Gene: BRD7

29117
BP75|CELTIX1|NAG4
bromodomain containing 7
protein-coding
16q12.1
Ensembl:ENSG00000166164 Vega:OTTHUMG00000133170 UniprotKB:Q9NPI1
NG_023418.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.618e-1 (AD)  1.296e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
URI10.91
KTN10.901
ACBD50.893
C4orf30.888
ZNF6640.884
RPL220.88
ZCRB10.877
GOLGA70.876
SEPT70.869
EEF1A10.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.728
OR4F5-0.679
SDIM1-0.182
SCRT2-0.167
HDGFL1-0.162
SLC22A13-0.159
C10orf113-0.153
GRHL2-0.138
TAS2R13-0.138
KRT82-0.133

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of BRD7 mRNA"19095052
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of BRD7 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of BRD7 mRNA22230336
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of BRD7 mRNA24449571
C044887beta-methylcholinebeta-methylcholine affects the expression of BRD7 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of BRD7 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BRD7 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of BRD7 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of BRD7 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD7 gene20938992
C031180chrysenechrysene results in increased expression of BRD7 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in increased expression of BRD7 mRNA21139344
C018021cobaltous chloridecobaltous chloride results in decreased expression of BRD7 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of BRD7 mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of BRD7 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BRD7 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BRD7 mRNA21266533
D004221DisulfiramDisulfiram results in decreased expression of BRD7 mRNA20530235
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRD7 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BRD7 mRNA29097150
D005485FlutamideFlutamide results in increased expression of BRD7 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD7 gene20938992
D005839GentamicinsGentamicins results in increased expression of BRD7 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BRD7 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BRD7 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BRD7 mRNA28628672
D007854LeadLead results in increased expression of BRD7 mRNA19921347
D008294MalathionMalathion results in increased expression of BRD7 mRNA18214912
D008627Mercuric ChlorideMercuric Chloride affects the expression of BRD7 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD7 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BRD7 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BRD7 mRNA23649840
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of BRD7 mRNA19095052
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BRD7 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of BRD7 mRNA18445702
D011374ProgesteroneProgesterone affects the expression of BRD7 mRNA17251523
D011794QuercetinQuercetin results in decreased expression of BRD7 mRNA21632981
C059514resveratrolresveratrol results in increased expression of BRD7 mRNA23419489
D012715Sesame OilSesame Oil results in increased expression of BRD7 mRNA29191790
D013501Surface-Active AgentsSurface-Active Agents results in increased expression of BRD7 mRNA22467014
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRD7 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BRD7 mRNA25613284
D013893ThiramThiram results in decreased expression of BRD7 mRNA20530235
C025643vinclozolinvinclozolin results in decreased expression of BRD7 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002039p53 binding-IPI20228809  
GO:0003713transcription coactivator activity-IDA20228809  
GO:0003714transcription corepressor activity-IDA16265664  
GO:0003714transcription corepressor activity-ISS-  
GO:0005515protein binding-IPI12489984  18329849  20228809  20660729  29568061  
GO:0008134transcription factor binding-IDA11025449  
GO:0042393histone binding-IDA12489984  
GO:0044212transcription regulatory region DNA binding-IDA20228809  
GO:0070577lysine-acetylated histone binding-IDA16265664  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IDA12489984  
GO:0007049cell cycle-IEA-  
GO:0008285negative regulation of cell proliferation-IDA20228809  
GO:0016055Wnt signaling pathway-IEA-  
GO:0035066positive regulation of histone acetylation-IDA20228809  
GO:0045892negative regulation of transcription, DNA-templated-IDA16265664  
GO:0045893positive regulation of transcription, DNA-templated-IDA20228809  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:2000134negative regulation of G1/S transition of mitotic cell cycle-IDA16265664  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA11025449  12489984  16265664  20228809  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-TAS10526152  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804758Regulation of TP53 Activity through AcetylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24585446Genetic variants in the SWI/SNF complex and smoking collaborate to modify the risk of pancreatic cancer in a Chinese population. (2015 Sep)Zhu BMol Carcinog
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res
22008115[Expression and clinical significance of bromodomain-containing protein 7 in non-small cell lung cancer]. (2011 Oct)Chen LZhongguo Fei Ai Za Zhi