Gene info: ID 2904

Gene: GRIN2B

GENE ID: 2904

Synonyms: EIEE27|GluN2B|MRD6|NMDAR2B|NR2B|NR3|hNR3

Description: glutamate ionotropic receptor NMDA type subunit 2B

Gene type: protein-coding

Location: 12p13.1

dbXrefs: Ensembl:ENSG00000273079 MIM:138252 Vega:OTTHUMG00000137373 UniprotKB:Q13224

RefSeq: NG_031854.2

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 17

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.464e-1 (AD) 6.226e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4763358	chr12:13720757 (GRCh38.p7)	G>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs7313149	chr12:13675353 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs12423978	chr12:13556918 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14351692	chr12:13716374	GRIN2B		2.910e-9	Alcohol consumption per day	27843151

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLXNA4	0.959
CHRNB2	0.959
TMEM178B	0.956
TMEM132D	0.949
WSCD2	0.947
KIAA1549L	0.946
DLG3	0.946
ATP8A2	0.944
UNC13A	0.944
LNX1	0.943

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.658
MYL3	-0.651
YES1	-0.649
RAB13	-0.642
COPZ2	-0.634
RNF135	-0.622
SNHG18	-0.619
ROM1	-0.618
REST	-0.613
GNG11	-0.61

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB00454	Pethidine	Small Molecule	57-42-1	Approved	Target
DB00502	Haloperidol	Small Molecule	52-86-8	Approved	Target
DB00949	Felbamate	Small Molecule	25451-15-4	Approved	Target
DB01043	Memantine	Small Molecule	19982-08-2	Approved\|Investigational	Target
DB01520	Tenocyclidine	Small Molecule	21500-98-1	Experimental\|Illicit\|Investigational	Target
DB01956	Taurine	Small Molecule	107-35-7	Approved\|Nutraceutical	Target
DB05956	EVT-101	Small Molecule	1189088-41-2	Investigational	Target
DB06151	Acetylcysteine	Small Molecule	616-91-1	Approved\|Investigational	Target
DB08954	Ifenprodil	Small Molecule	23210-56-2	Approved\|Investigational\|Withdrawn	Target
DB00659	Acamprosate	Small Molecule	77337-76-9	Approved\|Investigational	Target
DB06741	Gavestinel	Small Molecule	153436-22-7	Investigational	Target
DB09409	Magnesium acetate tetrahydrate	Small Molecule	16674-78-5	Approved	Target
DB09481	Magnesium carbonate	Small Molecule	546-93-0	Approved\|Investigational	Target
DB13146	Fluciclovine (18F)	Small Molecule	222727-39-1	Approved	Target
DB00289	Atomoxetine	Small Molecule	83015-26-3	Approved	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00418	Secobarbital	Small Molecule	76-73-3	Approved	Target
DB00996	Gabapentin	Small Molecule	60142-96-3	Approved\|Investigational	Target
DB01174	Phenobarbital	Small Molecule	50-06-6	Approved\|Investigational	Target
DB01708	Prasterone	Small Molecule	53-43-0	Approved\|Investigational\|Nutraceutical	Target
DB04896	Milnacipran	Small Molecule	92623-85-3	Approved\|Investigational	Target
DB06738	Ketobemidone	Small Molecule	469-79-4	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C024566	1,1,1-trichloroethane	"1,1,1-trichloroethane results in decreased activity of [GRIN1 protein binds to GRIN2B protein]"	11090101
C582212	1NMPP1 compound	[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of GRIN2B mRNA	27417517
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	25510870
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2B mRNA"	21190954
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	21277884
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIN2B protein"	17589592
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIN2B mRNA"	22467012
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIN2B protein"	22467012
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]	22824136
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIN2B mRNA"	19114083
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2B mRNA"	21190954
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	21277884
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	25510870
C570545	2-(4-benzylpiperidin-1-yl)-1-(6-hydroxy-1H-indol-3-yl)ethanone	2-(4-benzylpiperidin-1-yl)-1-(6-hydroxy-1H-indol-3-yl)ethanone inhibits the reaction [ifenprodil binds to GRIN2B protein]	22050212
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	25510870
C491996	(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid	"(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid analog binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]"	14718249
C491996	(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid	"(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]"	14718249
C050592	3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid	3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]	14718249
C104750	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole results in increased phosphorylation of GRIN2B protein	16407246
C104750	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole	FYN gene mutant form inhibits the reaction [3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole results in increased phosphorylation of GRIN2B protein]	16407246
C111258	4-(3-(4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl)-2-hydroxy-propoxy)-benzamide	"4-(3-(4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl)-2-hydroxy-propoxy)-benzamide binds to and results in decreased activity of GRIN2B protein"	9729614
