Gene info: ID 29079

Gene: MED4

GENE ID: 29079

Synonyms: ARC36|DRIP36|HSPC126|TRAP36|VDRIP

Description: mediator complex subunit 4

Gene type: protein-coding

Location: 13q14.2

dbXrefs: Ensembl:ENSG00000136146 MIM:605718 Vega:OTTHUMG00000016891 UniprotKB:Q9NPJ6

RefSeq: NC_000013.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.256e-1 (AD) 4.486e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs9316348	chr13:48092554 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EID1	0.948
ENY2	0.917
VMA21	0.917
CDC42	0.916
RAB18	0.915
PRKRA	0.915
VPS29	0.913
TAF9	0.913
POLR2K	0.912
ANAPC13	0.912

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.767
OR4F29	-0.739
ZBTB20	-0.252
MTRNR2L6	-0.245
MTRNR2L9	-0.244
SERPINH1	-0.237
HSPA6	-0.223
MTRNR2L10	-0.223
WDR38	-0.222
EVC2	-0.212

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of MED4 mRNA"	19162173
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MED4 mRNA"	19114083
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of MED4 protein	26194647
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of MED4 mRNA"	18648102
D000082	Acetaminophen	Acetaminophen affects the expression of MED4 mRNA	17562736
D001241	Aspirin	Aspirin results in increased expression of MED4 mRNA	15928584
D001280	Atrazine	Atrazine results in decreased expression of MED4 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MED4 mRNA	19770486\|2222880
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of MED4 mRNA	26496021
C006780	bisphenol A	bisphenol A affects the expression of MED4 mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of MED4 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of MED4 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MED4 mRNA	28628672
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of MED4 mRNA	23650126
D016572	Cyclosporine	Cyclosporine results in decreased expression of MED4 mRNA	25562108
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MED4 mRNA	28628672
C000944	dicrotophos	dicrotophos results in decreased expression of MED4 mRNA	28302478
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MED4 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MED4 mRNA	17942748
D018120	Finasteride	Finasteride results in increased expression of MED4 mRNA	24136188
D005839	Gentamicins	Gentamicins results in increased expression of MED4 mRNA	22061828
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MED4 mRNA	28628672
D007213	Indomethacin	Indomethacin results in increased expression of MED4 mRNA	28201806
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MED4 mRNA	28628672
C029938	nickel sulfate	nickel sulfate results in decreased expression of MED4 mRNA	22714537
D017239	Paclitaxel	MED4 protein affects the susceptibility to Paclitaxel	16217747
D010936	Plant Extracts	Plant Extracts results in increased expression of MED4 mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of MED4 protein	23718831
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of MED4 mRNA	19162173
D018038	Sodium Selenite	Sodium Selenite results in increased expression of MED4 mRNA	18175754
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MED4 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MED4 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MED4 mRNA	16267337
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MED4 mRNA	21215274
C025643	vinclozolin	vinclozolin results in increased expression of MED4 mRNA	23869203
D015032	Zinc	Zinc deficiency results in decreased expression of MED4 mRNA	22171008

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003712	transcription coregulator activity	-	IDA	10882111 12218053
GO:0005515	protein binding	-	IPI	14638676 15175163 16189514 17438371 21293490 21729782 24882805 25416956 26496610 27107014
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	-	NAS	10235266
GO:0038023	signaling receptor activity	-	IDA	12218053
GO:0042809	vitamin D receptor binding	-	NAS	10235266
GO:0046966	thyroid hormone receptor binding	-	IDA	10198638

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006357	regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	IDA	10882111
GO:0006367	transcription initiation from RNA polymerase II promoter	-	IDA	12218053
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0030518	intracellular steroid hormone receptor signaling pathway	-	IDA	11867769
GO:0030521	androgen receptor signaling pathway	-	IDA	12218053
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	10198638

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	10235267
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0016592	mediator complex	-	IDA	10882111 14638676
GO:0070847	core mediator complex	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	TAS
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	IEA
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal