Gene: ZC3H7A

29066
HSPC055|ZC3H7|ZC3HDC7
zinc finger CCCH-type containing 7A
protein-coding
16p13.13
Ensembl:ENSG00000122299 Vega:OTTHUMG00000129825 UniprotKB:Q8IWR0
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.861e-1 (AD)  8.562e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8043748chr16:11752375 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SENP60.891
SEC630.89
RBMX0.888
NBR10.881
USP160.879
UBXN40.874
RSPRY10.872
CUL4A0.869
SF3B10.868
TM9SF30.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.7
OR4F5-0.694
EPPIN-0.242
MMP23B-0.181
RAX2-0.172
IAPP-0.167
MTRNR2L6-0.166
OR4F16-0.161
MTRNR2L9-0.157
MTRNR2L10-0.149

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of ZC3H7A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ZC3H7A gene27153756
D001280AtrazineAtrazine results in increased expression of ZC3H7A mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ZC3H7A mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ZC3H7A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZC3H7A mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZC3H7A mRNA"20018196
D004958Estradiol[Dieldrin co-treated with Estradiol] results in decreased expression of ZC3H7A mRNA23041725
C006780bisphenol Abisphenol A affects the expression of ZC3H7A mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ZC3H7A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ZC3H7A gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ZC3H7A promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ZC3H7A mRNA27339419
C031180chrysenechrysene results in increased expression of ZC3H7A mRNA26377693
D016572CyclosporineCyclosporine results in increased expression of ZC3H7A mRNA25562108
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in decreased expression of ZC3H7A mRNA23041725
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ZC3H7A mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ZC3H7A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZC3H7A mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ZC3H7A mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of ZC3H7A mRNA23649840
D005839GentamicinsGentamicins results in increased expression of ZC3H7A mRNA22061828
D007854LeadLead affects the splicing of ZC3H7A mRNA28903495
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZC3H7A mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ZC3H7A mRNA"25620056
D009538NicotineNicotine results in increased splicing of ZC3H7A mRNA alternative form23825647
C006253pirinixic acidpirinixic acid results in decreased expression of ZC3H7A mRNA17426115
D011794QuercetinQuercetin results in increased expression of ZC3H7A mRNA21632981
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ZC3H7A mRNA"21148743
D012822Silicon DioxideSilicon Dioxide results in increased expression of ZC3H7A mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZC3H7A mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZC3H7A mRNA17942748
C483909torcetrapibtorcetrapib results in increased expression of ZC3H7A mRNA23228038
C012589trichostatin Atrichostatin A affects the expression of ZC3H7A mRNA28542535
D014415TunicamycinTunicamycin results in increased expression of ZC3H7A mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of ZC3H7A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZC3H7A mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0035198miRNA binding-IDA28431233  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010608posttranscriptional regulation of gene expression-IMP28431233  
GO:0035196production of miRNAs involved in gene silencing by miRNA-IMP28431233  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal