Gene: PRSS50

29122
CT20|TSP50
serine protease 50
protein-coding
3p21.31
Ensembl:ENSG00000283706 MIM:607950 UniprotKB:Q9UI38
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.000e-1 (AD)  4.813e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF70.603
PLCB30.597
ROBO30.594
MICALL20.587
PLXNB20.587
EVC0.581
SCRIB0.579
PXN0.579
PIEZO10.578
TCF30.577

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AARD-0.316
SV2C-0.286
HAPLN1-0.283
PTPRR-0.273
ENPP6-0.268
NPY2R-0.267
EYA4-0.264
PPEF1-0.261
EDN3-0.261
NXPH2-0.258

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C004363alantolactonealantolactone results in decreased expression of PRSS50 mRNA24252419
C004363alantolactonealantolactone results in decreased expression of PRSS50 protein24252419
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PRSS50 promoter]19654925
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PRSS50 mRNA21641980
D012834SilverSilver results in increased expression of PRSS50 mRNA27131904
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PRSS50 mRNA21641980
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRSS50 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activityNOTIBA21873635  
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0004298threonine-type endopeptidase activity-IBA21873635  
GO:0004298threonine-type endopeptidase activity-IMP17283160  
GO:0008236serine-type peptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA17283160  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA17283160  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA17283160  
GO:0019897extrinsic component of plasma membrane-IBA21873635  
GO:0046658anchored component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26067391Differential DNA methylation identified in the blood and retina of AMD patients. (2015)Oliver VFEpigenetics