Gene info: ID 29108

Gene: PYCARD

GENE ID: 29108

Synonyms: ASC|CARD5|TMS|TMS-1|TMS1

Description: PYD and CARD domain containing

Gene type: protein-coding

Location: 16p11.2

dbXrefs: Ensembl:ENSG00000103490 MIM:606838 Vega:OTTHUMG00000176753 UniprotKB:Q9ULZ3

RefSeq: NG_029446.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.278e-1 (AD) 3.768e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg27615603	chr16:31213045	PYCARD		6.100e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LST1	0.902
LY86	0.875
TYROBP	0.875
RNASE6	0.874
ARHGDIB	0.872
AIF1	0.868
CD74	0.867
RGS10	0.867
TNFAIP8L2	0.866
IL18	0.855

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ST6GAL2	-0.402
ATP2C2	-0.393
CHRNA4	-0.383
FUT9	-0.353
NEUROD6	-0.345
MARCH4	-0.344
NEUROG2	-0.337
KCNB2	-0.337
KCNA2	-0.332
YBX2	-0.33

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid results in increased expression of PYCARD mRNA	19435785
C070046	1,2-dioleoyloxy-3-(trimethylammonium)propane	"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of PYCARD mRNA"	22129739
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of PYCARD mRNA"	20453058
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PYCARD protein	26194647
C523668	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]"	25308879
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of PYCARD mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of PYCARD mRNA"	21346803
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
C003001	7-ketocholesterol	7-ketocholesterol affects the localization of PYCARD protein	28633109
C003001	7-ketocholesterol	Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]	28633109
C003001	7-ketocholesterol	SMPD1 protein affects the reaction [7-ketocholesterol affects the localization of PYCARD protein]	28633109
D000082	Acetaminophen	Acetaminophen affects the expression of PYCARD mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of PYCARD mRNA	27826632
C056165	acetovanillone	acetovanillone inhibits the reaction [Ethanol results in increased expression of PYCARD protein]	26079697
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of PYCARD protein]	26435000
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Ethanol results in increased expression of PYCARD protein]	26079697
D020106	Acrylamide	Acrylamide results in increased expression of PYCARD mRNA	28959563
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA	24149798
D000255	Adenosine Triphosphate	resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA]	24149798
D000255	Adenosine Triphosphate	[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]	23430110
D000255	Adenosine Triphosphate	PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]	23430110
D000255	Adenosine Triphosphate	PYCARD gene mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of G(M3) Ganglioside]	24475307
D000255	Adenosine Triphosphate	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]	18604214
D000255	Adenosine Triphosphate	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D000493	Allopurinol	Allopurinol inhibits the reaction [Glucose results in increased expression of PYCARD protein]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]	22426011
D000493	Allopurinol	Allopurinol inhibits the reaction [Glucose results in increased expression of PYCARD protein]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD mRNA]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD protein]	23647015
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of PYCARD mRNA	28070108
D000534	Alum Compounds	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Alum Compounds] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of PYCARD mRNA	21298039
D000536	Aluminum Hydroxide	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
C041524	aluminum sulfate	PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased secretion of IL1B protein]	24158569
D006710	Homocysteine	CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]	22647887
D006710	Homocysteine	[Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]	22647887
D006710	Homocysteine	Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]	22647887
D006710	Homocysteine	Homocysteine results in increased expression of PYCARD mRNA	22647887
D006710	Homocysteine	PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]	22647887
D006710	Homocysteine	PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]	22647887
D006710	Homocysteine	PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]	22647887
D000639	Amitriptyline	Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]	28633109
D000639	Amitriptyline	Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein]	28633109
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PYCARD mRNA	16483693
D000872	Anthocyanins	Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of PYCARD protein]	24795233
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PYCARD mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased methylation of PYCARD promoter	24993472
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PYCARD mRNA	24345465\|2499347
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PYCARD protein	24993472
C006632	arsenic trioxide	[sanguinarine co-treated with arsenic trioxide] results in increased expression of PYCARD mRNA	24345465
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PYCARD mRNA	19730151
D001194	Asbestos	PYCARD gene mutant form results in decreased susceptibility to Asbestos	26935421
D017638	Asbestos, Crocidolite	"PYCARD protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"	18403674
D017638	Asbestos, Crocidolite	"PYCARD protein affects the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]"	18403674
D017638	Asbestos, Crocidolite	"PYCARD protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"	18403674
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PYCARD mRNA	22209252
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PYCARD mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PYCARD mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PYCARD mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PYCARD mRNA	21569818\|2222880
C006780	bisphenol A	bisphenol A results in decreased expression of PYCARD mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased expression of PYCARD mRNA	25181051
C546611	brevetoxin 2	brevetoxin 2 results in increased expression of PYCARD mRNA	20498034
C584509	C646 compound	C646 compound results in increased expression of PYCARD mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PYCARD mRNA	25993096
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of PYCARD mRNA	23650126
D002737	Chloroprene	Chloroprene results in decreased expression of PYCARD mRNA	23125180
D004390	Chlorpyrifos	Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of PYCARD protein]	26435000
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of PYCARD protein	26435000
D004390	Chlorpyrifos	MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of PYCARD protein]	26435000
D002784	Cholesterol	Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein]	28633109
D002784	Cholesterol	Cholesterol analog affects the localization of PYCARD protein	28633109
D002784	Cholesterol	"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of PYCARD mRNA"	22129739
D002784	Cholesterol	SMPD1 protein affects the reaction [Cholesterol analog affects the localization of PYCARD protein]	28633109
D002784	Cholesterol	Cholesterol analog results in increased expression of PYCARD mRNA	19477266
D002784	Cholesterol	[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA	25833014
D002784	Cholesterol	[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein	25833014
D002784	Cholesterol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA]	25833014
D002784	Cholesterol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein]	25833014
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PYCARD mRNA	20938992
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PYCARD mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of PYCARD mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of PYCARD mRNA	25562108\|2798913
C014347	decitabine	decitabine affects the methylation of PYCARD promoter	17471463
C014347	decitabine	[decitabine affects the methylation of PYCARD promoter] which affects the expression of PYCARD mRNA	17471463\|1747146
C014347	decitabine	decitabine results in increased expression of PYCARD mRNA	16367923
C014347	decitabine	trichostatin A promotes the reaction [[decitabine affects the methylation of PYCARD promoter] which affects the expression of PYCARD mRNA]	17471463\|1747146
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PYCARD mRNA]	27941970
D003976	Diazinon	Diazinon affects the expression of PYCARD mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PYCARD mRNA	17361019\|2126653
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of PYCARD mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PYCARD mRNA	27392435
D002945	Cisplatin	"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]"	25308879
D002945	Cisplatin	Cisplatin results in increased expression of PYCARD protein	25308879
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased activity of PYCARD protein	27589886
D004008	Diclofenac	Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein]	25450234
D004026	Dieldrin	Dieldrin affects the expression of PYCARD mRNA	22546817
D004041	Dietary Fats	Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of PYCARD protein]	24795233
D004041	Dietary Fats	Dietary Fats promotes the reaction [PYCARD protein binds to NLRP3 protein]	24508291
D004041	Dietary Fats	Dietary Fats results in increased expression of PYCARD protein	24795233
D004041	Dietary Fats	PYCARD gene mutant form inhibits the reaction [Dietary Fats promotes the reaction [PYCARD protein binds to NLRP3 protein]]	24508291\|2450829
D004041	Dietary Fats	PYCARD gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of NPHS2 mRNA]	24508291