C111258	4-(3-(4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl)-2-hydroxy-propoxy)-benzamide	"Spermine inhibits the reaction [4-(3-(4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl)-2-hydroxy-propoxy)-benzamide binds to and results in decreased activity of GRIN2B protein]"	9729614
C488633	5-(3-(4-benzylpiperidin-1-yl)prop-1-ynyl)-1,3-dihydrobenzoimidazol-2-((11)C)one	"5-(3-(4-benzylpiperidin-1-yl)prop-1-ynyl)-1,3-dihydrobenzoimidazol-2-((11)C)one binds to and results in decreased activity of GRIN2B protein"	14642584
C498554	5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione	"5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]"	14718249
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]	22824136
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GRIN2B gene	27153756
C412373	AG 1879	AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of GRIN2B protein]	12211081
D000376	Agmatine	Agmatine results in decreased activity of [GRIN2B protein binds to GRIN1 protein]	15982768
C010845	aluminum chloride	aluminum chloride results in decreased expression of GRIN2B protein	21619818
D000602	Amino Acids, Peptides, and Proteins	"Amino Acids, Peptides, and Proteins results in increased expression of GRIN2B protein"	23313464
D000602	Amino Acids, Peptides, and Proteins	"praeruptorin C inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of GRIN2B protein]"	23313464
D015074	2-Aminoadipic Acid	2-Aminoadipic Acid binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]	14718249
C018824	ammonium acetate	ammonium acetate results in decreased expression of GRIN2B protein	20084674
D000643	Ammonium Chloride	GRIN2B protein affects the susceptibility to Ammonium Chloride	12971910
D000661	Amphetamine	Amphetamine affects the localization of GRIN2B protein	19349975
D000661	Amphetamine	Amphetamine results in decreased expression of GRIN2B protein	19349975
D000661	Amphetamine	Amphetamine results in increased expression of GRIN2B mRNA	20422365
D000661	Amphetamine	Amphetamine results in increased expression of GRIN2B protein	20422365
D000661	Amphetamine	GRIN2B protein results in decreased susceptibility to Amphetamine	19349975
D000661	Amphetamine	rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B mRNA]	20422365
D000661	Amphetamine	rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B protein]	20422365
C015001	arsenite	arsenite results in increased methylation of GRIN2B promoter	23974009
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of GRIN2B mRNA"	18687144
D001280	Atrazine	Atrazine results in decreased expression of GRIN2B mRNA	25929836
D001374	Azacitidine	Azacitidine results in decreased methylation of GRIN2B gene	18618247
D001554	Benzene	Benzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]	11090101
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GRIN2B mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GRIN2B mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GRIN2B mRNA	17606297
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GRIN2B protein	17606297
C481484	besonprodil	besonprodil binds to and results in decreased activity of GRIN2B protein	20303391
D004958	Estradiol	bisphenol A inhibits the reaction [Estradiol results in increased phosphorylation of GRIN2B protein]	20858508
D004958	Estradiol	Estradiol results in increased phosphorylation of GRIN2B protein	20858508
C006780	bisphenol A	bisphenol A results in decreased expression of GRIN2B mRNA	25385582
C006780	bisphenol A	bisphenol A results in decreased expression of GRIN2B protein	20206181\|2857202
C006780	bisphenol A	bisphenol A results in decreased methylation of GRIN2B promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of GRIN2B mRNA	22687993
C006780	bisphenol A	bisphenol A results in increased methylation of GRIN2B promoter	25385582
C006780	bisphenol A	diphenyldiselenide inhibits the reaction [bisphenol A results in decreased expression of GRIN2B protein]	28572023
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2B mRNA	25607892
C006780	bisphenol A	bisphenol A inhibits the reaction [Estradiol results in increased phosphorylation of GRIN2B protein]	20858508
C006780	bisphenol A	bisphenol A results in decreased expression of GRIN2B mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of GRIN2B protein	20821433
C006780	bisphenol A	bisphenol A results in increased methylation of GRIN2B gene	28505145
C006780	bisphenol A	bisphenol A results in increased phosphorylation of GRIN2B protein	20858508\|2176333
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN2B protein]	20858508\|2176333
C006780	bisphenol A	U 0126 inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN2B protein]	21763338
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2B mRNA	25607892
D002211	Capsaicin	Capsaicin results in increased phosphorylation of GRIN2B protein	18577691
D002211	Capsaicin	capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of GRIN2B protein]	18577691
D002211	Capsaicin	Excitatory Amino Acid Antagonists inhibits the reaction [Capsaicin results in increased phosphorylation of GRIN2B protein]	18577691
C071423	capsazepine	capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of GRIN2B protein]	18577691
D002245	Carbon Dioxide	ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]	24718106
D002245	Carbon Dioxide	Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]	24718106
D002245	Carbon Dioxide	[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein	24718106
D000068579	Celecoxib	Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA]	21589914
D002738	Chloroquine	"Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of GRIN2B]"	26327526
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of GRIN2B mRNA	17452286\|1944049
D002794	Choline	Choline analog affects the reaction [lead acetate results in decreased expression of GRIN2B mRNA]	20381573
C466858	ciguatoxin 3C	ciguatoxin 3C results in decreased expression of GRIN2B protein	25945544
C466858	ciguatoxin 3C	Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2B protein]	25945544
D015283	Citalopram	Citalopram results in decreased expression of GRIN2B protein	23260230
D003024	Clozapine	Clozapine results in decreased expression of GRIN2B mRNA	18923069
D003042	Cocaine	Cocaine affects the expression of GRIN2B mRNA	20187946
D003042	Cocaine	Cocaine affects the expression of GRIN2B protein	11032893\|1514020
D003042	Cocaine	Cocaine results in decreased phosphorylation of GRIN2B protein	16794574
D003042	Cocaine	Cocaine results in increased expression of GRIN2B protein	11801363\|1679457
D003042	Cocaine	Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]	11801363
D003042	Cocaine	GRIN2B protein affects the susceptibility to Cocaine	11801363
D003042	Cocaine	ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]	19474322
D003042	Cocaine	Ondansetron inhibits the reaction [Cocaine results in decreased phosphorylation of GRIN2B protein]	16794574
D003042	Cocaine	Ondansetron inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]	16794574
D005576	Colforsin	Colforsin results in increased expression of GRIN2B mRNA	20067577
D005576	Colforsin	Colforsin results in increased expression of GRIN2B protein	20067577
D005576	Colforsin	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of GRIN2B protein]	20067577
C055407	conotoxin GV	conotoxin GV results in decreased activity of [GRIN1A protein co-treated with GRIN2B protein]	21396956
C037304	cyhalothrin	cyhalothrin results in decreased expression of GRIN2B mRNA	28487251
C037304	cyhalothrin	cyhalothrin results in decreased expression of GRIN2B protein	28487251
D013759	Dronabinol	CNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of GRIN2B]	19912468
D013759	Dronabinol	Dronabinol results in decreased expression of and results in increased import of GRIN2B protein	19912468
D013759	Dronabinol	Dronabinol results in decreased expression of GRIN2B mRNA	19912468
D013759	Dronabinol	rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIN2B]	19912468
D003907	Dexamethasone	Dexamethasone results in decreased expression of GRIN2B mRNA	20032058
D003907	Dexamethasone	Dexamethasone results in increased expression of GRIN2B mRNA	29111458
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of GRIN2B mRNA]	20032058
D003976	Diazinon	Diazinon results in decreased expression of GRIN2B mRNA	23212306
D003976	Diazinon	Diazinon results in decreased expression of GRIN2B mRNA	19440498
D003993	Dibutyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA	25607892
D003633	Dichlorodiphenyl Dichloroethylene	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA	25607892
D004026	Dieldrin	Dieldrin results in decreased expression of GRIN2B mRNA	19440498
D004041	Dietary Fats	Dietary Fats results in increased expression of GRIN2B mRNA	25016146
D004051	Diethylhexyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA	25607892
C061132	diphenyldiselenide	diphenyldiselenide inhibits the reaction [bisphenol A results in decreased expression of GRIN2B protein]	28572023
D016291	Dizocilpine Maleate	[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate	19224577
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]	11801363
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]	28916251
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in decreased expression of GRIN2B mRNA	11169168
D007980	Levodopa	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of GRIN2B protein]	16365282
C108194	EMD 95885	EMD 95885 binds to and results in decreased activity of GRIN2B protein	15158791
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2B mRNA	25607892
C109476	epoxiconazole	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA	25607892
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in decreased expression of GRIN2B mRNA	21190954
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of GRIN2B mRNA	21277884
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein	21763338
C074283	estradiol 3-benzoate	fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein]	21763338
C074283	estradiol 3-benzoate	U 0126 inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein]	21763338
D000431	Ethanol	Ethanol results in decreased expression of GRIN2B mRNA	20655511
D000431	Ethanol	"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRIN2B mRNA]"	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GRIN2B mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2B mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GRIN2B mRNA	29097150
C004912	ethylbenzene	ethylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]	11090101
D018690	Excitatory Amino Acid Agonists	Excitatory Amino Acid Agonists results in decreased expression of GRIN2B mRNA	28987794
D018690	Excitatory Amino Acid Agonists	[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Excitatory Amino Acid Agonists	19224577
D018691	Excitatory Amino Acid Antagonists	Excitatory Amino Acid Antagonists inhibits the reaction [Capsaicin results in increased phosphorylation of GRIN2B protein]	18577691
C047360	felbamate	felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]	10690753
C047360	felbamate	GRIN2B protein binds to felbamate	18311896
C047360	felbamate	felbamate binds to and results in decreased activity of [GRIN1 protein binds to GRIN2B protein]	10215667
D005411	Flame Retardants	Flame Retardants results in decreased expression of GRIN2B protein	17589592
D005557	Formaldehyde	Formaldehyde results in increased expression of GRIN2B mRNA	12679049
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN2B protein]	20858508\|2176333
C070081	fulvestrant	fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein]	21763338
D006220	Haloperidol	FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein]	16407246
D006220	Haloperidol	Haloperidol results in increased phosphorylation of GRIN2B protein	16407246
D017313	Fenretinide	Fenretinide results in decreased expression of GRIN2B mRNA	28973697
C010739	ifenprodil	ifenprodil binds to and results in decreased activity of GRIN2B protein	9729614
C010739	ifenprodil	ifenprodil binds to GRIN2B protein	21192972
C010739	ifenprodil	ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]	19474322
C010739	ifenprodil	ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]	24718106
C010739	ifenprodil	ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]	22824136
C010739	ifenprodil	ifenprodil results in decreased activity of GRIN2B protein	16822975
C010739	ifenprodil	Magnesium inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein]	9729614
C010739	ifenprodil	Spermine inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein]	9729614
C010739	ifenprodil	[Zinc co-treated with ifenprodil] results in decreased activity of GRIN2B protein	16822975
C010739	ifenprodil	2-(4-benzylpiperidin-1-yl)-1-(6-hydroxy-1H-indol-3-yl)ethanone inhibits the reaction [ifenprodil binds to GRIN2B protein]	22050212
C010739	ifenprodil	ifenprodil binds to and results in decreased activity of GRIN2B protein	15140647\|1947432
C010739	ifenprodil	ifenprodil binds to GRIN2B protein	22050212
C010739	ifenprodil	ifenprodil results in decreased activity of GRIN2B protein	19776659
D015759	Ionomycin	Ionomycin promotes the reaction [CAMK2A protein binds to GRIN2B protein]	19217379
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of GRIN2B mRNA	26752646
D007608	Kainic Acid	Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA]	21589914
D007608	Kainic Acid	Kainic Acid results in decreased expression of GRIN2B mRNA	21589914
D007649	Ketamine	Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein]	20042082
D007854	Lead	Lead affects the expression of GRIN2B mRNA	12480136
C008261	lead acetate	lead acetate results in decreased expression of GRIN2B protein	25242007
C008261	lead acetate	lead acetate results in increased expression of GRIN2B mRNA	24260418
C008261	lead acetate	Choline analog affects the reaction [lead acetate results in decreased expression of GRIN2B mRNA]	20381573
C008261	lead acetate	lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]	12480136
C008261	lead acetate	[lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]] which results in decreased phosphorylation of CREB1 protein	12480136
C008261	lead acetate	lead acetate results in decreased expression of GRIN2B mRNA	20381573\|2216088
C008261	lead acetate	lead acetate results in decreased expression of GRIN2B protein	20381573
C045463	leflunomide	leflunomide results in decreased expression of GRIN2B mRNA	28988120
D008044	Linuron	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA	25607892
C009900	lipoteichoic acid	lipoteichoic acid results in increased expression of GRIN2B mRNA	19653804
C009900	lipoteichoic acid	[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA	18926851
C009900	lipoteichoic acid	Particulate Matter promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA]	19653804
C009900	lipoteichoic acid	[Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA	18926851
C009900	lipoteichoic acid	Vehicle Emissions promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA]	19653804
D008094	Lithium	[Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2B protein	16600505
D008148	Lovastatin	Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]	24718106
D008274	Magnesium	Magnesium inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein]	9729614
D008345	Manganese	Manganese results in decreased expression of GRIN2B mRNA	19643132\|2920566
D008345	Manganese	Manganese results in decreased expression of GRIN2B protein	19643132\|2920566
C025340	manganese chloride	manganese chloride results in decreased expression of GRIN2B mRNA	20175136
C025340	manganese chloride	manganese chloride results in decreased expression of GRIN2B protein	20175136
D008694	Methamphetamine	Methamphetamine results in increased expression of GRIN2B protein	17105907
