Gene: GRIN2A

2903
EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A
glutamate ionotropic receptor NMDA type subunit 2A
protein-coding
16p13.2
Ensembl:ENSG00000183454 MIM:138253 Vega:OTTHUMG00000129721 UniprotKB:Q12879
NG_011812.1
PubMed|SNP Mapped
CD|OD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.168e-2 (AD)  8.978e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7206714chr16:10084138 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs12920919chr16:9844123 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FRMPD40.954
KIAA1549L0.951
NBEA0.948
ATRNL10.946
CHRM30.945
STXBP5L0.943
AAK10.943
KCTD160.943
HECW10.941
TMEM132D0.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.625
HEY2-0.622
ROM1-0.608
YES1-0.597
MYL3-0.59
RNF135-0.589
CHST14-0.588
AGTRAP-0.583
COPZ2-0.58
FLT3LG-0.575

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB00454PethidineSmall Molecule57-42-1ApprovedTarget
DB00949FelbamateSmall Molecule25451-15-4ApprovedTarget
DB01043MemantineSmall Molecule19982-08-2Approved|InvestigationalTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01520TenocyclidineSmall Molecule21500-98-1Experimental|Illicit|InvestigationalTarget
DB06151AcetylcysteineSmall Molecule616-91-1Approved|InvestigationalTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB06741GavestinelSmall Molecule153436-22-7InvestigationalTarget
DB09409Magnesium acetate tetrahydrateSmall Molecule16674-78-5ApprovedTarget
DB09481Magnesium carbonateSmall Molecule546-93-0Approved|InvestigationalTarget
DB13146Fluciclovine (18F)Small Molecule222727-39-1ApprovedTarget
DB00289AtomoxetineSmall Molecule83015-26-3ApprovedTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00418SecobarbitalSmall Molecule76-73-3ApprovedTarget
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalTarget
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB04896MilnacipranSmall Molecule92623-85-3Approved|InvestigationalTarget
DB06738KetobemidoneSmall Molecule469-79-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased activity of [GRIN1 protein binds to GRIN2A protein]"11090101
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of GRIN2A mRNA27417517
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2A mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIN2A mRNA"21394737
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]22824136
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIN2A mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2A mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2A mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of GRIN2A protein"20297801
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased phosphorylation of GRIN2A protein18503570
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid analog binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]"14718249
C491996(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid"(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]"14718249
C0505923-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]14718249
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GRIN2A mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRIN2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
C4985545-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione"5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione results in decreased activity of GRIN2A protein"16822975
C4985545-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione"5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]"14718249
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRIN2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
D000336Aerosols[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in decreased expression of GRIN2A mRNA25361045
D000336Aerosols[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in decreased expression of GRIN2A mRNA25361045
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GRIN2A gene28458013
C412373AG 1879AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of GRIN2A protein]12211081
D000376AgmatineAgmatine results in decreased activity of [GRIN2A protein binds to GRIN1 protein]15982768
D000493AllopurinolAllopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein]20084674
C005915Allura Red AC Dye[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of GRIN2A protein23429044
C005915Allura Red AC Dye[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of GRIN2A protein23429044
D0150742-Aminoadipic Acid2-Aminoadipic Acid binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]14718249
C018824ammonium acetateAllopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein]20084674
C018824ammonium acetateammonium acetate results in decreased expression of GRIN2A protein20084674
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRIN2A mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride affects the localization of GRIN2A protein16678351
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of GRIN2A protein16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GRIN2A mRNA24449571
C058317arsenic disulfidearsenic disulfide results in increased expression of GRIN2A mRNA24865513
C058317arsenic disulfidearsenic disulfide results in increased expression of GRIN2A protein24865513
D001280AtrazineAtrazine results in decreased expression of GRIN2A mRNA25929836
D001554BenzeneBenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]11090101
D001578BenzopyransBenzopyrans metabolite results in decreased activity of [GRIN1 protein binds to GRIN2A protein]20858708