D004041	Dietary Fats	PYCARD gene mutant form inhibits the reaction [Dietary Fats results in increased activity of CASP1 protein]	24508291
D004041	Dietary Fats	PYCARD gene mutant form inhibits the reaction [Dietary Fats results in increased expression of DES mRNA]	24508291
D004041	Dietary Fats	PYCARD gene mutant form inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]	24508291
D004041	Dietary Fats	PYCARD gene mutant form inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]	24508291
D004041	Dietary Fats	PYCARD gene mutant form results in decreased susceptibility to Dietary Fats	24508291
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of PYCARD mRNA	25380136
C118739	entinostat	entinostat results in increased expression of PYCARD mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
D004875	Ergosterol	[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA	25833014
D004875	Ergosterol	[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein	25833014
D004875	Ergosterol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA]	25833014
D004875	Ergosterol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein]	25833014
D000431	Ethanol	acetovanillone inhibits the reaction [Ethanol results in increased expression of PYCARD protein]	26079697
D000431	Ethanol	Acetylcysteine inhibits the reaction [Ethanol results in increased expression of PYCARD protein]	26079697
D000431	Ethanol	Ethanol results in increased expression of PYCARD protein	26079697
D000431	Ethanol	Ethanol results in increased expression of PYCARD protein	26079697
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PYCARD mRNA	17606305
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PYCARD mRNA	16174780
D005492	Folic Acid	[Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]	22647887
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PYCARD mRNA	20938992
D005492	Folic Acid	PYCARD protein affects the reaction [Folic Acid deficiency results in increased activity of CASP1 protein]	22647887
D005492	Folic Acid	PYCARD protein affects the reaction [Folic Acid deficiency results in increased expression of IL1B protein]	22647887
D005492	Folic Acid	PYCARD protein affects the susceptibility to Folic Acid deficiency	22647887
D004397	Fonofos	Fonofos results in increased methylation of PYCARD promoter	22847954
D005620	Freund's Adjuvant	Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein]	25450234
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of PYCARD protein	25450234
D005620	Freund's Adjuvant	Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein]	25450234
D005632	Fructose	Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]	22426011
D005632	Fructose	Fructose results in increased expression of PYCARD protein	22426011
D005632	Fructose	Quercetin inhibits the reaction [Fructose results in increased expression of PYCARD protein]	22426011
D005632	Fructose	Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein]	22426011
C039281	furan	furan results in increased expression of PYCARD mRNA	22079235
D005839	Gentamicins	Gentamicins results in increased expression of PYCARD mRNA	22061828
D005947	Glucose	Allopurinol inhibits the reaction [Glucose results in increased expression of PYCARD protein]	23647015
D005947	Glucose	Glucose results in increased expression of PYCARD protein	23647015
D005947	Glucose	Quercetin inhibits the reaction [Glucose results in increased expression of PYCARD protein]	23647015
D005947	Glucose	Allopurinol inhibits the reaction [Glucose results in increased expression of PYCARD protein]	23647015
D005947	Glucose	Glucose results in increased expression of PYCARD protein	23647015\|2903153
D005947	Glucose	Quercetin inhibits the reaction [Glucose results in increased expression of PYCARD protein]	23647015
D005947	Glucose	rhodioloside inhibits the reaction [Glucose results in increased expression of PYCARD protein]	29031534
D005905	Glyburide	Glyburide inhibits the reaction [Paraquat results in increased expression of PYCARD protein]	25338942
D005679	G(M3) Ganglioside	PYCARD gene mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of G(M3) Ganglioside]	24475307
D017313	Fenretinide	Fenretinide results in increased expression of PYCARD mRNA	28973697
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of PYCARD mRNA	17183730
C492448	ICG 001	ICG 001 results in increased expression of PYCARD mRNA	26191083
D007530	Isoflurane	Isoflurane results in decreased expression of PYCARD mRNA	16978161
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of PYCARD mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of PYCARD mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PYCARD mRNA	23086925
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nanotubes, Carbon] results in increased expression of PYCARD protein"	21800904
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA	24149798
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA]	24149798
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]	23430110
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PYCARD mRNA	22147977
D008070	Lipopolysaccharides	PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]	23430110
D008070	Lipopolysaccharides	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]	18604214
D008070	Lipopolysaccharides	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D008070	Lipopolysaccharides	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Alum Compounds] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D008070	Lipopolysaccharides	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D008070	Lipopolysaccharides	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein]	18604214
D008070	Lipopolysaccharides	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D008070	Lipopolysaccharides	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]	18604214
D008070	Lipopolysaccharides	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D008070	Lipopolysaccharides	PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased secretion of IL1B protein]	24158569
D008070	Lipopolysaccharides	PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]	24158569
D008070	Lipopolysaccharides	PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with Poly dA-dT] results in increased secretion of IL1B protein]	24158569
D018021	Lithium Chloride	Lithium Chloride results in increased expression of PYCARD mRNA	23527032
D047311	Luteolin	Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of PYCARD protein]	25450234
D008276	Magnesium Hydroxide	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of PYCARD mRNA	20353558
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in decreased expression of PYCARD mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in decreased expression of PYCARD mRNA	19564919
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PYCARD mRNA	20938992
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PYCARD mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD mRNA]"	20230807
C555916	MitoTEMPO	MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of PYCARD protein]	26435000
D009020	Morphine	Morphine results in decreased expression of PYCARD mRNA	20144693
C523799	MRK 003	PYCARD results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nanotubes, Carbon] results in increased expression of PYCARD protein"	21800904
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PYCARD mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PYCARD mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of PYCARD mRNA	25380136
D009532	Nickel	Nickel results in increased expression of PYCARD mRNA	25583101
C022838	nickel chloride	PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]	24158569
C022838	nickel chloride	nickel chloride affects the expression of PYCARD mRNA	22546817
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PYCARD mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD mRNA]"	20230807
D009550	Nigericin	PYCARD protein affects the reaction [Nigericin results in increased secretion of IL1B protein]	18403674
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of PYCARD mRNA	17616710
C016340	o,p'-DDT	"o,p'-DDT analog results in decreased expression of PYCARD mRNA"	22937105
D010098	Oxycodone	Oxycodone results in decreased expression of PYCARD mRNA	23439660
D019308	Palmitic Acid	Palmitic Acid affects the localization of PYCARD protein	27689324
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of PYCARD mRNA	26272509
D010269	Paraquat	Paraquat results in decreased expression of PYCARD mRNA	18836921
D010269	Paraquat	Paraquat results in increased expression of PYCARD protein	29054699
D010269	Paraquat	Glyburide inhibits the reaction [Paraquat results in increased expression of PYCARD protein]	25338942
D010269	Paraquat	Paraquat results in increased expression of PYCARD mRNA	25338942
D010269	Paraquat	Paraquat results in increased expression of PYCARD protein	25338942
D010278	Parathion	Parathion results in increased methylation of PYCARD promoter	22847954
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of PYCARD mRNA	17097637
D010656	Phenylephrine	Phenylephrine results in decreased expression of PYCARD mRNA	18158353
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYCARD mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PYCARD mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PYCARD mRNA	19710929
D011067	Poly dA-dT	PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with Poly dA-dT] results in increased secretion of IL1B protein]	24158569
D011374	Progesterone	Progesterone results in decreased expression of PYCARD mRNA	23012394
D011794	Quercetin	Quercetin inhibits the reaction [Glucose results in increased expression of PYCARD protein]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Fructose results in increased expression of PYCARD protein]	22426011
