaine results in increased expression of GRIN1 mRNA12670717
D003042CocaineCocaine results in increased expression of GRIN1 protein11801363|1278707
D003042CocaineDizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]11801363
D003042CocaineGRIN1 protein affects the susceptibility to Cocaine11801363
D003042Cocaineifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]19474322
D005576ColforsinColforsin results in increased phosphorylation of GRIN1 protein14622123
D005576ColforsinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of GRIN1 protein]14622123
D003300CopperCopper promotes the reaction [PRNP protein binds to GRIN1 protein]22307640
D003300CopperCopper results in decreased expression of GRIN1 protein25007851
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of GRIN1 mRNA26033743
D003474CurcuminCurcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]23267840
D003474CurcuminCurcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]23267840
D016572CyclosporineCyclosporine results in decreased methylation of GRIN1 promoter27989131
C037304cyhalothrincyhalothrin results in decreased expression of GRIN1 mRNA28487251
C037304cyhalothrincyhalothrin results in decreased expression of GRIN1 protein28487251
C017160cypermethrincypermethrin affects the activity of GRIN1 protein16139540
D003907DexamethasoneDexamethasone results in decreased expression of GRIN1 mRNA29111458
D003976DiazinonDiazinon results in decreased expression of GRIN1 mRNA23212306
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA25607892
D004026DieldrinDieldrin results in increased uptake of GRIN1 protein19812363
D004026DieldrinDieldrin results in increased expression of GRIN1 mRNA19440498
D004041Dietary FatsDietary Fats results in decreased expression of GRIN1 protein18503570
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of GRIN1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of GRIN1 mRNA26033743
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA25607892
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GRIN1 mRNA15518916
C493087diphenylarsinic aciddiphenylarsinic acid results in decreased expression of GRIN1 protein24008832
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]19224577
D016291Dizocilpine MaleateDizocilpine Maleate results in decreased activity of GRIN1 protein19788891
D016291Dizocilpine Maleate[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate19224577
D016291Dizocilpine Maleate[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate19224577
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]11801363
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN1 protein]20406136
D016291Dizocilpine MaleateDizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]11249956
D016291Dizocilpine MaleateDizocilpine Maleate results in increased expression of GRIN1 mRNA25937004
D007980LevodopaLevodopa inhibits the reaction [Oxidopamine results in decreased expression of GRIN1 protein alternative form]16365282
D004298Dopamine[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein14622123
D004298DopamineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]14622123
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of GRIN1 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIN1 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA25607892
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased phosphorylation of GRIN1 protein21763338
C074283estradiol 3-benzoatefulvestrant inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN1 protein]21763338
C074283estradiol 3-benzoateU 0126 inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN1 protein]21763338
D000431EthanolEthanol results in decreased expression of GRIN1 mRNA18713641
D000431EthanolEthanol results in increased expression of GRIN1 mRNA20655511
D000431EthanolEthanol results in increased expression of GRIN1 protein12045474
C004912ethylbenzeneethylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]11090101
C004912ethylbenzeneethylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]11090101
C024565ethylene dichlorideethylene dichloride results in increased expression of GRIN1 protein17456392
D018690Excitatory Amino Acid AgonistsDizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]19224577
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]11812690
D018690Excitatory Amino Acid Agonists[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists19224577
D018690Excitatory Amino Acid Agonists[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Excitatory Amino Acid Agonists19224577
D018690Excitatory Amino Acid AgonistsUrethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]11812690
D018690Excitatory Amino Acid Agonists[[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA] which affects the susceptibility to Excitatory Amino Acid Agonists19285052
