Gene info: ID 29123

Gene: ANKRD11

GENE ID: 29123

Synonyms: ANCO-1|ANCO1|LZ16|T13

Description: ankyrin repeat domain 11

Gene type: protein-coding

Location: 16q24.3

dbXrefs: Ensembl:ENSG00000167522 MIM:611192 Vega:OTTHUMG00000175548 UniprotKB:Q6UB99

RefSeq: NG_032003.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.932e-1 (AD) 4.865e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg00169122	chr16:89488963	ANKRD11		9.320e-12	Maternal smoking in pregnancy	27040690
cg00169122	chr16:89488963	ANKRD11		7.310e-10	Maternal smoking in pregnancy	27040690
cg00169122	chr16:89488963	ANKRD11		3.500e-14	Smoking	27651444
cg00759807	chr16:89390789	ANKRD11		2.700e-9	Smoking	27651444
cg07929642	chr16:89390685	ANKRD11		1.200e-8	Smoking	27651444
cg09907628	chr16:89498634	ANKRD11		1.030e-9	Alcohol consumption der day	27843151
cg27513667	chr16:89408403	ANKRD11		1.500e-8	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LARP1	0.939
USP22	0.935
UBN1	0.934
MECP2	0.932
HERC2	0.932
PRRC2B	0.928
CAMSAP1	0.926
HYOU1	0.923
RAI1	0.921
EXOC7	0.92

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.582
OR4F29	-0.564
MYL3	-0.387
PHEX	-0.383
PON3	-0.378
COPZ2	-0.365
ZNF114	-0.356
IL18RAP	-0.354
IL24	-0.351
MTRNR2L10	-0.342

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of ANKRD11 mRNA	28329830
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ANKRD11 mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ANKRD11 mRNA"	28973690
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD11 mRNA"	27188386
C029370	4-toluidine	4-toluidine results in increased expression of ANKRD11 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD11 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of ANKRD11 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of ANKRD11 mRNA	17562736
D001151	Arsenic	Arsenic affects the methylation of ANKRD11 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ANKRD11 mRNA	22521957
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ANKRD11 mRNA	20458559
D001280	Atrazine	Atrazine results in decreased expression of ANKRD11 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ANKRD11 mRNA	20064835\|2010694
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANKRD11 mRNA"	19150397\|2001819
C044887	beta-methylcholine	beta-methylcholine affects the expression of ANKRD11 mRNA	21179406
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKRD11 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of ANKRD11 mRNA	29275510
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ANKRD11 mRNA	28628672
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ANKRD11 mRNA	28628672
C018475	butyraldehyde	butyraldehyde results in decreased expression of ANKRD11 mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of ANKRD11 mRNA	26191083
D002737	Chloroprene	Chloroprene results in increased expression of ANKRD11 mRNA	23125180
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ANKRD11 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ANKRD11 mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ANKRD11 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of ANKRD11 mRNA	20106945\|2163298
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ANKRD11 mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKRD11 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ANKRD11 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ANKRD11 mRNA	28628672
D002945	Cisplatin	Cisplatin results in decreased expression of ANKRD11 mRNA	19561079\|2759478
C000944	dicrotophos	dicrotophos results in increased expression of ANKRD11 mRNA	28302478
D004237	Diuron	Diuron results in decreased expression of ANKRD11 mRNA	25152437
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of ANKRD11 mRNA"	23811387
D000431	Ethanol	Ethanol affects the expression of ANKRD11 mRNA	26730594
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of ANKRD11 gene	17986521
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of ANKRD11 mRNA	28329830
D005472	Fluorouracil	Fluorouracil affects the expression of ANKRD11 mRNA	16584549
D005472	Fluorouracil	Fluorouracil results in increased expression of ANKRD11 mRNA	16510598
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of ANKRD11 mRNA	19376150
C492448	ICG 001	ICG 001 results in increased expression of ANKRD11 mRNA	26191083
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole results in decreased expression of ANKRD11 mRNA"	18762178
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKRD11 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ANKRD11 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ANKRD11 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANKRD11 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKRD11 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ANKRD11 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ANKRD11 mRNA	28628672
C410337	K 7174	K 7174 results in increased expression of ANKRD11 mRNA	24086573
D008694	Methamphetamine	Methamphetamine results in increased expression of ANKRD11 mRNA	26307267
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ANKRD11 mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD11 mRNA"	27188386
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ANKRD11 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ANKRD11 mRNA"	26251327
D009285	Naphthoquinones	Naphthoquinones results in increased expression of ANKRD11 mRNA	23811387
C028007	nickel monoxide	nickel monoxide results in increased expression of ANKRD11 mRNA	19167457
C025256	nonylphenol	nonylphenol results in increased expression of ANKRD11 mRNA	22982499
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of ANKRD11 mRNA	18593933
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of ANKRD11 mRNA	23892564
C046012	pentanal	pentanal results in decreased expression of ANKRD11 mRNA	26079696
D010634	Phenobarbital	Phenobarbital results in decreased expression of ANKRD11 mRNA	23091169
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of ANKRD11 mRNA	21061450
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ANKRD11 mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in decreased expression of ANKRD11 mRNA	23557933
D011137	Polystyrenes	Polystyrenes results in increased expression of ANKRD11 mRNA	25102311
D012834	Silver	Silver results in increased expression of ANKRD11 mRNA	26014281
C017947	sodium arsenite	sodium arsenite affects the methylation of ANKRD11 gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of ANKRD11 mRNA	20020861
C017947	sodium arsenite	sodium arsenite results in decreased expression of ANKRD11 mRNA	21297353
D013467	Sulindac	Sulindac results in increased expression of ANKRD11 mRNA	11906190
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of ANKRD11 mRNA"	26680231
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ANKRD11 mRNA	20055451
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ANKRD11 mRNA	26377647
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANKRD11 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased expression of ANKRD11 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ANKRD11 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of ANKRD11 gene	26756918
C483909	torcetrapib	torcetrapib results in increased expression of ANKRD11 mRNA	23228038
C057693	troglitazone	troglitazone results in decreased expression of ANKRD11 mRNA	28973697
D014520	Urethane	Urethane results in increased expression of ANKRD11 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of ANKRD11 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased methylation of ANKRD11 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of ANKRD11 gene	25560391
D014800	Vitallium	Vitallium analog results in increased expression of ANKRD11 mRNA	23825117
D024483	Vitamin K 3	Vitamin K 3 affects the expression of ANKRD11 mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of ANKRD11 mRNA	27188386
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of ANKRD11 mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001894	tissue homeostasis	-	IEA	-
GO:0009653	anatomical structure morphogenesis	-	IBA	21873635
GO:0035264	multicellular organism growth	-	IEA	-
GO:0042475	odontogenesis of dentin-containing tooth	-	IMP	21782149
GO:0048705	skeletal system morphogenesis	-	IMP	21782149
GO:0060325	face morphogenesis	-	IMP	21782149
GO:0060348	bone development	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	21782149
GO:0005654	nucleoplasm	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26756918	Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. (2016 Jul)	Zhu X	Environ Health Perspect
27903268	Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). (2016 Dec 1)	Chi GC	Environ Health