D011794	Quercetin	Quercetin inhibits the reaction [Glucose results in increased expression of PYCARD protein]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Streptozocin results in increased expression of PYCARD mRNA]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Streptozocin results in increased expression of PYCARD protein]	23647015
C059514	resveratrol	resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA]	24149798
C059514	resveratrol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA]	25833014
C059514	resveratrol	resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein]	25833014
C059514	resveratrol	resveratrol results in increased expression of PYCARD mRNA	25905778
C009172	rhodioloside	rhodioloside inhibits the reaction [Glucose results in increased expression of PYCARD protein]	29031534
D012431	Rutin	Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein]	22426011
C005705	sanguinarine	[sanguinarine co-treated with arsenic trioxide] results in increased expression of PYCARD mRNA	24345465
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in decreased expression of PYCARD mRNA	19564919
C534628	SCH 23390	SCH 23390 results in decreased expression of PYCARD mRNA	19564919
D012643	Selenium	Selenium results in increased expression of PYCARD mRNA	19244175
D012822	Silicon Dioxide	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein]	18604214
D012822	Silicon Dioxide	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D012822	Silicon Dioxide	PYCARD protein affects the reaction [Silicon Dioxide results in increased cleavage of CASP1 protein]	18403674
D012822	Silicon Dioxide	PYCARD protein affects the reaction [Silicon Dioxide results in increased secretion of IL1B protein]	18403674
C017947	sodium arsenite	sodium arsenite results in increased expression of and affects the splicing of PYCARD mRNA	25879800
C017947	sodium arsenite	sodium arsenite results in increased expression of PYCARD mRNA	22714537
C016104	sodium bichromate	sodium bichromate results in decreased expression of PYCARD mRNA	17685462
D013311	Streptozocin	Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD mRNA]	23647015
D013311	Streptozocin	Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD protein]	23647015
D013311	Streptozocin	Quercetin inhibits the reaction [Streptozocin results in increased expression of PYCARD mRNA]	23647015
D013311	Streptozocin	Quercetin inhibits the reaction [Streptozocin results in increased expression of PYCARD protein]	23647015
D013311	Streptozocin	Streptozocin results in increased expression of PYCARD mRNA	23647015
D013311	Streptozocin	Streptozocin results in increased expression of PYCARD protein	23647015
C012568	terbufos	terbufos results in increased methylation of PYCARD promoter	22847954
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of PYCARD protein	26901245
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PYCARD mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PYCARD mRNA	23238561
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PYCARD mRNA	19520675\|2323856
C009495	titanium dioxide	titanium dioxide results in increased expression of PYCARD mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PYCARD mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of PYCARD mRNA	20133372
C012589	trichostatin A	trichostatin A affects the methylation of PYCARD promoter	17471463
C012589	trichostatin A	[trichostatin A affects the methylation of PYCARD promoter] which affects the expression of PYCARD mRNA	17471463\|1747146
C012589	trichostatin A	trichostatin A promotes the reaction [[decitabine affects the methylation of PYCARD promoter] which affects the expression of PYCARD mRNA]	17471463\|1747146
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PYCARD mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PYCARD mRNA"	26179874
D014520	Urethane	Urethane results in decreased expression of PYCARD mRNA	28818685
D014527	Uric Acid	PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]	18403674
D014527	Uric Acid	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]	18604214
D014527	Uric Acid	PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]	18604214
D014527	Uric Acid	PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]	18403674
D014527	Uric Acid	PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]	18403674
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of PYCARD mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of PYCARD mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of PYCARD mRNA	23179753\|2915479
D014635	Valproic Acid	Valproic Acid results in increased expression of PYCARD mRNA	26272509
D014638	Vanadates	Vanadates results in decreased expression of PYCARD mRNA	22714537
D014640	Vancomycin	Vancomycin results in decreased expression of PYCARD mRNA	18930951
C025643	vinclozolin	vinclozolin affects the expression of PYCARD mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in increased expression of PYCARD mRNA	26682919
D014800	Vitallium	Vitallium analog results in decreased expression of PYCARD mRNA	23825117

