Gene: METTL5

29081
HSPC133
methyltransferase like 5
protein-coding
2q31.1
Ensembl:ENSG00000138382 Vega:OTTHUMG00000154117 UniprotKB:Q9NRN9
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.045e-1 (AD)  5.552e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3769769chr2:169819255 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCEAL80.939
NDUFV20.938
SUMO10.936
POLR2K0.931
NDUFB60.93
EMC40.929
DPY300.929
MRPL470.928
GGPS10.927
PSMD100.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.754
OR4F29-0.725
P2RY14-0.255
C8orf74-0.244
MTRNR2L6-0.22
MTRNR2L10-0.218
SLC26A5-0.214
KCNJ15-0.209
KLRB1-0.206
KIF2B-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of METTL5 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of METTL5 mRNA17562736
D001280AtrazineAtrazine results in increased expression of METTL5 mRNA25929836
D001280AtrazineAtrazine results in increased expression of METTL5 mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of METTL5 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of METTL5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of METTL5 mRNA25181051
C100187chloropicrinchloropicrin results in increased expression of METTL5 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of METTL5 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of METTL5 mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of METTL5 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of METTL5 mRNA25270620
D018120FinasterideFinasteride results in increased expression of METTL5 mRNA24136188
D005485FlutamideFlutamide results in increased expression of METTL5 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of METTL5 gene20938992
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of METTL5 mRNA26846883
D007213IndomethacinIndomethacin results in increased expression of METTL5 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of METTL5 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of METTL5 mRNA27392435
D007657Ketone BodiesKetone Bodies results in increased expression of METTL5 mRNA16807920
D007854LeadLead affects the splicing of METTL5 mRNA28903495
D007854LeadLead results in increased expression of METTL5 mRNA19921347
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of METTL5 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of METTL5 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of METTL5 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of METTL5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of METTL5 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of METTL5 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of METTL5 mRNA25729387
C016030pantogabpantogab results in decreased expression of METTL5 mRNA17379144
D011192Potassium DichromatePotassium Dichromate results in decreased expression of METTL5 protein23718831
D011794QuercetinQuercetin results in decreased expression of METTL5 mRNA21632981
D018038Sodium SeleniteSodium Selenite results in increased expression of METTL5 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of METTL5 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of METTL5 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of METTL5 mRNA26217789
C066340tolcaponetolcapone results in decreased expression of METTL5 mRNA24136188
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of METTL5 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of METTL5 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased methylation of METTL5 gene27618143
D014635Valproic AcidValproic Acid affects the expression of METTL5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of METTL5 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0008168methyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032259methylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal