Gene: GRM1

2911
GPRC1A|MGLU1|MGLUR1|PPP1R85|SCA44|SCAR13
glutamate metabotropic receptor 1
protein-coding
6q24.3
Ensembl:ENSG00000152822 MIM:604473 Vega:OTTHUMG00000015752 UniprotKB:Q13255
NG_012839.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.680e-1 (AD)  2.063e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A100.946
SLITRK50.941
AMPH0.94
THRB0.94
BHLHB90.94
FRMPD40.939
LMTK20.938
FAXC0.938
GABRA30.938
KCTD160.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.597
RNF135-0.572
RAB13-0.569
CSAG1-0.559
CMTM3-0.555
CHST14-0.555
COPZ2-0.554
YES1-0.548
GNG11-0.545
REST-0.543

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB042564-(1-Amino-1-Carboxy-Ethyl)-Benzoic AcidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole"1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole"1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
C0957561-aminoindan-1,5-dicarboxylic acid"1-aminoindan-1,5-dicarboxylic acid binds to and results in decreased activity of GRM1 protein"12373537|1656442
C0957561-aminoindan-1,5-dicarboxylic acid"1-aminoindan-1,5-dicarboxylic acid results in decreased activity of GRM1 protein"19597494
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRM1 mRNA"19114083
C5048762-aminoethoxydiphenylborane"2-aminoethoxydiphenylborane inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
C1099862-aminoethoxydiphenyl borate"2-aminoethoxydiphenyl borate inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
C0792153,5-dihydroxyphenylglycine"1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
C0792153,5-dihydroxyphenylglycine"1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
C0792153,5-dihydroxyphenylglycine"2-aminoethoxydiphenylborane inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
C0792153,5-dihydroxyphenylglycine"2-aminoethoxydiphenyl borate inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
C0792153,5-dihydroxyphenylglycine"3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein"14622174
C0792153,5-dihydroxyphenylglycine"[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium"14622174
C0792153,5-dihydroxyphenylglycine"[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased phosphorylation of MAP2 protein"15893642
C0792153,5-dihydroxyphenylglycine"Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
C0792153,5-dihydroxyphenylglycine"Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
C0792153,5-dihydroxyphenylglycine"Potassium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
C0792153,5-dihydroxyphenylglycine"Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
C0792153,5-dihydroxyphenylglycine"Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
C0792153,5-dihydroxyphenylglycine"Sodium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
C502015(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate binds to and results in decreased activity of GRM1 protein16564428|1935732
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GRM1 mRNA"18648102
C5054556-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide"6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide binds to and results in decreased activity of GRM1 protein"15976016
C5054556-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide"6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide binds to GRM1 protein"15976016
C5054556-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide"6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide results in decreased activity of GRM1 protein"19174448
C5054556-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide"7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester inhibits the reaction [6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide binds to GRM1 protein]"15976016
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine results in decreased expression of GRM1 protein21232601
C1214656-methyl-2-(phenylethynyl)pyridineBDNF protein inhibits the reaction [6-methyl-2-(phenylethynyl)pyridine results in decreased expression of GRM1 protein]21232601
C1177897-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester binds to and results in decreased activity of GRM1 protein19812363
C1177897-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester binds to GRM1 protein15976016
C1177897-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester"7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester inhibits the reaction [6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide binds to GRM1 protein]"15976016
C1177897-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester binds to and results in decreased activity of GRM1 protein20181581
D020106AcrylamideAcrylamide results in decreased expression of GRM1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRM1 gene27153756
C079694alpha-methyl-4-carboxyphenylglycinealpha-methyl-4-carboxyphenylglycine binds to and results in decreased activity of GRM1 protein15009663
D000641AmmoniaAmmonia inhibits the reaction [GRM1 protein results in increased phosphorylation of MAP2 protein]15893642
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRM1 mRNA16483693
D003913DextroamphetamineGRM1 protein affects the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]11566502
D003913DextroamphetamineGRM1 protein affects the susceptibility to Dextroamphetamine11566502
D000661AmphetamineAmphetamine results in increased expression of GRM1 mRNA11418936
C006632arsenic trioxidearsenic trioxide results in decreased expression of GRM1 mRNA24831965
C015001arsenitearsenite results in increased methylation of GRM1 promoter23974009
C005177benserazide, levodopa drug combination"[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of GRM1 protein"17596448
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GRM1 mRNA22154832
D004958EstradiolEstradiol results in increased expression of GRM1 mRNA22154832
D004958EstradiolEstradiol results in increased activity of GRM1 protein15901789
C006780bisphenol Abisphenol A results in increased expression of GRM1 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of GRM1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GRM1 gene28505145
D0200011-Butanol1-Butanol affects the localization of GRM1 protein15470141