D008694	Methamphetamine	Methamphetamine results in increased expression of GRIN2B mRNA	18419818
D003915	Dextromethorphan	Dextromethorphan results in increased expression of GRIN2B protein	28916251
D003915	Dextromethorphan	Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]	28916251
D003915	Dextromethorphan	traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]	28916251
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of GRIN2B protein	27012723
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GRIN2B mRNA	19409459\|2222348
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRIN2B mRNA"	20188158
D009020	Morphine	MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]	20519536
D009020	Morphine	Morphine results in increased phosphorylation of GRIN2B protein	20519536
D009020	Morphine	Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]	22713680
D009020	Morphine	Morphine results in increased expression of GRIN2B protein	22713680
D009020	Morphine	resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]	22713680
D009020	Morphine	resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]	22713680
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of GRIN2B protein]	20067577
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Sulfur Dioxide results in increased cleavage of GRIN2B protein]	21873648
D037742	Nanotubes, Carbon	"Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of GRIN2B]"	26327526
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GRIN2B"	26327526
D009284	Naphthols	Naphthols metabolite results in decreased activity of [GRIN1 protein binds to GRIN2B protein]	20858708
D009532	Nickel	Nickel results in decreased expression of GRIN2B mRNA	19440498
C017557	nickel subsulfide	nickel subsulfide results in increased activity of GRIN2B protein	21182900
C520612	N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid	"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRIN2B mRNA]"	20655511
C008661	nobiletin	nobiletin results in increased expression of GRIN2B mRNA	24964900
C072936	notoginsenoside R1	[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to notoginsenoside R1	19224577
C024268	n-propylbenzene	n-propylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]	11090101
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2B mRNA	25607892
D016627	Oxidopamine	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of GRIN2B protein]	16365282
D016627	Oxidopamine	Oxidopamine results in decreased expression of GRIN2B protein	16365282
D017294	Ondansetron	Ondansetron inhibits the reaction [Cocaine results in decreased phosphorylation of GRIN2B protein]	16794574
D017294	Ondansetron	Ondansetron inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]	16794574
D010069	Oxadiazoles	Oxadiazoles metabolite results in decreased activity of [GRIN1 protein binds to GRIN2B protein]	20858708
D010100	Oxygen	ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]	24718106
D010100	Oxygen	Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]	24718106
D010100	Oxygen	[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein	24718106
D010269	Paraquat	Paraquat results in increased expression of GRIN2B mRNA	22563483
D010269	Paraquat	Paraquat affects the expression of GRIN2B mRNA	15206577
D052638	Particulate Matter	[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA	18926851
D052638	Particulate Matter	Particulate Matter promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA]	19653804
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	25510870
C410127	PCB 180	"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2B mRNA"	21190954
C410127	PCB 180	"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GRIN2B mRNA"	21277884
D010424	Pentobarbital	Pentobarbital affects the expression of GRIN2B mRNA	9814547
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of GRIN2B mRNA	19756518\|1995407
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of GRIN2B protein	19954077
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of GRIN2B mRNA	19756518
D010616	Phenanthrenes	Phenanthrenes binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]	14718249
D010616	Phenanthrenes	Phenanthrenes metabolite results in increased activity of [GRIN1 protein binds to GRIN2B protein]	20858708
D010862	Pilocarpine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]	22824136
D010862	Pilocarpine	Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]	22824136
D010862	Pilocarpine	ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]	22824136
D010862	Pilocarpine	[Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2B protein	16600505
D010862	Pilocarpine	Pilocarpine results in decreased expression of GRIN2B protein	15857427
D010862	Pilocarpine	Pilocarpine results in increased expression of GRIN2B protein	22824136
D010879	Piperazines	Piperazines metabolite binds to and results in decreased activity of GRIN2B protein	19684252
C006253	pirinixic acid	pirinixic acid results in decreased expression of GRIN2B mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in increased expression of GRIN2B mRNA	20813756
D010936	Plant Extracts	Plant Extracts results in decreased expression of GRIN2B mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of GRIN2B mRNA	23608068
