Gene: ATAD2

29028
ANCCA|CT137|PRO2000
ATPase family, AAA domain containing 2
protein-coding
8q24.13
Ensembl:ENSG00000156802 MIM:611941 Vega:OTTHUMG00000165090 UniprotKB:Q6PL18
NC_000008.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.037e-1 (AD)  7.631e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C5orf510.854
RNF19A0.844
CEP570.842
CAPN70.824
TMEM167B0.823
UBR50.821
METTL140.82
CENPC0.82
XRN10.815
CLIP40.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.491
OR4F29-0.479
RNF223-0.306
RERGL-0.286
KLRB1-0.284
TTLL10-0.279
MTRNR2L6-0.277
MTRNR2L10-0.276
PTGDR2-0.268
MTRNR2L9-0.265

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ATAD2 mRNA"22698814|2890350
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ATAD2 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of ATAD2 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ATAD2 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATAD2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of ATAD2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATAD2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ATAD2 mRNA22230336
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of ATAD2 mRNA25596134
D001151ArsenicArsenic affects the methylation of ATAD2 gene25304211
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of ATAD2 mRNA26424790
D001379AzathioprineAzathioprine results in decreased expression of ATAD2 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of ATAD2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATAD2 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATAD2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATAD2 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATAD2 mRNA"19150397|2038263
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ATAD2 mRNA"26238291
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ATAD2 mRNA20660070
D004958EstradiolEstradiol results in increased expression of ATAD2 mRNA16474171|1831028
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ATAD2 mRNA17404688
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of ATAD2 mRNA26424790
C044887beta-methylcholinebeta-methylcholine affects the expression of ATAD2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of ATAD2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ATAD2 mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of ATAD2 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ATAD2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ATAD2 mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of ATAD2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride affects the expression of ATAD2 mRNA25596134
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ATAD2 mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of ATAD2 mRNA18500788
C004656chloroacetaldehydechloroacetaldehyde affects the expression of ATAD2 mRNA25596134
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ATAD2 mRNA28472532
C059262cidofovircidofovir results in increased expression of ATAD2 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of ATAD2 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of ATAD2 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ATAD2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of ATAD2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ATAD2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of ATAD2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of ATAD2 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of ATAD2 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of ATAD2 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of ATAD2 mRNA20579391
D003703DemecolcineDemecolcine results in decreased expression of ATAD2 mRNA23649840
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of ATAD2 mRNA26424790
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ATAD2 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ATAD2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ATAD2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ATAD2 mRNA25596134|2759478
D002945CisplatinCisplatin results in decreased phosphorylation of ATAD2 protein22006019
D002945CisplatinCisplatin results in decreased expression of ATAD2 mRNA22023808
C000944dicrotophosdicrotophos results in decreased expression of ATAD2 mRNA28302478
D000431EthanolEthanol results in decreased expression of ATAD2 mRNA29018328
D019833GenisteinGenistein results in increased expression of ATAD2 mRNA16474171
D005839GentamicinsGentamicins results in decreased expression of ATAD2 mRNA22061828
D017313FenretinideFenretinide results in increased expression of ATAD2 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of ATAD2 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of ATAD2 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATAD2 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of ATAD2 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ATAD2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ATAD2 mRNA27392435
C410337K 7174K 7174 results in decreased expression of ATAD2 mRNA24086573
D007840LatexLatex analog results in increased expression of ATAD2 mRNA24768652
D008154LucanthoneLucanthone results in decreased expression of ATAD2 mRNA21148553
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ATAD2 mRNA21641980
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ATAD2 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ATAD2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ATAD2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ATAD2 mRNA24810058
D009532NickelNickel results in increased expression of ATAD2 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ATAD2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ATAD2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ATAD2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of ATAD2 mRNA25596134
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ATAD2 protein26879310
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ATAD2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of ATAD2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ATAD2 mRNA19482888
D048789PhytoestrogensPhytoestrogens results in increased expression of ATAD2 mRNA18310284
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ATAD2 mRNA19710929
D010894PiroxicamPiroxicam results in decreased expression of ATAD2 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of ATAD2 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of ATAD2 mRNA16474171
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ATAD2 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ATAD2 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of ATAD2 mRNA17404688
D011441PropylthiouracilPropylthiouracil affects the expression of ATAD2 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of ATAD2 mRNA19167446
C059514resveratrolresveratrol results in increased expression of ATAD2 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ATAD2 mRNA23806026
D053260SootSoot results in increased expression of ATAD2 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ATAD2 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATAD2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ATAD2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATAD2 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of ATAD2 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATAD2 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of ATAD2 mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of ATAD2 protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ATAD2 mRNA19969065
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ATAD2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ATAD2 mRNA16249480
C011559tributyltintributyltin results in increased expression of ATAD2 mRNA29191790
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of ATAD2 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATAD2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ATAD2 mRNA26272509
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ATAD2 mRNA19042947
D014520UrethaneUrethane results in decreased expression of ATAD2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ATAD2 mRNA27188386
D014635Valproic AcidValproic Acid affects the expression of ATAD2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ATAD2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ATAD2 mRNA23034163
D014750VincristineVincristine results in decreased expression of ATAD2 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of ATAD2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IBA21873635  
GO:0005515protein binding-IPI17998543  25640309  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IBA21873635  
GO:0016887ATPase activity-IDA17998543  
GO:0042393histone binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS-  
GO:0031936negative regulation of chromatin silencing-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IDA17998543  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28968711Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients. (2017 Oct 26)Couto PPCarcinogenesis
22914773A comparative and integrative approach identifies ATPase family, AAA domain containing 2 as a likely driver of cell proliferation in lung adenocarcinoma. (2012 Oct 15)Fouret RClin Cancer Res