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of GRIN2A mRNA23684556
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIN2A mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIN2A protein21987461
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased expression of GRIN2A protein]21987461
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRIN2A mRNA17606297
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIN2A mRNA21839799|2210833
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GRIN2A mRNA22154832
D004958EstradiolEstradiol results in increased expression of GRIN2A mRNA22154832
D004958EstradiolEstradiol results in decreased expression of GRIN2A mRNA20068009
C006780bisphenol Abisphenol A results in decreased expression of GRIN2A protein20206181|2857202
C006780bisphenol Adiphenyldiselenide inhibits the reaction [bisphenol A results in decreased expression of GRIN2A protein]28572023
C006780bisphenol Abisphenol A results in decreased expression of GRIN2A protein20821433
C006780bisphenol Abisphenol A results in increased methylation of GRIN2A gene28505145
C006796brilliant blue[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of GRIN2A protein23429044
C006796brilliant blue[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of GRIN2A protein23429044
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GRIN2A mRNA24763279
D000068579CelecoxibCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA]21589914
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of GRIN2A mRNA26272509
D004390ChlorpyrifosChlorpyrifos affects the expression of GRIN2A mRNA17452286|1944049
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GRIN2A mRNA18668222
D002794CholineCholine analog affects the reaction [lead acetate results in decreased expression of GRIN2A mRNA]20381573
C466858ciguatoxin 3Cciguatoxin 3C results in decreased expression of GRIN2A protein25945544
C466858ciguatoxin 3CTetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2A protein]25945544
D003024ClozapineClozapine results in decreased expression of GRIN2A mRNA12608697|1892306
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of GRIN2A mRNA]17988634
D003042CocaineCocaine affects the expression of GRIN2A mRNA20187946
D003042CocaineCocaine affects the expression of GRIN2A protein19105975
D003042CocaineCocaine results in increased expression of GRIN2A mRNA17898221
D003042CocaineCocaine results in increased expression of GRIN2A protein19306440|1947432
D003042Cocaineifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2A protein]19474322
C055407conotoxin GVconotoxin GV results in decreased activity of [GRIN1A protein co-treated with GRIN2A protein]21396956
D003471CuprizoneCuprizone results in decreased expression of GRIN2A mRNA26577399
D003471CuprizoneCuprizone results in decreased expression of GRIN2A protein26577399
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of GRIN2A]19912468
D013759DronabinolDronabinol results in decreased expression of and results in increased import of GRIN2A protein19912468
D013759DronabinolDronabinol results in decreased expression of GRIN2A mRNA19912468
D013759Dronabinolrimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIN2A]19912468
D003975DiazepamGRIN2A protein affects the susceptibility to Diazepam15731593
D003976DiazinonDiazinon affects the expression of GRIN2A mRNA19440498
D003976DiazinonDiazinon results in increased expression of GRIN2A mRNA17452286
D004041Dietary FatsDietary Fats results in decreased phosphorylation of GRIN2A protein18503570
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GRIN2A mRNA28871463
C061132diphenyldiselenidediphenyldiselenide inhibits the reaction [bisphenol A results in decreased expression of GRIN2A protein]28572023
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]19224577
D016291Dizocilpine Maleate[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate19224577
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of GRIN2A mRNA]17434604
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN2A protein]20406136
D016291Dizocilpine MaleateDizocilpine Maleate results in increased phosphorylation of GRIN2A protein11249956
C118739entinostatentinostat results in increased expression of GRIN2A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRIN2A mRNA"27188386
D000431EthanolEthanol results in decreased expression of GRIN2A mRNA20655511
C004912ethylbenzeneethylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]11090101
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of GRIN2A mRNA23649840
D018690Excitatory Amino Acid AgonistsDizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]19224577
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]11812690
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists results in decreased expression of GRIN2A mRNA28987794
D018690Excitatory Amino Acid Agonists[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists19224577
D018690Excitatory Amino Acid AgonistsUrethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]11812690
C005842FD & C Yellow No. 6[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of GRIN2A protein23429044
C005842FD & C Yellow No. 6[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of GRIN2A protein23429044
C047360felbamatefelbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein]10690753
C047360felbamatefelbamate results in decreased activity of [GRIN1 protein binds to GRIN2A protein]10215667
D005473FluoxetineFluoxetine results in increased expression of GRIN2A protein20417256