C058808	praeruptorin C	"praeruptorin C inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of GRIN2B protein]"	23313464
C045362	prochloraz	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA	25607892
C035988	procymidone	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA	25607892
D011441	Propylthiouracil	Propylthiouracil results in increased expression of GRIN2B mRNA	24780913
C023666	pyridine	pyridine analog binds to and results in decreased activity of GRIN2B protein	17768047
C071741	remifentanil	Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein]	20042082
C071741	remifentanil	remifentanil results in increased phosphorylation of GRIN2B protein	20042082
C059514	resveratrol	resveratrol results in decreased expression of GRIN2B mRNA	27070252
C059514	resveratrol	resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]	22713680
C059514	resveratrol	resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]	22713680
C052714	rhyncophylline	rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B mRNA]	20422365
C052714	rhyncophylline	rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B protein]	20422365
C089032	rimonabant	rimonabant inhibits the reaction [Dronabinol results in decreased expression of GRIN2B]	19912468
C109643	Ro 25-6981	Ro 25-6981 binds to and results in decreased activity of GRIN2B protein	21182900
D012524	Sarin	Sarin results in increased expression of GRIN2B mRNA	19522546
C065286	SDZ EAA 494	SDZ EAA 494 binds to and results in decreased activity of [GRIN2B protein binds to GRIN1 protein]	14718249
D012834	Silver	Silver results in decreased expression of GRIN2B protein	27593553
C017947	sodium arsenite	sodium arsenite results in decreased expression of GRIN2B	29204679
D013096	Spermine	"Spermine inhibits the reaction [4-(3-(4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl)-2-hydroxy-propoxy)-benzamide binds to and results in decreased activity of GRIN2B protein]"	9729614
D013096	Spermine	Spermine inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein]	9729614
D013458	Sulfur Dioxide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Sulfur Dioxide results in increased cleavage of GRIN2B protein]	21873648
D013458	Sulfur Dioxide	Sulfur Dioxide results in decreased expression of GRIN2B mRNA	25534910
D013458	Sulfur Dioxide	Sulfur Dioxide results in increased cleavage of GRIN2B protein	21873648
D013467	Sulindac	Sulindac affects the expression of GRIN2B protein	15123337
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of GRIN2B mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2B mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GRIN2B mRNA	11742229\|1683960
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GRIN2B protein	16839606
D013779	Tetrodotoxin	Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2B protein]	25945544
D013849	Thimerosal	Thimerosal results in decreased expression of GRIN2B protein	15184908
C009495	titanium dioxide	titanium dioxide results in decreased expression of GRIN2B mRNA	25411160
C009495	titanium dioxide	titanium dioxide results in decreased expression of GRIN2B protein	25411160
D014050	Toluene	Toluene results in increased expression of GRIN2B mRNA	16737738\|2080478
D014050	Toluene	Toluene results in increased expression of GRIN2B protein	15695158
D014050	Toluene	Toluene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]	9655877
C095106	traxoprodil mesylate	traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]	28916251
C095106	traxoprodil mesylate	traxoprodil mesylate results in decreased activity of GRIN2B protein	20673310
C095106	traxoprodil mesylate	traxoprodil mesylate binds to and results in decreased activity of GRIN2B protein	15140647\|1875935
D014212	Tretinoin	Tretinoin results in increased expression of GRIN2B protein	17460065
C011559	tributyltin	tributyltin results in increased expression of GRIN2B mRNA	19591855
C046488	trimethyltin	trimethyltin results in decreased expression of GRIN2B mRNA	24002884
C025541	tri-o-cresyl phosphate	tri-o-cresyl phosphate results in decreased expression of GRIN2B protein	25199799
C113580	U 0126	U 0126 inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN2B protein]	21763338
C113580	U 0126	U 0126 inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein]	21763338
D014635	Valproic Acid	Valproic Acid results in increased methylation of GRIN2B gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of GRIN2B protein	17675408
D001335	Vehicle Emissions	[Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA	18926851
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA]	19653804
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride affects the expression of GRIN2B mRNA	25423262
C025643	vinclozolin	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA	25607892
D014992	Xylenes	Xylenes results in decreased activity of [GRIN1 protein binds to GRIN2B protein]	11090101
D015032	Zinc	[Zinc co-treated with ifenprodil] results in decreased activity of GRIN2B protein	16822975
D015032	Zinc	Zinc results in decreased activity of GRIN2B protein	16822975
C016837	zinc chloride	AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of GRIN2B protein]	12211081
C016837	zinc chloride	zinc chloride results in increased expression of and results in increased phosphorylation of GRIN2B protein	12211081

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004972	NMDA glutamate receptor activity	-	IBA	21873635
GO:0004972	NMDA glutamate receptor activity	-	IDA	26919761
GO:0004972	NMDA glutamate receptor activity	-	ISS	-
GO:0004972	NMDA glutamate receptor activity	-	TAS	17526495
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005234	extracellularly glutamate-gated ion channel activity	-	IEA	-
GO:0005515	protein binding	-	IPI	11937501 17047094 17997397 19453375 20018661
GO:0008270	zinc ion binding	-	ISS	-
GO:0016594	glycine binding	-	IDA	17047094
GO:0016595	glutamate binding	-	ISS	-
GO:0022849	glutamate-gated calcium ion channel activity	-	IDA	26875626
GO:0022849	glutamate-gated calcium ion channel activity	-	IMP	27839871

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0007215	glutamate receptor signaling pathway	-	TAS	8768735
GO:0007268	chemical synaptic transmission	-	TAS	10485705
GO:0007275	multicellular organism development	-	TAS	17526495
GO:0007420	brain development	-	NAS	17526495
GO:0007611	learning or memory	-	ISS	-
GO:0019722	calcium-mediated signaling	-	IEA	-
GO:0035235	ionotropic glutamate receptor signaling pathway	-	IEA	-
GO:0045471	response to ethanol	-	IDA	18445116
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0048167	regulation of synaptic plasticity	-	NAS	17526495
GO:0051290	protein heterotetramerization	-	ISS	-
GO:0060079	excitatory postsynaptic potential	-	IBA	21873635
GO:0060079	excitatory postsynaptic potential	-	IEA	-
GO:0060291	long-term synaptic potentiation	-	IBA	21873635
GO:0097553	calcium ion transmembrane import into cytosol	-	IDA	26875626
GO:0097553	calcium ion transmembrane import into cytosol	-	IMP	27839871
GO:0098976	excitatory chemical synaptic transmission	-	NAS	17526495
GO:1901216	positive regulation of neuron death	-	ISS	-
GO:1902951	negative regulation of dendritic spine maintenance	-	ISS	-
GO:2001056	positive regulation of cysteine-type endopeptidase activity	-	ISS	17526495