D0200011-ButanolPLD2 protein affects the reaction [1-Butanol affects the localization of GRM1 protein]15470141
D002110CaffeineCaffeine results in decreased expression of GRM1 protein15998294
D002118Calcium"1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
D002118Calcium"2-aminoethoxydiphenyl borate inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
D002118Calcium"[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium"14622174
D002118Calcium"Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
D002118CalciumGRM1 protein promotes the reaction [Propionates results in increased transport of Calcium]24582715
D002118Calcium"Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
D003042CocaineGRM1 affects the susceptibility to Cocaine19597494
D003300CopperCopper deficiency results in increased expression of GRM1 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of GRM1 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GRM1 mRNA23640034
D003976DiazinonDiazinon results in increased expression of GRM1 mRNA19440498
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GRM1 mRNA15620428
D019422Dietary SucroseDietary Sucrose results in increased expression of GRM1 mRNA26033743
C010117dihydroxyphenylethylene glycoldihydroxyphenylethylene glycol binds to and results in increased activity of GRM1 protein21911610
D007980Levodopa"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased phosphorylation of GRM1 protein"20808799
D000431EthanolEthanol results in decreased expression of GRM1 mRNA20655511
D005439Flufenamic Acid"Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
D005439Flufenamic Acid"Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
C039281furanfuran results in increased methylation of GRM1 gene22079235
D006220HaloperidolHaloperidol results in increased expression of GRM1 mRNA15860345
D006582HexachloropheneHexachlorophene results in decreased expression of GRM1 mRNA25943520
C008261lead acetatelead acetate results in decreased expression of GRM1 mRNA24260418
C008261lead acetatelead acetate affects the expression of GRM1 mRNA22362014
D008694MethamphetamineMethamphetamine results in increased expression of GRM1 mRNA18419818
D008713MethimazoleMethimazole results in increased expression of GRM1 mRNA22504374
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GRM1 mRNA"19285098
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased phosphorylation of GRM1 protein"20808799
D009020MorphineMorphine results in increased expression of GRM1 mRNA15183518
C025256nonylphenolnonylphenol results in decreased expression of GRM1 mRNA15620428
D016627Oxidopamine"[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of GRM1 protein"17596448
D010862PilocarpinePilocarpine results in decreased expression of GRM1 protein11463519
D010862PilocarpinePilocarpine results in increased expression of GRM1 protein11463519
D011188Potassium"Potassium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GRM1 mRNA22154832
D011422PropionatesGRM1 protein promotes the reaction [Propionates results in increased transport of Calcium]24582715
D011441PropylthiouracilPropylthiouracil affects the expression of GRM1 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of GRM1 mRNA22504374
D011803QuinineGRM1 protein affects the susceptibility to Quinine19174448
C037219quinolinequinoline analog results in decreased activity of GRM1 protein18005334
C523946(R)-N-cycloheptyl-6-((((tetrahydro-2-furyl)methyl)amino)methyl)thieno(2,3-d)pyrimidin-4-ylamine"(R)-N-cycloheptyl-6-((((tetrahydro-2-furyl)methyl)amino)methyl)thieno(2,3-d)pyrimidin-4-ylamine binds to and results in decreased activity of GRM1 protein"17597604
D012430Ruthenium Red"Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
D012430Ruthenium Red"Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]"14622174
D012964Sodium"Sodium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]"14622174
D012999SomanSoman results in decreased expression of GRM1 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of GRM1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRM1 mRNA21570461
D013806TheophyllineTheophylline results in decreased expression of GRM1 protein15998294
D014050TolueneToluene affects the expression of GRM1 mRNA21827849
D014635Valproic AcidValproic Acid results in increased expression of GRM1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in decreased expression of GRM1 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GRM1 gene25560391
C111237vorinostatvorinostat results in decreased expression of GRM1 mRNA27188386
D015032ZincZinc deficiency results in decreased expression of GRM1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS7476890  
GO:0005515protein binding-IPI19084525  
GO:0008066glutamate receptor activity-IBA21873635  
GO:0008066glutamate receptor activity-IDA10945991  24603153  
GO:0008066glutamate receptor activity-TAS7476890  
GO:0099530G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential-IBA21873635  
GO:0099583neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration-IBA21873635  
GO:0099583neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000186activation of MAPKK activity-IEA-  
GO:0000187activation of MAPK activity-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IDA24603153  
GO:0007186G-protein coupled receptor signaling pathway-IMP28886343  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IMP24603153  
GO:0007268chemical synaptic transmission-TAS9076744  
GO:0007626locomotory behavior-IEA-  
GO:0019233sensory perception of pain-IEA-  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IMP24603153  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0051966regulation of synaptic transmission, glutamatergic-IBA21873635  
GO:0071257cellular response to electrical stimulus-IEA-  
GO:0099566regulation of postsynaptic cytosolic calcium ion concentration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IMP24603153  
GO:0030425dendrite-IEA-  
GO:0038037G-protein coupled receptor dimeric complex-IDA24603153  
GO:0038038G-protein coupled receptor homodimeric complex-IPI10945991  
GO:0098839postsynaptic density membrane-IBA21873635  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22448230Deleterious GRM1 mutations in schizophrenia. (2012)Ayoub MAPLoS One