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists results in decreased expression of GRIN1 protein17550430
C047360felbamatefelbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein]10690753
C047360felbamatefelbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]10690753
C047360felbamatefelbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein]10690753
C047360felbamateGRIN1 protein binds to felbamate18311896
C047360felbamatefelbamate binds to and results in decreased activity of [GRIN1 protein binds to GRIN2B protein]10215667
C047360felbamatefelbamate results in decreased activity of [GRIN1 protein binds to GRIN2A protein]10215667
C047360felbamatefelbamate results in decreased activity of [GRIN1 protein binds to GRIN2C protein]10215667
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN1 gene20938992
D005492Folic AcidDizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN1 protein]20406136
D005492Folic AcidFolic Acid deficiency results in increased expression of GRIN1 protein20406136
C069837fullerene C60fullerene C60 results in decreased expression of GRIN1 mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN1 protein]21763338
C070081fulvestrantfulvestrant inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN1 protein]21763338
D019833GenisteinGenistein results in decreased expression of GRIN1 mRNA25136773
D005839GentamicinsGentamicins results in increased expression of GRIN1 mRNA15200423
D005839GentamicinsGentamicins results in increased expression of GRIN1 protein15200423
D006220HaloperidolHaloperidol results in decreased expression of GRIN1 mRNA12020038
D006220HaloperidolHaloperidol results in increased expression of GRIN1 mRNA12020038
D006540Herbicides"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Herbicides results in decreased expression of GRIN1 mRNA]"21318024
D006540HerbicidesHerbicides results in decreased expression of GRIN1 mRNA21318024
C010739ifenprodilifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]19474322
C010739ifenprodilifenprodil binds to and results in decreased activity of GRIN1 protein22713680
D007608Kainic AcidCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA]21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIN1 mRNA21589914
D007608Kainic AcidKainic Acid affects the expression of GRIN123159308
C468270Kangen-karyuKangen-karyu affects the expression of GRIN1 protein modified form20637274
D007649KetamineKetamine results in increased expression of GRIN1 mRNA17426105
D007649KetamineKetamine results in increased expression of GRIN1 mRNA19126600|2008015
D007649KetamineKetamine results in increased expression of GRIN1 protein23065140
C057416KT 5720KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein]19632277
D007736Kynurenic AcidKynurenic Acid analog binds to and results in decreased activity of GRIN1 protein18488496
D007736Kynurenic AcidKynurenic Acid binds to and results in decreased activity of GRIN1 protein18488496
D007854LeadLead affects the expression of GRIN1 mRNA28903495
D007854LeadLead affects the localization of GRIN1 protein21192972
D007854LeadLead affects the expression of and affects the splicing of GRIN1 mRNA12480136
D007854LeadLead affects the expression of GRIN1 mRNA12480136
C008261lead acetatelead acetate results in decreased expression of GRIN1 mRNA24260418|2524200
C008261lead acetatelead acetate results in decreased expression of GRIN1 protein25242007
C008261lead acetateCholine analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 mRNA]20381573
C008261lead acetateCholine analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 protein]20381573
C008261lead acetatelead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]12480136
C008261lead acetate[lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]] which results in decreased phosphorylation of CREB1 protein12480136
C008261lead acetatelead acetate results in decreased expression of GRIN1 mRNA20381573|2216088
C008261lead acetatelead acetate results in decreased expression of GRIN1 protein20381573
C029891lead chloridelead chloride results in increased expression of GRIN1 mRNA19651682
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA25607892
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of GRIN1 mRNA"24972896
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of GRIN1 mRNA"21290410
C009900lipoteichoic acid[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA18926851
C009900lipoteichoic acid[Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA18926851
D018021Lithium Chloride[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA19285052
D018021Lithium Chloride[[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA] which affects the susceptibility to Excitatory Amino Acid Agonists19285052