D005492Folic AcidDizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN2A protein]20406136
D005492Folic AcidFolic Acid deficiency results in increased expression of GRIN2A protein20406136
D005505Food Coloring AgentsFood Coloring Agents results in decreased expression of GRIN2A protein23429044
D005505Food Coloring AgentsFood Coloring Agents results in increased expression of GRIN2A protein23429044
D005557FormaldehydeDizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of GRIN2A mRNA]17434604
D005557FormaldehydeFormaldehyde results in increased expression of GRIN2A mRNA17434604
C039281furanfuran results in increased methylation of GRIN2A gene22079235
D019833GenisteinGenistein results in decreased expression of GRIN2A mRNA21782745
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GRIN2A mRNA24763279
D006220HaloperidolHaloperidol results in decreased expression of GRIN2A mRNA12608697|1586034
D006220HaloperidolHaloperidol results in decreased expression of GRIN2A protein18061412
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GRIN2A protein21179406
C010739ifenprodilifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2A protein]19474322
C010739ifenprodilifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]22824136
D007203Indigo Carmine[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of GRIN2A protein23429044
D007203Indigo Carmine[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of GRIN2A protein23429044
D007608Kainic AcidCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA]21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIN2A mRNA21589914
D007649KetamineGRIN2A protein affects the susceptibility to Ketamine15731593
D007649KetamineKetamine results in increased expression of GRIN2A mRNA20080153
D007854LeadLead affects the expression of GRIN2A mRNA12480136
D007854LeadLead results in decreased expression of GRIN2A protein12480136
C008261lead acetatelead acetate results in increased expression of GRIN2A mRNA24260418
C008261lead acetateCholine analog affects the reaction [lead acetate results in decreased expression of GRIN2A mRNA]20381573
C008261lead acetatelead acetate affects the expression of GRIN2A mRNA22362014
C008261lead acetatelead acetate results in decreased expression of GRIN2A mRNA20381573|2216088
C008261lead acetatelead acetate results in decreased expression of GRIN2A protein20381573
C008261lead acetatelead acetate results in increased expression of GRIN2A mRNA15973774
C017461lead nitratelead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]11891201
C045463leflunomideleflunomide results in increased expression of GRIN2A mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of GRIN2A mRNA"21290410
C009900lipoteichoic acid[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA18926851|1965380
C009900lipoteichoic acid[Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA18926851|1965380
D008094Lithium[Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2A protein16600505
D008345ManganeseManganese results in decreased expression of GRIN2A mRNA19643132|2920566
D008345ManganeseManganese results in decreased expression of GRIN2A protein19643132|2920566
C025340manganese chloridemanganese chloride results in decreased expression of GRIN2A mRNA20175136
C025340manganese chloridemanganese chloride results in decreased expression of GRIN2A protein20175136
C042720mercuric bromidemercuric bromide results in decreased expression of GRIN2A mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of GRIN2A mRNA18419818
D003915DextromethorphanDextromethorphan results in increased expression of GRIN2A protein28916251
D008727MethotrexateMethotrexate results in increased expression of GRIN2A mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRIN2A mRNA19409459|2222348
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRIN2A protein22223486
C004925methylmercuric chloridePolyphenols inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]22223486
C004925methylmercuric chloridePolyphenols inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein]22223486
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GRIN2A mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRIN2A mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of GRIN2A mRNA28688903
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of GRIN2A mRNA28688903
D008874MidazolamGRIN2A protein affects the susceptibility to Midazolam15731593
D008911MinocyclineMinocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA]19660546
D009020MorphineGRIN2A protein affects the susceptibility to Morphine12878694
D009020MorphineMorphine results in increased expression of GRIN2A protein12878694
D009284NaphtholsNaphthols metabolite results in decreased activity of [GRIN1 protein binds to GRIN2A protein]20858708
D009532NickelNickel results in decreased expression of GRIN2A mRNA24768652|2558310
C017557nickel subsulfidenickel subsulfide results in decreased activity of GRIN2A protein21182900
D009609Nitrous OxideGRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane]15731593
C008661nobiletinnobiletin results in increased expression of GRIN2A mRNA24964900
C024268n-propylbenzenen-propylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]11090101
C025589ochratoxin Aochratoxin A results in increased expression of GRIN2A mRNA27346841
D010069OxadiazolesOxadiazoles metabolite results in decreased activity of [GRIN1 protein binds to GRIN2A protein]20858708
D010126Ozone[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in decreased expression of GRIN2A mRNA25361045
D010126Ozone[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in decreased expression of GRIN2A mRNA25361045
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
D010269ParaquatParaquat results in increased expression of GRIN2A mRNA22563483
D010269ParaquatParaquat results in increased expression of GRIN2A mRNA18198484
D052638Particulate Matter[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in decreased expression of GRIN2A mRNA25361045
D052638Particulate Matter[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA18926851|1965380
D052638Particulate MatterParticulate Matter results in decreased expression of GRIN2A mRNA26291742
D052638Particulate MatterParticulate Matter results in increased expression of GRIN2A mRNA21663545
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2A mRNA"25510870
D010424PentobarbitalGRIN2A protein affects the susceptibility to Pentobarbital15731593
D010424PentobarbitalPentobarbital affects the expression of GRIN2A mRNA9814547
D010575PesticidesPesticides results in decreased methylation of GRIN2A gene28396702
D015232DinoprostoneGRIN2A results in increased susceptibility to Dinoprostone9113374
D010616PhenanthrenesPhenanthrenes binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]14718249
D010616PhenanthrenesPhenanthrenes metabolite results in increased activity of [GRIN1 protein binds to GRIN2A protein]20858708
D010622PhencyclidinePhencyclidine results in decreased expression of GRIN2A mRNA20659557
D010622PhencyclidinePhencyclidine results in decreased expression of GRIN2A protein20659557
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRIN2A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GRIN2A mRNA26272509
D010862Pilocarpine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]22824136
D010862Pilocarpineifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]22824136
D010862Pilocarpine[Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2A protein16600505
D010862PilocarpinePilocarpine results in decreased expression of GRIN2A protein15857427
D010862PilocarpinePilocarpine results in increased expression of GRIN2A protein22824136
C006253pirinixic acidpirinixic acid results in increased expression of GRIN2A mRNA20813756
D011066Poly CMinocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA]19660546
D011066Poly CPoly C results in increased expression of GRIN2A mRNA19660546
D059808PolyphenolsPolyphenols inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]22223486
D059808PolyphenolsPolyphenols inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein]22223486
C576297ponceau 4R[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of GRIN2A protein23429044
C576297ponceau 4R[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of GRIN2A protein23429044
C024273profenofosprofenofos results in decreased expression of GRIN2A mRNA17569032
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GRIN2A mRNA22154832
D015742PropofolGRIN2A protein affects the susceptibility to Propofol15731593
D011441PropylthiouracilPropylthiouracil results in decreased expression of GRIN2A mRNA24780913
D000548Amaranth Dye[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of GRIN2A protein23429044
D000548Amaranth Dye[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of GRIN2A protein23429044
C089032rimonabantrimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIN2A]19912468
C065286SDZ EAA 494SDZ EAA 494 binds to and results in decreased activity of [GRIN2A protein binds to GRIN1 protein]14718249
C009250sevofluraneGRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane]15731593
D012834SilverSilver results in decreased expression of GRIN2A protein27593553
D012834SilverSilver results in increased expression of GRIN2A mRNA26551752
C017947sodium arsenitesodium arsenite affects the methylation of GRIN2A gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of GRIN2A29204679
C017947sodium arsenitesodium arsenite results in decreased expression of GRIN2A mRNA19041379
C017947sodium arsenitesodium arsenite results in decreased expression of GRIN2A protein22421273
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of GRIN2A mRNA25534910
D013605T-2 ToxinT-2 Toxin results in increased expression of GRIN2A mRNA26314264
D013645Tartrazine[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of GRIN2A protein23429044
D013645Tartrazine[ponceau 4R co-treated with Allura Red AC Dye co-treated with FD & C Yellow No. 6 co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of GRIN2A protein23429044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GRIN2A mRNA11742229|1683960
D013779TetrodotoxinTetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2A protein]25945544
C009495titanium dioxidetitanium dioxide results in decreased expression of GRIN2A mRNA25411160
C009495titanium dioxidetitanium dioxide results in decreased expression of GRIN2A protein25411160
D014050TolueneToluene results in increased expression of GRIN2A mRNA17870172|2080478
D014050TolueneToluene results in increased expression of GRIN2A protein15695158
D014050TolueneToluene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]9655877
C011559tributyltintributyltin results in decreased expression of GRIN2A mRNA19591855
C012589trichostatin Atrichostatin A results in decreased expression of GRIN2A mRNA24935251
D014520UrethaneUrethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]11812690