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	24407287
GO:0005138	interleukin-6 receptor binding	-	IPI	24407287
GO:0005515	protein binding	-	IPI	11498534 11786556 12019269 12656673 14730312 15020601 15030775 17178784 17418785 17964261 19158675 19158676 22286270 24237704 24407287 24630722 25006247 25277106 25402006 25416956 25605870 28636595
GO:0005523	tropomyosin binding	-	IPI	24407287
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	-	NAS	12019269
GO:0017024	myosin I binding	-	IPI	24407287
GO:0019899	enzyme binding	-	IPI	24407287
GO:0032090	Pyrin domain binding	-	IPI	15030775
GO:0042802	identical protein binding	-	IPI	24630722 25006247 25416956
GO:0042803	protein homodimerization activity	-	IDA	15030775
GO:0070700	BMP receptor binding	-	IPI	24407287
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001773	myeloid dendritic cell activation	-	IMP	22732093
GO:0002218	activation of innate immune response	-	IDA	21575908
GO:0002277	myeloid dendritic cell activation involved in immune response	-	ISS	-
GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	-	ISS	-
GO:0002821	positive regulation of adaptive immune response	-	IMP	22732093
GO:0006915	apoptotic process	-	IBA	21873635
GO:0006915	apoptotic process	-	TAS	10567338
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	NAS	12019269
GO:0006954	inflammatory response	-	IEA	-
GO:0007165	signal transduction	-	NAS	12019269
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	-	IBA	21873635
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	IMP	14730312
GO:0030838	positive regulation of actin filament polymerization	-	ISS	-
GO:0031647	regulation of protein stability	-	ISS	-
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	IMP	16585594
GO:0032688	negative regulation of interferon-beta production	-	IMP	19158675
GO:0032729	positive regulation of interferon-gamma production	-	ISS	-
GO:0032755	positive regulation of interleukin-6 production	-	ISS	-
GO:0032760	positive regulation of tumor necrosis factor production	-	IMP	16982856 21487011
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	IDA	12656673
GO:0042104	positive regulation of activated T cell proliferation	-	ISS	-
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	-	IMP	14730312
GO:0043065	positive regulation of apoptotic process	-	IDA	12646168
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	12486103
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	15030775
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0044351	macropinocytosis	-	ISS	-
GO:0045087	innate immune response	-	IEA	-
GO:0046330	positive regulation of JNK cascade	-	IMP	21487011
GO:0050718	positive regulation of interleukin-1 beta secretion	-	IDA	15030775
GO:0050766	positive regulation of phagocytosis	-	ISS	-
GO:0050829	defense response to Gram-negative bacterium	-	IMP	16982856 21487011
GO:0050870	positive regulation of T cell activation	-	IMP	22732093
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IDA	19494289
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	12646168 12656673
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IPI	15817483
GO:0051607	defense response to virus	-	IDA	21575908
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IMP	21487011
GO:0071222	cellular response to lipopolysaccharide	-	IDA	12486103
GO:0071347	cellular response to interleukin-1	-	IDA	12486103
GO:0071356	cellular response to tumor necrosis factor	-	IDA	12486103
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IDA	12486103
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	-	IMP	14730312
GO:0090197	positive regulation of chemokine secretion	-	IMP	21487011
GO:0090200	positive regulation of release of cytochrome c from mitochondria	-	IDA	14730312
GO:2000406	positive regulation of T cell migration	-	ISS	-
GO:2000484	positive regulation of interleukin-8 secretion	-	IMP	16982856
GO:2000778	positive regulation of interleukin-6 secretion	-	IMP	16982856
GO:2001056	positive regulation of cysteine-type endopeptidase activity	-	IDA	19158676
GO:2001181	positive regulation of interleukin-10 secretion	-	IMP	16982856
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	-	IDA	16964285
GO:2001242	regulation of intrinsic apoptotic signaling pathway	-	IDA	14730312

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	IDA	-
GO:0005634	nucleus	-	ISS	-
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	14730312 15030775 19158679
GO:0005737	cytoplasm	-	NAS	12019269
GO:0005739	mitochondrion	-	IDA	14730312
GO:0005783	endoplasmic reticulum	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0008385	IkappaB kinase complex	colocalizes_with	IDA	12486103
GO:0008385	IkappaB kinase complex	-	TAS	12656673
GO:0034774	secretory granule lumen	-	TAS	-
GO:0035578	azurophil granule lumen	-	TAS	-
GO:0072558	NLRP1 inflammasome complex	-	IDA	12191486
GO:0072559	NLRP3 inflammasome complex	-	IDA	15030775
GO:0097169	AIM2 inflammasome complex	-	IDA	19158676

KEGG ID	KEGG Term
hsa04621	NOD-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	IEA
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5660668	CLEC7A/inflammasome pathway	TAS
R-HSA-622312	Inflammasomes	IEA
R-HSA-622312	Inflammasomes	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-844456	The NLRP3 inflammasome	TAS
R-HSA-844615	The AIM2 inflammasome	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19472401	The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)	Oka D	Cancer