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	ISS	17526495
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	27839871
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IDA	26875626 26919761
GO:0009986	cell surface	-	ISS	17526495
GO:0014069	postsynaptic density	-	ISS	-
GO:0017146	NMDA selective glutamate receptor complex	-	IBA	21873635
GO:0017146	NMDA selective glutamate receptor complex	-	IDA	10480938 17047094 26875626 26919761
GO:0017146	NMDA selective glutamate receptor complex	-	TAS	17526495
GO:0030054	cell junction	-	IEA	-
GO:0043005	neuron projection	-	ISS	-
GO:0045211	postsynaptic membrane	-	TAS	24607229
GO:0097060	synaptic membrane	-	ISS	-
GO:0098839	postsynaptic density membrane	-	IBA	21873635

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction
hsa04720	Long-term potentiation
hsa05010	Alzheimer's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05016	Huntington's disease
hsa05322	Systemic lupus erythematosus

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-3928662	EPHB-mediated forward signaling	TAS
R-HSA-3928662	EPHB-mediated forward signaling	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation	TAS
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	TAS
R-HSA-442742	CREB phosphorylation through the activation of Ras	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6794361	Neurexins and neuroligins	IEA
R-HSA-6794362	Protein-protein interactions at synapses	TAS
R-HSA-6794362	Protein-protein interactions at synapses	IEA
R-HSA-8849932	Synaptic adhesion-like molecules	TAS
R-HSA-9006115	Signaling by NTRK2 (TRKB)	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9032500	Activated NTRK2 signals through FYN	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25262781	Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. (2014 Nov)	Enoch MA	Genes Brain Behav
16911840	Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism. (2006 Oct)	Kim JH	Neurosci Res
26563126	Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders. (2016 Feb)	Dalvie S	Metab Brain Dis
16766085	GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype. (2006 Nov)	Buckley ST	Neurochem Int
25660313	Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)	Forero DA	Drug Alcohol Depend
28512340	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism. (2017 May 16)	Yang HC	Sci Rep
26771436	Association of N-Methyl-D-Aspartate receptor 2B Subunit (GRIN2B) polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects. (2017 Jan-Mar)	Paul P	J Addict Dis
20624154	Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. (2010 Jul)	Grucza RA	Addict Biol
24795156	A three-way parallel ICA approach to analyze links among genetics, brain structure and brain function. (2014 Sep)	Vergara VM	Neuroimage
25316095	GRIN2B predicts attention problems among disadvantaged children. (2015 Jul)	Riva V	Eur Child Adolesc Psychiatry
29704590	Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. (2018 Apr 25)	Yawalkar R	Neurochem Int
27498914	Genetic variation within GRIN2B in adolescents with alcohol use disorder may be associated with larger left posterior cingulate cortex volume. (2017 Aug)	Dalvie S	Acta Neuropsychiatr
23855403	Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. (2014 Sep)	Xie P	Addict Biol
28558131	An association between genetic variation in the glutamatergic system and suicide attempts in alcohol-dependent individuals. (2017 Sep)	Fudalej S	Am J Addict
19268276	Genome-wide association study of smoking initiation and current smoking. (2009 Mar)	Vink JM	Am J Hum Genet
28380057	Specific behavioral and cellular adaptations induced by chronic morphine are reduced by dietary omega-3 polyunsaturated fatty acids. (2017)	Hakimian J	PLoS One
28900078	[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. (2017 Jul-Aug)	Korytina GF	Mol Biol (Mosk)