D018021Lithium ChlorideLithium Chloride results in decreased expression of GRIN1 mRNA19285052
D008345ManganeseManganese results in decreased expression of GRIN1 mRNA19643132|2920566
D008345ManganeseManganese results in decreased expression of GRIN1 protein19643132|2920566
C025340manganese chloridemanganese chloride results in decreased expression of GRIN1 mRNA20175136
C025340manganese chloridemanganese chloride results in decreased expression of GRIN1 protein20175136
D008694MethamphetamineMethamphetamine results in increased expression of GRIN1 mRNA18419818
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN1 gene20938992
D003915DextromethorphanDextromethorphan results in increased expression of GRIN1 protein28916251
D008731MethoxychlorMethoxychlor results in increased methylation of GRIN1 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRIN1 mRNA19651682|2222348
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRIN1 protein22223486
C004925methylmercuric chloridePolyphenols inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]22223486
C004925methylmercuric chloridePolyphenols inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein]22223486
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRIN1 mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]"23538867
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]"23538867
C066851mithramycin A"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]"23538867
C066851mithramycin A"astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]"23538867
C066851mithramycin A"[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]"23538867
C066851mithramycin A"mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]"23538867
C066851mithramycin A"mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]"23538867
C066851mithramycin A"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]"23538867
C066851mithramycin A"mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]"23538867
D009020MorphineMMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]20519536
D009020MorphineMorphine affects the phosphorylation of GRIN1 protein17996026
D009020Morphine[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein17996026
D009020MorphineMorphine results in increased phosphorylation of GRIN1 protein20519536
D009020MorphineAgmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]20950603
D009020MorphineMorphine results in decreased phosphorylation of GRIN1 protein15287884
D009020MorphineMorphine results in increased expression of GRIN1 protein20950603|2271368
D009020MorphineMorphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]22713680
D009020Morphineresveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]22713680
D009020Morphineresveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]22713680
C097963N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin"N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Capsaicin results in increased phosphorylation of GRIN1 protein]"20054487
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]"14622123
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of GRIN1 protein]14622123
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]14622123
C481448N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]"16600209
C481448N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide"N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]"16600209
D009284NaphtholsNaphthols metabolite results in decreased activity of [GRIN1 protein binds to GRIN2A protein]20858708
D009284NaphtholsNaphthols metabolite results in decreased activity of [GRIN1 protein binds to GRIN2B protein]20858708
D009284NaphtholsNaphthols metabolite results in decreased activity of [GRIN1 protein binds to GRIN2C protein]20858708
D009284NaphtholsNaphthols metabolite results in decreased activity of [GRIN1 protein binds to GRIN2D protein]20858708
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of GRIN1 mRNA12832660
C028007nickel monoxidenickel monoxide results in decreased expression of GRIN1 mRNA19167457
C008661nobiletinnobiletin results in increased expression of GRIN1 mRNA24964900
C025256nonylphenolnonylphenol results in decreased expression of GRIN1 mRNA15518916
C072936notoginsenoside R1[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to notoginsenoside R119224577
C024268n-propylbenzenen-propylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]11090101
C024268n-propylbenzenen-propylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]11090101
C025589ochratoxin Aochratoxin A results in increased acetylation of GRIN1 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of GRIN1 promoter] which results in increased expression of GRIN1 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of GRIN1 mRNA29098329
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of GRIN1 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIN1 mRNA25607892
