Gene: TBK1

29110
FTDALS4|IIAE8|NAK|T2K
TANK binding kinase 1
protein-coding
12q14.2
Ensembl:ENSG00000183735 MIM:604834 Vega:OTTHUMG00000168796 UniprotKB:Q9UHD2
NG_046906.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.529e-1 (AD)  8.007e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC270.952
CD470.946
USP330.942
SACM1L0.937
BTF3L40.937
KPNA30.937
STAM0.936
ARMC80.936
MTMR60.932
LEPROTL10.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.589
OR4F29-0.549
MTRNR2L10-0.332
MTRNR2L6-0.329
MTRNR2L9-0.317
CSAG1-0.297
ASB4-0.293
MTRNR2L8-0.293
MTRNR2L2-0.284
KCNK5-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TBK1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TBK1 mRNA"21354444
C5859122,4-dihydroxy-N-(4-hydroxyphenyl)benzamide"2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide results in decreased activity of TBK1 protein"24144632
C0038982-anisidine2-anisidine results in decreased expression of TBK1 mRNA28089782
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of TBK1 protein26194647
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]"23452621
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of TBK1 mRNA]"26546572
D000082AcetaminophenAcetaminophen results in decreased expression of TBK1 mRNA27761495
D000082AcetaminophenAcetaminophen affects the expression of TBK1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TBK1 mRNA19770486
D001310AuranofinAuranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]17034761
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBK1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBK1 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of TBK1 mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TBK1 mRNA28472532
C043561chrysinchrysin results in decreased activity of TBK1 protein19426678
D002994ClofibrateClofibrate results in decreased expression of TBK1 mRNA17585979
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [TBK1 protein binds to TICAM1 protein]25780291
D019327Copper SulfateCopper Sulfate results in increased expression of TBK1 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]23452621
D016572CyclosporineCyclosporine results in increased expression of TBK1 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TBK1 mRNA]27941970
D002945Cisplatin"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of TBK1 mRNA]"26546572
D002945CisplatinCisplatin results in increased expression of TBK1 mRNA26546572
C000944dicrotophosdicrotophos results in decreased expression of TBK1 mRNA28302478
C007619eriodictyoleriodictyol results in decreased activity of TBK1 protein19426678
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TBK1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TBK1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBK1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TBK1 mRNA23649840
D005485FlutamideFlutamide results in increased expression of TBK1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of TBK1 mRNA20655997
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]23452621
D019833GenisteinGenistein results in increased methylation of TBK1 gene28505145
D005839GentamicinsGentamicins results in increased expression of TBK1 mRNA22061828
D007545IsoproterenolIsoproterenol results in increased expression of TBK1 mRNA20003209
C544151jinfukangjinfukang results in decreased expression of TBK1 mRNA27392435
D008070LipopolysaccharidesTBK1 protein results in increased susceptibility to Lipopolysaccharides21904615
D047311LuteolinLuteolin results in decreased activity of TBK1 protein19426678
D047311LuteolinLuteolin inhibits the reaction [TBK1 protein results in increased expression of IRF3 mRNA]19426678
C013592mangiferinmangiferin results in decreased expression of TBK1 mRNA15135318
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TBK1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TBK1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of TBK1 promoter"26251327
C051752nefazodonenefazodone results in increased expression of TBK1 mRNA24136188
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of TBK1 mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]23452621
D010416PentachlorophenolPentachlorophenol results in increased expression of TBK1 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TBK1 mRNA27153767
D010795Phthalic AcidsPhthalic Acids results in increased expression of TBK1 mRNA21061450
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]23452621
C045950propiconazolepropiconazole results in increased expression of TBK1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of TBK1 mRNA24780913
D011794QuercetinQuercetin results in decreased activity of TBK1 protein19426678
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]23452621
C059514resveratrolresveratrol inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]16678799
C059514resveratrolresveratrol inhibits the reaction [TBK1 protein results in increased phosphorylation of IRF3 protein]16116226
C059514resveratrolTBK1 protein affects the susceptibility to resveratrol21612158
C017947sodium arsenitesodium arsenite results in decreased expression of TBK1 protein24866292
C017947sodium arsenitesodium arsenite results in increased expression of TBK1 mRNA19822182
D018038Sodium SeleniteSodium Selenite inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]18279804
D053260SootSoot results in increased expression of TBK1 mRNA26551751
D013467SulindacSulindac results in increased expression of TBK1 mRNA11093808
D013629TamoxifenTamoxifen affects the expression of TBK1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBK1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBK1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBK1 mRNA17942748
D014118Toxins, Biological"Toxins, Biological affects the expression of TBK1 mRNA"19682533
D014415TunicamycinTunicamycin results in decreased expression of TBK1 mRNA17127020

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0004672protein kinase activity-TAS-  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA25803835  27103069  
GO:0004674protein serine/threonine kinase activity-TAS21042276  
GO:0005515protein binding-IPI14743216  15841462  16281057  17568778  17599067  18307994  
18583960  18636086  18724357  19153231  19416887  19419966  
19433799  20098747  20174559  20562859  21813773  21903422  
21931555  21988832  22000020  22939624  23096996  23414517  
23542348  24056301  24335286  24560620  24643253  24696485  
24706939  24807708  25736436  25803835  27086836  27103069  
27135603  
GO:0005524ATP binding-IEA-  
GO:0042802identical protein binding-IPI14743216  17599067  
GO:0051219phosphoprotein binding-IPI14530355  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA27103069  
GO:0006954inflammatory response-TAS21042276  
GO:0007249I-kappaB kinase/NF-kappaB signaling-TAS21042276  
GO:0009615response to virus-TAS21042276  
GO:0010629negative regulation of gene expression-IEA-  
GO:0016032viral process-IEA-  
GO:0016239positive regulation of macroautophagy-IDA27103069  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IDA25803835  27103069  
GO:0018107peptidyl-threonine phosphorylation-IDA27103069  
GO:0032479regulation of type I interferon production-TAS-  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0032606type I interferon production-TAS21042276  
GO:0032727positive regulation of interferon-alpha production-IDA16127453  
GO:0032728positive regulation of interferon-beta production-IDA16127453  
GO:0033138positive regulation of peptidyl-serine phosphorylation-NAS22412986  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0044565dendritic cell proliferation-IEA-  
GO:0045087innate immune response-TAS21042276  
GO:0045359positive regulation of interferon-beta biosynthetic process-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16127453  
GO:0050830defense response to Gram-positive bacterium-IEA-  
GO:0051607defense response to virus-IEA-  
GO:0071345cellular response to cytokine stimulus-TAS-  
GO:1901214regulation of neuron death-NAS25803835  
GO:1904417positive regulation of xenophagy-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA21813773  
GO:0005829cytosol-TAS-  
GO:0010008endosome membrane-TAS-  
GO:0016235aggresome-IDA-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1606322ZBP1(DAI) mediated induction of type I IFNsIEA
R-HSA-1606322ZBP1(DAI) mediated induction of type I IFNsTAS
R-HSA-1606341IRF3 mediated activation of type 1 IFNIEA
R-HSA-1606341IRF3 mediated activation of type 1 IFNTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1834941STING mediated induction of host immune responsesTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA IEA
R-HSA-3134975Regulation of innate immune responses to cytosolic DNATAS
R-HSA-3249367STAT6-mediated induction of chemokinesTAS
R-HSA-3270619IRF3-mediated induction of type I IFNTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-9008059Interleukin-37 signalingTAS
R-HSA-9013973TICAM1-dependent activation of IRF3/IRF7TAS
R-HSA-918233TRAF3-dependent IRF activation pathwayTAS
R-HSA-933541TRAF6 mediated IRF7 activationTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS
R-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21618603Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. (2011 Sep)Beaty THGenet Epidemiol