Gene: DROSHA

29102
ETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASEN
drosha ribonuclease III
protein-coding
5p13.3
Ensembl:ENSG00000113360 MIM:608828 Vega:OTTHUMG00000161976 UniprotKB:Q9NRR4
NG_051574.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.354e-1 (AD)  6.316e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KAT70.955
XPO70.95
KPNA60.945
SENP20.944
RALGAPB0.944
LARP10.942
SPTAN10.942
CKAP50.942
DSTYK0.941
SUPT16H0.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.602
OR4F29-0.572
MTRNR2L6-0.364
TFPI2-0.359
MTRNR2L9-0.344
CSAG1-0.341
KLRB1-0.341
MTRNR2L10-0.335
MYL3-0.332
HEY2-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DROSHA mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DROSHA mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of DROSHA mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of DROSHA mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DROSHA mRNA24449571
C006780bisphenol Abisphenol A results in decreased expression of DROSHA mRNA28483554|2927551
C006780bisphenol Abisphenol A results in decreased expression of DROSHA mRNA26063408|2848355
C006780bisphenol Abisphenol A results in increased methylation of DROSHA gene28505145
C043211carvedilolcarvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]24334028
C043211carvedilolcarvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]24334028
D007464Clioquinol[Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein22415087
D019327Copper SulfateCopper Sulfate results in decreased expression of DROSHA mRNA19549813
C000944dicrotophosdicrotophos results in increased expression of DROSHA mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DROSHA mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DROSHA mRNA17942748
D018120FinasterideFinasteride results in increased expression of DROSHA mRNA24136188
D005485FlutamideFlutamide results in increased expression of DROSHA mRNA24136188
C492448ICG 001ICG 001 results in decreased expression of DROSHA mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DROSHA mRNA25613284
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DROSHA mRNA"20188158
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DROSHA mRNA25729387
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DROSHA mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DROSHA mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of DROSHA mRNA29247641
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DROSHA mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of DROSHA mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of DROSHA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DROSHA mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DROSHA gene25560391
C016837zinc chloride[Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein22415087

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IDA20180804  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0004525ribonuclease III activity-IBA21873635  
GO:0004525ribonuclease III activity-IDA14508493  15574589  
GO:0005515protein binding-IPI15574589  18548003  19626115  22222205  22796965  23232809  
23995758  24219989  24581491  26496610  
GO:0017151DEAD/H-box RNA helicase binding-IPI18548003  
GO:0042803protein homodimerization activity-IDA15574589  
GO:0046332SMAD binding-IPI18548003  
GO:0046872metal ion binding-IEA-  
GO:0070412R-SMAD binding-IPI18548003  
GO:0070878primary miRNA binding-IPI18548003  
GO:0070878primary miRNA binding-NAS15574589  
GO ID GO Term Qualifier Evidence PubMed
GO:0006396RNA processing-IBA21873635  
GO:0010586miRNA metabolic process-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0016075rRNA catabolic process-IEA-  
GO:0030422production of siRNA involved in RNA interference-IBA21873635  
GO:0031053primary miRNA processing-IBA21873635  
GO:0031053primary miRNA processing-IDA14508493  15574589  
GO:0031053primary miRNA processing-IMP14508493  
GO:0031054pre-miRNA processing-IBA21873635  
GO:0042254ribosome biogenesis-IEA-  
GO:0045589regulation of regulatory T cell differentiation-IEA-  
GO:0050727regulation of inflammatory response-IEA-  
GO:0050829defense response to Gram-negative bacterium-IDA20180804  
GO:0050830defense response to Gram-positive bacterium-IDA20180804  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO:2000628regulation of miRNA metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0070877microprocessor complex-IDA15574589  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
Reactome ID Reactome Term Evidence
R-HSA-203927MicroRNA (miRNA) biogenesisTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25127693A let-7 microRNA polymorphism in the KRAS 3'-UTR is prognostic in oropharyngeal cancer. (2014 Oct)De Ruyck KCancer Epidemiol
21092244Involvement of microRNAs in physiological and pathological processes in the lung. (2010 Nov 23)Tomankova TRespir Res