D016627OxidopamineLevodopa inhibits the reaction [Oxidopamine results in decreased expression of GRIN1 protein alternative form]16365282
D016627OxidopamineOxidopamine results in decreased expression of GRIN1 mRNA15518916
D016627OxidopamineOxidopamine results in decreased expression of GRIN1 protein alternative form16365282
D019319Okadaic AcidOkadaic Acid results in increased activity of GRIN1 protein16139540
D010069OxadiazolesOxadiazoles metabolite results in decreased activity of [GRIN1 protein binds to GRIN2A protein]20858708
D010069OxadiazolesOxadiazoles metabolite results in decreased activity of [GRIN1 protein binds to GRIN2B protein]20858708
D010069OxadiazolesOxadiazoles metabolite results in increased activity of [GRIN1 protein binds to GRIN2C protein]20858708
D010069OxadiazolesOxadiazoles metabolite results in increased activity of [GRIN1 protein binds to GRIN2D protein]20858708
D010126Ozone[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in increased expression of GRIN1 mRNA25361045
D010126Ozone[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in increased expression of GRIN1 mRNA25361045
D010269ParaquatParaquat results in decreased expression of GRIN1 mRNA19146868|2891632
D010278ParathionParathion results in decreased expression of GRIN1 mRNA19146868
D052638Particulate MatterParticulate Matter affects the methylation of GRIN1 promoter28153600
D052638Particulate MatterParticulate Matter results in increased expression of GRIN1 mRNA28153600
D052638Particulate Matter[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in increased expression of GRIN1 mRNA25361045
D052638Particulate Matter[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA18926851
D052638Particulate MatterParticulate Matter results in increased expression of GRIN1 mRNA19653804
C410127PCB 180PCB 180 results in increased expression of GRIN1 protein20297801
D010424PentobarbitalPentobarbital affects the expression of GRIN1 mRNA10717408
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of GRIN1 mRNA20136073
D010616PhenanthrenesPhenanthrenes binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]14718249
D010616PhenanthrenesPhenanthrenes binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]14718249
D010616PhenanthrenesPhenanthrenes binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]14718249
D010616PhenanthrenesPhenanthrenes binds to and results in decreased activity of [GRIN2D protein binds to GRIN1 protein]14718249
D010616PhenanthrenesPhenanthrenes metabolite results in decreased activity of [GRIN1 protein binds to GRIN2C protein]20858708
D010616PhenanthrenesPhenanthrenes metabolite results in decreased activity of [GRIN1 protein binds to GRIN2D protein]20858708
D010616PhenanthrenesPhenanthrenes metabolite results in increased activity of [GRIN1 protein binds to GRIN2A protein]20858708
D010616PhenanthrenesPhenanthrenes metabolite results in increased activity of [GRIN1 protein binds to GRIN2B protein]20858708
D010616PhenanthrenesPhenanthrenes metabolite results in increased activity of [GRIN1 protein binds to GRIN2C protein]20858708
D010616PhenanthrenesPhenanthrenes metabolite results in increased activity of [GRIN1 protein binds to GRIN2D protein]20858708
D010622PhencyclidinePhencyclidine results in decreased expression of GRIN1 mRNA17266109
C029217phenyl-N-tert-butylnitronephenyl-N-tert-butylnitrone inhibits the reaction [Capsaicin results in increased expression of GRIN1 protein modified form]17317010
D010672PhenytoinPhenytoin results in increased expression of GRIN1 mRNA20345932
C003121phosphinothricinphosphinothricin binds to GRIN1 protein25268653
C003121phosphinothricinphosphinothricin metabolite binds to GRIN1 protein25268653
D010795Phthalic AcidsPhthalic Acids results in decreased expression of GRIN1 mRNA15518916
D010846Picloram"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of GRIN1 mRNA]"21318024
D010846PicloramPicloram results in decreased expression of GRIN1 mRNA21318024
D010862PilocarpinePilocarpine results in decreased expression of GRIN1 mRNA18086456
D010862PilocarpinePlant Preparations inhibits the reaction [Pilocarpine results in decreased expression of GRIN1 mRNA]18086456
D028321Plant PreparationsPlant Preparations inhibits the reaction [Pilocarpine results in decreased expression of GRIN1 mRNA]18086456
D059808PolyphenolsPolyphenols inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]22223486
D059808PolyphenolsPolyphenols inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein]22223486
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA25607892
D011441PropylthiouracilPropylthiouracil results in decreased expression of GRIN1 mRNA24780913
C059514resveratrol[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate co-treated with resveratrol] affects the phosphorylation of GRIN1 protein24885036
C059514resveratrolresveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]22713680
C059514resveratrolresveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]22713680
C059514resveratrolresveratrol results in decreased expression of GRIN1 protein modified form27093858
C065286SDZ EAA 494SDZ EAA 494 binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]14718249
C065286SDZ EAA 494SDZ EAA 494 binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]14718249
C065286SDZ EAA 494SDZ EAA 494 binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]14718249
C065286SDZ EAA 494SDZ EAA 494 binds to and results in decreased activity of [GRIN2D protein binds to GRIN1 protein]14718249
C118258SN50 peptide[SN50 peptide affects the localization of [RELA protein binds to NFKB1 protein]] inhibits the reaction [Tretinoin results in increased expression of GRIN1 protein]18280257
D013311StreptozocinCurcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]23267840
D013311StreptozocinCurcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]23267840
D013311StreptozocinINS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]23267840
D013311StreptozocinINS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]23267840
D013311StreptozocinStreptozocin results in increased expression of GRIN1 mRNA23267840
D013311StreptozocinStreptozocin results in increased expression of GRIN1 protein23267840
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of GRIN1 mRNA25534910
D013467SulindacSulindac affects the expression of GRIN1 protein15123337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GRIN1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GRIN1 mRNA14984010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GRIN1 protein14984010
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein"14622123
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]"14622123
D013849ThimerosalThimerosal results in decreased expression of GRIN1 protein15184908
C009495titanium dioxidetitanium dioxide results in decreased expression of GRIN1 mRNA25411160
C009495titanium dioxidetitanium dioxide results in decreased expression of GRIN1 protein25411160
D024505TocopherolsTocopherols results in increased expression of GRIN1 mRNA17654050
D014050TolueneToluene results in increased expression of GRIN1 mRNA20804784
D014050TolueneToluene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]9655877
D014050TolueneToluene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]9655877
D014212Tretinoin[SN50 peptide affects the localization of [RELA protein binds to NFKB1 protein]] inhibits the reaction [Tretinoin results in increased expression of GRIN1 protein]18280257
D014212TretinoinTretinoin results in increased expression of GRIN1 protein18280257
C011559tributyltintributyltin results in decreased expression of GRIN1 mRNA19591855
C032742triclopyr"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [triclopyr results in decreased expression of GRIN1 mRNA]"21318024
C032742triclopyrtriclopyr results in decreased expression of GRIN1 mRNA21318024
C040533trimethyltin chloridetrimethyltin chloride results in decreased expression of GRIN1 mRNA19651682
C113580U 0126U 0126 inhibits the reaction [TNF results in increased activity of GRIN1 protein]20383154
C113580U 0126U 0126 inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN1 protein]21763338
C113580U 0126U 0126 inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN1 protein]21763338
D014520UrethaneUrethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]11812690
D014635Valproic AcidValproic Acid results in decreased expression of GRIN1 mRNA19651682
D001335Vehicle Emissions[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in increased expression of GRIN1 mRNA25361045
D001335Vehicle Emissions[Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA18926851
D001335Vehicle EmissionsVehicle Emissions results in increased expression of GRIN1 mRNA19653804
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GRIN1 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA25607892
D014992XylenesXylenes results in decreased activity of [GRIN1 protein binds to GRIN2A protein]11090101
D014992XylenesXylenes results in decreased activity of [GRIN1 protein binds to GRIN2B protein]11090101

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004972NMDA glutamate receptor activity-IBA21873635  
GO:0004972NMDA glutamate receptor activity-IDA26919761  28105280  
GO:0004972NMDA glutamate receptor activitycontributes_toIDA7679115  7685113  
GO:0004972NMDA glutamate receptor activity-ISS-  
GO:0004972NMDA glutamate receptor activity-TAS17526495  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-IEA-  
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO:0005262calcium channel activitycontributes_toIDA7685113  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI17047094  17997397  
GO:0005516calmodulin binding-ISS-  
GO:0016594glycine binding-IDA7685113  28105280  
GO:0016594glycine binding-IMP17047094  
GO:0016595glutamate binding-IDA7685113  
GO:0022849glutamate-gated calcium ion channel activity-IDA26875626  
GO:0042165neurotransmitter binding-ISS-  
GO:0044877protein-containing complex binding-ISS-  
GO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001661conditioned taste aversion-IEA-  
GO:0001967suckling behavior-IEA-  
GO:0001975response to amphetamine-IEA-  
GO:0006812cation transport-IDA7685113  
GO:0007420brain development-NAS17526495  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0007616long-term memory-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0008355olfactory learning-IEA-  
GO:0008542visual learning-ISS-  
GO:0010524positive regulation of calcium ion transport into cytosol-ISS-  
GO:0018964propylene metabolic process-ISS-  
GO:0019233sensory perception of pain-IEA-  
GO:0019722calcium-mediated signaling-IEA-  
GO:0021586pons maturation-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0035176social behavior-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-ISS-  
GO:0035249synaptic transmission, glutamatergic-IEA-  
GO:0042391regulation of membrane potential-IDA7679115  7685113  17047094  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043278response to morphine-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043576regulation of respiratory gaseous exchange-IEA-  
GO:0045471response to ethanol-IDA18445116  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048167regulation of synaptic plasticity-NAS17526495  
GO:0048169regulation of long-term neuronal synaptic plasticity-IEA-  
GO:0048814regulation of dendrite morphogenesis-IEA-  
GO:0050770regulation of axonogenesis-IEA-  
GO:0051290protein heterotetramerization-ISS-  
GO:0051963regulation of synapse assembly-IEA-  
GO:0055074calcium ion homeostasis-ISS-  
GO:0060079excitatory postsynaptic potential-ISS-  
GO:0060134prepulse inhibition-IEA-  
GO:0060179male mating behavior-IEA-  
GO:0097553calcium ion transmembrane import into cytosol-IDA26875626  
GO:0098976excitatory chemical synaptic transmission-NAS17526495  
GO:1903428positive regulation of reactive oxygen species biosynthetic process-ISS-  
GO:1903539protein localization to postsynaptic membrane-IEA-  
GO:1904646cellular response to amyloid-betaNOTIGI21883149  
GO:1905429response to glycine-IDA28105280  
GO:2000463positive regulation of excitatory postsynaptic potential-ISS-  
GO:2001056positive regulation of cysteine-type endopeptidase activity-ISS17526495  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-ISS17526495  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA7685113  26875626  26919761  28105280  
GO:0008021synaptic vesicle-ISS-  
GO:0009986cell surface-ISS17526495  
GO:0014069postsynaptic density-ISS-  
GO:0017146NMDA selective glutamate receptor complex-IBA21873635  
GO:0017146NMDA selective glutamate receptor complex-IDA7679115  10480938  17047094  26875626  26919761  28105280  
GO:0017146NMDA selective glutamate receptor complex-TAS17526495  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IDA10749211  
GO:0043005neuron projection-ISS-  
GO:0043083synaptic cleft-ISS-  
GO:0043195terminal bouton-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0045202synapse-ISS-  
GO:0045211postsynaptic membrane-ISS-  
GO:0060076excitatory synapse-ISS-  
GO:0097060synaptic membrane-ISS-  
GO:0098839postsynaptic density membrane-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04720Long-term potentiation
hsa05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-438066Unblocking of NMDA receptor, glutamate binding and activationTAS
R-HSA-442729CREB phosphorylation through the activation of CaMKIITAS
R-HSA-442742CREB phosphorylation through the activation of RasTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-442982Ras activation upon Ca2+ influx through NMDA receptorTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26289945The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving. (2015 Nov)Bach PAddict Biol
25262781Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. (2014 Nov)Enoch MAGenes Brain Behav
15635650GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal. (2005 Feb 5)Rujescu DAm J Med Genet B Neuropsychiatr Genet
22924764Array-based profiling of DNA methylation changes associated with alcohol dependence. (2013 Jan)Zhang HAlcohol Clin Exp Res
29704590Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. (2018 Apr 25)Yawalkar RNeurochem Int
29478698Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans. (2018 Jan 11)Cheng ZBiol Psychiatry