D014635Valproic AcidValproic Acid affects the expression of GRIN2A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRIN2A mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of GRIN2A mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of GRIN2A protein17675408
D001335Vehicle Emissions[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in decreased expression of GRIN2A mRNA25361045
D001335Vehicle Emissions[Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA18926851|1965380
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of GRIN2A mRNA26291742
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GRIN2A gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of GRIN2A mRNA21663545
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride affects the expression of GRIN2A mRNA25423262
D014992XylenesXylenes results in decreased activity of [GRIN1 protein binds to GRIN2A protein]11090101
D015032ZincZinc results in decreased activity of GRIN2A protein16822975
C016837zinc chlorideAG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of GRIN2A protein]12211081
C016837zinc chloridezinc chloride results in increased expression of and results in increased phosphorylation of GRIN2A protein12211081

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004972NMDA glutamate receptor activity-IBA21873635  
GO:0004972NMDA glutamate receptor activity-ISS-  
GO:0004972NMDA glutamate receptor activity-TAS17526495  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO:0005515protein binding-IPI10748123  11937501  17360663  17997397  
GO:0008270zinc ion binding-ISS-  
GO:0022849glutamate-gated calcium ion channel activity-IDA26875626  
GO:0022849glutamate-gated calcium ion channel activity-IMP27839871  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001964startle response-IEA-  
GO:0001975response to amphetamine-IEA-  
GO:0007215glutamate receptor signaling pathway-TAS8768735  
GO:0007268chemical synaptic transmission-TAS7816096  
GO:0007420brain development-NAS17526495  
GO:0007611learning or memory-TAS7816096  
GO:0007613memory-IEA-  
GO:0008542visual learning-IEA-  
GO:0009611response to wounding-IEA-  
GO:0019233sensory perception of pain-IEA-  
GO:0019722calcium-mediated signaling-IEA-  
GO:0022008neurogenesis-IEA-  
GO:0030431sleep-IEA-  
GO:0033058directional locomotion-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-IEA-  
GO:0042177negative regulation of protein catabolic process-IEA-  
GO:0042417dopamine metabolic process-IEA-  
GO:0042428serotonin metabolic process-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0045471response to ethanol-IDA18445116  
GO:0048167regulation of synaptic plasticity-NAS17526495  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0060079excitatory postsynaptic potential-IBA21873635  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060291long-term synaptic potentiation-IBA21873635  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0097202activation of cysteine-type endopeptidase activity-TAS17526495  
GO:0097553calcium ion transmembrane import into cytosol-IDA26875626  
GO:0097553calcium ion transmembrane import into cytosol-IMP27839871  
GO:0098976excitatory chemical synaptic transmission-NAS17526495  
GO:1900273positive regulation of long-term synaptic potentiation-IEA-  
GO:1903539protein localization to postsynaptic membrane-IEA-  
GO:1904646cellular response to amyloid-betaNOTIGI21883149  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA27839871  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA26875626  
GO:0008021synaptic vesicle-IEA-  
GO:0009986cell surface-ISS-  
GO:0014069postsynaptic density-ISS-  
GO:0017146NMDA selective glutamate receptor complex-IBA21873635  
GO:0017146NMDA selective glutamate receptor complex-IDA10480938  26875626  
GO:0017146NMDA selective glutamate receptor complex-TAS17526495  
GO:0030054cell junction-IEA-  
GO:0042734presynaptic membrane-IEA-  
GO:0043005neuron projection-IEA-  
GO:0097060synaptic membrane-ISS-  
GO:0098839postsynaptic density membrane-IBA21873635  
GO:0099061integral component of postsynaptic density membrane-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04720Long-term potentiation
hsa05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-438066Unblocking of NMDA receptor, glutamate binding and activationTAS
R-HSA-442729CREB phosphorylation through the activation of CaMKIITAS
R-HSA-442742CREB phosphorylation through the activation of RasTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-442982Ras activation upon Ca2+ influx through NMDA receptorTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26289945The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving. (2015 Nov)Bach PAddict Biol
19268276Genome-wide association study of smoking initiation and current smoking. (2009 Mar)Vink JMAm J Hum Genet
25939814CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. (2015 Aug)Chen JHum Brain Mapp
26277529Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry. (2016 Jan 4)Levran OProg Neuropsychopharmacol Biol Psychiatry
23940648Analysis of variations in the glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene reveals their relative importance as genetic susceptibility factors for heroin addiction. (2013)Zhao BPLoS One
29704590Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. (2018 Apr 25)Yawalkar RNeurochem Int
21507155Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism. (2012 Jul)Domart MCAddict Biol
27490364High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model. (2016 Aug)Lo CLPLoS Genet